트리할로스 , 포도당 및 유당이 한탄바이러스 백신의 안정성에 미치는 영향

고은주(Eun Joo Ko),성인화(In Hwa Sung) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.4

Most of the currently licensed viral and bacterial vaccines produced in the world are in state of antigen suspension and the immunogenicity of vaccines could be maintained for one or two years only by keeping in the refrigerator, but without refrigeration vaccines would easily lose their immunogenicites. In this study, as a step to develope the method of increasing the stability of vaccines and maintaining the immunogenicity of vaccines for a long time at room temperature or higher temperature, trehalose, glucose and lactose at different concentration were added into the Hantaan virus vaccines and then kept at 37℃ for 12, 24, 48 hours and at room temperature for seven days respectively. Treated vaccines were then inoculated respectively into ICR mice and the titers of antibody against the antigen of Hantaan virus from the mice sera were evaluated. Vaccine without sugar lost immunogenicity completely in 24 hour at 37℃, but the vaccines containing trehalose could maintain some of the immunogenicity even after exposure at 37℃ for 48 hours and the best concentration of trehalose for maintaining the immunogenicities of vaccines was 7.5-10 percent. The results suggest that addition of trehalose could increase the stability of Hantaan virus vaccine.

패션 온라인 커뮤니티 특성이 브랜드 충성도에 미치는 영향 - 라이프스타일 집단 간 비교

고은주(Ko Eun Joo),김경훈(Kyung Hoon Kim),권준희(Joon Hee Kwon) 한국마케팅과학회 2006 마케팅과학연구 Vol.16 No.3

  인터넷의 보급과 함께 기업의 마케팅 도구로서 온라인 커뮤니티가 등장하였으며 최근 그 중요성이 점차 증가되고 있다. 패션 기업에서도 적은 비용으로 고객과 관계를 형성하며 궁극적으로는 고객 충성도를 제고할 수 있는 방안이라는 측면에서 온라인 커뮤니티에 주목하고 있다. 본 연구의 목적은 1) 패션 온라인 커뮤니티의 특성을 분석하고 2) 라이프스타일에 따라 세분화된 집단 유형별로 브랜드 충성도에 미치는 커뮤니티 특성 차이를 규명함으로써 라이프스타일 집단에 따른 효율적인 온라인 커뮤니티 마케팅 전략을 제안하고자 한다. 본 연구의 결과를 요약하면, 첫째, 패션 온라인 커뮤니티에서 제공되는 특성은 ‘상호작용성’, ‘정보제공성’, ‘흥미제공성’ 3개의 요인으로 나타났다. 둘째, 라이프스타일에 따라 집단을 세분화한 결과 ‘무관심형’, ‘감각추구형’, ‘합리추구형’의 3집단으로 구분되었으며, 라이프스타일 집단에 따라 온라인 커뮤니티특성이 브랜드 충성도에 미치는 영향 요인의 차이를 분석한 결과, 무관심형 집단은 커뮤니티의 상호작용성이, 감각추구형 집단은 정보제공성이, 합리추구형 집단은 흥미제공성과 정보제공성이 브랜드 충성도를 높이는 중요한 요인으로 나타났다. 본 연구는 패션 온라인 커뮤니티 회원들의 커뮤니티 이용 특성을 분석함으로서 궁극적으로 패션 기업의 온라인 커뮤니티 전략 수립에 필요한 기초정보를 제시하였다.   Importance of on-line community has been increased and also on-line community has been used as an important marketing tool. Fashion companies also considered that on-line community provides opportunities to develop customer relationship and to improve customer loyalty. The purpose of this study is 1) to identify the characteristics of fashion on-line community, 2) to investigate the differences of factors affecting brand loyalty among fashion lifestyle groups. For data collection, on-line survey was conducted for fashion on-line community members in Daum portal site and total 404 subjects were used for this study. Factor analysis, cluster analysis, and regression analysis were used for data analysis. The results of this study were as follow : first, characteristics of fashion on-line community were classified as three factors : "interactivity", "information provision" and "interest provision". Second, the impact of fashion on-line community characteristics on brand loyalty were found to be significantly different among lifestyle groups. The results from this empirical study provide basic information for strategic planning about fashion on-line community by analyzing characteristics of on-line community users.

