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      • KCI등재

        고급지방산 메틸 에스테르류의 합성 및 소포특성

        박종권,김아람,황준배,정노희,Park, Jong-Kwon,Kim, A-Ram,Hwang, Jun-Bae,Jeong, Noh-Hee 한국응용과학기술학회 2015 한국응용과학기술학회지 Vol.32 No.1

        고급지방산 메틸 에스테르류의 소포제를 합성하고 FT-IR과 $^1H-NMR$ 분석을 통해 확인하였다. FT-IR을 이용하여 합성된 물질의 특징인 -C=O기는 $1740cm^{-1}$ 부근에서, 그리고 C-O기는 $1175cm^{-1}$ 피크 값을 가지는 것을 확인하였다. 또한 $^1H-NMR$ 분석을 통해 에스테르의 -C=O의 Chemical shift가 2.29 ppm에서 나타나는 것을 확인하였다. 표면장력은 Surface Tensiometer CBVP-43을 이용하여 측정하였다. 표면장력은 17.7에서 21 dyne/cm 값을 가진다. SLS 수용액에서의 소포능은 Ross-Miles법을 통해 측정되었다. 4종류의 소포제 중 소포능은 스테아르산메틸을 이용하여 제조한 소포제가 가장 뛰어난 것으로 측정됐다. In this study, anti-foaming agents of a fatty acid methyl esters was synthesized and confirmed by FT-IR and $^1H-NMR$ spectroscopy. Synthesized material of characteristic of -C=O group having a $1740cm^{-1}$ and -C-O group $1175cm^{-1}$ peak by using FT-IR, and it was confirmed that k. Surface tensions were measured by surface tensiometer CBVP-43. Their surface tension values was 17.7 to 21 dyne/cm. Anti-foaming abilities in the SLS solution was measured through the Ross-Miles method. Performance of the 4 type of anti-foaming agent was determined and the best anti-foaming agent was prepared using stearic acid methyl.

      • 얇은 막 수화법을 이용한 리포좀의 제조 및 물성

        박종권 ( Jong Kwon Park ),정현욱 ( Hyeon Wook Jeong ),정노희 ( Noh Hee Jeong ) 충북대학교 산업과학기술연구소 2014 산업과학기술연구 논문집 Vol.28 No.1

        Liposomes has a number of advantages activation, targeting a good compatibility. low toxicity, the immune system activation, so that research in Drug Delivery System is active. However, Liposomes have a number of problems like low emulsion stability, low encapsulation efficiency of the active ingredient and the structure by the external environment like pH, salt, a surfactant, is destroyed easily. This study have prepared liposomes and examined the changes in encapsulation efficiency according to the molar ration of the phosphatidylcholin and surfactant i have prepared liposome in mixture of cationic surfactant CTAB and phosphatidylcholine by the molar ratio of 90:1 from 60:1 This study have prepared liposome in mixture of nonionic surfactant NP-POE(9) and phosphatidylcholine by the molar ratio of 9:1 from 6:1 As a result. liposomes prepared with phosphatidylcholine alone showed a encapsulation efficiency of 67.40%. Encapsulation efficiency of liposomes mixed CTAB at a molar ratio of 90:1 showed the highest encapsulation efficiency 89.08%. Encapsulation efficiency of liposomes mixed NP-POE(9) at a molar ratio of 9:1 showed 66.56%.

      • KCI등재
      • KCI등재

        서울의 오피스빌딩 시장에서 자본자산가격결정모형(CAPM) 의 적용가능성

        박종권(Park, Jong-Kwon),전재범(Jun, Jae-Bum) 대한건축학회 2015 대한건축학회논문집 Vol.31 No.8

        This research aims to find out the impact of systematic risk on risk-premium and understand if CAPM (Capital Asset Pricing Model) is applicable to office building market at Seoul city in South Korea. In light of this notion, this research, specifically, considers four different office building markets in Seoul city area, called GBD(Gangnam Business District), YBD(Yeouido Business District), CBD(Central Business District), and Other Business District, to figure out whether there exists any positive-linearity between systematic risk and risk-premium for each business district. Afterward, this research seeks to verify applicability of CAPM to four office building markets based upon Black, Jensen, and Scholes(1972)"s statistical method. Finally, the results show some meaningful findings that there is positive linear-relationship between systematic risk and risk-premium in all business districts apart from YBD, which means capital-asset could be fairly priced in GBD, CBD, and other Business District, and that the applicability of CAPM should be only taken into account in Other Business District.

