운동장애성 소화불량환자에서 위배출과 구강맹장 통과시간에 관한 연구

박승국(Soong Kook Park),황재석(Jae Seok Hwang),강영우(Young Woo Kang) 대한내과학회 1997 대한내과학회지 Vol.52 No.6

N/A Objectives: Although DLFD is the most common subtype of functional dyspepsia in the Orient including Korea, previous studies on gastric emptying in DLFD patients are inconclusive and reports on small bowel transit in these patients are uncommon. This study is to evaluate the occurrence of delayed gastric emptying(GET) and orocecal transit time(OCTT) in DLFD patients.' Methods: 98 DLFD patients without organic disease including diabetes (M:F=23:75, Mean Age=43.1(23-69)) and 67 normal subjects (20 for GET and 47 for OCTT, Mean Age=39.9(25-69)) without gastrointestinal problems were recruited. Solid phase gastric emptying was assessed by radionuclide scintigraphy using ADAC dual head gamma camera after ingestion of 99mTc labeled 425 calorie solid meal. OCTT was determined by the measuring exhaled hydrogen every 10 minutes for 3 hours after ingestion of 60.5 calorie potato soap with 20gm lactulose. OCTT was defined by the time interval between test meal to sustained increase in exhaled breath hydrogen by 10ppm above baseline. A delayed GET was defined as T1/2 above the mean value plus 1 SD of controls (74.6±17.6 min, M±SD) and a delayed OCTT as time exceeding the mean value plus 2 SD(81.9±13.3 min, MSD). Results: Among the 98 DLFD patients, only 7(7.1%) patients had a delayed GET(66.04±16.1 min vs 74.6±17.6 min, p=0.14) while a delayed OCTT was found in 36(36.7%) patients(100±32.9 min vs 81.9±13.3 min, p<0.01) and 3(3.1%) had both delayed GET and OCTT. Conclusion: Delayed OCTT was more frequently observed than delayed GET which was not significant comparing to wide ranged controls. Small bowel transit rather than gastric emptying plays some role in pathophysiology of the patients with DLFD.

결핵성 복막염의 복강경검사 성적

박승국(Soong Kook Park),윤덕구(Duk Koo Yun) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2

N/A Biopsy proven thirty four tuberculous peritonitis patients among of two hundred fifty one patients underwent peritoneoscopy were analyzed. The age was from 19 to 83, average 42. The most prevalent age group was between 30 to 50 and the male to female ratio was 1:2. The major symptoms were increased abdominal girth, anorexia, malaise, and febrile sense. Three most frequent abnormal physical findings were abdominal tenderness, rebound tenderness and palpable mass. White soft granular nodules on peritoneoscopy were most characteristically noted in all of the patients, which were frequently obsereved on parietal peritoneum, liver surface, diaphragm and bowel serosa in order. Fibrous veil and intestinal adhesion were other distinct scopic findings and observed in 10 and 19 patients respectively. In 10 cases of patients, peritoneoscopic findings were similar to tuberculous peritonitis but proved as metastatic adenocarcinoma and chronic inflammation in 8 cases and 2 cases respectively by biopsy afterward. The ascites was single most frequent scopic finding, usually straw in color. 5 patients had ascites too minimal to remove. Ascitis less than 500cc in 12 patients, 500 to 2000cc in 13 patients and over 2000cc in 4 patients were able to be removed. No major complications were noted during and after the procedures. Lower abdominal wall and scrotal edema were seen after procedure in cases of incompletly removed ascitis. The authors concluded that peritoneoscopic examination and biopsy was safe and the most useful method to make differential diagnosis of patients who suspected tuberculous peritonitis.

인후부 및 전흉부 이물감을 호소하는 환자에서의 식도운동 질환

박승국(Soong Kook Park),강영우(Young Woo Kang),한창엽(Chang Yeob Han) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2

N/A Our aim was to determine whether globus sense in throat or anterior chest could be a manifestation of esophageal motility disorders. We have performed solid state esophageal manometry in, 88 patients who complained of globus in throat or anterior chest without abnormalities on upper gastrointestinal endoscopy, indirect laryngos- copy, chest PA and electrocardiogram. Twenty six patiente had complaint of globus sense in throat, 57 patients in anterior chest and 5 patients in both. Among them, twenty eight patients had esophageal motility disorders: nonspecific esophageal motility disorder in 16 (18%), nutcracker esophagus in 10 (11.4%), and hypertensive lawer esophageal sphincter in 2 (2.3%). While four patients (15.4%) had esophageal motility disorders among 26 patients with globus sense in throat, 22 patients (38.6%) had esophageal motility disorders among 57 patients with globus sense in anterior chest and two patients (40%), among five patients with globus sense in throat and anterior chest. In concluaion, a part of patients with globus sense do have real esophageal motility disorders, especially patients with globus sense in anterior chest

