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      • KCI등재후보

        갑상선암에서 BRAF 돌연변이의 임상적 의미

        홍아람,박영주,A Ram Hong,Young Joo Park 대한갑상선-내분비외과학회 2014 The Koreran journal of Endocrine Surgery Vol.14 No.3

        The BRAF<sup>V600E</sup> mutation is the most common genetic alteration and presents in 40∼80% of all papillary thyroid cancer (PTC), showing the highest prevalence in the Korean population, close to 80%. Previous studies published in the past 10 years showed a significant correlation between BRAF<sup>V600E</sup> mutation and poor prognostic outcomes of PTC, including recurrence and mortality. Therefore, its clinical application for the diagnosis of thyroid nodule or for decisions regarding the management policy by prediction of the prognosis of thyroid cancer has been proposed. However, some recent studies have reported conflict results, and there appear to be growing concerns regard to the cost-benefit of tests for detection of the BRAF<sup>V600E</sup> mutation. In this paper, we reviewed previous studies regarding the BRAF<sup>V600E</sup> mutation and attempted to evaluate the clinical implication of the BRAFV600E mutation in clinical practice.

      • KCI등재

        증례 : 내분비-대사 ; 그레이브스병에서 메티마졸 투여 후 발생한 무과립구증과 급성충수염

        홍아람 ( A Ram Hong ),박경선 ( Kyeong Seon Park ),조용숙 ( Yong Suk Jo ),박도준 ( Do Joon Park ),박영주 ( Young Joo Park ),김정희 ( Jung Hee Kim ) 대한내과학회 2014 대한내과학회지 Vol.86 No.2

        무과립구증은 메티마졸을 복용하는 환자에서 드물게 발생하나 치명적인 부작용으로서 대부분 상기도 감염의 형태로 발현한다. 그레이브스병으로 메티마졸을 복용하던 환자에서 무과립구증이 급성충수염으로 발현한 증례는 보고된 바 없다. 본 저자들은 그레이브스병으로 메티마졸을 복용하던 중 발생한 무과립구증이 드물게 급성충수염으로 발현한 환자에서 적절한 내과적 치료 및 수술적 치료 후 양호한 경과를 확인하였기에 문헌고찰과 함께 보고하는 바이다. Agranulocytosis is a rare, but life-threatening, adverse effect of methimazole, which usually manifests as an upper respiratory infection. Agranulocytosis together with acute appendicitis is especially rare in patients with Graves` disease taking methimazole. A 44-year-old woman presented to our hospital with abdominal pain and a fever. She had been taking methimazole and propranolol for Graves` disease for the previous 8 weeks. Her symptoms were compatible with acute appendicitis. Computed tomography of the abdomen revealed acute appendicitis with impending rupture. However, the circulating absolute neutrophil count was 10/mm3. We managed her with antibiotics and granulocyte colony stimulating factor rather than with emergency surgery. The thyrotoxicosis was treated with intravenous contrast medium while fasting, followed by Lugol`s solution and lithium. After recovering from the neutropenia, she underwent a total thyroidectomy combined with an appendectomy. Here, we report a patient with Graves` disease who developed methimazole-induced agranulocytosis presenting as acute appendicitis. (Korean J Med 2014;86:232-236)

      • KCI등재

        유・아동, 청소년 대상 투사 그림검사 동향 연구(2010-2020):국내 학술지 중심으로

        홍아람(Hong, Ah-Ram),정보라(Jung, Bo-Ra),이모영(Lee, Mo-Young) 한국예술심리치료학회 2021 예술심리치료연구 Vol.17 No.3

