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간질환(肝疾患)의 Immungoglobulin 양 변동에 관한 임상적(臨床的) 연구
김종극,고광도 대한소화기학회 1975 대한소화기학회지 Vol.7 No.1
Author has studied 62 subjects who had been admitted to the Department of Gastroenterology, Medical College of Korea University and diagnosed by liver biopsy and 10 healthy Koreans from July, 1972 to Sept., 1973. Blood collected from the patients had been stored in freezing at -20 degree centigrade. The results of this study are as follows, 1. Blood levels of immunoglobulins (Mean±Standard Deviation) in healthy Koreans are: IgG 1,387±254, IgA 171±78 IgM 94±33. The unit is mg/dl. 2. In acute hepatitis including icteric and nonicteric cases IgG is 1,616±314 and increased above normal range in 50 per cent of cases by mild degree with statistical significance. IgA is 313±86 and increased in 63 per cent by high degree with statistical significance and IgM is 133±66 and increased in 44 per cent by moderate degree with statistical significance. 3. In chronic hepatitis IgG is 1,788±302 and increased above normal range in 64 per cent of cases by mild degree with statistical significance. IgA is 347±127 and increased in 73 per ceat by high degree with statistical sig.ificance. IgM is 143±80 and increased in 46 per cent by moderate degree without statistical significance. 4. In liver cirrhosis IgG is 1,958±449 and increased above normal range in 78 per cent by moderate degree with statistical significance. IgA is 390±129 and increased in 83 per cent by high degree with statistical significance. IgM is 160±69 and increased in 72 per cent by high degree with statistical significance. 5. In primary hepatoma IgG is 1,649±402 And increased above normal range in 71 per cent by mild degree without. Statistical significance. IgA is 316±171 and increased in 71 per cent by high degree with statistical significance. IgM is 149±66 and increased in 57 per mild degree without statistical significance. 6. In reactive hepatitis IgG is 1,571±383 and increased above normal range in 40 per cent by mild degree without statistical significance. IgA is 333±130 and increased in 80 per cent by high degree with statistical significance. IgM is 123±62 and increased in 40 per cent by mild degree without statistical significance.
김종극,김하룡,박용주,정규혁,오승민 환경독성보건학회 2011 환경독성보건학회지 Vol.26 No.-
Objectives: In order to identify the possibility of slender bitterling (SB) (Acheilognathus yamatsutae) being used as a test species for estrogenic endocrine disrupting chemicals (EEDCs), we carried out the cloning and sequence characterization of the estrogen receptor (ER). Methods: The ER from a slender bitterling was obtained by reverse transcriptase-polymerase chain reaction (RT-PCR), 5’- and 3’-rapid amplification of cDNA ends (5’-RACE and 3’-RACE) and T-vector cloning. The expression of ER mRNA was also analyzed in six tissues (brain,liver, kidney, gill, gonad, and intestines) by real-time PCR. Results: We obtained an ER from the slender bitterling. The SB ER cDNA was 2189 base pairs (bp) in length and contained a 1707 bp open reading frame that encoded 568 amino acid residues. The SB ER amino acid sequence clustered in a monophyletic group with the ERαof other fish, and was more closely related to zebrafish ERα(88% identity) than to the ERαof other fish. The SB ER cDNA was divided into A/B,C, D, E and F domains. The SB ER has conserved important sequences for ER functions, such as the DNA binding domain (D domain), which are consistent with those of other teleosts. Conclusions: The ER of the slender bitterling could provide basic information in toxicological studies of EEDCs in the slender bitterling.