Graves 병 환자에서 항갑상선제 투여에 의한 TSH 수용체 항체의 변동에 관한 연구 : 치료 용량 및 기간에 따른 차이 및 임상상과의 관계 its relation to dose and duration of treatment~and clinical features

이문호,조보연,문대혁,고창순,민헌기,서교일 대한내과학회 1986 대한내과학회지 Vol.30 No.3

We undertook a prospective study of 59 patients with Graves' disease in order to clarify the influence of antithyroid drug on the immunological indices and to determine the association of the changes of TSH receptor antibodies activities with drug dosage, duration of treatment and clinical features according to mode of antitbyroid drugs treatment. Patients were divided into two groups. High dose group included 28 patients and conventional dose group 31 patients. We measured TBII activities, antimicrosomal antibodies, and the size of goiter every 3 months, comparing them with clinical features and laboratory findings. TBII activities declined from R months until 9 months following drug treatment. Therafter no significant change of TBII activities were observed. Antimicrosomal antibodies showed the same pattern of change. There was no statistically significant difference of declining rate of TBII activities, antimicrosomal antibodies, and reduction of size of thyroid between two treatment groups. TBII activities fell into normal range in 15 patients among those 44 patients who had been followed for more than 9 months (8 high dose group, 7 conventional dose group). In those 15 patients, TBII activities and frequency of exophthalmos were less than those whose TBII activity did not normalized. We conclude that TSH receptor antibodies activities and antithyroid autoantibodies are diminished by antithyroid drug treatment in patients with Graves disease and there is no relationship between dose of drug and declining of TBII activities. We suggest that changing levels of TBII activities might be secondary phenomenon which can be achieved by control of thyroid function by antithyroid drug rather than direct immunosuppressive effect of antithyroid drug per se.

現職敎師와 師大生의 敎職觀의 比較

長赫杓,朴榮煥 부산대학교 학생생활연구소 1974 硏究報 Vol.10 No.1

This study is to investigate differences between teachers and teacher's college students about teaching profession. The object of the study samples 1004 teachers and 126 junior or senior students of teacher's college. Average age of the object is 35.7 years in case of teachers, whose average educational histories are 10.7 years, and 22.8 years in case of teacher's college students. I used my own making questionnaire as an instrument by making refference to R. center's view of profession. T. E. Smith's and Hak-Soo Kim's and Jae-Eun Kim's testing of teacher's attitude and etc. The data were dealt with per-centage statistical method about frequency of answers to each question by teachers and students. The following is the results of answers of each item. 1. To choose teaching profession Most of teachers made up minds to choose teaching profession after graduation from college and teacher's college students decided to be a teacher in junior or senior high school days. The reason teachers chose teaching profession is emphasized by accident, while leadership and security are emphasized in case of students. 2. Satisfactions about teaching profession. 64.05 percent among teachers like their jobs and 35.96 percent dislike their jobs, while 72.96 percent among students want to be teachers. and 27.04 percent don't want to be teachers. This shows that the number of teachers who dislike teaching profession is more than the number of students who teaching profession. Most of teachers and students don't think of teaching profession as their conviction of lifetime. 3. Treatment about teachers. This data show that teachers who say they receive medial social treatment are fewer than students who say teachers receive medial social treatment. Both groups answers teaching profession is not given preferential economical treatment. 4. Speciality of teaching profession Both groups answer that all of us can't be a teacher. They emphasize personality very much as basic condition of teaching profession. Teacher group has more confidence than student group about a subject of special study. 5. Opinion about teaching profession. Teachers desires economical security most, while students hope to improve arrangement of personal affairs. 6. Teacher's character Both group think that their characters have comprehensive faculty. I hope that the result of this study becomes a data to be able to give a suggestion to guidance of students of teacher's college and teacher's education.

A Case of Cerebral Aneurysmal Subarachnoid Hemorrhage in Fabry's Disease

Chang, Youn Hyuk,Hwang, Sung-Kyun The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.53 No.3

We report an unusual case of cerebral aneurysmal subarachnoid hemorrage (SAH) with Fabry's disease. A 42-year-old woman presented with aneurysmal SAH originated from a saccular aneurysm of the right posterior communicating artery. The patient was treated by an endovascular coil embolization of aneurysm. Postoperatively the patient recovered favorably without any neurological deficit. During her admission, the patient had a sign of proteinuria in urine analysis. The pathologic findings of kidney needle biopsy implied nephrosialidosis (mucolipidosis of lysosomal stroage disease), which is consistent with a Fabry's disease. It is uncommon that Fabry's disease is presented with aneurysmal SAH, especially in middle-aged patients, but could be a clinical concern. Further investigations are needed to reveal risk factors, vascular anatomy, and causative mechanisms of Fabry's disease with aneurysmal SAH.