중증 간경변환자에서 공복 및 식후 혈청 Gastrin 치의 변동

박승국(Soong Kook Park),강영우(Young Woo Kang),송영성(Young sung Song),이인규(In Gyu Lee) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3

N/A Increased incidence (5-40%) of peptic ulceration in the patients with liver cirrhosis has been observed but the pathogenesis has not been clarified. The liver eliminates more than 90% of short gastrin peptides. This study was conducted to investigate the changes of serum gastrin concentration in patients with liver cirrhosis. Fifteen patients with advanced liver cirrhosis and 12 normal control subjects were randomly selected for this study, and the gastrin concentration of each subject was measured at fasting, 15, 45, 90 and 120 minutes after ingestion of 200 ml of commercial milk. The following results were obtained. 1) In the normal control group, the postprandial serum gastrin concentration increased significant- ly at 15, 45 minutes and reached its peak level at 45 minutes. In the patients with advanced liver cirrhosis, it increased significantly at 15, 45, 90 minutes and reached its peak level at 90 minutes. 2) Compared with that of normal control group, postprandial secretory response was blunt signifi- cantly (p<0.01) at 15, 45 minutes in the patients with advanced liver cirrhosis but there was no significant difference in peak level. 3) There was no significant difference in fasting and postprandial serum gastrin concentration between ulcer group and non-ulcer group in the patients with liver cirrhosis.

위장관 폐쇄로 나타난 호산구성 위장관염 1 예

김혜순(Hae Soon Kim),박승국(Soong Kook Park),윤영호(Young Ho Yoon),조광범(Kwang Bum Cho),권두영(Du Young Kwon),전상훈(Sang Hoon Jeon),박혜원(Hae Won Park),황재석(Jae Seok Hwang),허정욱(Jung Wook Hur),안성훈(Sung Hoon Ahn) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.2

Eosinophilic gastroenteritis is a rare disease of unknown etiology characterized by eosinophilic infiltration of the gastrointestinal wall and peripheral eosinophilia. It was first described by Kaijser in 1937. Histologically, it is mainly characterized by infiltration of eosinophilic leukocytes. Clinical features vary according to which layer and location are involved. Its pathogenesis is not clear, but allergic and immunologic etiologies are strongly suggested. In many cases of eosinophilic gastroenteritis, allergic diseases such as seasonal rhinitis, asthma and atopic eczema are often combined. A 52-year-old woman presented with dyspepsia, weight loss and abdominal discomfort. Partial obstruction of the distal jejunum and proximal dilatation confirmed by abdominal computed tomogram and small bowel series. We report this case with the review of relevant literature. (Korean J Gastroenterol 2002;39:119-122)

간성뇌증환자에서 혈장 및 뇌척수액내 아미노산의 변동

박원대(Won Dae Park),박승국(Soong Kook Park),곽춘식(Choon Sik Kwak) 대한내과학회 1987 대한내과학회지 Vol.32 No.4

N/A This study was carried out to investigate the metabolic alteration of plasma and CSF amino acids in patients with liver cirrhosis only and liver cirrhosis with hepatic encephalopathy. Plasma amino acids were measured in 20 cases of liver cirrhosis only, 17 cases of patients with hepatic encephalopathy and 20 cases of normal person as a control. Among above groups of patients, CSF amino acid concentrations were measured in 15 cases of liver cirrhosis only, 17 cases of patients with hepatic ence-phalopathy and 15 cases of normal person. The plasma amino acid concentrations were determined by high performance liquid chromatography. The results were as follow: The plasma concentrations of branched chain amino acids (valine, leucine, isoleucine) were lower in cirrhotic patients and patients with hepatic encephalopathy (p<0.05) than control group and more decreased in patients with hepatic encephalopathy than cirrhotic patients. The plasma concentrations of phenylalanine in aromatic amino acids increased in hepatic encephalopathy (p<0.05), but tyrosine increased in both group of patients (p<0.05). 1n the study of CSF, there were no significant changes in branched chain amino acid concentrations, but in aromatic amino acid concentrations (phenylalanine, tyrosine) increased (p<0.05). In hepatic encephalopathy compare to liver cirrhosis only, phenylalanine concentration was higher (p<0.05) in CSF. The molar ratio between branched chain amino acids and aromatic amino acids (Val.+Leu.+Isoleu./Phen.+Tyr,) of plasma and CSF were lower in both groups of patients than control. In hepatic encephalopathy com-pare to liver cirrhosis only, the molar ratio was lower in hepatic encephalopthy.

