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권다혜,김민영,황보현,지선영,박철,최영현,홍수현 대한한의학방제학회 2020 大韓韓醫學方劑學會誌 Vol.28 No.2
Objectives : This experiment was designed to assess the single oral toxicity of Ethanol Extract Inulae Flos (IF) ethanol extracts. IF is one of the important herbs to remove phlegmy which is the viscous turbid pathological product that can accumulate in the body, causing a variety of diseases. Nevertheless, there has been a lack of research on the pharmacology toxicity of IF. Methods : In this study, IF was orally administered to 5 weeks ICR mice as an oral dose of 2,000 or 3,000 or 5,000 mg/kg. The condition of the mice was observed for 14 days and their weights were measured every two days. Results : None of the mice died for 14 days. The abnormal clinical symptoms and anatomical signs of toxicity were not found in any treatment groups. The gain of net body weight was observed. There was also no significant difference in the organ weight. The serum biochemistry and hematological analysis showed a decrease in BUN, red blood cells, white blood cells and platelets although within the normal ranges. Conclusions : These results suggest that the 50% lethal dose of IF is more than 5,000 mg/kg. This could be thought that IF is a safe drug without acute toxicity and side effects. However, IF showed some weight loss and change in blood test, so it will need to be careful when using it for high doses.
권다혜,김민영,황보현,지선영,박철,최영현,홍수현,Kwon, Da-hye,Kim, Min-young,Hwangbo, Hyun,Ji, Seon-yeong,Park, Cheol,Choi, Yung-hyun,Hong, Su-hyun 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objectives: The aim of this study was to estimate the single oral toxicity of Peucedani Radix (PR) ethanol extracts. PR is one of the important herbs for removal of phlegm, the viscous turbid pathological product that can accumulate in the body and cause a variety of diseases. However, research on the pharmacologic toxicity of PR is lacking. Methods: In this study, PR was orally administered to 5-week-old male ICR mice at an oral dose of 2,000, 3,000, or 5,000 mg/kg. After a single-dose administration, the mortality and behavioral changes were observed daily and body weights were measured every two days. After 14 days, the organ weight, organ index, macroscopy, hematological analysis, and serum biochemistry analysis were determined. Results: No mortality, body weight changes, abnormal behavioral changes, or anatomical signs of toxicity were found. The organ weight, organ index, hematological analysis, and serum biochemistry analysis were also within the normal ranges. Conclusions: These results suggest that the 50% lethal dose of PR is more than 5,000 mg/kg. This could indicate that PR is a safe drug without acute toxicity and side effects.
Lipopolysaccharide로 자극된 RAW 264.7 대식세포에서 Nrf2/HO-1 경로 활성화를 통한 십육미류기음(十六味流氣飮) 추출물의 항염증 및 항산화 효과
권다혜,황보현,김민영,지선영,홍수현,박철,황혜진,최영현 대한한의학방제학회 2019 大韓韓醫學方劑學會誌 Vol.27 No.1
Inflammatory and oxidative stimuli play a critical role not only in the process of transforming normal cells into cancer cells, but also in the proliferation process of cancer cells. Sipyukmiryukieum (SYMRKU), a traditional Korean herb-combined remedy, is composed of 16 kinds of herbal medicines, which were recorded for “Ongjeo” treatment in “Dongeuibogam’. In this study, we investigated the inhibitory effect of SYMRKU against inflammatory and oxidative responses in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Our results showed that SYMRKU significantly inhibited LPS-induced secretion of pro-inflammatory mediators including nitric oxide (NO) and prostaglandin E2 without showing any significant cytotoxicity. Consistent with these results, SYMRKU down-regulated LPS-induced expression of their regulatory enzymes such as inducible NO synthase and cyclooxygenase-2. SYMRKU also inhibited LPS-induced production and expression of pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6. In addition, SYMRKU significantly reduced the production of reactive oxygen species by LPS and showed a strong, which was associated with induction of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 expression. Although further studies are needed to fully understand the anti-inflammatory effects associated with the antioxidant capacity of SYMRKU, the findings of the current study suggest that SYMRKU may have potential benefits by inhibiting the onset and/or treatment of inflammatory and/or oxidative diseases.
Dopamine conjugated nanoparticle device as a resistive switching device
권다혜,정지희,이효선,정헌상,이현호 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
Dopamine (DOPA) is a well-known neurotransmitter in nerve system. In this study, in order to construct a nanobiotechnology-based electronics, zinc oxide nanoparticles (ZnO NPs) were coupled with dopamine and adopted as nanotraps for resistive switching device. The resistive switching device was fabricated in a structure of metal (Al)/DOPA-ZnO NPs+PVP(polyvinylphenol)/metal (ITO: Indium Tin Oxide). Resistive switching characteristics between ZnO NPs and DOPA-ZnO NPs devices were characterized and compared. This resistive switching device can be further developed to form neuromorphic analog device, which can open up a bioelectronic device acting as memory and calculation elements.
Resistive switching characteristics of dopamine conjugate nanoparticle device
권다혜,정지희,정헌상,김요한,이효선,이현호 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Dopamine(DOPA) is a well-known neurotransmitter in nerve system. In this study, zinc oxide nanoparticles(ZnO NPs) were coupled with dopamine and adopted as nanotraps for resistive switching device as information storing on metal(Al) / DOPA-ZnO NPs+PVP(polyvinylphenol) / metal(ITO: Indium Tin Oxide). Resistive switching characteristics depending on DOPA coupling and PVP concentration were characterized and compared. Based on this results, this resistive switching device can open up a bioelectronic device acting as memory and calculation elements as neuromorphic device.