The Role of Surgery in the Treatment of Spinal Myeloma

Kwon, Austin-Hyuk,Chang, Ung-Kyu,Gwak, Ho-Shin,Youn, Sang-Min,Rhee, Chang-Hun The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.37 No.3

Objective: Spinal myeloma has been treated with radiation therapy and chemotherapy. However, the role of surgery was not fully evaluated. This study is performed to evaluate the efficacy of surgery in the treatment of spinal myeloma. Methods: 22 patients who were treated with surgery for spinal myeloma from August 1999 to April 2003 were analyzed. Radiological finding, surgical methods and result were reviewed in retrospective study. For compression fracture due to myeloma infiltration, percutaneous vertebroplasy(PVP) was done. Decompression surgery with or without fixation was performed for patients with neurologic deficit. The modalities of surgery consist of PVP (14 cases), corpectomy and fixation (7 cases), and laminectomy and epidural mass removal (3 cases). To evaluate clinical outcome, visual analogue pain score and Frankel neurological scale were used. Results: In 14 cases of PVP, total 57 vertebral segments were treated including 21 thoracic vertebral bodies and 36 lumbar vertebral bodies. Pain relief was achieved in all cases. The pain score changed from 7.7 (preoperatively) to 2.5 (postoperatively). And pain relief effect was maintained over than one year. Frankel grade improved in decompression cases. Conclusion: Surgical treatment can alleviate pain and improve neurologic deficit immediately in spinal myeloma patients.

B형 만성 간 질환이 있는 소아와 성인에서 HBV core promoter, precore/core 유전자 부위의 돌연변이에 대한 고찰

정정명,박영홍,설상영,이상혁,장윤식,이연재,채창식 인제대학교 1998 仁濟醫學 Vol.19 No.2

B형 간염은 전세계적으로 수억의 인구가 감염되었을 뿐아니라 간경변증 및 간암의 중요한 원인으로 알려져 있다. 특히 우리나라는 B형 간염바이러스에 전 인구의 약 60%가 과거 HBV에 감염되었던 소견이 있다. 또한 만성 간질환 및 간암 환자의 약 60∼70%가 HBsAg 양성으로 우리나라에서는 HBV가 간질환의 가장 중요한 원인임을 알 수 있다. 그러나 현재까지 간염의 중증도에 어떤 요인이 작용하는지 밝혀져 있지 않다. 이런 점에서 저자들은 B형 간염 바이러스의 변이종과 간질환의 관계를 조사하였다. 변이는 성인에서 많은 경향을 나타내었는데 변이가 주로 발생하는 부위는 core promoter, precore/core 영역에 공히 존재하나 변이와 질환의 중증도와의 직접적인 관계는 관찰되지 않았다. Objectives: To clarify the frequency of mutations in core promoter, precore and core region of HBV(hepatitis B virus) and their possible effects on the clinical course of HBV associated chronic liver diseases. Methods and Materials: we performed PCR (polimerase chain reaction) and direct sequencing for the sera of 48 patients who had been HBsAg positive for more than 6 months (adult 31, children 17). And in this study, adult patients were divided into 3 groups according to the histopathological severity of liver disease i.e. Group 1 as minimal change and chronic persistent hepatitis. Group 2 as chronic active and lobular hepatitis, Group 3 as liver cirrhosis and hepatocellular carcinoma, respectively. Results: 1.The number of mutations at core promoter region did not show statistically significant difference between children and adults. In comparisons among Group 1 vs Group 2 and Group 1 vs Group 3, statistically significant differences were not seen either. About 53.3% of mutations occurred at nucleotide 1753, 1762 and 1764. 2.The number of mutations at precore region which were associated with amino acid changes did not show statistically significant differences between children and adults. And 63.3% of mutations were developed at codon 28(nucleotide 1896). In comparisons among Group 1 vs. Group 2 and Group 1 vs. Group 3, there were no differences in the numbers of mutations. The mutations at this region were more prevalent in Anti-HBe positive group rather than in HBeAg positive group (p= 0.013). 3.At the core region, total number of mutations which were associated with amino acid changes were more frequent in adults than in children. At CTL epitome (codon 18∼27), there were no significant differences of mutations between adults and children, In comparisons among Group 1 vs Group 2 and Group 1 vs Group 3, statistically significant differences were not seen either. CD4 epitope showed statistically significant differences between children and adults (p=0.025), but the histopathological severity was not related with the frequency of mutations. At the B cell epitome, there were significantly different rates of mutations between children and adults(p=0.038). Group 1 and 2 did not show differences, but Group 1 and 3 showed significance. Assuming that the hot spot as mutations over 10% of total cases, 5 spots were identified in children and 11 spots were identified in adults. The area of more frequent mutations in adults were codon 13∼27, 33∼49, 59∼63, 92∼97, 113∼117, which comprise 67.5% of all mutations. Conclusion: We could not find the definite relationships between the mutation in the core promoter, precore/core gene region of HBV and the histopathological severity of HBY associated liver diseases. Further investigations are needed with larger number of patients.

A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypes.

