파제트병으로 인한 외이도 협착 1예

국진호,채수량,송지남,서재현 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.5

Paget’s disease is a localized bone disorder that affects widespread areas of skeleton characterized by increased bone remodeling. It is a chronic, progressive disease of unknown etiology. The pathologic process is initiated by hyperactive osteoclastic bone resorption followed by a compensatory increase in the osteoblastic new bone formation. New pagetic bones are disorganized and more susceptible to deformities and fractures. Paget’s disease can affect one or multiple bones in the systemic skeleton, including the temporal bone. We experienced a case of chronic otitis media combined with an external auditory canal stenosis due to Paget’s disease of the temporal bone. We report clinicopathologic features of this rare case.

뇌신경과학기술 인식이 어려운 이유와 기술 도달 단계에 근거한 구체적 시나리오의 필요성

국진호,류영준 한국생명윤리학회 2020 생명윤리 Vol.21 No.1

'Neuroscience and technology' refers to a study that researches the structure, function, and development of the animal's nervous system and studies how to regulate the function of the nervous system through the results. It is also refer to the legal definition of the 'Brain Research Promotion Act'. Broadly, it can be included that all research areas targeting the animal nervous system can fall into this category. Specifically, all brain-related research fields, such as natural science, medicine, pharmacology, engineering, psychology, cognitive science, and anthropology, can be included in brain research. In this field, new fields are rapidly created every year, and the existing fields are differentiating or converging with other fields. In addition, the humanities research is also active in line with the rapid expansion of the domain. In 2002, at the conference hosted by the Dana Foundation in San Francisco, USA, the new definition of neuroethics suggested that neuroethical responses to neuroscience research products should not be limited to existing ethical issues, but should be addressed in a complex way, including social and legal issues. To this end, each country has begun efforts to respond to neuroethics in earnest, but due to its vagueness and confusion, it faced difficulties. Due to the characteristics of the brain research field that are different from those of other science fields, the traditional bioethical approach is facing limitations. Despite this difficulty in the recognition of brain neuroscience and technology, humanities research cannot be put off due to the large social impact of the results. This study aims to find out why it is difficult to recognize brain research as a research subject of humanities and to find solutions. In addition, the reason for the confusion of words and academic difficulties used by the brain research community is found in the complex system characteristics of the neuroscience research and its community. For that purpose, the 'Brain Research Promotion Act' and the Korea Research Foundation's academic classification are analyzed, and it is checked whether the brain research field satisfies the characteristics of the complex system. It is intended to argue that the humanities approach to the brain field with these unique characteristics requires a very specific and reality-based technology ethics scenario and the preparation of multiple scenarios for multi-domain brain neuroscience. 뇌신경과학기술’이란 동물 신경계의 구조, 기능, 발달 등을 연구하고 그 결과를 통해 신경계의 기능을 조절하는 방법을 연구하는 학문을 말한다. 법정용어로는 『뇌연구촉진법』 상의 ‘뇌연구’를 말하기도 하며 넓게는 동물의 뇌를 대상으로 하는 모든 연구 영역이 이 범주로 들어올 수 있다. 구체적으로는 자연과학, 의학, 약학, 공학, 심리학, 인지과학, 인류학 등 뇌와 관련된 모든 분야가 포함될 수 있다. 이 분야는 매년 새로운 분야가 활발히 발생하고 있는데 이것은 기존의 분야가 분화하거나 다른 분야와 융합하는 현상을 보인다. 한편 이런 급속한 영역 확장에 맞춰 인문학연구도 활발해지고 있다. 2002년 미국 샌프란시스코에서 열린 다나 재단 주최 회의에서 뇌연구 산물에 대한 신경윤리적 대응을 기존의 윤리 문제에 한정할 것이 아니라 사회적 및 법적 문제를 포함하여 복합적으로 다루어져 사회에 다방면의 실질적인 도움이 되기 위하여 연구 설계 단계에서 인문학이 참여하여야 한다는 주장 등 새로운 신경윤리의 정의와 개념이 제시됐다. 이를 위해 각 나라에서는 본격적으로 신경윤리적 대응을 위한 노력을 시작하였으나 인문학자들에게 이런 모호한 뇌연구 분야가 처음부터 인식조차 되지 않는 등 막연함과 혼란으로 인하여 난관에 봉착하고 있다. 이것은 뇌연구 분야가 다른 과학 분야와 구별되는 특성으로 인한 것으로 기존 생명윤리학적 접근법으로는 연구 초기 단계부터 참여하여 각 분야에서 복합적으로 실질적인 토론을 통해 상호 영향으로 발전하고자 하는 새로운 신경윤리 패턴에 적응하지 못하는 현상으로 보인다. 그러나 뇌신경과학기술에 대한 인문학자들의 인식 어려움에도 불구하고 그 결과물이 가져올 큰 사회적 영향력 때문에 인문학적 연구가 미뤄질 수는 없을 것이다. 본 연구는 인문학의 연구대상으로서의 뇌연구 인식이 어려운 이유를 찾고 그 해결책을 알아보고자 하였다. 저자들은 뇌연구계가 사용하고 있는 혼란스러운 단어 사용이나 학문적 난해함을 뇌연구계의 복잡계적 특성에서 그 이유를 찾아보았다. 이를 위해 뇌연구촉진법, 한국연구재단의 학문분류표를 분석하여 뇌연구 분야가 복잡계가 갖추어야 하는 특징인 구성요소를 충족하는지 알아보았다. 이런 독특한 특성을 가진 뇌 분야에 대한 인문학적 접근을 위해서는 현재 기술이 도달해 있는 아주 구체적이고 현실적 사실에 근거한 기술윤리시나리오가 필요하며 다중영역을 가진 뇌신경과학기술을 위한 복수의 시나리오 마련이 필요함을 주장하고자 한다.

