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임창영(Chang Young Lim),김주이(Ju Ee Kim),박국양(Kook Yang Park),이현재(Hyeon Jae Lee),박철현(Chul Hyun Park),현성렬(Sung Youl Hyun),안태훈(Tae Hoon Ahn),하승연(Seung Yeon Ha),조현이(Hyuni Cho),박흠례(Heum Rye Park) 대한흉부외과학회 1997 The Korean Journal of Thoracic and Cardiovascular Vol.30 No.6
N/A Background/Aims: Chemokines play an important role in the recruitment of neutrophil and mono- cyte. Recently, the implication of the cytokines in the ulcerative colitis is increasingly emphasized. The purpose of this study was to explore the profile of the chemokine gene expression in the colonic mucosa in patients with ulcerative colitis, and to quantify cytokine mRNA by way of quantitative reverse transcriptional PCR using synthetic standard RNA. Methods: Total tissue RNA was extracted from colonic biopsies of normal controls(NC, n=10) and patients with ulcerative colitis (n=8) [from active(Uca, n=8) and normal looking mucosa(Ucnlm, n=7) areas]. The chemokines for study were interleukin-8(IL-8), monocyte chemotactic & activating factor(MCAF), and additionally granulocyte macrophage colony stimulating factor(GM-CSF). Detection and quantification of chemokine gene expression were performed by quantitative reverse transcriptional PCR. Results: IL-8 mRNA was detected in 6 from 8 Uca, 3 from 7 Ucnlm, and 3 from 10 NC. MCAF mRNA was detected in 7 from 8 Uca, 3 from 7 Ucnlm, and 1 from 10 NC. GM-CSF mRNA was detected in 1 from 8 Uca, and none from 10 NC. IL-8 and MCAF mRNA expression was increased in the Uca compared to normal controls, and their mRNA expression level was higher in Uca compared to normal controls. Conclusions: These findings sugge.t that the chemokines such as IL-8 and MCAF may play an important role in the pathogenesis of ulcerative colitis. Further studies are demanded to reach a conclusion on whetber highly expressed IL-8 and MCAF in normal looking mucosa of ulcerative colitis could be involved in pathogenesis of UC. (Korean J Gastroenterol 1995;27:394 - 402)