Comparison of Group A, B and C Rotaviral Gastroenteritis among Children in Korea: Prevalence and Clinical Features

배길성,배우리,김지훈,빈중현,김현희,이희진,이원배 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.2

Purpose: The aim of this study is that the prevalence of rotavirus infection was evaluated by each group and clinical featuresof group A, B and C rotaviruses infections were described respectively to compare one with another. Methods: Between January 2010 and December 2010, we enrolled a group of children below 10 years of age admittedfor management of acute diarrhea at the Catholic University of Korea Bucheon St. Mary's Hospital. A total of 310 stoolsamples documented to be free of common bacterial pathogens were collected from children with diarrhea. The presenceof group A, B or C rotavirus is indicated by amplification of DNA segments of the expected lengths after the first andsecond PCRsResults: In a total of 310 stool specimens, 40 (12.9%) specimens were positive for rotaviruses. These included 23 (7.4%)positive for group A, 5 (1.6%) for group B and 12 (3.9%) for group C rotaviruses. Group B rotavirus infected patients hadsignificantly less diarrheas per day (group A: P =0.01, group C: P =0.01) and shorter duration of vomiting days (group A:P =0.03, group C: P =0.03) than those with group A and C rotaviruses infection respectively. All the group B rotaviruseshad been isolated in March and October. Group C rotavirus infections were prevalent during late summer and early winterand peaked in October. Conclusion: These findings indicate that group B and C rotaviruses are notable causes or the contributing causes of diarrheaamong infants and children in Korea.

만성 B형 간염 소아청소년 환자에서의 라미부딘 치료 효과

최유정,배길성,김기환,고대균,김종현,Choi, Yujung,Bae, Kil Seoung,Kim, Ki Hwan,Koh, Dae Kyun,Kim, Jong-Hyun 대한소아감염학회 2018 Pediatric Infection and Vaccine Vol.25 No.2

목적: 만성 B형 간염으로 치료가 필요하였던 소아청소년 중 lamivudine을 투여하면서 전향적으로 관찰한 자료를 검토하여 약제에 대한 치료 효과를 파악하고자 하였다. 방법: 2003년 6월 1일부터 2015년 10월 30일까지 가톨릭대학교 성빈센트병원 소아청소년과를 방문하여 만성 B형 간염의 첫 치료로 lamivudine (3 mg/kg, 최대 100 mg)을 3개월 이상 투여한 55명을 대상으로 하였다. 약제 투여 후 1개월, 3개월째, 이후는 매 3개월마다 B형 간염 바이러스(hepatitis B virus [HBV]) 표지자, HBV-DNA, 간기능을 추적하였다. 치료 중단은 alanine aminotransferase (ALT) 정상, HBeAg 음성 및 anti-HBe 양성 결과가 처음 발견된 시기로부터 12개월 후로 정하였다. 결과: 연구군은 남자가 31명(56.4%), 여자가 24명(43.6%)이었고, 약제의 첫 투여 연령은 평균 8.1세, 투여기간은 평균 23.4개월이었다. ALT 정상화는 98.2% (54/55), HBeAg 양성에서 anti-HBe 양성으로의 혈청 전환은 70.6% (36/51), HBsAg 소실은 10.9% (6/55)에서 이루어졌는데 모두 7세 미만 연령이었다. 약제 투여 6개월 시 HBV-DNA <2,000 IU/mL 바이러스 반응은 78.7% (37/47)이었고, 약제 중단 12개월 후에도 바이러스 반응이 유지되는 경우는 87.2% (34/39)이었다. Lamivudine 약제 내성이 발현된 경우는 16.4% (9/55)이었다. 결론: 만성 B형 간염을 가진 국내 소아청소년에 대한 lamivudine의 치료 효과는 유사한 외국 연구 결과에 비해 더 우수하였다. 새로 권고되고 있는 다른 항바이러스제 치료에 대한 국내에서의 지속적인 연구도 필요할 것으로 판단된다.