      • KCI등재
      • KCI등재

        생쥐에서 간문맥수혈에 의한 췌장도세포동종이식 후 이식생존율의 향상

        박종권(Jong Kwon Park) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.6

        Purpose: Considering the complications of nonspecific immunosuppression, as well as the availability of insulin, heavy immunosuppressive treatment to pancreatic islet transplantation patients is not justified. Antigen administration via the portal vein has been demonstrated to induce immunosuppression, and may present a possible mechanism for the induction of tolerance. Using a mouse model, without any immunosuppressive treatment, the islet allograft survivals were compared between portal venous transfusion and portal venous saline injection groups. Methods: Six C57BL/6J mice were used as pancreatic islet donors per Balb/c recipient mouse. Islets were harvested by digestion of the pancreata with collagenase, with subsequent Ficoll density gradient separation. Recipient mice were divided into two groups: seven mice received a portal venous injection of 0.1 cc saline (PVS) and eight a portal venous transfusion of 0.1 cc donor blood (PVT). Islets were transplanted into the subcapsular space of the left kidney. Transplantation failure was determined if the transplanted mouse failed to show a blood glucose level less than 200 ㎎/㎗ at 24 hours after the transplantation; these mice were not included in the statistics. Rejection was determined when the normalized blood glucose level (<200 ㎎/㎗) returned to above 300 ㎎/㎗. Results: The mean islet equivalent numbers (IEQ) of the seven PVS and eight PVT mice were 893±262 and 911±288, respectively. The islet allograft survival of the PVS group ranged between 1 to 9 days; whereas, that of the PVT group ranged between 6 to 16 days. The PVT group showed significantly higher islet allograft survival than the PVS group (P=0.0443). Conclusion: A portal venous transfusion prolonged the islet allograft survival.

      • KCI등재

        법률상 성차별 규정의 개정 방향

        박종권 ( Park Jong-kwon ) 한국외국어대학교 법학연구소 2008 외법논집 Vol.31 No.-

        Traditional law was studied on men’s sense of sight, but modern law has focused on sexual equality in every area. This paper aims to examine discrimination clauses on the ground of gender in current laws, and suggests amendment direction. Firstly, it makes clear the ‘standard discrimination’ through examining definitions and measurement of gender discrimination. Secondly, it proposes amendment direction by investigating gender discrimination, particularly in Family Law, Criminal law, welfare/labor-related law, and Affirmative Action. The division of pension right does not take place immediately at the time of divorcement, but later at the time that each couple reaches the pensionable age(60years). Sometime this leads to the negative results that the pension-division right of the women will not to realized if the divorced spouse is disabled or dead on the course of coverage. To recognize the nature of the sexual crime, the objective of the rape need to extend from the woman to the men. So by the same lessen, simply a wife is also to be the objective of the rape, to considerate the relationship of husband and wife. The great reason a sexual crime to be a victim's complaint is a victim's honor and privacy. According to the result the masculine government employee think the feminine government employees has the professionalism in public organization and participating they endeavor devotedly to perform organizational aim. Results show that gender discrimination in the law is involved with assumption that women are the minority in both private and social areas, based on traditional gender division. Such discrimination stems from the perception that women are different from men. Except for biological abilities in women, the protection, which is applied only for women due to social and cultural norms, could enable gender inequality to be fixed. Therefore, the priority of women compared to men should be restricted to biological ability relating to pregnancy and childbirth. To realize gender equality, structural inequality should be eliminated and the definition of equality should be changed.

      • KCI등재

        이혼에 따른 재산분할의 합리적 산정

        박종권 ( Park Jong-kwon ) 한국외국어대학교 법학연구소 2007 외법논집 Vol.26 No.-

        The forms of legislation on Property division are different from country to country, but roughly divided into two forms; one is the legislation giving judges broad discretion about deciding the proportion of property division, and the other the legislation that has fixed rules. They have their own efficiencies and deficiencies, so, more important thing is keeping balance between the two extreme poles. The right of claim for the division of property means that each party, in a divorce suit, claims to the other an appropriate division of the property accumulated during their marital life. In general, this claim is required to recognize the couple’s substantial contribution to the accumulated property, regardless of its being in husband or wife’s name, and guarantee the equality between the sexes during their marital life. The claim for the division of property should be discussed together with the matrimonial property system since they are mutually dependent. In the latter, the common property system makes it possible that the property is appropriately divided for the party according to principles of the equality between the sexes in a divorce suit, whereas the separate property system does not. This claim for the division of property has almost the same effect as the common property system, and is also very useful since it maintains that each party should be responsible for supporting the other who gets into destitution after divorce, but Korea has not. And so, it would be desirable that the claim stipulated in Sub-Sec. 2 of Sec. 839 of the Korean civil law should be adaptable interpreted in terms of general principles of the responsibility for supporting after divorce. Korean Civil Cede has only one article about property division giving judges broad discretion. But before changing the law, we have to arrive the social consensus on equal division and the family courts have starting point of equal division when determining the proportion of property division, and such court decisions be supported by social consensus. Consequently, we have to pursue both the reform of legislation and the social change toward the equal division.