의료기관인증평가 전후 인증기준 준수율의 변화

고은주(Eun-Ju Ko),이진용(Jin-Yong Lee),배석환(Seok-Hwan Bae),김현주(Hyun-Joo Kim) 대한방사선과학회(구 대한방사선기술학회) 2013 방사선기술과학 Vol.36 No.4

이 연구는 의료기관인증 획득 당시와 인증획득 이후 인증기준 준수율이 얼마나 향상 또는 감소되었는지를 확인하고자 의료기관인증을 획득한 대전지역의 4개 대학병원에 종사하며 의료기관 인증평가를 경험한 방사선사를 대상으로 하였다. 연구방법으로는 의료기관인증평가 기준 틀을 재분류하여 환자안전, 직원 및 환경안전영역에 대해 평가하였다. 환자안전(patient safety) 8문항, 직원안전(staff Safety) 5문항, 환경안전(environmental safety) 3문항으로 총 16문항으로 구성하였고 인증기준 준수율은 10점 척도로 인증평가 당시와 현재의 인증기준 준수율을 측정하였다. 연구결과 인증기준 준수율은 인증평가 당시에 비해 2012년 12월 현재 평균적으로 환자안전, 직원 및 환경안전 영역 모두가 떨어졌다. 세부문항 16개 중에서 가장 많이 떨어진 문항은 환자안전 영역의 손위생이었다. 손위생은 개인의 노력 및 필요성에 대한 인식도 중요하지만 지속적인 교육과 관리·감독이 역시 중요하다. 따라서 의료기관들은 인증기준 준수의 필요성에 대해 지속적인 교육 시행과 적극적인 관리·감독이 필요하다. This study aimed to assess whether the changes in compliance rates of evaluation criteria after healthcare accreditation among radiologic technologists working at four university hospitals which had acquired healthcare accreditation in Daejeon metropolitan area. In this study, the evaluation criteria of healthcare accreditation were reclassified and reevaluated to three areas which include patient safety, staff safety, and environmental safety. Each area has eight, three, and five questions, respectively. Each compliance rate was quantitatively measured on a scale of 0 to 10 before and after in this study. The result shows that the overall compliance rates were decreased on all areas compared to the time healthcare accreditation was obtained. The compliance rate of hand hygiene was drastically reduced. To maintain the compliance rates, not only individuals but healthcare organizations should simultaneously endeavor. In particular, healthcare organizations should make an effort to provide continuous education opportunity to their workers and supervise the compliance regularly.

의류브랜드 소비자의 고객관계관리 경험에 관한 탐색적 연구 - 남성복, 여성복, 캐주얼, 스포츠의류 소비자의 비교를 중심으로 -

고은주 ( Eun Ju Ko ),이주연 ( Joo Yun Lee ),윤혜림 ( Hye Lim Yun ) 대한가정학회 2006 Human Ecology Research(HER) Vol.44 No.5

상표자산과 구매의도와의 관계에 관한 국제비교연구 - 아시아와 유럽의 의류시장을 중심으로 -

김경훈,고은주,이동해,정홍섭,전병주,문학일,Kim, Kyung-Hoon,Ko, Eun-Ju,Graham, Hooley,Lee, Nick,Lee, Dong-Hae,Jung, Hong-Seob,Jeon, Byung-Joo,Moon, Hak-Il 한국마케팅과학회 2008 마케팅과학연구 Vol.18 No.4

