후박(厚朴)과 토후박(土厚朴)의 소장운동에 미치는 영향에 대한 연구

이경진 ( Kyung Jin Lee ),박근용 ( Geun Yong Park ),박규하,류광현 ( Kwang Hyeon Liu ),김태완 ( Tae Wan Kim ),함인혜 ( In Hye Ham ),부영민 ( Young Min Bu ),최호영 ( Ho Young Choi ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.4

Objectives: Magnoliae officinalis Cortex (MOC) has been used in traditional medicine for digestive diseases in Korea, China and Japan. However, Machili thunbergii Cortex (MTC) also has been used as a substitute of MOC in Korea sometimes. Thus, this study was carried out to investigate and compare the effects of MOC and MTC on intestinal motility of isolated small intestinal segments from ICR mouse. Methods: Changes in motility were recorded via isometric transducers connected to a data acquisition system and amplitude, frequency and area under the curve (AUC) of intestinal spontaneous phasic contraction were compared. Results: The MOC extracts (1~30μg/mL) dose-dependently decreased both amplitudes and frequencies of the spontaneous phasic contraction, but not AUC. However, high concentration of MOC (100 μg/mL) evoked tonic contraction. And it was not inhibited by tetrodotoxin, a sodium channel blocker, and nifedipine, a L-type Ca2+ channel antagonist. These results suggested that MOC (100 μg/mL)-induced tonic contraction is not mediated by nerve or L-type Ca2+ channel. On the other hand, the MTC extracts dose-dependently inhibited amplitude and AUC, but not the frequency. Conclusions:Although both MOC and MTC affected intestinal motility, MOC is more effective on intestinal motility than MTC. And MOC has been used as a traditional medicine for a long time but not MTC. Thus, we suggested that MTC should not be used in Korea as a substitute of MOC and MOC might be useful traditional medicine for gastrointestinal disease. The mechanism of MOC is still remained to elucidate.

Evaluation of the Usefulness of the Respiratory Guidance System in the Respiratory Gating Radiation Therapy

이영철,김선명,도경민,박근용,김건오,김영범,Lee, Yeong-Cheol,Kim, Sun-Myung,Do, Gyeong-Min,Park, Geun-Yong,Kim, Gun-Oh,Kim, Young-Bum Korean Society for Radiation Therapy 2012 대한방사선치료학회지 Vol.24 No.2

목 적: 호흡동조방사선치료(Respiratory Gating Radiation Therapy, RGRT)에서 호흡의 안정성은 매우 중요한 인자이다. 이러한 호흡의 안정을 위해 본인의 호흡주기를 직접 확인할 수 있도록 시청각시스템을 이용한 호흡유도시스템을 개발하였고 이의 유용성을 평가하고자 하였다. 대상 및 방법: 2011년 6월부터 2012년 4월까지 본원에서 호흡동조방사선치료를 받은 7명의 환자를 대상으로 시청각시스템을 이용하지 않는 자유호흡을 먼저 측정하고 자체개발한 호흡유도시스템을 이용한 호흡을 측정하였다. 시청각시스템을 이용한 호흡연습 후에는 치료실내에서의 자가호흡과 시청각시스템을 이용한 호흡을 각각 측정하였다. 측정된 데이터는 호흡주기, 호흡함수의 면적을 구하여 표준편차를 구하였으며, 이를 분석하여 치료전후의 호흡변화를 알아 보았다. 결 과: 자유호흡과 오디오 유도시스템, 시청각 유도시스템의 표준편차는 PTP (peak to peak)가 각각 0.343, 0.148, 0.078이다. 호흡주기는 각각 0.645, 0.345, 0.171이며, 호흡함수의 면적은 각각 2.591, 1.008, 0.877로 나타났다. 전체 환자의 CT실과 치료실에서의 차이를 평균한 값은 PTP가 0.425, 호흡주기가 1.566, 호흡면적이 3.671로 측정되었다. 호흡유도시스템 적용전후의 표준편자는 PTP가 0.265, 호흡주기가 0.474, 호흡면적이 1.714의 차이를 나타내었다. 자유호흡과 시청각유도시스템 적용전후의 값을 T-검정한 결과에서는 PTP, 주기, 호흡함수면적에서 각각 P-value 0.035, 0.009, 0.010의 값을 나타냈다. 결 론: 호흡동조방사선치료에서 호흡조절은 치료의 성패를 좌우할 만큼 중요한 인자이다. 자유호흡이나 청각에 의존한 호흡주기 획득에 비해 시청각 호흡유도 시스템을 이용한 경우에 보다 안정적인 호흡을 얻을 수 있었다. 특히, 치료실에서도 같은 시스템을 이용하여 호흡을 조절함으로써 호흡주기의 재현성이 뛰어났다. 이러한 시스템은 호흡불안정에 의한 치료시간의 지연을 줄이고 좀 더 정확하고 정밀한 치료가 가능하게 되었다. Purpose: The respiration is one of the most important factors in respiratory gating radiation therapy (RGRT). We have developed an unique respiratory guidance system using an audio-visual system in order to support and stabilize individual patient's respiration and evaluated the usefulness of this system. Materials and Methods: Seven patients received the RGRT at our clinic from June 2011 to April 2012. After breathing exercise with the audio-visual system, we measured their spontaneous respiration and their respiration with the audio-visual system respectively. With the measured data, we yielded standard deviations by the superficial contents of respiratory cycles and functions, and analyzed them to examine changes in their breathing before and after the therapy. Results: The PTP (peak to peak) of the standard deviations of the free breathing, the audio guidance system, and the respiratory guidance system were 0.343, 0.148, and 0.078 respectively. The respiratory cycles were 0.645, 0.345, and 0.171 respectively and the superficial contents of the respiratory functions were 2.591, 1.008, and 0.877 respectively. The average values of the differences in the standard deviations among the whole patients at the CT room and therapy room were 0.425 for the PTP, 1.566 for the respiratory cycles, and 3.671 for the respiratory superficial contents. As for the standard deviations before and after the application of the PTP respiratory guidance system, that of the PTP was 0.265, that of the respiratory cycles was 0.474, and that of the respiratory superficial contents. The results of t-test of the values before and after free breathing and the audio-visual guidance system showed that the P-value of the PTP was 0.035, that of the cycles 0.009, and that of the respiratory superficial contents 0.010. Conclusion: The respiratory control could be one of the most important factors in the RGRT which determines the success or failure of a treatment. We were able to get more stable breathing with the audio-visual respiratory guidance system than free breathing or breathing with auditory guidance alone. In particular, the above system was excellent at the reproduction of respiratory cycles in care units. Such a system enables to reduce time due to unstable breathing and to perform more precise and detailed treatment.

