http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 김제학 (검색결과 37 건)
- 무료
- 기관 내 무료
- 유료
-
-
김제학,이혜선,김달현,조남진,곽규범 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.4
The distribution features of recombinant human alpha-interferon (rHuIFN- αA) and ^(14)C-radiolabeled rHuIFN- αA (^(14)C-rHuIFN- αA) were investigated in ICR mice after i.v. injection. The level of rHuIFN- αA in the kidney was significantly higher than those in lung and liver at 10min after the injection. But the level was reduced significantly at 60min. The level of radioactivity in the kidney was also significantly higher than those in other organs after i.v. injection of ^(14)C-rHuIFN- αA, but it was reduced at much slower speed than was rHuIFN- αA. These results show that interferon is distributed repidly and the kidney is the main site of distribution and metabolism of rHuIFM- αA.
-
텍스트마이닝을 활용한 학교폭력 관련 뉴스 분석 : 2008-2022년 뉴스 데이터를 중심으로
김제학,정백 국제차세대융합기술학회 2023 차세대융합기술학회논문지 Vol.7 No.8
This study attempted to explore keywords and topic changes for ‘School Violence’ using text mining techniques. We collected 107,267 data on school violence from 2008 to 2022 using the news big data analysis system Big KINDS, and compared and analyzed keyword changes by dividing the entire period three times every five years. The results of the analysis by period were visualized as word clouds, and the main keyword network was visualized by analyzing the connection centrality and prestige centrality between major keywords. The implications of combining these are as follows. First, the subject of solving the school violence problem has changed from solving school violence cases to solving school violence relationships. Second, the types of school violence recognized have diversified and the sensitivity to violence has increased. Finally, social consensus has spread due to changes in perception of the seriousness of school violence. 본 연구는 텍스트마이닝 기법을 활용하여 학교폭력에 대한 키워드와 주제 변화를 탐색하고자 뉴스 빅데이터 분석시스템 빅카인즈를 활용하여 2008년부터 2022년까지의 학교폭력 관련 뉴스 107,267개의 데이터를 수집하였다. 전체 기간을 5년 단위, 3개 시기로 나누어 키워드 변화를 비교·분석하였고, 주요 키워드를 워드 클라우드로 시각화하였으며, 키워드 간 중심성분석을 실시하여 네트워크를 시각화하였다. 연구 결과, 전체 기간에 상위 10 개 키워드는 ‘학교폭력’, ‘학교’, ‘학생’, ‘예방’, ‘교육’, ‘교육청’, ‘청소년’, ‘경찰서’, ‘경찰’, ‘센터’ 순으로 나타났고, 시기별 특징된 주요 키워드로 1시기에는 ‘교사’, ‘대책’, ‘근절’, ‘자살’, ‘해결’ 등이, 2시기에는 ‘캠페인’, ‘근절’, ‘교사’, ‘전담’, ‘홍보’ 등이, 3시기에는 ‘상담’, ‘피해’, ‘캠페인’, ‘온라인’, ‘폭로’ 등이 도출되었다. 이를 종합한 함의로는 첫째, 학교폭력 문제 해결에 대한 주체가 학교폭력 사건 해결에서 학교폭력 관계 해결의 관점으로 변화되었으며, 둘째, 학교폭력으로 인식하는 유형이 다양화되고 폭력에 대한 민감도가 높아졌다. 마지막으로 학교폭력의 심각성에 대한인식의 변화로 사회적 공감대가 확산되었다.
-
김제학,김병각,최응칠,김종찬 한국균학회 1983 韓國菌學會誌 Vol.11 No.4
To find antibiotics among the microbes from Korean soil, a strain which had a high antibacterial activity againstgram-positive bacteria was isolated. As morphological and physiologcal characters on several media and utilization of carbon sources were examined, it was identified as one of Streptomyces species according to International Streptomyces Project method. An antibacterial component was isolated from the fermentation broth and purified with silica-gel column chromatography. Attempts were made to determine its chemical properties.
