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중년 여성의 렙틴 수용체 유전자 다형성과 신체구성상 특성의 관련성
김기진 ( Ki Jin Kim ),안나영 ( Na Young Ahn ),천우광 ( Woo Kwang Cheon ),박주식 ( Ju Sik Park ),홍창배 ( Chang Bae Hong ),신윤정 ( Yoon Jung Shin ),김상현 ( Sang Hyun Kim ),김태호 ( Tae Ho Kim ),이지은 ( Ji Eun Lee ) 한국운동생리학회 2004 운동과학 Vol.13 No.2
Kim, K.J., Ahn, N.Y., Cheon, W.K., Park, J.S., Hong, C.B., Shin, Y.J., Kim. S.H., Kim, T.H., Lee, J.E. Relationship between Gln223Arg polymorphism in the leptin receptor gene and body composition in middle-aged women. Exercise Science, 13(2): 233-240, 2004. Previous studies have been found for the polymorphism in the leptin receptor gene being involved in human obesity, We examined relationship between the Gln223Arg polymorphism in the leptin receptor gene and body composition. Subjects were consisted of obese group (N=94) and normal weight group (N=95) in middle-aged women. Body weight, %fat, BMI, skinfold thickness, body circumferences, and WHR we measured for the analysis of the detailed physique. Leptin receptor polymorphism was detected by PCR-RELP assays. The Gln223Arg polymorphism in the leptin receptor gene was no significant difference between obese and normal weight group, and heterozygous for the leptin receptor gene showed the highest values in both groups. The allele frequency was no significant difference between obese and normal weieht group. Body weight and BMI showed a significant (p<0.05) difference between mutant homozygous and heterozygous of the Gln223Arg in the leptin receptor gene in both groups. Hip and high circumferences showed a significant (p<0.05) difference between mutant homozygous and heterozygous of Gln223Arg in the leptin receptor gene in both groups. Although it was no significance, skinfold thickness of mutant homozygous group showed a high values than mutant heterozygous group in obese group. Therefore the Gln223Arg polymorphism of the leptin gene receptor not appeared to be a risk factor for obesity in middle-aged Korean women, but we suggest that the Gln223Arg polymorphism of the leptin gene receptor affect to the body composition.
최근 10년간 ``체육과학연구``의 연구 동향: 운동생리학
김기진 ( Ki Jin Kim ) 한국스포츠과학원 2012 체육과학연구 Vol.23 No.1
The main purpose of this article is to examine current status and trends of research in relation to exercise physiology by analyzing 177 articles published in KJSS (Korea Journal of Sport Science) from 2000 until 2011. From this basis, this study proposes future-oriented direction of the research. Reviewing all articles focused on improving athletes` performance and promoting general people`s health were carried out to classify them into detailed research fields, topics, procedures, subjects, and applications. The detailed research fields were found out to be various including general exercise physiology, nutrition, training and adapted physical activity. For the maximizing performances of athletes, most studies emphasized the importance of maintaining athletes` optimum condition for the competition, as well as physical training. The major experimental procedures in the study of exercise physiology consisted of the analysis of athletes` cardio pulmonary function and changes of blood markers followed by more conclusive contents such as the evaluation and prediction of maximum athletes` performances (abilities), the evaluation and analysis on the effects of training, the changes of physiological functions in accordance with training levels, optimal maintenance of athletes` conditioning arid fatigue analysis, athletes` nutritional status and biochemical components analysis. The subjects of the study were athletes of diverse sport events such as long distance running, soccer, boxing, arid so on. The examined studies showed that molecular biological analysis about effect on exercise for health improvement through mainly analyzing immunology and genetic factors has used so far, and this trend will be largely utilized in the researches of exercise physiology. In addition, these advanced researches will be expected to clarify the relationship between phenotypic factors and genotypic factors examined in the process of analyzing the effect of long term, or short term training and keeping up the optimal conditioning of athletes.
김기진(Kim Ki-Jin),천우광(Chun Woo-Kwang),주성범(Joo Sung-Buem),양혜영(Yang Hae-Young),권정자(Kwon Jung-Ja),박영미(Park Young-Mi) 한국체육과학회 2001 한국체육과학회지 Vol.10 No.1
This study was examined the relationship between body composition and cardiopulmonary function in long distance runners and nonathletes. Arm circumferences, and skinfold thickness of abdomen, suprailiac crest, and calf showed a significant(P<0.05, 0.01) difeerences between two groups. Exercise duration and VO2max of long distance runners showed a significant(P<0.001) higher values than nonathletes. Exercise duration and VO2max showed a significant(P<0.01) correlationship with skinfold thickness of abdomen, suprailiac crest, and calf in total subjects, respectively. Exercise duration and VO2max showed a significant(P<0.01) correlationship with skinfold thickness of calf in long distance runners group, but showed a significant(P<0.01) correlationship with skinfold thickness of abdomen in nonathletes, respectively. This results could be confirmed that the negative effects of skinfold thickness compartment to cardiopulmonary function showed a differences following to the characteristics of subjects.
