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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
이승환,김용주,한경희,정연택,강승욱 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-
In this paper, we proposes two phase chopper system with flour. separate groups of D.C motor for regenerative braking. The main circuit consists of four sets of chopping parts, eight diodes and four separate groups of D.C motor. Although the proposed chopper circuit requires more circuit elements than the conventional two phase chopper system with, combined output, it has the following advantages: (1) The region of regenerative braking becomes twice as that of the conventional two phase chopper system. (2)Current division of load becomes equalized. Therefore. it is possible to drive not only series motor but also shunt and separately excited motor (3) The harmonic component of the source current is greatly diminished.
동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종
이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2
저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.
Si 이온이 주입된 단결정 GaAs(100)에서의 sputtering 및 reflection에 대한 컴퓨터 계산
이연환 東國大學校 1993 東國論叢 Vol.32 No.-
A computer simulation based on the binary collision approximation has been performed to investigated the reflection coefficients and sputtering yields as function of incident angles, implantation doses, and implantation energies for Si-implanted GaAs(100) crystal. The results reveled a strong dependence on the incident angle of the Si ions. An enhanced reflection at 86° is found to occur at critical angle which can be described by the surface channeling theory. However, the reflection coefficient and the sputtering yield does not vary significantly as the implantation dose varied. In low energy region, reflection coefficient and spittering yield reveal a strong oscillatory structure. These results can be considered being due to the back scattering.
정치적 통합과 안정 : 정치적 충원의 신중성 : 텍스트[孟子]에의 분석
이윤환,윤대식 建陽大學校 1998 建陽論叢 Vol.- No.6
Of many thinkers in Confucian tradition, Mencius stands on the very special position. In contrasted with Confucius, he lived in Warring States Period. The text Mencius contains Mencius' own political thought obviously, he himself was very political. Mencous' historical view is based on his own understanding of situation. His cyclic view alternating order and chaos every five hundreds years in history is very original. Reflecting history, Mencius believed that new prince and order coming soon inevitably. To verify it, he constitenly preceding example as ideal model. Mencius intended to gain legitimacy of political power and to establish stability in political unity. He had aspiration for new king and order to achieve his aim. To realize it, he distinguished between Kingly government and Power government. On one hand, Kingly government is ruled by king who has virtue and benevolence. On the other hand, Power government is ruled by force. He supposed how to realize Kingly government, and emphasized virtue and benevolence. Especially he demanded that king and political elites in political process should cultivate benevolence as personal virtue. Mencius recognized that nature of politics should be 'for the people,' and statemen should take care of their people. Therefore political recruitment is needed prudence. Regardless of status and positions, talents and ambitions was the first principle of political recruitment at that time. But struggle for political hegemony in Warring States Period was enlarged, Mencius regarded that it was attribute to an unprincipled race for the spoils of success. He judged this situation as growing conditions that new king and order coming soon. Political legitimacy depends on political unity and order.