Chang, Hun Soo,Kim, Jung Sun,Lee, June Hyuk,Cho, Jung Il,Rhim, Tai Youn,Uh, Soo-Taek,Park, Byung Lae,Chung, Il Yup,Park, Choon-Sik,Shin, Hyoung Doo Williams Wilkins 2005 JOURNAL OF IMMUNOLOGY Vol.174 No.3

<P>Eotaxin1 plays a pivotal role in eosinophil-associated inflammation. Previously, we demonstrated 14 single-nucleotide polymorphisms (SNPs) in the human eotaxin1 gene and the association between the EOT+67G>A allele and the level of IgE. In this study, we investigated the association between the SNPs and plasma eotaxin1 levels, peripheral blood eosinophil counts, and PC20 methacholine values in normal and asthmatic subjects, and the effects of SNPs on the process of eotaxin1 production. The EOT-576C>T and EOT-384A>G polymorphisms and haplotypes (ht1 and ht4) were significantly associated with plasma eotaxin1 levels in the asthmatics (p < 0.001-0.040). The log [plasma eotaxin1] values correlated with the log [serum total IgE] values in the asthmatics and the normal controls (p = 0.012 and p = 0.004, respectively), and with the log [PC20 methacholine] values in the asthmatics (p = 0.014). A DNA-protein complex was formed with EOT-384A>G, but not with the other SNPs of the promoter. The interaction was stronger with the minor allele than with the common allele, and was reduced upon TNF-alpha exposure. TNF-alpha-stimulated PBMCs from the asthmatics with the minor allele homozygote expressed significantly lower levels of eotaxin1 mRNA than those from individuals with the common allele. The EOT+67G>A polymorphism, which substitutes alanine with threonine, did not affect eotaxin1 production or activity. Our data suggest that the EOT-384A>G SNP participates in the regulation of eotaxin1 expression by providing a potential binding site for a repressor, and that the ANOVA of EOT-384A>G may predict asthma phenotypes.</P>

Quantitative Detection of Rotator Cuff Tears using a 3D Ultrasound Imaging System

Chang Hyuk Choi,Jun Young Kim,Jeong-Ho Park,Anna Seo,Jae Youn Hwang 대한견주관절의학회 2019 대한견주관절학회 학술대회논문집 Vol.2019 No.3

한방병원에 입원한 환자군에서 간기능 검사 이상자의 빈도 조사

한창우(Chang-Woo Han),김수영(Su-Young Kim),민관식(Kwan-Sik Min),이진혁(Jin-Hyuk Lee),이상호(Sang-Ho Lee),윤유석(You-Suk Youn) 대한한의학회 2010 대한한의학회지 Vol.31 No.2

주성분 분석을 이용한 고객 공정의 불량률 예측 모형 개발

장윤희(Youn-Hee Jang),손지욱(Ji-Uk Son),이동혁(Dong-Hyuk Lee),오창석(Chang-Suk Oh),이득중(Duek-Jung Lee),장중순(Joongsoon Jang) 한국신뢰성학회 2016 신뢰성응용연구 Vol.16 No.2

Purpose: The purpose of this paper is to get a meaningful information for improving manufacturing quality of the products before they are produced in client’s manufacturing process. Methods: A variety of data mining techniques have been being used for wide range of industries from process data in manufacturing factories for quality improvement. One application of those is to get meaningful information from process data in manufacturing factories for quality improvement. In this paper, the failure rate at client"s manufacturing process is predicted by using the parameters of the characteristics of the product based on PCA (Principle Component Analysis) and regression analysis. Results: Through a case study, we proposed the predicting methodology and regression model. The proposed model is verified through comparing the failure rates of actual data and the estimated value. Conclusion: This study can provide the guidance for predicting the failure rate on the manufacturing process. And the manufacturers can prevent the defects by confirming the factor which affects the failure rate.

갑상선암 환자에서 I - 131의 진단적 전신스캔과 치료후 전신스캔의 비교

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),이동수(Dong Soo Lee),문대혁(Dae Hyuk Moon),이범우(Bum Woo Lee) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.1

N/A Fifty seven patients with differentiated thyroid carcinoma were performed radioactive iodine- 131 whole body scans after administration of diagnostic dose (2∼10 mCi) and therapeutic dose (30∼150 mCi) within three months. We evaluated the state of radioactive iodine-131 uptakes in whole body scan to detect correct metastasis of thyroid carcinoma. The results are as follows: 1) In 20 of the 57 patients (35%), the therapeutic scan showed the additional uptakes that were not seen in the diagnostic scan. 2) In 9 (64.2%) of the 14 patients who had been received the thyroid ablation theraphy with I-131 previously, new additional lesions were found in the therapeutic scan but only 11 (25%) of the 32 patients who had not been received the thyroid ablation theraphy disclosed new uptake lesions (p〈0.01). 3) The additional uptake lesions of therapeutic scan were significantly more common in the bony metastatic foci (65.7%) than other areas (p〈0.01). In 11 (55%) of 20 patients, additional uptake regions were anterior neck areas (thyroid bed or regional lymph node). We conclude that diagnostic scan with 2∼5 mCi I-131 is inadequate in evaluating residual iodine avid tissues of patients with thyroid carcinoma. Also post-theraphy I-131 whole body scan would be important to evaluate the correct staging and prognosis of thyroid carcinoma, and to follow-up patients.