김기진(Kim, Ki-Jin),배석환(Bae, Seok-Hwan),김가중(Kim, Ga-Jung) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.5
PET/CT촬영 시 호흡에 의해 병소의 움직임으로 인한 영상의 왜곡이 발생한다. 본 연구에서는본원에서 보유 하고 있는 호흡보정 Plumonary Toolkit을 이용한 폐결절부위를 영상화 함으로써 보정을 하지 않은 영상과 비교하여 SUV값의 변화와 영상의 왜곡을 어느 정도 교정할 수 있는지 실험하였다. 2008년 5월에서 8월까지 폐암을 진단받은 환자 17명을 대상으로 하였다. 실험결과 Max SUV값은 최소 4.08%에서 최대 43.10%까지의 증가율을 보였고 폐결절 의 평균 Max SUV값은 6.07에서 7.00로 12.16%로 증가가 되었다. 호흡보정 PET/CT의 경우 영상의 왜곡이 개선되었 다. SCC-Adenocarcinoma에서는 호흡보정 전.후에 통계적의로 유의한 수준(P<0.05)을 보였으나 SCC와 Adenocarcinom 에 대한 각각의 비교에서는 유의성을 보이지 않아 Cell type과 관계없이 호흡보정에 효과가 있었다. 실험 결과 Pulmonary Toolkit을 사용할 경우 표준섭취 계수값과 영상에서의 왜곡이 보정되었다. 따라서 폐암의 진단 및 추적관 찰에 도움을 줄 수 있을 것이다. When taking PET/CT, the distortion of the image happens due to the movement of a lesion with respiration. In this study, the experiment was conducted to see if the change in SUV value and distortion of the image could be somewhat corrected by comparing the image which was not compensated with that of the region of lung nodule, compensated with respiration compensation Plumonary Toolkit possessed by this hospital. The records of 17 patients with Lung cancer between May and August 2008. As the result of the experiment, Max SUV value increased by from 4.08% minimum to 43.10% maximum, and the average Max SUV value of lung nodule increased from 6.07 to 7.00(12.16%). In the case of respiration compensation PET/CT, the distortion of the image improved. As there was no significance in the comparison of SCC and Adenocarcinom respectively, though there was a statistically significant level(P<0.05) before and after respiration compensation in SCC-Adenocarcinoma, there was an effect in respiration compensation regardless of Cell types. As the result of the experiment, it was found out that the distortion of standard intake coefficient value and the image was compensated Therefore, the diagnosis of lung cancer and follow up will be able to help.
식이유도 비만 생쥐의 식이제한과 운동처치 후 대식세포와 단핵구의 IL-6 및 TNF-α생성의 변화
김기진 ( Ki Jin Kim ) 한국운동생리학회 2010 운동과학 Vol.19 No.2
This study was performed the analysis of blood cell numbers related immune function and lipopolysaccharide (LPS) stimulated production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by retroperitoneal macrophage in diet-induced obesity and obesity intervention of male C57Bl/6 mice. Diet-induced obesity was fed a high-fat or a standard chow diet for 6 weeks, and obesity intervention was drived by treadmill running exercise program or food intake restriction. Test items were measured by blood cell numbers related immune function and LPS stimulated production of TNF-α and IL-6 by retroperitoneal macrophage. Subjects of diet-induced obesity showed a significant increase of body weight as compared to normal diet group. High fat diet (HFD)-diet restriction (DR), HFD-exercise (EX) and HFD-DR-EX groups showed a significant decrease of body weight after 8 week intervention as compared to HFD-HFD group. And HFD-DR showed the highest decrease of body weight among intervention groups. Diet-induced obese groups showed a decreasing tendency of blood cell numbers related immune function, and the intervention groups showed an increase of blood cell numbers related immune function after 8 week intervention. LPS stimulated production of TNF-α by retroperitoneal macrophage in diet-induced obesity showed a significant decrease than a ND group, and LPS stimulated production of TNF-α and IL-6 by retroperitoneal macrophage in intervention groups showed a significant decrease after 8 week of food intake restriction or exercise training. In conclusion, diet-induced obesity showed a attenuation of immune function, and improved the blood cell numbers related immune function and LPS stimulated production of TNF-α and IL-6 by retroperitoneal macrophage after exercise intervention and food intake restriction.
김기진(Kim, Ki-Jin),한정란(Han, Jung-Ran) 한국지역사회복지학회 2010 한국지역사회복지학 Vol.0 No.32
본 연구는 충청남도의 노인 평생교육 현황을 파악하고 그 문제점을 분석하기 위하여 충청남도 내 노인 평생교육 기관을 대상으로 전화통화, 방문, 이메일 등을 통하여 자료를 수집?분석하였다. 그 결과, 전반적으로 충청남도는 높은 고령인구에 비하여 노인 평생교육 기반이 취약한 것으로 나타났다. 마지막으로, 지역별 고령인구 수와 비율을 고려한 노인 평생교육시설 확충, 노인교실 등록절차 간소화 및 등록혜택의 확대, 노인교실 지원금에 대한 지방과 중앙정부의 분담, 종교기관 노인교육연합회 활성화, 농촌형 노인 평생교육 모형 개발, 찾아가는 노인 평생교육 서비스의 전문성 제고 등을 제안하였다. The purpose of this research is to analyze the current situation and problems of the lifelong education for the elderly in Chungcheongnam-Do. To achieve this purpose, data have been collected through phone-contacts, visits, emails with representatives of organizations. The results of this research are as follow. First, the number of registered classes for the elderly was totally 58, regionally unbalanced, and the elder"s classes were mostly managed by religious organizations. Second, there were 22 colleges for the elderly operated by Korean Association for Elderly and 16 of them were officially registered. Third, there were 17 social welfare centers and 13 elder"s welfare centers but no welfare center in 3 of cities or provinces at all. Fourth, 25 Protestant churches and 3 Catholic churches managed the elder"s colleges. Fifth, there were 4 elder"s colleges managed by National Agricultural Cooperative Federation and 15 education programs for the elderly operated by Agricultural Technical centers. Sixth, 23 life health leaders were arranged by National Sport Council to help the elderly. Overall, infrastructures of the lifelong education for the elderly in Chungcheongnam-Do were very weak compared to its high aging ratio.