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OK-432 (Picibanil(R)) 경화요법으로 치료한 림프관종
김보석 ( Bo Suk Kim ),원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Lymphangioma is an uncommon, benign hyperproliferation of the lymphatic vessels, and this consists of dilated lymphatic channels lined by a normal, single layer of endothelial cells. Various methods have been tried for the treatment of lymphangioma, including cryotherapy, electrocauterization, surgical excision, laser therapy, radiotherapy and itralesional injection of sclerosing agents. Yet these methods have shown low success rates and various side effects. It has recently been reported that intralesional injection of OK-432 is a safe and effective alternative therapy for lymphangioma, and especially for macrocystic lesion. In this report, we describe a patient with lymphangioma on the upper labial mucosa and this patient was successfully treated with intralesional injection of OK-432 without any serious complications. To the best of our knowledge, this is the first such case reported on in the Korean dermatological literature. (Korean J Dermatol 2008;46(10):1398∼1401)
김보석 ( Bo Suk Kim ),박세영 ( Se Young Park ),유동오 ( Dong O You ),박석돈 ( Seok Don Park ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.8
Fibroma of the tendon sheath is a benign soft tissue tumor and this mostly occurs in the distal portion of an extremity. The tumor usually appears as a slow-growing, firm, painless, small nodule in association with tendons and tendon sheaths. Histopathologically, it shows a well-demarcated nodule that consists of haphazardly-arranged, fibroblast-like spindle cells that are embedded in a dense collagenous matrix. A 52-year-old woman presented with a tender, solitary, 2.5×2.0 cm-sized, subcutaneous nodule on the right elbow. The skin biopsy specimen showed that the well-circumscribed tumor contained densely-arranged collagen areas with spindle cells and slit-like vascular channels. We herein report on a rare case of fibroma of a tendon sheath on the right elbow. (Korean J Dermatol 2009;47(8):964~966)
김보석 ( Bo Suk Kim ),박석돈 ( Seok Don Park ),김종필 ( Jong Pil Kim ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.4
Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. It has recently been reported that various clinical manifestations and treatments of leprosy are associated with increased angiogenesis. However, there are few reports on this topic. Objective: This study aims to examine the differences in angiogenesis according to clinical forms of leprosy. Methods: Thirty-three cutaneous lesions that represented the clinical spectrum of leprosy and 7 normal skins were selected for this study. Clinical forms of leprosy included in this study were 7 cases of tuberculoid (TT), 8 cases of borderline tuberculoid (BT), 8 cases of borderline lepromatous (BL), and 10 cases of lepromatous (LL) leprosy. A total of 40 sections of formalin-fixed, paraffin embedded tissues were investigated for Factor VIII-related antigen (FVIIIRA) expression using immunohistochemical staining. The number of FVIIIRA positive blood vessels in hot spot at a power of ×40 was observed by 2 independent dermatologists. Results: The number of vessels ranged from 4 to 12 (mean 8.43±2.64) in the normal cutaneous tissues, 23 to 38 (mean 28.86±5.46) in the TT, 46 to 71 (mean 56.50±8.68) in the BT, 49 to 77 (mean 64.75±9.82) in the BL, and 74 to 159 (mean 104.40±27.71) in the LL. The mean numbers of vessels in the BT, BL, and LL leprosy lesions were significantly higher than the mean number in the normal cutaneous tissues. Also, an overall increase was observed in the mean number of vessels from TT through BT, BL to LL leprosy lesions. Conclusion: We suggest that increased angiogenesis is associated with pathogenesis in leprosy. This study should prove helpful to future research into leprosy treatment. (Korean J Dermatol 2010;48(4):278~282)
김보석 ( Bo Suk Kim ),박세영 ( Se Young Park ),박건 ( Kun Park ),박석돈 ( Seok Don Park ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.9
Several hair dressing procedures, for example, bleaching and dyeing of the hair, are currently being frequently performed for cosmetic purposes. While allergic contact dermatitis due to hair dressing products has often been described, only a few cases of burns caused by hair dressing chemicals have been reported. A 6-year-old girl presented with an 8×6 cm sized round ulcerative lesion on the occipital area after hair bleaching with ammonium persulfate mixed with hydrogen peroxide. The skin biopsy specimen showed epidermal necrosis and sclerosing change in the dermis. She was referred to another burn center and then she was treated with skin grafting by a plastic surgeon. To the best of our knowledge, this is the first reported case of chemical burn due to a hair bleaching agent in the Korean dermatologic literature. (Korean J Dermatol 2010;48(9):814~816)
김보석 ( Bo Suk Kim ),원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.11
