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      • KCI등재

        임신중 시행한 유전적 양수천자 1,062 예

        윤성도,김택훈,김종인,이정호,배정만,강석선,전효진 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1

        Genetic amniocentesis has become established as a widely used tool for the diagnosis of fetal chromosome abnormalities, neural tube defect, and a variety of metabolic disease. This is an analysis of our experience with 1,062 case that have been undergone amniocentesis at Department of Obstetrics and Gynecology, School of Medicine, Keimyung University and Dr Kim`s Ob & Gyn Clinic from Janua ry 1993 to December 1996. High maternal serum alpha fetoprotein(MSAFP) was the most common indication of amniocentesis(31.3%) and the most common age distribution at amniocentesis was 31∼35 years(35.6%). Chromosomal aberration were diagnosed in 66 cases(6.23%) of which numerical aberration was 20 cases(1.88%) and structural aberration was 25 cases(2.35%) with 21 cases (1.97%)normal varients. Autosomal aberration was observed in 15 cases(75%) and sex chromosome aberration was observed five cases(25%). Among the autosomal aberration, six cases of trisomy 21, seven cases of trisomy 18, two cases of trisomy 13 were found. Among the sex chromosome aberration, two cases of Turner syndrome, two cases of Kleinefelter syndrome , one case of triplody were found. Among the structural aberration, 46,XX,t(13:14) Robersonian translocation was the most common( four cases). No complication was found such as preterm labor, fetal death, and neonatal complication. This is a report of a relatively large series of genetic amniocentesis from a single institution, with analysis of the indication, age distribution, results and complication.

      • KCI등재후보

        Pregnancy Associated Osteoporosis

        윤성도 대한골다공증학회 2009 Osteoporosis and Sarcopenia Vol.7 No.3

        It is thought that normal pregnancy does not cause osteopenia or osteoporosis in most women. Although there is bone loss during the first 6 months of lactation, subsequent recovery is generally expected. It has been reported that women can develop pregnancy-associated idiopathic osteoporosis during pregnancy or while lactating. The cause of this is controversial, but most authorities believe that pregnancy unmasks a pre-existing bone disease. In more than one-half of pregnant women, no apparent cause for osteoporosis can be identified. Some known causes of pregnancy-associated idiopathic osteoporosis include heparin therapy, prolonged bed rest, and corticosteroid therapy. In a few cases, overt hyperparathyroidism or thyrotoxicosis eventually develops. Bone mass is the main predictor of fractures. Maximum bone-mass accumulation is reached by the end of the second decade, just before the childbearing age. Pregnancy and lactation are associated with considerable changes in calcium homeostasis to meet fetal calcium demands for skeletal calcification. Although renal conservation of calcium is less efficient during pregnancy, the active absorption of calcium by the intestine doubles by 20weeks. In theory, since there is 30~35g of calcium in the full-term neonate, and considering that the maternal skeleton contains 1,000g of calcium, the effect on the mother should be relatively slight. To help understand the effects of pregnancy on bone turnover and osteoporosis, the author has reviewed the some literature and studies have utilized biochemical markers of bone formation, resorption, and bone turnover before, during, and after pregnancy.

