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B형 만성활동성간염 환자에서 Prednisolone 단기 이탈 및 Alpha-Interferon 병합요법의 효과
김인환(In Hwan Kim),이일세(Il Se Lee),신현수(Hyeon Soo Shin),신영호(Young Ho Shin),김양식(Yang Sig Kim),김호규(Ho Gyu Kim),배효근(Hyo Keun Bae),김경환(Kyung Hwan Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
Background/Aims: This study was conducted to investigate the effect of alpha-interferon after prednisolone withdrawa] therapy on chronic active hepatitis B with HBeAg. Methods: Twenty- three CAH patients were recruited at a general hospital in Pohang city from August 1990 to July 1991. Dose of 45mg, 30mg and 15mg of prednisolone were administered to patients for two weeks and two weeks pause, after that three million units of alpha-interferon 2b was injected once a day for the first week, and then the same dose was injected three times per week for eleven weeks. Patients were followed up for side effect and changes in serum ALT, HBsAg and HBsAb, HBeAg and HBeAb, HBV-DNA, DNA-polymerase and peripheral blood smear during and after treatment. Results: Seroconversion rate of twenty three HBeAg positives at 6 months after treatment was 61% and that of HBV-DNA positives was 48% and both seroconversions occurred in 39% of patients. The normalization rate of ALT was 61% after alpha-interferon therapy. However there were no patients who was become negative among HBsAg positives, Serum ALT decreased at four weeks after administering the alpha-interferon, and a continued decrease was obsered during therapy. However, a gradual increasing of ALT happened after finishing therapy and reached the average level of 79.6IU/L in the eighth week after theropy. The incidence of side effects after alpha-interferon therapy was not serious enough to withdraw therapy, They reported mild symptomes such as, anorexia(69.6%), myalgia(56.5%), fever(52.2%), fatigue(34.8%), arthralgia (26%), nausea(26%), mild hair loss(17.4%) and headache(13%). Conclusions: It was shown that alpha-interferon with prednisolone withdrawal therapy was effective in patients with CAH in terms of seroconversion of HBeAg and decreasing activity of HBV-DNA and normalization of ALT value.(Korean J Gastroenterol 1997; 29:199-206)
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탄소나노튜브 합성 시 촉매 금속의 분산도 향상을 위한 Ti Substrate의 표면 개질 연구
곽성열,김호규,변종민,박주혁,석명진,오승탁,김영도,Kwak, Seoung Yeol,Kim, Ho Gyu,Byun, Jong Min,Park, Ju Hyuk,Suk, Myung-Jin,Oh, Sung-Tag,Kim, Young Do 한국분말야금학회 2014 한국분말재료학회지 (KPMI) Vol.21 No.1
This paper describes the surface modification effect of a Ti substrate for improved dispersibility of the catalytic metal. Etching of a pure titanium substrate was conducted in 50% $H_2SO_4$, $50^{\circ}C$ for 1 h-12 h to observe the surface roughness as a function of the etching time. At 1 h, the grain boundaries were obvious and the crystal grains were distinguishable. The grain surface showed micro-porosities owing to the formation of micro-pits less than $1{\mu}m$ in diameter. The depths of the grain boundary and micro-pits appear to increase with etching time. After synthesizing the catalytic metal and growing the carbon nano tube (CNT) on Ti substrate with varying surface roughness, the distribution trends of the catalytic metal and grown CNT on Ti substrate are discussed from a micro-structural perspective.
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류마티스 관절염에 의한 고도의 무지 외반증과 소족지 갈퀴족 변형에 대한 중족골 종축 감압 절골술을 이용한 관절 보존술의 결과
남일현,안길영,문기혁,이영현,최성필,김호규,오동호,Nam, Il-Hyun,Ahn, Gil-Yeong,Moon, Gi-Hyuk,Lee, Yeong-Hyeon,Choi, Seong-Pil,Kim, Ho-Gyu,Oh, Dong-Ho 대한족부족관절학회 2012 대한족부족관절학회지 Vol.16 No.1
Purpose: The purpose of this study is to evaluate the effect of axial shortening metatarsal osteotomy on the treatment of advanced rheumatoid arthritis patients with severe hallux valgus and claw toe deformity of lesser toes which is used for preserving the metatarsophalangeal joint. Materials and Methods: From January 2005 to June 2009, 18 cases of axial shortening metatarsal osteotomy in advanced rheumatoid arthritis were reviewed ; all of them followed up for more than 2 years after surgical procedures and the mean follow up period was 3.4 years. We performed axial shortening Scarf osteotomy and Akin osteotomy for hallux valgus and Weil osteotomy with soft tissue release for claw toe of lesser toes, respectively. We measured preoperative and postoperative hallux valgus angle, each metatarsal shortening length and the range of motion of the metatarsophalangeal joints through radiographic and clinical examination and compared them each other. Clinical results were evaluated by American Orthopedic Foot and Ankle Society (AOFAS) score and subjective satisfaction of the patients. Results: The hallux valgus angle was reduced from the preoperative mean value of 44.8 degree to 9.0 degree postoperatively and the range of motion of the metatarsophalangeal joint of great toe and lesser toes was increased from the mean of 21.7 degree and 11.0 degree preoperatively to 38.0 degree and 32.5 degree, respectively at postoperation. Also, the mean AOFAS score was improved from 26.5 points to 67.4 points. Conclusion: Axial shortening osteotomy is a useful method to correct the deformity and preserve the metatarsophalangeal joint for severe hallux valgus and claw toe deformity in advanced rheumatoid arthritis.
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김양식,정재혁,김호규,원영준,최성대,서영배,배효근,조창호,한승묵 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.6
Blood-borne metastatic involvement of the gastric mucosa as a result of cancer is a rare occurrence. The tumors which were most commonly reported to metastasize to the stomach include melanoma, breast carcinoma, and lung carcinoma. Some reports document that large cell carcinoma and squamous cell carcinoma of the lungs have a higher pre- dilection for gastrointestinal tract metastases. Upper gastrointestinal endoscopic findings of metastatic lesions may vary but often produce a characteristic single or multiple bulls eye or target lesion. Therefore, whenever single or multiple target lesions are seen in the stomach on upper gastrointestinal endoscopy or barium study, the examination should include careful radiographic evaluation of the chest. Moreover, when the patient is known to have lung cancer, metastatic disease should be suspected. With a correct diagnosis and proper treatment, relief of symptoms and prolongation of life can sometimes be achieved, A case in reported involving squamous cell lung cancer with stomach metastasis in a 73 year-old woman. The patient was diagnosed by bronchoscopy, upper gastrointestinal endoscopy, chest CT, and abdominal CT. The chest and abdominal CT revealed a poorly marginated, lobulated, and 4 x 3 cm sized mass lesion in the right lower lobe causing obstruction of right lower lobe bronchus with invasion to the left atrium. right inferior pulmonary vein, and superior vena cava. Mediastimal lymph node enlargement and liver metastasis was also detected. Upper gastrointestinal endoscopy showed two $quot;bulls eye$quot; lesions with different sizes and two nodules without tip ulceration.
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