Hyperpigmentation caused by medication or toxic agents accounts for 10∼20% of all the cases of acquired hyperpigmentations. Nonsteroidal anti-inflammatory drugs, antimalarials, amiodarone, cytotoxic drugs, tetracyclines, heavy metals and psychotropic drugs are most commonly responsible for hyperpigmentation. A 74-year-old man who had taken antituberculosis drugs (rifampin and isoniazid) for 4 months developed generalized hyperpigmentation. The histopathologic finding revealed an increased number of dermal melanophages with pigment incontinence. Eight months after termination of the antituberculosis medication, his skin lesion improved without any treatment. To the best of our knowledge, this is the first reported case of generalized hyperpigmentation due to rifampin and isoniazid in a patient without adrenal insufficiency in the dermatological literature. (Korean J Dermatol 2008; 46(11): 1513∼1516)
비정형 항정신병약물 복용 중인 과체중 환자에서 체중 감량을 위한 행동수정요법의 개발 - 예비연구 -
신홍범,박종호,차보석,김병수,이숙경,김학령,김용식,안용민,강웅구,Shin, Hong Beom,Park, Jong Ho,Cha, Bo Seok,Kim, Byung Soo,Lee, Suk Kyung,Kim, Hak Lyung,Kim, Yong Sik,Ahn, Young Min,Kang, Ung Gu 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2
Objects:The authors devebped a behavioral modification program for oveweight outpatients with schi-zophrenia and bipolar disorder will had teen treated with atypical antipsychotics, and evaluated the applicability of this program to outpatients Methods:Two men and nine women who had been treated with atypical antipsychotics and will had gained at least 5 percent of their pre-treatment body weight for 10 weeks, attended a behavioral modification program. The patients' weight, body mass index and the diet-activity scale were assessed and were compared with those of a matched comparison group will dd not attend the behavioral modification program Results:The body weight of patients who attended the behavioral modification program reduced with statistical significance, The treatment group showed significant improvement in diet-related items but not in activity-related items of the diet-activity scale Conclusions:This study suggested the applicability of a eehavioral mcdification program on weight reduction to overweight patients taking atypical antipsychotics for the frrst time in Korea Additional large scale studies are needed to validate the effectiveness of this program.
박세영 ( Se Young Park ),김보석 ( Bo Suk Kim ),유동오 ( Dong O You ),박석돈 ( Seok Don Park ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.8
Lentigo maligna (LM) is a subtype of melanoma in situ that may become lentigo maligna melanoma. LM is a pigmented lesion that most commonly occurs on sun-exposed skin inthe elderly. Intense exposure to ultraviolet light also accounts for nonmelanotic skin tumors, and particularly basal cell carcinoma (BCC). We herein report on a case of LM and BCC on the right face of a 76-year-old woman. She presented with a longstanding irregular-shaped brown to black pigmented patch on the right infra-orbital area, and a pigmented dome-shaped papule on the right nasolabial fold. The histopathologic findings were consistent with LM and BCC. We performed surgical excisions and there has been no recurrence for 10 months. (Korean J Dermatol 2009;47(8):937~940)
원태혁 ( Tai Hyok Won ),김보석 ( Bo Suk Kim ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Mucoepidermoid carcinoma is a rare disease that usually occurs in the salivary gland. In extremely rare cases, it can originate from the skin. These cases are more aggressive than the usual mucoepidermoid carcinoma, so they have high mortality and high recurrence rates. Herein we report a case of primary cutaneous mucoepidermoid carcinoma on the cheek. A 34-year-old man had a 1.0×1.0 cm sized cystic lesion. This lesion displayed central erosion and oily discharge. He had been operated on 4 times at a private hospital, but the lesion had recurred. Histopathologically, there were many tumor islands that consisted of mucoid cells, epidermoid cells, intermediate cells and clear cells. The tumor islets showed mild positivity for Alcian blue (pH 2.5), PAS, and d-PAS stain. There was no parotid tumor on the neck-CT scan, nor on positron emission tomography. We therefore diagnosed this cheek lesion as primary cutaneous mucoepidermoid carcinoma, and it was removed completely. (Korean J Dermatol 2008; 46(8):1083~1086)
정현철(Hyun Chul Jung),김보석(Bo Suk Kim),송상헌(Sang Heun Song),김용범(Yong Bum Kim),신호진(Ho Jin Sin),이동원(Dong Won Lee),이우철(Woo Chul Lee),이수봉(Soo Bong Lee),곽임수(Ihm Soo Kwak),나하연(Ha Yeon Rha) 대한내과학회 1999 대한내과학회지 Vol.57 No.6
N/A Although the most of mushroom poisoning have a clinical menifestation of mild to moderate gastroenteritis, some mushroom may cause a serious illness; acute renal failure, hepatic necrosis. We experienced two cases of acute renal failure complicated by the poisoning of amanita virosa. Amanita virosa have a amatoxin. Amatoxin deteriorate hepatocytes, renal tubular cells, intestinal mucosal cells, and pancreas. They were transferred from local hospital for renal failure management. On admission, blood urea nitrogen and serum creatinine were highly elevated. We diagnosed acute renal failure complicated by poisoning of amanita virosa. In one case, renal function was further deteriorated compared with initial laboratory findings after creatinine was normalized at fifth day. Thus, we did a kidney biopsy. Light microscopy and EM showed interstitial inflammation and moderate tubular atrophy. They were recovered with the supportive management. We report two cases of mushroom poisoning-induced acute renal failure with review of literature. (Korean J Med 57:1053-1056, 1999)