증례 : 내분비-대사; 갑상선암과 자궁내막암에서 동시에 전이된 경부림프절에 관한 증례

박경선 ( Kyeong Seon Park ),박효진 ( Hyo Jin Park ),홍아람 ( A Ram Hong ),김영기 ( Yeong Gi Kim ),문재훈 ( Jae Hoon Moon ),박영주 ( Young Joo Park ) 대한내과학회 2014 대한내과학회지 Vol.86 No.3

A 54-year-old woman presenting with dizziness was diagnosed with a metastatic brain tumor. Imaging studies to identify the primary cancer revealed endometrial thickening with a left adnexal mass, enlarged bilateral external iliac lymph nodes, and multiple attenuated nodules in both lobes of the thyroid gland with enlarged central neck nodes. After curettage of the uterine endometrium and ultrasonography-guided gun biopsy of the thyroid gland to confirm uterine and thyroid cancers, respectively, total abdominal hysterectomy with bilateral salpingo-oophorectomy and total thyroidectomy with bilateral central neck dissection were performed. Histopathologic examination of the removed tissues demonstrated both endometrial carcinoma metastasis to the thyroid gland and primary thyroid cancer with synchronous central neck node metastasis originating in the endometrium and thyroid. Three of the four right central lymph nodes were positive for metastatic papillary carcinoma; on the other hand, the remaining right central lymph node and one of the two left central lymph nodes were confirmed to be positive for metastatic endometrial carcinoma.

과도안정도 향상을 위한 전압형 HVDC 유효 전력 제어에 관한 연구

박경선(Kyeong-Seon Park),이동영(Dong-Yeong Lee),박우신(Woo-Shin Park),송성윤(Sung-Yoon Song),윤민한(Min-Han Yoon),송지영(Ji-Young Song),구현근(Hyun-Keun Ku),장길수(Gil-Soo Jang) 대한전기학회 2022 대한전기학회 학술대회 논문집 Vol.2022 No.7

황사의 PM10이 WI-26 VA4 Cells에서 Reactive Oxygen Species, NF-κB, TGF-β, Fibronectin의 발현에 미치는 영향

박경선 ( Kyeong Seon Park ),김유진 ( Yu Jin Kim ),윤진영 ( Jin Young Yoon ),경선영 ( Sun Young Kyung ),안창혁 ( Chang Hyeok An ),이상표 ( Sang Pyo Lee ),박정웅 ( Jeong Woong Park ),정성환 ( Sung Hwan Jeong ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.6

연구배경: 황사는 동북아시아에서 자연 발생하는 현상으로, 지름 10μm 이하의 미세먼지(particulate matter 10, PM10)를 다수 포함하여, 흡입하면 하부기관지 및 폐의 가스-교환부분까지 침착 가능하여 호흡기계에 손상을 일으킬 수 있다. 본 연구에서는 황사에 포함된 PM10을 기관지상피세포에 작용시켜 활성산소 및 NF-κB, TGF-β, fibronectin이 증가 여부를 확인하고 섬유화의 신호경로를 규명하고자 하였다. 방법: 공기포집기로 포집한 PM10 입자를 추출하여 기관지 상피세포인 WI-26 VA4 cells (KCLB)에 PM10을 농도에 맞게 노출시켰다(0, 50, 100μg/ml). ROS는 DCF-DA를 세포에 반응시킨 후 생성된 DCF를 FACScan을 이용해 측정하였다. TGF-β, fibronectin, NFκB는 western blotting으로 분석하였다. 항산화제인 NAC를 이용하여 각 물질의 발현 억제 여부를 측정하였다. 결과: PM10을 가했을 때 대조군에 비하여 50μg/ml, 100μg/ml에서 ROS, TGF-β, fibronectin, NFκB 발현이 유의하게 증가하였고, 항산화제인 NAC를 처리한 세포는 ROS, TGF-β, fibronectin, NFκB의 발현이 50μg/ml, 100μg/ml에서 유의하게 감소하였다. 결론: 황사의 PM10은 WI-26 VA4 cells에서 ROS 생성을 증가시키고 NF-κB, TGF-β, fibronectin 생성을 증가시켜 섬유화에 기여할 것으로 사료된다. Background: Particulate matter may be toxic to human tissue. Ambient air particulate matter≤10μm in aerodynamic size (PM10), which changes under different environmental conditions, is a complex mixture of organic and inorganic compounds. The Asian dust event caused by meteorological phenomena can also spread unique particulate matter in affected areas. We evaluated production of ROS, TGF-β, fibronectin, and NFκB by exposing normal epithelial cells to Asian dust particulate matter. Methods: Bronchial epithelial cells were exposed to 0, 50, 100μg/ml of a uspension of PM10 for 24 h. ROS were detected by measurement of DCF release from DCF-DA by FACScan. TGF-β, fibronectin, and NFκB were detected by western blotting. Results: PM10 exposure increased the expression of TGF-β, fibronectin, and NFκB. ROS production and TGF-βlevels were significantly higher with 50 or 100μg/ml PM10. Fibronectin and NFκB production were significantly higher after 100μg/ml of PM10. Conclusion: PM10 from Asian dust particles might have fibrotic potential in bronchial epithelial cells via ROS induction after PM10 exposure. (Tuberc Respir Dis 2008;65:504-511)