본 연구는 상표자산의 구성요소에 대한 선행요인을 분석하고 이를 토대로 하여 상표자산 구성요소와 상표자산 영향요인간의 관계 그리고 상표자산 구성요소와 구매의도간의 관계를 규명하고 한국과 영국을 중심으로 비교하여 상표자산관리 방안을 도출해보고자 하였다. 연구결과, 정보탐색은 제품지식에 정(+)의 영향을 미치며, 상표태도와 상표지식은 상표 충성도와 상표 가치에 정(+)의 영향을 미치는 것으로 나타났다. 그리고 상표충성도와 상표가치는 구매의도에 정(+)의 영향을 미치는 것으로 나타났다. 정보원천의 경우, 한국에서는 제품지식에 정(+)의 영향을 미치고 있는 반면, 영국에서는 영향을 미치지 않는 것으로 나타났다. Brand equity is one of the most important concepts in business practice as well as in academic research. Successful brands can allow marketers to gain competitive advantage (Lassar et al.,1995), including the opportunity for successful extensions, resilience against competitors' promotional pressures, and the ability to create barriers to competitive entry (Farquhar, 1989). Branding plays a special role in service firms because strong brands increase trust in intangible products (Berry, 2000), enabling customers to better visualize and understand them. They reduce customers' perceived monetary, social, and safety risks in buying services, which are obstacles to evaluating a service correctly before purchase. Also, a high level of brand equity increases consumer satisfaction, repurchasing intent, and degree of loyalty. Brand equity can be considered as a mixture that includes both financial assets and relationships. Actually, brand equity can be viewed as the value added to the product (Keller, 1993), or the perceived value of the product in consumers' minds. Mahajan et al. (1990) claim that customer-based brand equity can be measured by the level of consumers' perceptions. Several researchers discuss brand equity based on two dimensions: consumer perception and consumer behavior. Aaker (1991) suggests measuring brand equity through price premium, loyalty, perceived quality, and brand associations. Viewing brand equity as the consumer's behavior toward a brand, Keller (1993) proposes similar dimensions: brand awareness and brand knowledge. Thus, past studies tend to identify brand equity as a multidimensional construct consisted of brand loyalty, brand awareness, brand knowledge, customer satisfaction, perceived equity, brand associations, and other proprietary assets (Aaker, 1991, 1996; Blackston, 1995; Cobb-Walgren et al., 1995; Na, 1995). Other studies tend to regard brand equity and other brand assets, such as brand knowledge, brand awareness, brand image, brand loyalty, perceived quality, and so on, as independent but related constructs (Keller, 1993; Kirmani and Zeithaml, 1993). Walters(1978) defined information search as, "A psychological or physical action a consumer takes in order to acquire information about a product or store." But, each consumer has different methods for informationsearch. There are two methods of information search, internal and external search. Internal search is, "Search of information already saved in the memory of the individual consumer"(Engel, Blackwell, 1982) which is, "memory of a previous purchase experience or information from a previous search."(Beales, Mazis, Salop, and Staelin, 1981). External search is "A completely voluntary decision made in order to obtain new information"(Engel & Blackwell, 1982) which is, "Actions of a consumer to acquire necessary information by such methods as intentionally exposing oneself to advertisements, taking to friends or family or visiting a store."(Beales, Mazis, Salop, and Staelin, 1981). There are many sources for consumers' information search including advertisement sources such as the internet, radio, television, newspapers and magazines, information supplied by businesses such as sales people, packaging and in-store information, consumer sources such as family, friends and colleagues, and mass media sources such as consumer protection agencies, government agencies and mass media sources. Understanding consumers' purchasing behavior is a key factor of a firm to attract and retain customers and improving the firm's prospects for survival and growth, and enhancing shareholder's value. Therefore, marketers should understand consumer as individual and market segment. One theory of consumer behavior supports the belief that individuals are rational. Individuals think and move through stages when making a purchase decision. This means that rational thinkers have led to the identification of a consumer buying decision process. This decision process with i

마우스 비장세포의 증식과 생존율에 대한 BCG-CWS의 면역자극 효과

이제욱,고은주,주홍구,Lee, Che-Wook,Ko, Eun-Ju,Joo, Hong-Gu 대한수의학회 2012 大韓獸醫學會誌 Vol.52 No.2