“머리 이식” 수술 계획에 대한 비판적 검토

국진호,류영준 한국생명윤리학회 2019 생명윤리 Vol.20 No.2

This study contains a summary and critical analysis of the recent "head transplant" plan known in the media. The plan, dubbed the “Heaven Project,” was announced in 2017 by Dr. Sergio Canavero, an Italian neurosurgeon, a surgical plan to connect the body of a brain death patient to the head of a quadriplegic patient. The word "head transplantation", which frequently appears in the press, is the expression Dr. Canavelo used in his lectures and press interviews. The medical technology process used in the surgical procedure of this plan was named "GEMINI protocol." In a poll of 1,000 Koreans who were commissioned by Gallup Korea, 58% had negative opinions and 15% had positive opinions to “Heaven Project”. However, 41% of the respondents thought it would be technically possible. In this paper, the authors attempted to analyze the exact contents of the plan, to ensure proper naming, to ensure technical safety, to be feasible under current Korean law, and to public opinion on the technology. The term "hair transplant" is not logically consistent in light of the content, but rather the term "body transplant" or "head-to-body joint surgery" is more appropriate. In addition, the “Heaven Project”, which does not provide sufficient technical collateral for neurorecovery such as animal testing and micromanipulation at this stage, it has not the technical sufficient to secure the safety and resilience required when applied to humans. In legal review, it was unlikely to be done in Korea under the current domestic laws, such as the Medical Law and the Bioethics and Safety Act etc. There were many problems in the review of compliance with ethical regulations, and criticism of the humanities occurred because they attempted to justify research that insufficient theoretical background appealed to public sentiment rather than expert opinion. The results of this study will provide neuroethics and humanists who wish to discuss body transplantation with the scientific and medical evidence necessary for an academic approach and provide the knowledge necessary for the humanities review of neuroscience and neurosurgery. 본 연구는 최근 언론을 통해 알려진 인간 “머리 이식” 계획에 관한 내용 정리와 비판적 분석을 그 내용으로 담고 있다. 일명 “헤븐 프로젝트”로 명명한 이 계획은 2017년 이탈리아 신경외과 의사인 세르지오 카나벨로 (Sergio Canavero) 박사가 발표한 것으로 뇌사자의 몸통과 사지 마비 환자의 머리를 연결하겠다는 수술 계획을 말한다. 언론에 자주 등장하는 “머리 이식(Head transplantation)”이라는 단어는 카나벨로 박사 본인이 직접 강연과 언론 인터뷰에서 사용한 표현이다. 이 계획의 수술 과정에서 사용되는 의학적 기술 과정을 “제미니 프로토콜(GEMINI protocol)”이라 이름하였다. 한국 갤럽에 의뢰하여 실시한 “머리이식”에 대한 여론 조사에서 부정적인 의견이 58% 긍정적인 의견이 15%였다. 하지만 응답자의 41%가 기술적으로 가능할 것으로 판단하고 있었다. 본 논문에서 저자들은 계획의 정확한 내용 분석, 명명의 적정함, 기술적인 안전성 확보 여부, 현행 한국의 법률하에서의 시행 가능성, 이 기술에 대한 국민 여론을 알아보고자 했다. 연구 결과에 따르면 “헤븐 프로젝트”는 총 다섯 단계로 이루어져 있다. 이식 전 냉각과정, 척수 절단, 생체용 접착제를 이용한 척수 연결, 혈관 연결, 재활 훈련과정이 그것이었다. “머리 이식”이라는 용어는 내용에 비추어 볼 때 논리적으로 부합되지 않으며 오히려 ”몸통 이식“ 또는 ”머리-몸통 접합 수술“ 등의 용어가 더 적합하다. 또 현 단계에서 충분한 동물시험과 미세조작 등의 신경 회복에 대한 구체적인 기술적 담보를 제시하지 못하고 있는 ”헤븐 프로젝트“는 인간에게 적용하였을 때 필요한 안전성과 기능 회복성을 담보할 만한 기술적 충분성을 가지고 있지 못했다. 법률적 검토에서는 「의료법」과 「생명윤리 및 안전에 관한 법률」 등 한국의 현행 법률하에서는 국내에서 이루어질 가능성이 낮았다. 윤리규정준수 여부에 대한 검토에서 많은 문제점을 가지고 있었으며 전문가의 의견보다는 대중의 감정에 호소한 이론적 배경이 불충분한 연구의 정당성을 확보하려 시도했다는 점에서 인문학적 비판점이 발생했다. 이 연구 결과는 신체 이식을 논의하고자 하는 신경 윤리학자와 인문학자들에게 학문 접근에 필요한 과학적 및 의학적 근거를 제공할 것이며, 신경과학과 신경외과학도의 인문학적 검토에 필요한 지식을 제공해 줄 것으로 기대한다.

