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상용량의 아세트아미노펜 복용 후 발생한 횡문근융해에 의한 급성신부전
김형진(Heung Jin Kim),김일두(Il Doo Kim),황영훈(Yeoung Hoon Whang),배용목(Yong Mock Bae),서길동(Gil Dong Seo),김명준(Myong June Kim),김수형(Soo Heung Kim),이인상(In Sang Lee) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1
A 21-year-young man had an episode of myalgia and chilling 3 days prior to hospital admission. He had consumed common doses of acetaminophen for one day, and was presented in the sauna room for an hour. On the next morning, he complained of dyspnea and was admitted. He presented in rhabdo-myolysis and acute renal failure with increased up-take in the proximal muscles by (99m)Tc-MPD bone scan. He was treated by hemodialysis and discharged on the twenty-eighth hospital day. Rhabdomyolysis has the variable causes. The causes of this case are two, the first cause is common doses of acetaminophen. But, there is no reports for rhabdomyolysis by common doses of acetaminophen only. However, we should consider that acetaminophen is a contributing factor in this case. The second cause is viral infection. Our patient had myalgia and chilling prior to hospital admission. Heat- stroke is well known cause of rhabdomyolysis. The mechnisms for rhabdomyolysis in this disease are hypovolemia, total body potassium deficit, and increased variable cytokines. Sauna, the last cause of our rhabdomyolysis case may have the same mechanisms with heatstroke. Our case had two causative factors, common doses of acetaminophen and sauna. These factors might be cooperated in our case of rhabdomyolysis and acute renal failure.
양철오(Chul-Oh Yang),김형진(Heung-Jin Kim),이대성(Dae-Sung Lee),임동순(Dong-Soon Lim),이경석(Gyeong-Seok Lee),박규남(Kyu-Nam Park),송명현(Myung-Hyun Song) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
본 연구에서는 DC 모터의 전류 신호 해석을 통해 권선 단락 및 정류자편 단락 고장을 진단하는 방법을 제안하였다. 연구에 사용된 DC 모터는 태양광 발전 시스템의 트랙커 구동용 전동기로, 12개의 슬롯과 12개의 정류자편을 갖는 영구자석 DC 모터이다. 권선 단락과 정류자편 단락을 갖는 모터를 제작하여, 세 가지 상태(정상, 권선 단락, 정류자편 단락)의 DC 모터 전류 신호를 비교 · 분석하여 전류 신호의 특성을 수치화하고, 실험을 통해 얻어진 각 상태별 DC 모터의 특성 수치를 비교하여 DC 모터의 단락 고장을 진단할 수 있는 진단 문턱값을 제시하였다.
박규남(Kyu-nam Park),송명현(Myung-hyun Song),양철오(Chul-oh Yang),김형진(Heung-jin Kim) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
본 연구에서는 경 부하 구간에서 유도전동기의 회전자 바고장 진단을 개선하는 방법을 제안하였다. 유도전동기의 회전자 바 고장 진단에 있어 25% 이하의 경 부하에서 정확한 진단이 어렵다. 경 부하에서는 종래의 방법에서 적용했던 회전자 바 고장 특징주파수 대역과 다른 특징 주파수 대역을 적용하여 진단하는 방법을 제안하였다. 기존에 진단이 어려웠던 경 부하에서 유도전동기 회전자 바 고장 진단을 개선하는 방법을 제안하고 실험을 통해 그 타당성을 입증하였다.
강직척추염 환자에서 TNF-α 억제제 사용 후 악화된 건선
오지민 ( Ji Min Oh ),고은미 ( Eun Mi Koh ),김형진 ( Hyung Jin Kim ),이재준 ( Jae Joon Lee ),안중경 ( Joong Kyong Ahn ),차훈석 ( Hoon Suk Cha ),이주흥 ( Joo Heung Lee ),장기택 ( Kee Taek Jang ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.2
TNF-α antagonists have been successfully utilized in the treatment of autoimmune diseases, including psoriasis and psoriatic arthritis. Paradoxically, new onset or exacerbation of psoriatic lesions during treatment with TNF-α antagonists have been reported. It has been postulated that TNF-α blockade may cause disruption in the balance between TNF-α and type 1 interferon (IFN)-α, which are the key players in the pathogenesis of psoriasis. We report a case of psoriasis exacerbation during TNF-α antagonist therapy in a 53-years-old man with ankylosing spondylitis. The patient has been treated with etanercept for 3 years and 7 months when he developed accelerated deterioration of psoriasis. His condition was previously under control solely by local treatment. Physical examination revealed vigorous desquamative lesions with silvery scale in both lower legs. Deterioration of psoriasis was attributed to etanercept therapy and was subsequently discontinued. Clinical improvement of psoriasis has been observed 2 months following cessation of etanercept.
Thiopental 마취 흰쥐에서 출혈시 심박수 및 혈압 변이도의 스펙트럼 분석
김형진,이기흥,홍정길,구양희 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.3
Background : This study was aimed to elucidate the effect of thiopental anesthesia on circulatory response to hemorrhage in rats by power spectral analysis of heart rate and blood pressure variability. Methods : Sixteen male Sprague-Dawley rats weighing 350∼475 g were divided into thiopental(50 mg/kg, ip)-anesthetized(T, n=10) and conscious(C, n=6) groups. Hemorrhage was induced with a withdrawal pump from the femoral artery at 3 ml/kg/min for 5 min. Arterial pressure was measured with a pressure transducer connected to the contralateral femoral artery for 5 min before, during and after hemorrhage. The blood pressure signal digitized at 500 Hz through a data acquisition system was analyzed with fast Fourier transform algorithm to yield power spectra of sytolic(SP) and diastolic(DP) blood pressure and instantaneous heart rate(HR). Powers of very low frequency(VLF, 0.02∼0.26 Hz), low frequency(LF, 0.26∼0.75 Hz) and high frequency(HF, 0.75∼5.00 Hz) band were expressed as percent of total power. Results : BefHemorrhage blood pressure was lower in T(113 6/83 6 mmHg) than in C(157 4/101 2) rats, but was not changed by hemorrhage in both groups. Before Hemorrhage HR was lower in T(331 22 beats/min) than in C(378 27) rats. HR was significantly increased to 412 26 beats/min in C, but was not changed in T during hemorrhage. Total powers of Before Hemorrhage blood pressure and HR variability were lower in T than in C. During hemorrhage, total power of blood pressure variability tended to increase in both groups, and that of DP was significantly increased during hemorrhage in T. Total power of HR was significantly increased in C, but was not changed in T. T rats showed lower LF and higher HF power of blood pressure, and lower VLF and LF and higher HF power of HR than C rats. During hemorrhage, both groups showed no significant change in spectral distribution of HR power, except for a significant increase in LF of HR after hemorrhage in C. Spectral distribution of blood pressure power was not changed by hemorrhage in C. In T rats, VLF of DP was significantly increased and HF of DP was decreased during hemorrhage. Conclusions : It suggests that autonomic activity, especially cardiac sympathetic activity is increased in response to hemorrhage in C. Thiopental anesthesia depresses overall autonomic activity, especially sympathetic activity, and vasomotor tone. Hemorrhage under thiopental anesthesia induces depression of baroreceptor reflex activity, while increased levels of vasoconstrictor hormones help to maintain the blood pressure. (Korean J Anesthesiol 1997; 33: 399∼406)