Mycobacterial cell-wall skeleton (CWS) is an immunoactive and biodegradable particulate adjuvant and has been tried to use for immunotherapy. The CWS of Mycobacterium bovis bacillus Calmette-Guerin (BCG-CWS) was studied as an universal vaccine vehicle for antigen conjugation, to develop potentially effective and safe vaccine. Although a variety of biological activities of BCG-CWS have been studied, the effects of BCG-CWS on spleen cells are not fully elucidated. Using MTT assay and trypan blue exclusion test, we found that BCG-CWS significantly enhanced the viability and proliferation of cells. Multiple clusters, indicating proliferation, were observed in BCG-CWS-treated spleen cells and surface marker staining assay revealed that BCG-CWS promoted the proliferation of $CD19^+$ B lymphocyte rather than $CD4^+$ or $CD8^+$ T lymphocyte. In addition, BCG-CWS up-regulated the expression of anti-apoptotic molecules such as bcl-2, bcl-xL. BCG-CWS increased the surface expression of CD25 and CD69 as well as IL-2 production of spleen cells, suggesting increased activation. Furthermore, BCG-CWS enhanced the antigen-specific cell proliferation and interferon-gamma production of spleen cells. Taken together, these results demonstrate the immunostimulatory effects of BCG-CWS on spleen cells via multiple mechanisms, providing valuable information to broaden the use of BCG-CWS in clinical and research settings.

청소년의 인터넷 사용특성에 따른 의복행동, 구매 평가기준, 정보원에 대한 연구

장남경(Nam Kyung Jang),고은주(Eun Joo Ko) 한국복식학회 2004 服飾 Vol.54 No.7

The internet is one of the modern facilities that has been diffused very rapidly in recent years and tremendously influenced on our life. Although the adolescents are major users of internet. the literature in clothing and textile area has not addressed the relationships between adolescents` internet use and clothing behavior. The purpose of this study was to examine the differences of adolescents clothing behavior, purchase evaluative criteria, and information source according to the use of internet. Descriptive statistics, t test, Analysis of Variance (ANOVA), and Duncan test were employed to analyze the data collected from the convenience sample of 572 middle and high school students in Gyeongnam, Korea. The use of internet was partially related to the adolescents` clothing behaviors, purchase evaluative criteria, and information source. Also, it was observed that the frequency and purpose of fashion website tended to be related more than the amount and purpose of internet did. Marketing implications from the results were suggested.

결절성 경화증과 동반된 폐의 임파관평활근종증

백정민 ( Jung Min Baik ),홍한기 ( Han Ki Hong ),오영배 ( Young Bae Oh ),이상무 ( Sang Moo Lee ),박만실 ( Man Sil Park ),유탁근 ( Tak Keun Yoo ),고은주 ( Eun Joo Ko ),김은경 ( Eun Kyung Kim ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.5

