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만성 B형 간염에서의 페그인터페론 치료 시 망막병증의 임상양상
권용대,임지원,Yong Dae Kwon,Ji Won Lim 대한안과학회 2011 대한안과학회지 Vol.52 No.1
Purpose: To evaluate the clinical features of retinopathy in chronic hepatitis B patients treated with peginterferon. Methods: Chronic hepatitis B patients treated with peginterferon were evaluated during regular routine ophthalmic examinations including fundus examination before and during the 1-year follow-up after treatment. A total of 88 patients were included in the study. Results: Retinopathy developed in 11 (12.5 %) out of 88 patients at a mean of 7 weeks after initiation of treatment. Peginterferon treatment was continued in all patients and retinal abnormalities including cotton wool spot, retinal hemorrhage and microaneurysm resolved without visual impairment. The incidence of hypertension between the retinopathy group and the group without retinopathy was significantly different (P = 0.020). Conclusions: The incidence of retinopathy with peginterferon in chronic hepatitis B patients was low and the prognosis was benign. Thus, routine screening for peginterferon retinopathy is not necessary. J Korean Ophthalmol Soc 2011;52(1):41-45
Bisphosphonate, 구강악안면외과 영역의 새로운 위험 요소인가?
권용대,윤병욱,Kwon, Yong-Dae,Yoon, Byung-Wook,Walter, Christian 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.5
Since the first description of bisphosphonate related osteonecrosis of the jaw (BRONJ) in 2002, the number of report on the disease has rapidly been increasing. Now, BRONJ is considered as a new entity, which is emerging problem in oral and maxillofacial surgery. Bisphosphonates (BPs) can be categorized into 2 groups: nitrogen-containing and non-nitrogen containing, and nitrogen-containing BPs are considered to have more efficacy and toxicity possibly. It is unusual for osteonecrosis to occur in the maxilla but BRONJ is found in both the mandible and the maxilla, which is one of the special features of BRONJ compared with common infectious osteomyelitis of the jaws. Intravenous BPs are usually more likely to cause BRONJ than oral BPs which are frequently prescribed for osteoporosis and osteopenia. Nonetheless, the use of intravenous BPs cannot be prevented because of systemic condition of the patients. Although it is rare that oral BPs cause BRONJ in osteoporosis/osteopenia patients, we should be aware of BRONJ since the population of the patients is exceedingly increasing with the prolonging of life expectancy. So, we'd like to enlighten upon the problems and solutions of BRONJ.
권용대,이백수,주성숙,Kwon, Yong-Dae,Lee, Baek-Soo,Jue, Sung-Sook 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.3
In oral and maxillofacial surgery, there are many cases requiring the graft of epidermal tissues such as maxillectomy, and vestibuloplasty. There have been so many challenges for the culture of the epidermal tissue. Observing the ultrastructure of the cultured human oral kertinocytes, we could compare this findings with that of in vivo ones. With that, we could find the differencies and similarities between cultured cells and in vivo ones, and evaluate the clinical applications of cultured tissue. Human gingiva was obtained and the specimen was explanted on 24-well plate. Two types of culture media were used in this culture system. One was for the growth of the keratinocytes (Media I), and the other was for the stratification (Media II). Media I had special ingredients for the epidermal growth. Those were 0.5% dimethyl sulfoxide (DMSO), 30ng/ml of epidermal growth factor (EGF), 30ng/ml of cholera toxin, and $5{\mu}g/ml$ of transferrin. We cultured the oral keratinocytes for 3 weeks, and at that time the cultured keratinocytes were processed to prepare the specimen for the TEM study. The results were as follows.; 1. In the phase contrast micrograph, epidermal outgrowth firstly appeared on the 3rd day after explantation, and the growing keratinocytes were activley mitotic, and had polygonal shape and increased N/C ratio. 2. In the phase contrast micrograph, the outer most cells exhibited areas where broad cytoplasmic processes extended out onto the culture subtratum(fan-like appaearance). 3. In the TEM micrographs, the cultured keratinocytes showed stratification. The cells were in elongated form, and there were no morphologic differencies among the layers usually found in the in vivo gingiva. 4. Most of cellular organelles underwent lysis, and keratohyaline granules were seen. Tonofibrils were dispersed in the cytoplasm. 5. The cells were interconnected by desmosomes, and their frequency of distribution was considered to be lower than that of in vivo keratinocytes. 6. We could conclude the cultured oral keratinocytes exhibited signs of terminal differentiation.
