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子宮頸癌組織의 Carcinoembryonic Antigen에 對한 免疫酵素組織學的 硏究
朴欽禮,李大一,白承龍 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3
Carcinoembryonic antigen is relaeased by tumor cell of various orgins, as well as by inflammatory and hypertrophic lesions, and pressence has been demonstrated by radiommunoassay of plasma or immunohistologic reaction of the tumor tissue. Uterine cervical cancer which is the most common malignnant tumor among Korean women is also reported that it shows elevationed plasma CEA level in some cases and its cellular CEA can be demonstrated by immunoenzyme histologic method. However, there are only few report on pattern of distribution of CEA in each histologic type or age group. The author collected 79 cases of alcohol fixed, paraffin embedded uterine cervical cancer specimens and performed immunoenzyme histological stain using hourseradish peroxidase conjugated rabbit antihuman CEA antibody and analyzed their reaction pattern by histologic types and age groups. The results obtained are as following: 1. Among 79 cases of uterine cervical carcinoma, 64 cases (81.0%) revealed positive reaction to anti-CEA. 2. Uterine cervical carcinoma showing positive reaction to anti-CEA could be classifed into two patterns, diffuse and focal, which their ratio of 2 to 1. 3. Incidence of positive reaction ti anti-CEA in 46 cases of keratinizing squamous cell carcinoma and 30 cases of non keratinizing sqaumous cell carcinoma were 78.3% and 83.4% respectively and their ratio of diffuse to focal pattern was 2 to 1. 4. Each one case of undifferentiated carcinoma, adenocarcinoma and adenosquamous carcinoma of uterine cervix revealed positive reaction in diffuse pattern. 5. There was no difference in incidence of positive reaction by age group between age of 31 to 70. 6. The cases showing diffuse positive reaction were noted between age of 31 to 80 and focal positive reaction were noted between age of 21 to 60. Above results show that about 80% of uterine cervical carcinomas of occuring in Korean woman are CEA positive in cellular level, bearing diffuse or focal positive reaction, and reveal no significant difference in positivity or reaction pattern by histologic type of the tumor or age group of patients.
박흠례(Heum Rea Park),최덕주(Duck Joo Choi),박현철(Hyun Chul Park),박종재(Jong Jae Park),이성광(Sung Kwang Lee),강동훈(Dong Hoon Kang),김주현(Ju Hyun Kim),김득조(Duk Jo Kim),오수용(Soo Yong Oh),강영숙(Young Sook Kang),이정남(Jong Nam 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1
Hepatocellular carcinoma in pregnancy is very rare. Because it is associated with high maternal and fetal rnortality, the risk group of developing hepatocellular carcinoma in pregnant women must be closely monitored. The risk group includes pregnant women who are HBsAg carriers with cirrhosis, long term users of oral contraceptives, and who have a history of multiparity. An elevated a fetoprotein(AFP) level is useful for the diagnosis. The risk group should be closely monitered with a careful physical examination and AFP measurement. Then hepatocellular carcinoma can be detected at an early stage. We have experienced a case of hepatocellular carcinoma in a pregnant woman with an elevated AFP level who was an user of oral contraceptives and had a history of multiparity. It was confirmed by operation and histologic examination. (Korean J Gastroenterol 1997;30:126-130)
최유덕,박흠례,방보영,권현정,추욱진,하승연,박성혜 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
Tuberculosis of the vulva is very rare and is of interest because it clinically may resemble carcinoma which should be ruled out in the differential diagnosis of the indurated ulcerating lesion of the vulva. We experienced a case of tuberculosis of the vulva and report with a brief review of literature.
김득순,박흠례,이명임,전우식,우연숙 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.5
저자들은 최근 본원 산부인과에서 희귀하게 보고되는 난소 성기삭 종양과 유사한 자궁종양 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Uterine tumors with ovarian sex-cord like differentiation are composed predominantly or entirely of tubular epithelial-like structures. They wre probably of endometrial stromal differentiation because similar epithelial-like nests can be found in otherwise characteristic endometrial stromal tumors. Most of the patients in whom the tumors occurred were in the fifth decade of life. It has been suggested that the plexiform tumor is a type of epithelioid leiomyoma, but it also has some similarity to the uterine sex cord-like tumors, since both are composed of epithelial-like cords set within a fibrillar stroma. Because of the rarity of the tumor and its uncertain histogenesis, the case report of a patient with uterine tumor resembling ovarian sec-cord tumor is summarized and present with a brief review of its literature.
흉추에서 발생한 척삭종의 세포학적 및 조직학적 소견 - 1예 보고 -
하승연,김인선,박성혜,박흠례,Ha, Seung-Yeon,Kim, In-Sun,Park, Sung-Hye,Park, Heum-Rye 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Chordoma is relatively uncommon tumor comprising $1\sim4%$ of primary malignant bone tumors, and believed to arise from the remnants of notochordal tissue. Because of its rare occurrence in the thoracic spine, we report a case of chordoma involving the thoracic spine. A 45-year-old male was sufferred from chest pain radiating to the back. Chest CT showed a well marginated, round huge mass with multiseptated enhancement at the thoracic spine from T5 to T8 level. After percutaneous needle aspiration, piecemeal resection of the tumor was done. On cytologic smears, two types of neoplastic cells were arranged in sheets and cords in mucinous background. One type of cells consisted of medium sized cells with pink cytoplasm and round nuclei. The other type had voluminous bubbly or clear cytoplasm divided by intracytoplasmic septae imparting a feathery or basket-like appearance. Histologically, the tumor showed lobulated feature divided by fibrous septae and the tumor cells were pink eosinophilic or physaliphorous in morphology. Immunohistochemically, the tumor cells revealed strong positivity for low(AE1) and high (AE3) molecular weight cytokeratins.