황사의 PM₁₀이 WI-26 VA4 Cells에서 Reactive Oxygen Species, NFκB, TGF-β, Fibronectin의 발현에 미치는 영향

박경선,김유진,윤진영,경선영,안창혁,이상표,박정웅,정성환,Park, Kyeong Seon,Kim, Yu Jin,Yoon, Jin Young,Kyung, Sun Young,An, Chang Hyeok,Lee, Sang Pyo,Park, Jeong Woong,Jeong, Sung Hwan 대한결핵및호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.6

연구배경: 황사는 동북아시아에서 자연 발생하는 현상으로, 지름 $10{\mu}m$ 이하의 미세먼지(particulate matter 10, $PM_{10}$)를 다수 포함하여, 흡입하면 하부기관지 및 폐의 가스-교환부분까지 침착 가능하여 호흡기계에 손상을 일으킬 수 있다. 본 연구에서는 황사에 포함된 $PM_{10}$을 기관지상피세포에 작용시켜 활성산소 및 $NF{\kappa}B$, $TGF-{\beta}$, fibronectin이 증가 여부를 확인하고 섬유화의 신호경로를 규명하고자 하였다. 방 법: 공기포집기로 포집한 $PM_{10}$ 입자를 추출하여 기관지 상피세포인 WI-26 VA4 cells (KCLB)에 $PM_{10}$을 농도에 맞게 노출시켰다(0, 50, $100{\mu}g/ml$). ROS는 DCF-DA를 세포에 반응시킨 후 생성된 DCF를 FACScan을 이용해 측정하였다. $TGF-{\beta}$, fibronectin, $NF{\kappa}B$는 western blotting으로 분석하였다. 항산화제인 NAC를 이용하여 각 물질의 발현 억제 여부를 측정하였다. 결 과: $PM_{10}$을 가했을 때 대조군에 비하여 $50{\mu}g/ml$, $100{\mu}g/ml$에서 ROS, $TGF-{\beta}$, fibronectin, $NF{\kappa}B$ 발현이 유의하게 증가하였고, 항산화제인 NAC를 처리한 세포는 ROS, $TGF-{\beta}$, fibronectin, $NF{\kappa}B$의 발현이 $50{\mu}g/ml$, $100{\mu}g/ml$에서 유의하게 감소하였다. 결 론: 황사의 $PM_{10}$은 WI-26 VA4 cells에서 ROS 생성을 증가시키고 $NF-{\kappa}B$, $TGF-{\beta}$, fibronectin 생성을 증가시켜 섬유화에 기여할 것으로 사료된다. Background: Particulate matter may be toxic to human tissue. Ambient air particulate matter ${\leq}10{\mu}m$ in aerodynamic size ($PM_{10}$), which changes under different environmental conditions, is a complex mixture of organic and inorganic compounds. The Asian dust event caused by meteorological phenomena can also spread unique particulate matter in affected areas. We evaluated production of ROS, $TGF-{\beta}$, fibronectin, and $NF{\kappa}B$ by exposing normal epithelial cells to Asian dust particulate matter. Methods: Bronchial epithelial cells were exposed to 0, 50, ${\leq}100{\mu}g/ml$ of a suspension of $PM_{10}$ for 24 h. ROS were detected by measurement of DCF release from DCF-DA by FACScan. $TGF-{\beta}$, fibronectin, and $NF{\kappa}B$ were detected by western blotting. Results: $PM_{10}$ exposure increased the expression of $TGF-{\beta}$, fibronectin, and $NF{\kappa}B$. ROS production and $TGF-{\beta}$ levels were significantly higher with 50 or ${\leq}100{\mu}g/ml$ $PM_{10}$. Fibronectin and $NF{\kappa}B$ production were significantly higher after ${\leq}100{\mu}g/ml$ of $PM_{10}$. Conclusion: $PM_{10}$ from Asian dust particles might have fibrotic potential in bronchial epithelial cells via ROS induction after $PM_{10}$ exposure.