      • KCI등재후보

        Kainic acid에 의해 유발된 경련이 흰쥐 해마의 Nitric Oxide Synthase의 미치는 영향

        박종권(Jong Kwon Park),박 찬(Chan Park),강민정(Min Jeong Kang),강경란(Kyoung Lan Kang),이재룡(Jae Ryong Lee),김정혜(Jung Hye Kim),유진화(Jin Hwa Yoo),허영범(Young Buhm Huh),안희경(Hee Kyoung Ahn) 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.5

        지금까지의 연구에 의하면 kainic acid (KA)-유도 경련은 해마에 존재하는 신경세포를 손상시키고 nitric oxide synthase(NOS)신경세포의 소실을 유발시키는 것으로 알려졌다. 또한 nitric oxide (NO)는 신경세포의 손상을 유발하는 것으로 알려졌다. 따라서 본 연구에서 KA를 흰쥐에게 투여하여 경련을 유발한 다음 6시간, 1일, 3일, 6일 경과 후에 해마에 일어나는 신경세포의 손상과 NOS신경세포의 활성과 발현의 변화를 은 침착법 (silver impregnation), nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) 조직화학 그리고 역전사효소 연쇄반응 (reverse transcriptase-polymerase chain reaction)을 이용하여 분석하였다. 그 결과, 신경세포의 손상은 1일군에서 부터 관찰되었으며, 3일군에서 가장 많은 세포 손상이 관찰되었다. NADPH-d의 염색성은 대조군에 비해 KA를 투여한 실험군에서 통계적으로 유의성 있게 증가하였다. 특히 1일과 3일군에서 강한 염색 성을 보였고, 6일군에서는 염색성이 약해지는 경향을 보였다. 해마의 부위에 따른 NADPH-d 신경세포 수의 변화를 측정한 결과 KA 투여 후 3일군에서 CA1/CA2과 CA3/CA4 부위에서 NADPH-d 신경세포가 통계적으로 유의성 있게 감소하였으 나, 치아이랑 (dentate gyrus)에서는 유의성 있는 변화를 보이지 않았다. 또한 nNOS, iNOS 그리고 eNOS의 mRNA의 발현은 모두 대조군에 비해 KA 투여 후 6시간과 1일군에서 증가하며, 3일군과 6일군에서는 감소하는 경향을 보였다. 이상의 결과에서 경련 발생후 유발되는 신경세포의 손상은 NOS 신경세포의 활성의 증가와 시기적으로 일치하는 것으로 보아 경련에 의한 해마 신경세포의 손상에 NOS 관여하는 것으로 생각되며, NOS의 활성은 mRNA 수준에서 조절되는 것으로 생각된다. We have investigated the neural cell damage and the change in the expression of NOS in the rat hippocampus, one of the brain structures most vulnerable to seizures. Rats were injected with kainic acid (KA) and sacrificed 6 h, 1 d, 3 d and 6 d after KA administration. The neural cell damage and the expression pattern of NOS was studied using silver impregnation, NADPH-diaphorase (NADPH-d) histochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analysis. Silver impregnation revealed that kainic acid caused pyramical cell damage which was most severe in the CA1/CA2 subfield and hilus and to a lesser degree in the CA3 region. The optical densities of NADPH-dpositive neurons in the CA1, CA3 and dentate gyrus (DG) regions of the hippocampus were shown to have increased in samples obtained 1 d and 3 d after injection of KA. The number of NADPH-d-positive neurons in the CA1 and CA3 regions of the hippocampus was shown to have decreased in samples obtained 3 d and 6 d after injection of KA. However, the number of NADPH-d-positive neurons in the DG region did not change significantly. The increase in the levels of nNOS, iNOS and eNOS mRNA reached maximal values in samples obtained 1 d after KA treatment. Our findings indicate that the KA-induced seizures induce neural cell damage, increase NOS activity and upregulate the expression of NOS mRNA, which suggests the possibility of a functional role of NOS in bringing about changes in the cells in the hippocampus following seizures.

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