박스 형태의 복합레진 수복시 충전법 및 와동벽에 따른 결합력 차이에 관한 연구

고은주,신동훈 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.4

복합 레진은 중합되는 동안 수축으로 인한 응력이 발생하게 되고 이는 결합력 실패를 야기한다. 치질과의 결합력은 접착면의 성질에 영향을 받게 되는데 대부분의 연구들은 편평한 접착면상에서 이루어졌으며 와동내 와벽 위치에 따른 결합력 차이에 관한 연구는 미미한 실정이다. 이에 본 연구에서는 I 급 복합레진 수복시 단일 충전한 경우와 적층 충전한 경우에 있어서 와동의 치수벽과 측벽에서의 결합력 차이를 알아보고자 하였다. 발거된 20개의 건전한 제3 대구치를 대상으로 6 × 4 × 3 mm 크기의 박스 형태로 와동을 형성한 후 레진 충전방법과 와동벽에 따라 4개 군으로 분류하였다. 단일 충전하고 치수벽의 결합력을 측정한 A군, 단일 충전하고 측벽의 결합력을 측정한 B군, 적층 충전하고 치수벽의 결합력을 측정한 C군, 적층 충전하고 측벽의 결합력을 측정한 D군으로 설정하였다. 제조사의 지시에 따라 Clearfil SE bond^(Ⓡ) (Kuraray Corp., Osaka, Japan)로 치면 처리한 후 Filteck Z 250^(Ⓡ)(3M/ESPE., St. Paul, USA)을 사용하여 와동을 충전하였다. 적층 충전군의 경우 1.5 mm씩 두 번에 나누어 충전하고 각각 40초씩 중합하였다. 37℃의 증류수에서 24시간 보관 후 교합면쪽 법랑질을 제거하고 수복물의 근원심 폭의 절반되는 지점에서 협설 방향으로 치아를 잘랐다. 주수하에 고속 diamond saw를 사용하여 각 치아의 접착면에 수직으로 1 × 1 × 7 mm의 막대 형태의 시편을 만들었으며 만능시험기에 부착하고 1 mm/min의 속도로 미세인장 결합강도를 측정하였다. 2-way ANOVA test와 t-test를 이용하여 95% 유의수준으로 통계 분석한 결과는 다음과 같다. 1. 충전 방법의 경우, 적층 충전군이 단일 충전군보다 높은 평균값을 보였으나 통계적 유의성은 없었다. 2. 와동벽에 따른 결합력 차이의 경우, 치수벽 군이 측벽 군보다 결합력이 큰 것으로 나타났으나 유의성은 없었다. 본 연구 결과만을 토대로 볼 때 , 충전 방법과 와동벽의 두 가지 요소가 치질과의 결합력에 미치는 영향이 크지 않았다. Bond strength depends on characteristics of bonding surface and restorative technique. The majority of studies dealing with dentin bond strength were carried out on flat bonding surface, therefore, difference of bond strength between axial wall and pulpal wall is not clear yet. This study evaluated bonding difference between cavity walls in class I composite resin restoration with different filling techniques. Twenty extracted caries-free human third molars were used. Cavities were prepared in 6 × 4 × 3 mm box-type and divided into four groups according to filling technique and bonding surface: Group I; bulk filling - pulpal wall, Group II; bulk filling - axial wall, Group III; incremental filling - pulpal wall, Group IV ; incremental filling - axial wall. Cavities were filled with Filtek Z250^(Ⓡ) (3M/ESPE., USA) and Clearfill SE bond^(Ⓡ) (Kuraray, Japan). After 24 hour-storage in 37℃ water, the resin bonded teeth were sectioned bucco-lingualy at the center of cavity. Specimens were vertically sectioned into 1.0 × 1.0 mm thick serial sticks perpendicular to the bond surface using a low-speed diamond saw (Accutom 50, Struers, Copenhagen, Denmark) under water cooling. The trimmed specimens were then attached to the testing device and in turn, was placed in a universal testing machine (EZ test, Shimadzu Co., Kyoto, Japan) for micro-tensile testing at a cross-head speed of 1mm/min. The results obtained were statistically analyzed using 2-way ANOVA and t-test at a significance 1eve1 of 95%. The results were as follows: 1. There was no significant difference between bulk filling and incremental filling. 2. There was no significant difference between pulpal wall and axial wall, either. Within the limit of this study, it was concluded that microtensile bond strength was not affected by the filling technique and the site of cavity walls.