-
-
Streptococcus pyogenes의 소아에서의 감염 양상 및 항균제 감수성
이환종,박수은,정혜선,김의종,김제학 대한감염학회 1998 감염 Vol.30 No.5
목적: Streptococcus pyogenes에 의한 침습성 감염이 1980년대에 들어와서 다시 증가하는 소견과 함께 세균성 인두염 치료시 penicillin의 부작용을 우려하여 처방되는 erythromycin과 그 외의 macrolide의 사용 빈도 또한 증가하는 추세이다. 최근 erythromycin을 많이 사용하는 지역에서는 이에 대한 내성 S. pyogenes 비율이 높다는 여러 보고가 있다. 연구자들은 한국에서의 S. pyogenes의 감염 양상 및 항균제 감수성을 조사하고자 하였다. 방법: 1991년 10월부터 1998년 4월까지 서울대학교 소아병원에서 각종 임상 검체로부터 S.pyogenes가 분리되었던 28명의 환아들을 대상으로 하여 의무기록을 후향적으로 검토하였다. S. pyogenes 31주에 대한 penicillin, ceftriaxone, vancomycin, clindamycin, erythromycin, roxythromycin, clarithromycin의 최소 억제 농도를 한천 희석법 또는 E-test로 측정하였다. 결과: S. pyogenes의 감염 양상으로는 연조직 감염과 인후염이 가장 흔하였다. 그 외에 패혈증, 폐렴, 질염, 림프절염, 신생아 제대염, 원발성 복막염, 심염을 동반한 류마티스성 열, 성홍열, 급성 중이염 및 전신성 감염 등의 임상 양상을 보였다. Penicillin, ceftriaxone 및 vancomycin에 대하여 100%의 균주가 감수성을 보인 반면, clindamycin에는 10%가, 그리고 erythromycin에는 16%가 내서을 보였으며, erythromycin에 내성인 주는 clarithromycin과 roxythromycin에도 교차 내성을 보였다. 결론: S. pyogenes는 상기도 감염과 이에 따르는 후유증 외에도 다양한 양상의 침습성 질환을 일으키는 중요한 세균이다. 국내에서 S. pyogenes에 의한 감염의 치료제로 항균제를 선택할 때 macrolide 및 clindamycin에 대한 내성균이 출현하고 있음을 주의해야 하며, 이러한 내성균의 출현에 대한 지속적인 감시가 필요하다. Background: Streptococcus pyogenes causes most often pharyngistis or tonsillitis but may also be responsible for severe diseases including bacteremia and pneumonia. Recent publications from several geographic areas showed high rates of resistance to erythromycin and newer macrolides, often used in patients allergic to penicillin, in clinical isolates of S. pyogenes. Methods: Minimum inhibitory concentration of 31 strains of S. pyogenes, isolated at the Seoul National University Children's Hospital from October 1991 through April 1998, were determined for penicillin, ceftriaxone, vancomycin, clindamycin, erythromycin, roxythromycin, and clarithromycin by agar dilution method or E-test. In addition, clinical features of the patients from whom the organisms were isolated were reviewed retrospectively. Results: Of the 28 patients whose medical records were reviewed, the most common clinical presentations were soft-tissue infection (8 cases) and pharyngitis (5 cases). Other presentations included bacteremia without focus, pneumonia, vaginitis, lymphadenitis, omphalitis(two of each); primary peritonitis, rheumatic fever with carditis, scarlet fever, acute otitis media, and disseminated disease (one of each). All of the isolates were susceptible to penicillin, ceftriaxone, and vancomycin. However, 5 isolates (16%) were resistant to erythromycin, and all of the erythromycin-resistant to erythromycin, and all of the erythromycin-resistant strains were resistant to roxythromycin and clarithromycin as well. Three of these erythromycin-resistant strains were also resistant to clindamycin. Conclusion: S. pyogenes may cause serious infections in children. Emergence of resistance in clinical isolates of S. pyogenes to macrolides and clindamycin should be considered in empirical antimicrobial therapy of suspected group A streptococcal infections and in establishment of antibiotic policy in Korea.