괴사성 간경변증에서의 골이영양증

조성래(Sung Rae Cho),박경아(Kyung Ah Park),여준기(Joon Kee Yoe),박정모(Chung Mo Park),박근용(Geun Young Park),이인규(In Gyu Lee),허정욱(Jeong Wook Hur),안성훈(Sung Hoon Ahn),박승국(Soong Kook Park) 대한내과학회 1994 대한내과학회지 Vol.47 No.6

N/A Objectives: Patients with chronic liver disease are at increased risk to develop metabolic bone disease. Although the etiology of the osteopathy in patients with primary biliary cirrhosis has not been defined, vitamin D deficiency and calcium malabsorption have been suggested as possible pathogenetic factors. In Korea, Patients with postnecrotic liver cirrhosis due to chronic hepatitis B are numerous, however, data on the prevalence and severity of osteopenia in these patient are rare. This study was performed to elucidate the mechanism of osteopenia and to examine its severity in postnecrotic liver cirrhosis. Methods: Thirty four patients with postnecrotic liver cirrhosis and thirty controls matched in age and sex were included in this study group. To obtain bone mineral density of lumbar spines in postnecrotic liver cirrhosis and control groups, measurements and comparisons of following tests were performed: Dual energy xray absorptimetry, serum calcium, serum osteocalcin, and serum 25 (OH) vitamin D. In addition, initial morning urine sample was collected to measure pyridinoline crosslinks. Results: 1) The average bone density of lumbar spines was 1.03±0.03 gm/cm² in postnecrotic liver cirrhosis group and 1.15±0.02 gm/cm² in normal controls (p<0.01). 2) The prevalence of osteopenia in the lumbar spine was 50% in postnecrotic cirrhotics compaired to 13% in controls. 3) The levels of serum calcium, 25 (OH) vitamin D and serum osteocalcin were 2.12±0.04 mmol/L, 7.38±1.00 ng/ml and 1.92±0.18 ng/ml in postnecrotic liver cirrhosis, 2.54±0.05 mmol/L and 21.68±1.90 ng/ml and 3.31±0.31 ng/ml in control group (p<0.05). 4) The levels of urinary pyridinoline crosslinks in postnecrotic liver cirrhosis and control were 82.87±7.50 nM/mM and 43.48±3.52 nM/mM, respectively (p<0.05). Conclusion: This study suggests that the incidence of lumbar osteopenia is more common in postnecrotic liver cirrhosis patients. In addition, its pathogenesis is related to vitamin D deficiency, decreased osteoblastic activity, and increased osteoclastic activity. Further studies including several hormones and histopathology of bones are needed to clearly define the mechanisms of osteopenia in postnecrotic liver cirrhosis.