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수면 중 발생한 대퇴경부 골절로 발견된 직장 소세포암 1예
황지주,전성국,황일순,김은주,임창훈,정호연,한기옥,장학철,윤현구,한인권,문우남,홍성란 대한내과학회 2002 대한내과학회지 Vol.62 No.5
Small cell carcinoma of the colon and rectum is a rare primary epithelial malignancy at this location. Histologically, this tumor represents a spectrum of neuroendocrine differentiation. The neuroendocrine cancers of the colon manifest a highly aggressive behavior, even more than their adenocarcinoma counterpart of the same stage. Small cell carcinoma in the colon has early metastasis and the prognosis is extremely poor. We report a case of small cell carcinoma of the rectum manifesting as femur neck fracture during sleep.
폐경후 여성에서 에스트로겐 치료에 대한 혈중 지질의 반응과 에스트로겐 수용체 다형성과의 관계
황정규,한인권,장학철,임창훈,정호연,한기옥,윤현구,박재은,박소라,정필호 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.3
Backgound: Several biologically plausible mechanisms have been proposed for estrogen-mediated caridoprotection, including estrogen-assocaited changes in lipid metabolism and endothelial function of vessel walls. These effects are thought to be mediated via estrogen receptor (ER). Relationships between ER polymorphisms and serum lipid levels were not investigated enoughly. Methods: Three restriction fragment length polymorphisms (RFLPs) at the ER gene locus, represented as B-variant, PvuII and XbaI, and their relationship to serum lipid levels were examined in 318 postmenopausal women. Their mean age was 54.5±6.5 years (mean+SD). An association between ER genotypes and changes in lipid levels after 1 year of estrogen replacement therapy was also investigated in follow-up 251 women. Results: The B-variant was not found in Korean women. The distribution of the PvuII and XbaI polymorphisms was as follows: PP 109 (34%), Pp 166 (52%), pp 43 (14%), and XX 204 (64%), Xx 95 (30%), xx 19 (6%). Significant relationshipwas found between genotypes and changes in serum total cholesterol levels after lyr estrogen replacement therapy. There was no significant relationship between ER genotypes and changes in HDL cholesterol, LDL cholesterol and triglyceride levels after estrogen therapy. Conclusion: These data indicate that these polymorphisms are possible predictor on lipid response to estrogen replacement therapy (J Kor Soc Endocrinol 14:553-561, 1999).