      • KCI등재

        사무소건물의 개보수에 따른 실내환경의 거주후 평가 연구

        윤성도,김종진,손장열 대한건축학회 2006 대한건축학회논문집 Vol.22 No.3

        This study evaluates the office environment satisfaction from the questionnaire and the improvement effects for the remodeled office building which is built for 26 years ago and located in Seoul, Korea. The questionnaire is carried out three times; August 2002 (Summer, before remodeling), December 2002 (Summer, after remodeling), and July 2003 (Winter, after remodeling). The questionnaire for office occupant includes general consideration, sensation of indoor environment, satisfaction of indoor and outdoor space, sensation of working environment, experience of illness and allergy, and response to sick building syndrome. The results of this study is outlined below. 1) Before and after remodeling building the office occupants are questioned about the satisfaction of office environment. It is resulted that indoor environment such as thermal environment, indoor air quality, lighting and noise is improved remarkably. The improvement of storage size and design, and office network system affects the occupant's satisfaction, however, influences a little bit. The improvement effect is small for exterior design and color and outside view. 2) After remodeling the office building the occupants are more satisfied with new working environment, however do not feel the need for reform. Because of the improvement of indoor environment the anxiety of sick building syndrome is decreased a little bit. 3) The sensation of air stream, cold or hot sensation, and thermal sensation felt by human body is improved a little. Moreover, the office occupants are more satisfactory with indoor office environment questioned with air-conditioning, cold or hot sensation, indoor air quality, odor, and noise. It is inferred that HVAC (heating, ventilating, and air-conditioning) systems are operated properly.

      • KCI등재
      • KCI등재

        행정중심복합도시 및 혁신도시 건설이 실업비용에 미치는 영향

        윤성도,이성우 한국지역학회 2007 지역연구 Vol.23 No.3

        The present study investigates the impact of the construction of a multifuctional administrative city and innovative cities on unemployment cost. Along with a spatial econometrics model(GWR: Geographically Weighted Regression) that is free from spatial selection bias, we construct a methodology to estimate the aggregate costs caused by the construction of the multifunctional administrative city and the relocation of the 179 public agencies. Utilizing the 2005 City and County data from the National Statistical Office, we construct a model to calculate hypothetical employment opportunities for the destined areas of the public agencies. The present study found that the total cost per annum caused by the relocations is in between 27billion Won to 47 billion Won for the capital region and the benefit for the rest of the area is far less than those for the capital region. The present study concludes that while there are some positive effects due to the relocation policies, the policies aimed at relocating people and jobs from the capital region mainly targeting the public agencies are not much effective than expected. The present study expresses concerns on excessive drive of balanced development policy by the incumbent administration and recommends policies focusing primarily on the objective of fostering national productivity growth. 본 연구에서는 행정중심복합도시 및 혁신도시의 건설에 따른 사회적 편익에 대해 주로 규범적 논의를 바탕으로 진행되고 있는 현재의 논의를 인구이동 효과에 따른 노동시장에서의 편익 및 실업비용의 측면에서 고찰하였다. 이를 위해 현재 논의되고 있는 행정중심복합도시 및 혁신도시의 내용을 바탕으로 작성된 시나리오에 따른 사회적 비용을 계산하였다. 2000년 인구및주택총조사 2% 표본과 시군구의 단위의 집계자료에 대해 공간적 종속성 문제를 유발하지 않는 GWR 모형을 사용하여 분석하였다. 행정중심복합도시 및 혁신도시의 건설에 대한 사회적 발생 비용을 금액가치로 환산하여 구체적 논거를 제시할 수 있다는 의의를 가진 본 연구의 결과는 다음의 시사점을 가진다. 첫째, 행정중심복합도시 및 혁신도시 건설에 따른 균형 있는 발전의 효과는 고용기회 증대를 위한 다양한 노력이 병행될 때 의미가 있다. 둘째, 수도권과 충청권은 지리적으로 상당히 가까운 거리에 위치하며 수도권에 자본이 상대적으로 집중되어 있는 상태이므로 수도권과 충청권의 연담도시화 가능성에 대한 고려가 필요하다. 이러한 시사점은 행정중심복합도시 및 혁신도시 건설의 비수혜지역인 수도권에 대한 배려가 있어야 한다는 논의로 귀결될 수 있으며 또한, 재정투자에 의한 추가적인 효과를 고려한 해석이 필요할 것이다. 지방분권과 국토의 균형 있는 발전에 대한 사회적 요구는 향후 지속적으로 증대할 것으로 예상되며 특히 성장의 논의와 결부된 행정중심복합도시 및 혁신도시의 건설 논의는 더욱 다양한 사회적 요구와 압력에 직면할 것이다. 따라서 향후 심층적이고 복합적인 논의를 통해 이들 해당 도시의 타당성에 대한 종합적인 접근이 보다 발전적인 방향으로 진행되어야 할 것이다.

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