증례 : 내분비-대사 ; 그레이브스병에서 메티마졸 투여 후 발생한 무과립구증과 급성충수염

홍아람 ( A Ram Hong ),박경선 ( Kyeong Seon Park ),조용숙 ( Yong Suk Jo ),박도준 ( Do Joon Park ),박영주 ( Young Joo Park ),김정희 ( Jung Hee Kim ) 대한내과학회 2014 대한내과학회지 Vol.86 No.2

무과립구증은 메티마졸을 복용하는 환자에서 드물게 발생하나 치명적인 부작용으로서 대부분 상기도 감염의 형태로 발현한다. 그레이브스병으로 메티마졸을 복용하던 환자에서 무과립구증이 급성충수염으로 발현한 증례는 보고된 바 없다. 본 저자들은 그레이브스병으로 메티마졸을 복용하던 중 발생한 무과립구증이 드물게 급성충수염으로 발현한 환자에서 적절한 내과적 치료 및 수술적 치료 후 양호한 경과를 확인하였기에 문헌고찰과 함께 보고하는 바이다. Agranulocytosis is a rare, but life-threatening, adverse effect of methimazole, which usually manifests as an upper respiratory infection. Agranulocytosis together with acute appendicitis is especially rare in patients with Graves` disease taking methimazole. A 44-year-old woman presented to our hospital with abdominal pain and a fever. She had been taking methimazole and propranolol for Graves` disease for the previous 8 weeks. Her symptoms were compatible with acute appendicitis. Computed tomography of the abdomen revealed acute appendicitis with impending rupture. However, the circulating absolute neutrophil count was 10/mm3. We managed her with antibiotics and granulocyte colony stimulating factor rather than with emergency surgery. The thyrotoxicosis was treated with intravenous contrast medium while fasting, followed by Lugol`s solution and lithium. After recovering from the neutropenia, she underwent a total thyroidectomy combined with an appendectomy. Here, we report a patient with Graves` disease who developed methimazole-induced agranulocytosis presenting as acute appendicitis. (Korean J Med 2014;86:232-236)

증례 : 순환기; 위암 환자 급성 심막염에 NSAID 사용 후 발생한 위심막루에 의한 심낭기종

김영기 ( Yeong Gi Kim ),김학진 ( Hak Jin Kim ),박경선 ( Kyeong Seon Park ),홍아람 ( A Ram Hong ),이상진 ( Sang Jin Lee ),우상명 ( Sang Myung Woo ) 대한내과학회 2014 대한내과학회지 Vol.86 No.4

Here, we report a case of gastropericardial fistula associated with the treatment of acute pericarditis using non-steroidal anti-inflammatory drugs (NSAIDs) in the presence of gastric cancer. The patient presented with acute pericarditis with pericardial effusion that had progressed into definite gastropericardial fistula with pneumopericardium after the administration of NSAIDs. The patient improved after conservative management. Based on the current case, we advise caution when using NSAIDs to treat acute pericarditis in the presence of gastric cancer or possible gastropericardial fistula. (Korean J Med 2014;86:489-493)