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Radial Basis Function을 사용한 격자 변형에 대한 연구
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유가충격이 한국의 주식시장에 미치는 영향: Granger 및 Toda-Yamamoto 인과성검정을 중심으로
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범패의 연행 형식과 의례 행위
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Coexposure of Environmental Concentrations of cis-Bifenthrin and Graphene Oxide: Adverse Effects on the Nervous System during Metamorphic Development of Xenopus laevis
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- 저자 : 김영설(Y .S .Kim) (검색결과 3 건)
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말단비대증 환자의 박동빈도에 따르는 임상적 내분비학적 특성
이규춘(G . C . Lee),양인명(I . M . Yang),우정택(J . T . Woo),김성운(S . W . Kim),김진우(J . W . Kim),김영설(Y .S .Kim),최영길(Y . K . Choi) 대한내과학회 1997 대한내과학회지 Vol.52 No.4
N/A Objectives: Pulsatile secretion of GH are present in acromegalics and normal men. GH concentration profiles in patients with acromegaly are characterized by rapid GH pulsatility and high interpulse concentrations. There is also variations of GH pulse frequency in individual acromegalic patients. We performed this study to investigate any correlation between GH pulse frequency and clinical or endocrinological findings. Material and Methods: We have studied pulse frequency in 18acromegalic patients by modified Santen and Bardin Method through blood sampling every 1hour for 24hours. TRH stimulation test, LHRH stimulaton test, Somatostatin suppression test and bromocriptine suppression test was done in this patients. We sequenced from cordon 184 to cordon 251 of Gsa gene in pituitary tumor tissue of this acromegalic patients. Clinical findings or endocrinological test results studied above matched to GH pulse frequency to find any correlation by simple regression analysis or Chi-square test. Results: There is no correlation between GH pulse frequency and age, sex, grade of tumor, size of tumor or GH fluctuations. We can not find any difference at incidence of gsp oncogene by pulse frequency of acromegalic patients. GH pulse frequency of acromegalic patients in our study did not identified any difference in paradoxical response to TRH or LHRH and % suppression of GH by somatostatin or bromocriptine. Conclusions: There is no correlation between GH pulse frequency and clinical or endocrinological test. This suggest that GH pulse frequency is not correlated with the expression of various hormone receptors such as dopamine receptor, TRH receptor, LHRH receptor and SSTR.
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Gsa 유전자의 돌연변이가 쥐의 소마토스타틴 수용체 유전자의 발현에 미치는 효과
양인명,박승준,장호강,이군자,오승준,김성운,김진우,김영설,최영길 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4
Background: The growth hormone (GH)-secreting pituitary adenoma with mutation of Gsa gene (gsp oncogene) is known to show a higher response to somatostatin. The mechanism for the higher response is unclear. We previously demonstrated that transcription of the rat somatostatin receptor (SSTR) gene was increased by cAMP. Therefore, we investigated whether the mutation of Gsa gene can increase SSTR gene expression. Methods: The mutant Gsa expressing plasmid of which arginine of codon 201was replaced with histidine was transfected transiently and permanently into GH3 cells. cAMP and rat GH were measured by radioimmunoassay. mRNA expression of the rat SSTR2 was determined by a semiquantitative RT-PCR. Results: The intracellular cAMP production was increased by 1.8 folds in the transiently transfected cells and by 1.5 folds in permanently transfected cells compared to those in the cells transfected with the vehicle plasmid, plasmid expressing the wild type or the plasmid expressing the silent mutant of codon 226. The transcriptional activation by cAMP response element of somatostatin.gene was also increased by 2 folds 24 hours after transient transfection and by 3.5 folds in the permanently transfected cells. The transcriptional activation was not enhanced by forskolin in the transiently transfected cells, whereas it was more remarkably inhibited by somatostatin compared to that in the other transfected cells. The expression of SSTR2 was increased by 1.8 folds 24 hours after transfection in the transiently transfected cells and by 3 folds in the permanently transfected cells, and it was not enhanced by forskolin and isobutylmethylxanthine. The secretion of GH from the transiently transfected cells was not significantly higher than that from the wild type-expressing cells, but it was higher in the permanently transfected cells. The suppression of GH by somatostatin was more prominent in the permanently transfected cells compared to the other transfected cells. Conclusion: This study suggests that a higher expression of SSTR induced by the mutant Gsa may be a mechanism by which gsp-positive adenomas showed a higher response to somatostatin (J Kor Soc Endocrinol 14:657-666, 1999).
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건강증진센터 자료를 이용한 한국인의 비만지표에 대한 평가
이태희,김상만,이득주,김영설 대한비만학회 2000 The Korean journal of obesity Vol.9 No.4
To determine the obesity indices (BMI, Waist, WHR) as the factors on risk of obesity related chronic disease in Korea. We have examined 14,018 adults (6964 men, 7054 women) in Ajou university hospital (suwon, Korea) who took the annual examination from June, 1994 through Jan, 1999. We measured height, weight, waist and hip circumference. All blood samples were taken after 12 hours fast, at the same time point as anthropometric indices measurements. Electrocardiography and Abdominal sonography were taken at the same time. The obesity related chronic disease were estimated in conjunction with obesity indices. We defined the sum of obesity related disease as morbidity index. In men, the prevalence of obese (more than 30 kg/㎡) and overweight (25~29.9 kg/㎡) was 1.4%, 29.4%, respectively. In women, the prevalence of obese (more than 30 kg/㎡) and overweight(25~29.9kg/㎡). The prevalence of obesity related disease increased with age was 1.9%, 19.4%, respectively. This results show that the prevalence of obesity inea is relatively low. The percentile by BMI, Waist circumference, waist to hip ratio for men and women. The 80 th percentile for the BMI is 25 kg/㎡ in men and women. The 80 th percentile for the waist circumference was 94 cm in men, The 80 th percentile for the waist circumference was 80 cm in women. The 95 th percentile for the BMI was 28 kg/㎡ in men and women. This value is smaller than that of Caucasians. The 80 th percentile for the waist to hip ratio of men and women was 0.90, 0.83 respectively. The prevalence of obesity related disease increased with BMI, reaching a peak at 25 kg/㎡ in men and women. And the prevalence of obesity related disease in men and women increased with waist circumference, reaching a peak at 90cm, 80 cm, respectively. In waist to hip ratio, at the 0.8 in women, 0.9 in men, the prevalence of obesity related disease especially increased. The obesity related chronic disease increased with BMI at 23 kg/㎡, reaching a peak at 25~28 kg/㎡ in men and women. And the morbidity index ised with waist circumference at 94 cm in men, 80 cm in women. The morbidity index increased with waist to hip ratio 0.9 in men, 0.83 in women.
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