스키용품 원산지 정보와 제품관여도에 따른 제품평가와 브랜드 관계의 질, 브랜드 충성도의 차이

국진호(Kook, Jin-Ho),정태욱(Chung, Tae-Wook) 한국사회체육학회 2015 한국사회체육학회지 Vol.0 No.62

This study aimed to find the difference of production evaluation, brand relationship quality, and brand loyalty based on the information about origins of ski supplied and product involvement. Based on preliminary investigations, ski supplies were classified into a high involvement product(plate) and low involvement product(pole), and each of them were again divided into two groups to set up a survey of four areas: agreement or disagreement between the origin of the brand and manufacturer. Subjects of our analysis were the 415 (25 out of 440 were excluded due to loose answers) users of 4 ski resorts in Gangwon-do and Gyeonggi-do who provided serious answers to our questionnaire. SPSSWIN 18.0 was utilized to carry out factor analysis, reliability analysis, correlation analysis, two-way ANOVA, regression analysis. In accordance with the result, firstly, when the origins of brand and manufacturer agree, the subjects showed higher result, compared to disagreeing cases, in perceived quality of product evaluation, perceived value and brand relationship quality(satisfaction, trust, commitment), and brand loyalty. Secondly, the effect of agreement/disagreement of origins on product evaluation, brand relationship quality and brand loyalty is that the high involvement products had higher perceived quality than low involvement products had, and, although high involvement products had lower perceived risk than low involvement products did, there was not any significant difference in other variables.