        본 연구는 국내 학술지에 게재된 유・아동, 청소년을 대상으로 한 투사 그림검사의 동향을 분석하여 기존 연구의 흐름을 파악하고 추후의 연구 방향을 제시하는 것에 그 목적이 있다. 이에 2010-2020년도까지 국내 학술지에 게재된 논문 중 청소년을 대상으로 한 투사 그림검사 관련 연구 140편을 수집 및 선별하여 연구연도, 연구출처, 연구방법, 주제에 따른 정신병리적 특성, 그림검사 사용설계에 따라 분석하였다. 연구 결과, 기간 전체적으로 매해 HTP, KFD, KSD 연구가 가장 많이 이루어졌다. 예술관련 치료 계열에서 연구가 가장 많이 이루어지고 있으나 다양한 분야에서 활용되고 있음을 알 수 있으며, 연구 장소의 대부분이 교육기관이었다. 초등학생, 중학생을 대상으로 한 연구가 많고, 고등학생을 대상으로 한 연구가 저조하며, 정신병리적 특성 주제는 자기관련변인과 정서관련변인이 가장 높은 빈도를 보였다. 연구방법은 성과연구가 가장 많으며, 그 중 단일 사례 사전 사후 분석 연구가 주를 이루고 있고, 문헌연구, 과정연구는 연구가 저조한 실정이다. HTP, KFD, KSD를 활용한 사전-사후 설계 빈도가 가장 높았고, 이와 같은 결과를 토대로 투사 그림검사의 연구, 분석, 개발 및 후속연구에 대한 제언을 제안하였다. The purpose of this study is to analyze the research trend of projective drawing tests for young childrens and adolescents published in Korean journals to understand the flow of existing research and to suggest a direction of the future research. For this, 140 dissertations published in Korean journals from 2010-2020 were collected and the year of the research, research sources, research subjects, research methods, research topic of psychopathological characteristics and study designs of drawing tests were analyzed. As a result, HTP, KFD and KSD studies were most conducted annually throughout the period. It is most often used in the field of art therapy and is used in various fields, and it is that most of the research sites were educational institutions. The highest number of researches was targeted on elementary and middle school in terms of age organization and the lowest number of researches was targeted on high school students. And for the trend of research topic of psychopathological characteristics have been a lot of research on variables of emotional and self. For the trend of research methods, outcome research was most common, and ex-post analysis of single case study was dominated, and analsis of literature review and process research studies have not been well studied. The ex-post design frequency using HTP, KFD and KSD was the highes, and based on these results, we propose sugeestion for the research, analysis, development and follow-up studieds of projective drawing tests.

      • 악하선 부위에 발생한 부신경절종

        김재구(Jae Gu Kim),홍아람(A Ram Hong),김조헌(Jo Heon Kim),이동훈(Dong Hoon Lee) 대한두경부종양학회 2020 대한두경부 종양학회지 Vol.36 No.2

        Paraganglioma is a rare benign neuroendocrine tumor arising from the paraganglia of the autonomic nervous system. Paraganglioma occurs mainly in the carotid body, jugular foramen, and vagus nerve in the head and neck region. Herein, we report a case of paraganglioma of the submandibular region that has not been reported. This case highlights paraganglioma as a rare differential diagnosis for submandibular region tumors.

      • KCI등재

        증례 : 순환기; 위암 환자 급성 심막염에 NSAID 사용 후 발생한 위심막루에 의한 심낭기종

        김영기 ( Yeong Gi Kim ),김학진 ( Hak Jin Kim ),박경선 ( Kyeong Seon Park ),홍아람 ( A Ram Hong ),이상진 ( Sang Jin Lee ),우상명 ( Sang Myung Woo ) 대한내과학회 2014 대한내과학회지 Vol.86 No.4

        Here, we report a case of gastropericardial fistula associated with the treatment of acute pericarditis using non-steroidal anti-inflammatory drugs (NSAIDs) in the presence of gastric cancer. The patient presented with acute pericarditis with pericardial effusion that had progressed into definite gastropericardial fistula with pneumopericardium after the administration of NSAIDs. The patient improved after conservative management. Based on the current case, we advise caution when using NSAIDs to treat acute pericarditis in the presence of gastric cancer or possible gastropericardial fistula. (Korean J Med 2014;86:489-493)

      • KCI등재

        증례 : 내분비-대사; 갑상선암과 자궁내막암에서 동시에 전이된 경부림프절에 관한 증례

        박경선 ( Kyeong Seon Park ),박효진 ( Hyo Jin Park ),홍아람 ( A Ram Hong ),김영기 ( Yeong Gi Kim ),문재훈 ( Jae Hoon Moon ),박영주 ( Young Joo Park ) 대한내과학회 2014 대한내과학회지 Vol.86 No.3

        A 54-year-old woman presenting with dizziness was diagnosed with a metastatic brain tumor. Imaging studies to identify the primary cancer revealed endometrial thickening with a left adnexal mass, enlarged bilateral external iliac lymph nodes, and multiple attenuated nodules in both lobes of the thyroid gland with enlarged central neck nodes. After curettage of the uterine endometrium and ultrasonography-guided gun biopsy of the thyroid gland to confirm uterine and thyroid cancers, respectively, total abdominal hysterectomy with bilateral salpingo-oophorectomy and total thyroidectomy with bilateral central neck dissection were performed. Histopathologic examination of the removed tissues demonstrated both endometrial carcinoma metastasis to the thyroid gland and primary thyroid cancer with synchronous central neck node metastasis originating in the endometrium and thyroid. Three of the four right central lymph nodes were positive for metastatic papillary carcinoma; on the other hand, the remaining right central lymph node and one of the two left central lymph nodes were confirmed to be positive for metastatic endometrial carcinoma.

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