상표자산과 구매의도와의 관계에 관한 국제비교연구 : 아시아와 유럽의 의류시장을 중심으로

김경훈,고은주,Graham Hooley,Nick Lee,이동해,정홍섭,전병주,문학일 가야대학교 2009 가야대학교 논문집 Vol.18 No.-

본 연구는 상표자산의 구성요소에 대한 선행요인을 분석하고 이를 토대로 하여 상표자산 구성요소와 상표자산 영향요인간의 관계 그리고 상표자산 구성요소와 구매의도간의 관계를 규명하고 한국과 영국을 중심으로 비교하여 상표자산관리 방안을 도출해보고자 하였다 연구결과, 정보탐색은 제품지식에 정(+)의 영향을 미치며, 상표태도와 상표지식은 상표 충성도와 상표 가치에 정(+)의 영향을 미치는 것으로 나타났다 그리고 상표충성도와 상표가치는 구매의도에 정(+)의 영향을 미치는 것으로 나타났다. 정보원천의 경우, 한국에서는 제품지식에 정(+)의 영향을 미치고 있는 반면, 영국에서는 영향을 미치지 않는 것으로 나타났다. Brand equity is one of the most important concepts in business practice as well as in academic research. Successful brands can allow marketers to gain competitive advantage (Lassar et al.,1995), including the opportunity for successful extensions, resilience against competitors' promotional pressures, and the ability to create barriers to competitive entry (Farquhar, 1989). Branding plays a special role in service firms because strong brands increase trust in intangible products (Berry, 2000), enabling customers to better visualize and understand them. They reduce customers' perceived monetary, social, and safety risks in buying services, which are obstacles to evaluating a service correctly before purchase. Also, a high level of brand equity increases consumer satisfaction, repurchasing intent, and degree of loyalty. Brand equity can be considered as a mixture that includes both financial assets and relationships. Actually, brand equity can be viewed as the value added to the product (Keller, 1993), or the perceived value of the product in consumers' minds. Mahajan et al. (1990) claim that customer-based brand equity can be measured by the level of consumers’ perceptions. Several researchers discuss brand equity based on two dimensions: consumer perception and consumer behavior. Aaker (1991) suggests measuring brand equity through price premium, loyalty, perceived quality, and brand associations. Viewing brand equity as the consumer’s behavior toward a brand, Keller (1993) proposes similar dimensions: brand awareness and brand knowledge. Thus, past studies tend to identify brand equity as a multidimensional construct consisted of brand loyalty, brand awareness, brand knowledge, customer satisfaction, perceived equity, brand associations, and other proprietary assets (Aaker, 1991, 1996; Blackston, 1995; Cobb-Walgren et al., 1995; Na, 1995). Other studies tend to regard brand equity and other brand assets, such as brand knowledge, brand awareness, brand image, brand loyalty, perceived quality, and so on, as independent but related constructs (Keller, 1993; Kirmani and Zeithaml, 1993). Walters(1978) defined information search as, "A psychological or physical action a consumer takes in order to acquire information about a product or store." But, each consumer has different methods for informationsearch. There are two methods of information search, internal and external search. Internal search is, "Search of information already saved in the memory of the individual consumer"(Engel, Blackwell, 1982) which is, "memory of a previous purchase experience or information from a previous search."(Beales, Mazis, Salop, and Staelin, 1981). External search is "A completely voluntary decision made in order to obtain new information"(Engel & Blackwell, 1982) which is, "Actions of a consumer to acquire necessary information by such methods as intentionally exposing oneself to advertisements, taking to friends or family or visiting a store."(Beales, Mazis, Salop, and Staelin, 1981). There are many sources for consumers’ information search including advertisement sources such as the internet, radio, television, newspapers and magazines, information supplied by businesses such as sales people, packaging and in-store information, consumer sources such as family, friends and colleagues, and mass media sources such as consumer protection agencies, government agencies and mass media sources. Understanding consumers’ purchasing behavior is a key factor of a firm to attract and retain customers and improving the firm’s prospects for survival and growth, and enhancing shareholder’s value. Therefore, marketers should understand consumer as individual and market segment. One theory of consumer behavior supports the belief that individuals are rational. Individuals think and move through stages when making a purchase decision. This means that rational thinkers have led to the identification of a consumer buying decision process. This decision process with its different levels of involvement and influencing factors has been widely accepted and is fundamental to the understanding purchase intention represent to what consumers think they will buy. Brand equity is not only companies but also very important asset more than product itself. This paper studies brand equity model and influencing factors including information process such as information searching and information resources in the fashion market in Asia and Europe. Information searching and information resources are influencing brand knowledge that influences consumers purchase decision. Nine research hypotheses are drawn to test the relationships among antecedents of brand equity and purchase intention and relationships among brand knowledge, brand value, brand attitude, and brand loyalty. H1. Information searching influences brand knowledge positively. H2. Information sources influence brand knowledge positively. H3. Brand knowledge influences brand attitude. H4. Brand knowledge influences brand value. H5. Brand attitude influences brand loyalty. H6. Brand attitude influences brand value. H7. Brand loyalty influences purchase intention. H8. Brand value influence purchase intention. H9. There will be the same research model in Asia and Europe. We performed structural equation model analysis in order to test hypotheses suggested in this study. The model fitting index of the research model in Asia was X2=195.19(p=0.0), NFI=0.90, NNFI=0.87, CFI=0.90, GFI=0.90, RMR=0.083, AGFI=0.85, which means the model fitting of the model is good enough. In Europe, it was X2=133.25(p=0.0), NFI=0.81, NNFI=0.85, CFI=0.89, GFI=0.90, RMR=0.073, AGFI=0.85, which means the model fitting of the model is good enough. From the test results, hypotheses were accepted. All of these hypotheses except one are supported. In Europe, information search is not an antecedent of brand knowledge. This means that sales of global fashion brands like jeans in Europe are not expan