소아의 기도 내 이물 흡인 48예: 임상 증상 및 경과

강성희 ( Sung Hee Kang ),배길성 ( Kil Seong Bae ),방경원 ( Kyung Won Bang ),김환수 ( Hwan Soo Kim ),전윤홍 ( Yoon Hong Chun ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.2

Purpose: This study aimed to have a deeper insight into the clinical spectrum of foreign body aspiration in children and to prospect the further clinical implications of early diagnosis. Methods: We conducted a retrospective medical chart review of 48 children with foreign bodies at The Catholic University of Korea, Seoul St. Mary`s Hospital, between January 2009 and December 2013 in terms of age, sex, symptoms and signs, radiologic findings, and clinical courses. Patients were divided into 2 groups according to the time from aspiration to a definite diagnosis. The 2 groups were compared for clinical courses, radiologic findings, and the length of hospitalization. Results: Approximately 85% of patients were 3 years of age or younger. About one-fifth of patients had no history of foreign body aspiration. Cough and coarse breathing sounds were the most common symptoms and signs. The most frequent radiologic finding was pulmonary air trapping (33.3%). The mostly commonly aspirated foreign body was peanut and detected in left main bronchus. Cough, sputum, and absence of aspiration history were more common in the delayed diagnosed group than in the early diagnosed group. Conclusion: Our results suggest that the number of accidents associated with foreign body aspiration can be reduced by keeping infants with nut formula under close observation and by conducting assertive bronchoscopic examination on children with delayed recovery from respiratory infections. After removal of foreign bodies, close monitoring and expectation of possible complications can prevent patients from a long hospital stay. (Allergy Asthma Respir Dis 2016;4:107-113)

천명이 있는 소아에서 인터페론-감마 유도 단백질 10 kDa의 임상적 특성

김범준 ( Beom Joon Kim ),배길성 ( Kil Seong Bae ),김환수 ( Hwan Soo Kim ),전윤홍 ( Yoon Hong Chun ),윤종서 ( Jong-seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.3

Purpose: Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it correlates with other clinical variables. Methods: A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emergency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent assay in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray findings. Results: Age showed a significant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also significantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no significant difference in the serum IP-10 level according to the other factors, including allergic sensitization. Conclusion: Serum IP-10 is significantly associated with inflammation of the lung and age, but not with allergic inflammation. (Allergy Asthma Respir Dis 2016;4:174-180)

Community-acquired Escherichia coli Enteritis in Korean Children: The Clinical Application of a Stool Polymerase Chain Reaction Assay

김유이,김효진,임수연,배길성,한승범,정대철,강진한,신국재,이건동,박연준 대한감염학회 2017 Infection and Chemotherapy Vol.49 No.4

Background: Although Escherichia coli is a common cause of bacterial enteritis in Korea, reports on community-acquired E. coli enteritis in Korean children are scarce. This study aimed to determine the clinical characteristics and pathotype distribution of community- acquired E. coli enteritis diagnosed by a multiplex polymerase chain reaction (PCR) assay in Korean children. Materials and Methods: The medical records of children aged 18 years or less who were diagnosed with acute gastroenteritis by the attending physician between 2013 and 2016 were retrospectively reviewed. The clinical characteristics of children diagnosed with E. coli enteritis were investigated and compared with those diagnosed with Salmonella enteritis. E. coli and Salmonella infections were diagnosed by a stool PCR assay. Results: Among 279 children, in whom PCR assays for E. coli and Salmonella spp. were performed, Salmonella enteritis and E. coli enteritis were diagnosed in 43 (15.4%) and 39 (14.0%) children, respectively. Among the 39 children with E. coli enteritis, enteropathogenic E. coli (n=21, 53.8%) and enteroaggregative E. coli (n=15, 38.4%) were the most common causative agents. Empirical antibiotics were administered to 33 (84.6%) children. A total of 31 (79.5%) children developed fever, and 25 (80.6%) of them had the fever for 3 days or less, which resolved a median of 1 day (range 0-3 days) after hospitalization. The most frequent gastrointestinal symptom was diarrhea (n=36, 92.3%). Significantly more children with E. coli enteritis were aged 2 years or less as compared with those with Salmonella enteritis (41.0% vs. 21.9%, P = 0.021). Children with Salmonella enteritis more frequently complained of fever (97.7% vs. 79.5%, P = 0.012), abdominal pain (90.7% vs. 64.1%, P = 0.004), and hematochezia (46.5% vs. 10.3%, P <0.001) than those with E. coli enteritis. Erythrocyte sedimentation rate and C-reactive protein levels were significantly higher in children with Salmonella enteritis than those with E. coli enteritis (P <0.001). Conclusion: Enteropathogenic E. coli was the most frequent pathotype in Korean children with E. coli enteritis that caused mild clinical symptoms. A stool PCR assay for E. coli may be useful for epidemiological purpose and for an early diagnosis of E. coli enteritis.