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An Unusual Juvenile Xanthogranulomaon a Finger MCP Joint
차상희,조상현,이정덕 대한피부과학회 2008 Annals of Dermatology Vol.20 No.4
Juvenile xanthogranuloma (JXG) is a benign self-limited histiocytic proliferative disorder that usually occurs in early childhood. JXG appears as reddish to yellow, papules, or nodules, and although the head, neck, and trunk are the most frequent locations, it can occur at any body site. However, JXG involving the finger is rare. Histologically, JXG is characterized by an ill-defined, unencapsulated, dense histiocytic infiltrate within the dermis, some of which is contained in Touton giant cells, foreign body giant cells and foamy cells. Because the cutaneous lesions spontaneously regress, treatment is not usually indicated. The authors report a case of JXG in a 4-year-old girl who had tender, yellowish papule on the ventral aspect of the MCP joint of the right fourth finger consistent with JXG. (Ann Dermatol(Seoul) 20(4) 200∼203, 2008) Juvenile xanthogranuloma (JXG) is a benign self-limited histiocytic proliferative disorder that usually occurs in early childhood. JXG appears as reddish to yellow, papules, or nodules, and although the head, neck, and trunk are the most frequent locations, it can occur at any body site. However, JXG involving the finger is rare. Histologically, JXG is characterized by an ill-defined, unencapsulated, dense histiocytic infiltrate within the dermis, some of which is contained in Touton giant cells, foreign body giant cells and foamy cells. Because the cutaneous lesions spontaneously regress, treatment is not usually indicated. The authors report a case of JXG in a 4-year-old girl who had tender, yellowish papule on the ventral aspect of the MCP joint of the right fourth finger consistent with JXG. (Ann Dermatol(Seoul) 20(4) 200∼203, 2008)
차상희 ( Sang Hee Cha ),조상현 ( Sang Hyun Cho ),이제훈 ( Je Hoon Lee ),박철종 ( Chul Jong Park ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.1
Backgroud: Herpes zoster is caused by the reactivation of varicella zoster virus. Many factors are involved in the reactivation of viruses, but most of them are unknown, except for immunosuppression and old age. A relationship between an increased level of total serum IgE and viral infection has been observed in a few previous studies. Objective: The purpose of this study was to evaluate the quantitative changes, as well as the role of the total serum IgE, in patients suffering with herpes zoster. Methods: We retrospectively reviewed the medical records and laboratory data of 205 patients with herpes zoster. We evaluated the clinical findings such as the affected dermatomes, the duration of illness and the persistence of herpes zoster-associated pain. The relationships of the clinical findings and the level of total serum IgE, which was measured by competitive chemiluminescence immunoassay, were also evaluated. Results: The level of total serum IgE was elevated in 95 (46.3%) of 205 patients with herpes zoster and who did not have any medical history that would influence the level of total serum IgE. The amount of elevation of the total serum IgE was higher in the younger patient group than that in the older patient group. However, there were no statistically significant relationships between the level of total serum IgE and the clinical features. Conclusion: The level of total serum IgE in patients with herpes zoster was increased to more than the normal level. This may contribute to an overt defect of the cellular immune system in patients with herpes zoster. (Korean J Dermatol 2009;47(1):50~54)