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Illite 분제 원액의 육모 활성 시험 및 단회 투여 경구 독성시험
이충재(Choong Jae Lee),박형섭(Hyung Sup Park),임동술(Dong Sool Yim),김박광(Bak Kwang Kim),정재훈(Jae Hoon Cheong) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.4
N/A The hair-growth effect of Illite was suggested by some people who were using Illite as a beautifying material. We investigated the hair-growth effect of Illite powder. The hair-growth effects were investigated by two methods; the activity of hair-growth after shaving the hairs on the black mouse (C57BL/6) and the recovery activity of hair-growth after hair-loss induced by cyclophosphamide treatment. Suspension of Illite powder was applied to the back of the black mouse by method of skin paste. Illite promoted significantly the hair growth of mouse in both conditions of shaving and hair-loss. And then we investigated the toxicity which may be induced by Illite when it was administrated orally as a single dose. We could not find out any significant toxicity induced by single dose oral administration of Illite.
노환성,김운자,박건구,조영환,박형섭,Ro, Hwan-Seong,Kim, Oon-Ja,Park, Kun-Ku,Cho, Young-Hwan,Park, Hyung-Sup 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4
Development of hyperlipidemic animal model is prerequisite for the screening of drugs lowering the blood lipoprotein level. In this study, two kinds of diet regimens were tried for the hyperlipidemic effect. The model will be used for the screening of current prescriptions to a variety of diseases related to hyperlipidemia by practioner of traditional herbal medicine. Fifteen male Wister rats of 200g were divided into three groups, and given normal, or either one of the two high cholesterol diets for up to 2 weeks. Regimen HC-1 and regimen HC-2 contained I% and 2% cholesterol in diet, respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and lower density lipoprotein cholesterol (LDL) levels in the serum were measured before the start of the diet, at 1 week after the start, and at 2 week point. Both regimens resulted in hyperlipidemia with the typical characteristics of increase in TC and LDL, and reduction in HDL, and showed no observable side effects such as diarrhea. In conclusion, both of HC-1 and HC-2 regimens appeared appropriate as diet regimens for the hyperlipidemic rat model.
고지혈증 랫트를 이용한 수종 전통 한약제의 항고지혈 효과
노환성,고우경,김운자,박건구,조영환,박형섭,Ro, Hwan-Seong,Ko, Woo-Kyoung,Kim, Oon-Ja,Park, Kun-Koo,Cho, Young-Hwan,Park, Hyung-Sup 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4
Three herbal medicine recipes were tried on the animal model of diet induced hypercholesterolemia to screen for the lipid-lowering effect. The recipes adopted were based on the prescription for atherosclerosis-related symptoms by folk-medicine practioners. Hyperlipidemia was induced in rats by giving the high lipid/cholesterol diet for 7 days. Then, the recipes started with the normal diet. Blood was sampled at 1,2,3 and 5 week-points of the treatment, and levels of total cholesterol, triglyceride, high density lipoprotein and lower density lipoprotein were measured. Dae-shiho-tang decreased total cholesterol level significantly. Hwangryun-haedok-tang and Samhwang-sasim-tang slightly decreased total cholesterol level, although it was not statistically significant.
고지혈증 랫트를 이용한 시호 , 작약 , 조구등의 항고지혈 효과
노환성(Hwan Seong Ro),고우영(Woo Kyoung Ko),박건구(Kun Koo Park),조영환(Young Hwan Cho),박형섭(Hyung Sup Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1
Effects of Bupleuri Radix, Paeoniae Radix or Uncariae Ramulus et Uncus on experimental hyperlipidemia were studied. Hyperlipidemia was induced on male Wistar rats by feeding them on high cholesterol diet for one week, as previously described by the authors. Blood lipid profile was varified on these rats by measuring total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL) and low density lipoprotein cholesterol(LDL). Then, the rats were followed by feeding normal diet. At the same time, methanol extracts of the three individual herb medicines were orally administered to the rats for 4 weeks and the parameters above mentioned were monitered. Methanol extract of Bupleuri Radix reduced the TC value significantly at 2 week point and Paeoniae Radix reduced the TC value at 4 week point in compare to control group, suggesting the antihyperlipidemic effect of the two herbal medicines in vivo. The extract of Uncariae Ramulus et Uncus however did not show antihyperlipidemic effect in our experiment.
노환성,양현옥,김재연,조영환,박형섭 한국병원약사회 2001 병원약사회지 Vol.18 No.4
In our previous report, the water extract of Bupleuri radix showed the lowering effect of total cholesterol level in the experimentally induced hyperlipidemic rats. In order to elucidate the active ingredient(s), the water extract were dialyzed, ad two fractions, high molecule fraction and low molecule fraction, were obtained. These two fractions were tested on the experimentally induced hyperlipidemia in rats for lowering effect of serum lipoprotein contents. Hyperlipidemia was induced on male Wistar rats by feeding high cholesterol diet for 7 days. After oral administration of above samples for 4 weeks, serum lipids profile was monitored by measuring total cholesterol, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol level. Low molecule fraction decreased total cholesterol and triglyceride levels significantly (p<0.05) at 4 week point when they were compared with the control group.
고지혈증 랫트를 이용한 수종 전통 한약제의 항고지혈 효과
조영환,노환성,김운자,박형섭,고우경,박건구 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4
Three herbal medicine recipes were tried on the animal model of diet induced hypercholesterolemia to screen for the lipid-lowering effect. The recipes adopted were based on the prescription for atherosclerosis-related symptoms by folk-medicine practioners. Hyperlipidemia was induced in rats by giving the high lipid/cholesterol diet for 7 days. Then, the recipes started with the normal diet. Blood was sampled at 1,2,3 and 5 week-points of the treatment, and levels of total cholesterol, triglyceride, high density lipoprotein and lower density lipoprotein were measured. Dae-shiho-tang decreased total cholesterol level significantly. Hwangryun-haedok-tang and Samhwang-sasim-tang slightly decreased total cholesterol level, although it was not statistically significant.
조영환,노환성,김운자,박건구,박형섭 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4
Development of hyperlipidemic animal model is prerequisite for the screening of drugs lowering the blood lipoprotein level. In this study, two kinds of diet regimens were tried for the hyperlipidemic effect. The model will be used for the screening of current prescriptions to a variety of diseases related to hyperlipidemia by practioner of traditional herbal medicine. Fifteen male Wister rats of 200 g were divided into three groups, and given normal, or either one of the two high cholesterol diets for up to 2 weeks. Regimen HC-1 and regimen HC-2 contained 1% and 2% cholesterol in diet, respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and lower density lipoprotein cholesterol (LDL) levels in the serum were measured before the start of the diet, at 1 week after the start, and at 2 week point. Both regimens resulted in hyperlipidemia with the typical characteristics of increase in TC and LDL, and reduction in HDL, and showed no observable side effects such as diarrhea. In conclusion, both of HC-1 and HC-2 regimens appeared appropriate as diet regimens for the hyperlipidemic rat model.