정상인에서 반고형식 Lactulose 수소호기검사법을 이용한 구강맹장 통과시간의 측정

강영우(Young Woo Kang),박승국(Soong Kook Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.4

N/A Lactulose hydrogen breath test has been used for rneasurement of orocecal transit time (OCTT) because of its non invasiveness and simplicity. Recently, the lack of reproducibility of OCTT which measured by hydrogen breath test using water diluted lactulose resulted in the need to develop a new semisolid or solid meal combined lactulose hydrogen breath test. We measured OCTT in 47 norrnal subjects(male 17, female 30, age 24 69 years, average 35.5 years) after ingestion of semisolid meal including potato soup and lactulose syrup 20g. OCTT was defined as the time from test meal ingestion to a sustained increase of more than 10pprn above the baseline in end expiratory hydrogen concentration with 10 minutes interval for 3 hours. OCTT was 79.2+11.9(mean+SD) minutes in male, 81.5+15.2 minutes in female, and average 81.9+13.3 minutes. Although there was no significant difference according t,o sex, OCTT in sixth and seventh decades were delayed compared to third decades(P<0.05). These results will be useful for comparison of OCTT in different group of patients.(Korean J Gastro- enterol 1994; 26: 619 624)

대구,경북 지역 성인의 바이러스성 간염 표지자 양성률에 관한 연구 -건강검진 수진자를 대상으로-

박경식 ( Kyung Sik Park ),이영석 ( Yeong Seok Lee ),이석근 ( Seok Guen Lee ),황준영 ( Jun Young Hwang ),정우진 ( Woo Jin Chung ),조광범 ( Kwang Bum Cho ),황재석 ( Jae Seok Hwang ),안성훈 ( Sung Hoon Ahn ),박승국 ( Soong Kook Pa 대한소화기학회 2003 대한소화기학회지 Vol.41 No.6

Backgroud/Aims: In spite of continuous decrease in prevalence of hepatitis B virus (HBV) infection, hepatic diseases including hepatic cancer still are major causes of death in Korea. As a large portion of hepatic diseases is caused by HBV and hepatitis C virus (HCV) in Korea, we reviewed the serologic markers of HBV and HCV in adults in Daegu and Gyungbuk area for the last five years. Then, we compared them with the reported data of other areas. Methods: We studied total 21, 291 adults who had received medical examination at health promotion center of Dongsan Hospital from 1997 to 2001. Results: The overall serologic positivity of HBsAg and anti-HCV was 6.1% and 0.9%, respectively. Seven (0.03%) of 21, 291 were positive for both HBsAg and anti-HCV. The positivity of HBsAg was higher in male, highest in 4th and 5th decades. It decreased yearly from 1997 to 2001. The positivity of anti-HCV increased with age but there was no difference between both genders or examined years. Conclusions: The overall trend of viral markers in Daegu and Gyungbuk area was not different significantly from previously reported data of other areas. (Korean J Gastroenterol 2003;41:473-479)

증례 : 장티푸스성 심근염의 증례 - 2 예의 보고 및 문헌적 고찰

박희명 ( Hi Myung Park ),박의현 ( Wee Hyun Park ),이성동 ( Sung Dong Lee ),문종웅 ( Chong Woong Moon ),오상염 ( Sang Yeoum Oh ),서정규 ( Chung Gyu Suh ),박승국 ( Soong Kook Park ) 대한내과학회 1976 대한내과학회지 Vol.19 No.4

각종 간질환환자에서 혈청 N - acetyl - β- D - Glucosaminidase 와 Monoamine Oxidase 의 활성도 변화

허정욱(Jung Wook Hur),박승국(Soong Kook Park),정태호(Tai Ho Chung) 대한내과학회 1987 대한내과학회지 Vol.34 No.1

N/A Glycosaminoglycan, a component of connective tissue, increased significantly in tissue fibrosis including liver cirrhosis. It has been reported that N-acetyl-0-D- glucosaminidase takes place important role in tissue fibrosis and that the degree of fibrosis is reflected in serum N-acetyl- β -D-glucosaminidase activity in hepatic fibrosis. Morevoer, in tissue fibrosis collagen formation is the main event. And in Collagen formation monoamine oxidase has function of fixation of the soluble collagen molecule and of stimulation of the connective tissue maturation. It also has been reported that serum monoamine oxidase activity reflects hepatic monoamine oxidase activity and the activity is related to the synthetic activity more than the accumulated amount of the collagen. The authors have investigated the activities of N- acetyl-β-D-glucosaminidase and monomaine oxidase in the serum in 15 healthy subjects and 55 patients with various liver diseases. In patients with chronic hepatitis, liver cirrhosis and hepatoma, serum N-acetyl- β -D-glucosaminidase activity increased twice as the value of healthy subjects. Serum monomaine oxidase increased significantly in chronic hepatitis (p<0.001) and liver cirrhosis (p<0.01). No definite correlation was found between any of liver function tests or the evidence of protal hypertention and these two enzyme activities on patients with liver cirrhosis. These results suggest that serum N-acetyl- β -D- glucosaminidase and monomamine oxidase activities can be used as an important index in the evaluation of the hepatic fibrogenesis and its therapy.