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Recent Trends (1991-2010) of Metastatic Skin Cancers in Korea
방철환,배정민,김혜성,김경문,유동수,박현정,오신택,강훈,박철종,이정덕,이준영,김형옥,박영민 대한의학회 2013 Journal of Korean medical science Vol.28 No.7
The incidence of overall cancer has increased over time. The incidence of top-ranking cancers has changed in the 1990s and the 2000s. However, few studies have evaluated the trends in metastatic skin cancers during this period. We evaluated the recent trends in incidence, peak age and location of metastatic skin cancers from 1991 to 2010. This 20-yr survey was divided into two decades to determine the trends by comparing the statistics. Out of 694,466 outpatients (1991-2010), 174 (0.025%) were diagnosed with metastatic skin cancer. The incidence of metastatic skin cancer increased significantly from 20.64 per 100,000 outpatients in the 1990s to 28.70 per 100,000 outpatients in the 2000s (P = 0.030). The peak age of skin metastasis shifted from the 40s to the 50s in women,and from the 50s to the 60s in men. The percentage of metastatic skin cancers originating from intra-abdominal organs increased from 10% in the 1990s to 23.1% in the 2000s (P = 0.027). The percentage of metastatic skin cancers located on the abdomen increased from 7.1% in the 1990s to 15.4% in the 2000s (P = 0.011). The higher proportion of metastatic skin cancers located on the abdomen may be related to the increase in skin metastases from intra-abdominal organs.
Non-familial Acrokeratosis Verruciformis of Hopf
방철환,김혜성,박영민,김형옥,이준영 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Acrokeratosis verruciformis of Hopf is a rare genodermatosis with an autosomal dominant mode of inheritance. It is a disorder of keratinization, characterized by multiple, flattopped,skin-colored keratotic lesions resembling plane warts typically observed on the dorsum of the hands and feet. Histopathologically, the lesion shows considerable hyperkeratosis,acanthosis, and papillomatosis, mimicking a “church spire”, and a thickened granular layer. It arises in early life,often at birth or infancy. Herein, we report on a rare sporadic case of acrokeratosis verruciformis of Hopf. A 44-year-old Caucasian man presented with multiple, grouped, hyperkeratotic,whitish, flat papules on his shins and feet, which had been present for more than one year. Histopathological examination showed typical findings of acrokeratosis verruciformis of Hopf. Our case is unique in that the patient had no familial history of similar skin lesions. (Ann Dermatol 23(S1) S61∼S63, 2011)
측면형과 다른 임상형의 원위외측손발톱밑 손발톱진균증의 치료효과의 차이에 대한 연구
방철환,조백기,이영복,박현정 대한의진균학회 2011 대한의진균학회지 Vol.16 No.4
Background: Onychomycosis is a common fungal infection accounting for 50% of all nail disorders. Above all the clinical types of onychomycosis, distal and lateral subungual onychomycosis (DLSO) is the most common clinical type seen up to 70~90% in onychomycosis patients. Even though the cure rate and recurrence rate of DLSO are considered to be different according to the clinical type of DLSO. Clinical experience, there is a few clinical study showing the difference. Objectives: This is to investigate the therapeutic efficacy of lateral type of DLSO comparing with the other types of DLSO. Methods: We reviewed 81 DLSO cases who visited our clinic from June 1st, 2006 to June 31st, 2010,and classified them into 2 groups; lateral type and non-lateral types including edge, distal and linear type. We treated the patients with oral antifungal agent for 4 months, and followed them up in 2 months. Scoring clinical index for onychomycosis (SCIO) was checked and photography was taken before treatment and after treatment. Results: There are no significant differences in average age and male to female ratio between lateral DLSO and non-lateral DLSO. The comparison of SCIO score distribution before treatment between lateral DLSO and non-lateral DLSO showed no significant statistical difference. However, there was significant change in SCIO score distribution after the treatment. Decreased SCIO score in lateral DLSO was 6.99, while non-lateral DLSO was 11.1 (p=0.018). There was 2cases worsen cases in lateral DLSO, while there was no worsen case in non-lateral DLSO (p=0.019). Conclusion: Lateral DLSO is more difficult to treat than non-lateral DLSO.