시뮬레이션 기반 자작 전기차 프레임의 경량화 설계

국진호(J. H. Kook),이종선(C. S. Lee) 한국생산제조학회 2023 한국생산제조시스템학회 학술발표대회 논문집 Vol.2023 No.7

국소 침범한 갑상선암에서 부분 인후두부분절제술을 통한 후두 보존 2예

국진호 ( Jin-ho Kook ),박준욱 ( Jun-ook Park ),주영훈 ( Young-hoon Joo ),선동일 ( Dong-il Sun ),김민식 ( Min-sik Kim ) 대한갑상선학회 2010 International Journal of Thyroidology Vol.3 No.2

The surgical treatment of advanced hypopharynx or thyroid cancer with infiltration of the laryngeal skeleton often needs total laryngectomy for oncologic safety and functional reasons, although tumor infiltration is limited to the half of the larynx. We have performed partial pharyngolaryngectomy in locally advanced laryngopharyngeal cancer to preserve the laryngeal function by the reconstruction of radial forearm free flap with tendon. We have applied the partial pharyngolaryngectomy in locally advanced thyroid cancer with laryngeal invasion in two cases which are needs to take a total laryngectomy. In the cases, we had completely resection of the tumor with sufficient margin including supraglottis and paraglottic space, and reconstructed the defect by using the radial forearm free flap. The oncological and functional results were satisfactory.

편도아데노이드 절제술이 수면호흡장애 소아의 증상과 성장에 미치는 영향:장기 추적관찰 결과

주영훈,김병국,김수환,김영하,국진호,진선영,강준명 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.4

Background and Objectives:Chronic upper airway obstruction attributable to adenotonsillar hypertrophy is the most common cause of sleep disordered breathing (SDB) in children. The objective of this study was to evaluate the long-term effects of adenotonsillectomy on the degree of SDB and growth in children with SDB. Subjects and Method:Forty-three children (mean age, 6.1±2.4 years) clinically diagnosed as SDB were enrolled, and they were scheduled for adenotonsillectomy (T&A) based on their response to the validated, 22-item sleep related breathing disorder (SRBD) scale and a physical examination that showed adenotonsillar hypertrophy. Weight, height, and BMI (body mass index) were evaluated before and three years after T&A. Results:SRBD scales decreased significantly after T&A (p<0.001). Their Z scores (standard deviation scores) for weight, height, and BMI of 43 children were significantly higher three years after T&A compared with before T&A (p<0.01). Conclusion:Children with SDB who underwent adenotonsillectomy showed significant long-term increases in weight, height, and BMI as well as a significant long-term improvement in quality of the sleep.

The Status and Prospect of Seasonal Climate Prediction of Climate Over Korea and East Asia: A Review

정지훈,이현수,유진호,권민호,예상욱,국종성,이준이,김백민,손석우,민승기,이한수,이우섭,윤진호,김현경 한국기상학회 2017 Asia-Pacific Journal of Atmospheric Sciences Vol.53 No.1

Over the last few decades, there have been startling advances in our understanding of climate system and in modelling techniques. However, the skill of seasonal climate prediction is still not enough to meet the various needs from industrial and public sectors. Therefore, there are tremendous on-going efforts to improve the skill of climate prediction in the seasonal to interannual time scales. Since seasonal to interannual climate variabilities in Korea and East Asia are influenced by many internal and external factors including East Asian monsoon, tropical ocean variability, and other atmospheric low-frequency variabilities, comprehensive understanding of these factors are essential for skillful seasonal climate prediction for Korea and East Asia. Also, there are newly suggested external factors providing additional prediction skill like soil moisture, snow, Arctic sea ice, and stratospheric variability, and techniques to realize skills from underlying potential predictability. In this review paper, we describe current status of seasonal climate prediction and future prospect for improving climate prediction over Korea and East Asia.

경미로 접근법을 통해 제거한 추체골의 광범위한 진주종 2예

서재현(Jae-Hyun Seo),최진(Jin Choi),국진호(Jin-Ho Kook),장기홍(Ki-Hong Chang) 대한두개저학회 2008 대한두개저학회지 Vol.3 No.2

Cholesteatoma of the petrous bone is rare lesion, which may be congenital or acquired in nature, and presents difficulties in its diagnosis and treatment. The availability and the advances in imaging techniques render petrous bone cholesteatoma feasible to diagnose and manage. The removal of the petrous bone cholesteatoma is not easy for the anatomical difficulty of approach. The surgical aim should be complete removal of the cholesteatoma with preservation of existing neuronal function and prevention of CSF leakage. We describe two cases of extensive petrous bone cholesteatoma in which complete removal was accomplished using translabyrinthine approach. One case is supralabyrinthine type petrous cholesteatoma with antero-medial extension and the other is massive labyrinthine type. In both cases, complete removal was possible by using translabyrinthine approach.