-
정재훈,송흥수,임준홍,김한수,김제학 啓明大學校 産業技術硏究所 1997 産業技術硏究所 論文報告集 Vol.20 No.-
This study is looking up the change of land use utilities the aerial photographs in the structural analysis of the city. Results of research are as follow. First, the change of land use is clearly known with the aerial photographs Second, the ratio of the building-story and the floor area ratio is high compaceng to the past, but there is no difference in the block. Third, the building constructure is good, however the danger of fire is still high in the block.
-
Chlamydia trachomatis에 대한 Fluoroquinolone CFC-222의 시험관내 약효시험
강정옥,박일규,최효선,안정열,최태열,김제학 대한감염학회 1996 감염 Vol.28 No.5
목 적 : Chlamydia trachomatis는 비임균성뇨도염, 영유아 폐염 등 여러 질환의 중요 원인균이다. 새고운 fluoroquinolone제제중의 하나인 CFC-222와 다른 quinolone제제와 함께 C. trachomatis에 대한 항균력을 측정하였다. 방 법 : 96-well microtiter cell culture plate에 McCoy을 키운 후 균접종을 하였고, 15개 표준균주 (A-L₃)와 36개 국내 분리 균주를 사용하였다. CFC-222, ciprofloxacin(CPFX), ofloxacin(OPLX), 및 minocycline(MC)을 2배수 희석하여 각 항균제의 최소억제 농도를 측정하였다. 결 과 : 표준균주의 MIC?는 CFC-22 0.15/ml, CPFX 2.5㎍/ml, OFLX 0.6㎍/ml 및 MC 0.08㎍/ml였다. 국내 분리 균주의 MIC?는 CFC-222 0.3㎍/ml, CPFX 1.2㎍/ml, OFLX 0.6㎍/ml 및 MC은 및 MC은 0.06㎍/ml였다. 결 론 : 새로운 fluoroquinolone CFC-222는 Chlamydia trachomatis에 탁월한 감수성을 나타내었다. Background : Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen. Our purpose is to investigate the antimicrobial activity of new fluoroquinolone CFC-222 (CFC-222)to C. trachomatis. Methods : In vitro antibacterial activity of CFC-222 against 15 control strains(A-L3) and 36 clinical strains of C. trachomatis were determined in 96-well microtiter cell culture plates, and compared with that of ciprofloxacin(CPFX), ofloxacin(OFLX) and minocycline(MC). The lowest concentration of antibiotic at which no inclusions could be observed was defined as the minimum inhibitory concentration(MIC). Results : The MIC? of CFC-222, CPFX, OFLX, and MC against control strains were 0.15㎍/ml, 2.5㎍/ml, 0.6㎍/ml, and 0.008㎍/ml respectively. The MIC? of CFC-222, CPEX, OFLX, and MC against isolates were 0.3㎍/ml, 1.2㎍/ml. 0.6㎍/ml, 0.04㎍/ml, and 0.06㎍/ml, respectively. Conclusion : The new fluoroquinolone CFC-222 was effective in vitro against C. trachomatis.
-
김제학(Je Hak Kim),김현수(Hyun Su Kim),김영훈(Young Hoon Kim),정성목(Seong Mok Jeong),신재규(Jae Kyu Shin),최재묵(Jae Mook Choi),고형곤(Hyung Kon Ko) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
CJ-50001 is a recombinant granulocyte-colony stimulating factor (rG-CSF) synthesized by recombinant DNA technology using E. coli as an expression system. The general pharmacological properties of CJ50001 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses are 100, 300 and 1,000 ㎍/㎏, i.v. for mice and rats, 1, 10 and 100 ㎍/㎏, i.v. for dogs and 1 and 10㎍/ml for isolated guinea pig ileum. Intravenous administration of CJ-50001 at this dose range did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electrolytes excretion. In summary, CJ-50001 had no harmful pharmacological effect in these studies even up to the 200-fold expected clinical dose, 250 ㎍/man.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