권용대,임지원,Yong Dae Kwon,Ji Won Lim 대한안과학회 2010 대한안과학회지 Vol.51 No.8
Purpose: To report a case of lacrimal gland stone initiated by an eyelash. Case summary: A 31-year-old woman presented with foreign body sensation, pain, and conjunctival injection in the lateral palpebral conjunctiva of her right eye over 6 months in duration. The physical examination revealed a small, firm nodule at the lateral canthal area. The excisional biopsy was performed, and the mass was a concretion that contained an eyelash in the center. During one-year follow-up, the patient showed no signs of recurrence or complication after excision. Conclusions: Although rare in occurence, eyelashes may be the initial nidus for lacrimal gland stone formation. J Korean Ophthalmol Soc 2010;51(8):1139-1141
플리커 저감 디스플레이 시스템 설계를 위한 인광체 잔광 특성의 정량적 해석
權容大(Yong-Dae Kwon),崔德圭(Duk-Kyu Choi),韓纘豪(Chan-Ho Han),李光淳(Gwang-Soon Lee),金銀洙(Eun-Su Kim),李相勳(Sang-Hoon Lee),宋奎翼(Kyu-Ik Sohng) 大韓電子工學會 2000 電子工學會論文誌-SP (Signal processing) Vol.37 No.6
최근 컴퓨터의 급속한 보급에 따라 고밀도 CRT(cathode ray tube)가 요망되고 있다. 이를 위하여 신호 대역과 주사 속도의 증가에 따론 주사선 수를 증가 시켜야 하고 플리커(flicker)도 줄여야 한다. 플리커 현상은 PC작업을 장시간 하는 경우 더욱 심하게 느켜지므로, 플리커 현상을 줄이는 연구가 필요하다. 본 논문에서는 플리커가 덜 느껴지도록 하는 디스플레이 시스템의 설계를 위한 기초 연구로서, CRT에 사용된 인광체의 잔광 특성 및 화면의 밝기에 따른 플리커와 프레임 주파수와의 관계를 정량적으로 해석하였으며, 또한 디스플레이 전화면에 대해서 시각을 고려하여 플리커를 덜 느끼도록 하는 프레임 주파수를 제시하였다. The perception of flicker on the computer display devices depends upon the temporal waveform of the phosphor decay characteristic, the frame rate, and the display size. The lowest frequency at which flicker is not perceived is called the critical fusion frequency or critical frequency. Critical fusion frequency is evaluated by the display illuminance and the modulation (m) defined as the ratio of the amplitude of first harmonic frequency to the DC of the waveform. In this paper, we analyze the relationship between the critical fusion frequency, relating to the decay characteristic of the phosphors and luminance on the monitor, and the frame frequency. Also under considering the viewing angle, we presented the frame frequency that is less sensitive to the full size of the display device.
권용대(Yong-Dae Kwon),이현우(Hyun-Woo Lee) 대한치과의사협회 2013 대한치과의사협회지 Vol.51 No.6
Among the occlusal discrepancies, maxillary transverse deficiency is quite common in several reasons. The reasons are comprised of maxillary hypoplasia, thumb sucking habits, non-syndromic palatal synostosis and syndromal patients including cleft patients. Orthodontic treatment is used routinely to correct a deficiency in young patients while it has limitations for a skeletally mature patient. Surgical treatments help provide effective maxillary expansion to correct a deficiency in adults. Surgical methods can be categorized to segmental Le Fort I osteotomy and surgically assisted rapid maxillary expansion(SARME). Both methods seem successful but each method would have its own indication. We give a review on transverse maxillary deficiency and two surgical methods.