RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 원문제공처
          펼치기
        • 등재정보
          펼치기
        • 학술지명
          펼치기
        • 주제분류
          펼치기
        • 발행연도
          펼치기
        • 작성언어
        • 저자
          펼치기

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재

        盛明巴蜀文人楊慎對孔明的批評

        楊釗(Yang Zhao) 동아인문학회 2017 동아인문학 Vol.39 No.-

        Yang Shen had made many comments on Kong Ming, which can be seen in his works, poems, poetic criticisms and “the Whole Shu Yiwenzhi”. Yang Shen mainly focused on the analysis of hot issues such as the moral and utilitarian achievements, the academic and governance abilities of Kong Ming. Yang Shen’s purpose in comments on Kong Ming aimed was to admire for former worthies and educate the future generation, not pedantically to look for quotes in order to embellish his writings.

      • KCI등재

        MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

        Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

        Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.

      • KCI등재

        楊愼 《全蜀藝文志》 編輯的文化背景考論

        楊釗(Yang Zhao) 중국어문학연구회 2016 중국어문학논집 Vol.0 No.98

        Yang Shen, in the introduction to “Arts and Literatures History of the Whole Shu nation”, provided that the cultural background of editting this book was to “carry forward the fragrance of the Si Zi, and write the Su nation’s history”. Thus the selected works in this book were not only the literatural ones but also those that reflected the Bashu’s history and academic thoughts. Meanwhile, he had self-consciously assumed the responsibilities of the inheritance of the rural culture and encouraging the backwards through editting the book. Yang Shen and his son had carried forward the local culture through the following three aspects, that is, to devote much attention to the nation’ history, to praise the local loyal bachelors and to place emphasize on the moral education.Besides, Yang Shen and his son had taken great pains to discuss these issues and carry out the social pracitice.

      • KCI등재

        論錢穆對漢代『春秋』學的硏究

        楊兆貴 ( Yang¸ Zhao Gui ),趙殷尙 ( Cho¸ Eun Sang ) 한국중국학회 2021 중국학보 Vol.97 No.-

        錢穆對秦漢史、漢代經學研究飮譽學林, 影響很大。他這兩方面的論著大多已逾半世紀, 在出土文獻日益增多、研究方法多元化等學風下, 他的論著有哪些價值?對當代相關研究有什麼影響?筆者結合他這兩方面的研究, 聚焦他的漢代『春秋』學, 以見他治學、見解之一斑。 要探討他對漢代『春秋』學的看法, 則先簡介他對『春秋』及三傳的看法。他與傳統主張孔子作『春秋』的看法相同, 並從史學肯定『春秋』、『左傳』的史學價值。他認為漢代經學今古文之別是王官學與百家言之殊, 而非文字古今之異。這是他論漢代經今古文最具特色的部分。他撰『孔子與春秋』一文, 著重闡釋『公羊』學的精神, 強調孔子『春秋』以百家言而成為新的王官學。他在不同時期對『公羊』學與董仲舒的評價不同。他認為漢儒多通古今, 因此治『春秋』者多能兼採三傳或兩傳之義、說。他又指出, 『春秋』學與漢代思想尤其是災異說、禪讓說、禮制說有密切的關係。 Prof. Qian Mu has a great influence on the honorary scholars of Qin and Han history and Han dynasty studies. Most of his works in these two areas have been over half a century. With the increasing number of unearthed documents and diversified research methods, what is the value of his works? And what is the impact on contemporary related research? This essay combines his research in these two areas and focuses on his study of Chun Qiu in the Han Dynasty, so as to see his academic research methods and insights. To explore his views on the study of Chun Qiu in the Han Dynasty, the first part of the essay introduces his views on Chun Qiu and the three ‘Zhuan’. He is the same as the traditional view that Confucius wrote Chun Qiu, and affirmed the historical value of Chun Qiu and Zuo Zhuan from his historiography. He believes that the difference between modern and ancient literatures in Han dynasty is the difference between Ancient Official Document and Philosophers, rather than the difference between ancient and modern writing. He wrote the article Confucius and Chun Qiu, focusing on explaining the spirit of school of Gong Yang, emphasizing that Confucius' Chun Qiu became a new official ideology with the philosophical thought in Han China. He had different evaluations of Gong Yang and Dong Zhongshu in different periods. He believes that the Han scholars are mostly integrated with the ancient and modern literatures, so most of them who studied Chun Qiu can adopt the meaning and theories of the three or two ‘Zhuan’ at the same time. He also pointed out that the study of Chun Qiu has a close relationship with the thoughts of the Han Dynasty, especially the theory of catastrophe, concession, and etiquette.

      • KCI등재

        Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

        Zhao Junxiong,Wu Qian,Yang Ting,Nie Liangui,Liu Shengquan,Zhou Jia,Chen Jian,Jiang Zhentao,Xiao Ting,Yang Jun,Chu Chun 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

        Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO2) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2. However, exogenous SO2 donors could up-regulate AAT1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO2 can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

      • KCI등재

        Ablation resistance under different heat fluxes of HfC‑ZrC‑SiC multiphase coating prepared by supersonic atmospheric plasma spraying for C/C composites

        Yang Yang,Chun Zhao,Qiaojuan Gong,Jie Wang 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.2

        To prevent the ablation of C/C composites, an HfC-ZrC-SiC multiphase coating was prepared by supersonic atmospheric plasma spraying. The morphology and microstructure of the coating were examined by X-ray diffraction and scanning electron microscopy, respectively. The as-prepared coating showed a compact structure with a few defects. The ablation resistance test of the coatings was carried out using an oxyacetylene torch under different heat fluxes. The samples ablated under different heat fluxes showed different ablation properties and ablation morphologies. During the ablation, the thickness and weight of the coating decreased with an increase in the heat flux from 2.38 to 4.18 MW/m2. Under the heat flux of 2.38 MW/m2, the coating remained intact because of its low surface temperature and the pinning effect of the newly formed HfSiO4 and ZrSiO4 phases. With an increase in the heat flux, the surface temperature increased beyond the melting point of HfO2 and ZrO2 and the coating suffered a violent flush of the oxyacetylene torch, which resulted in severe evaporation of the oxides and the weakening of the pinning effect.

      • Robust MAVE for single-index varying-coefficient models

        Zhao Yang,Yue Lili,Li Gaorong 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.4

        In this paper, a robust, efficient and easily implemented estimation procedure for single-index varying-coefficient models is proposed by combining minimum average variance estimation (MAVE) with exponential squared loss. The merit of the proposed method is robust against outliers or heavy-tailed error distributions while asymptotically efficient as the original MAVE under the normal error case. A practical minorization–maximization algorithm is proposed for implementation. Under some regularity conditions, asymptotic distributions of the resulting estimators are derived. Simulation studies and a real data example are conducted to examine the finite sample performance of the proposed method. Both theoretical and empirical findings confirm that our proposed method works very well.

      • KCI등재

        Joint FrFT‐FFT basis compressed sensing and adaptive iterative optimization for countering suppressive jamming

        Yang Zhao,Chaoxuan Shang,Zhuangzhi Han,Yuanwei Yin,Ning Han,Hui Xie 한국전자통신연구원 2019 ETRI Journal Vol.41 No.3

        Accurate suppressive jamming is a prominent problem faced by radar equipment. It is difficult to solve signal detection problems for extremely low signal to noise ratios using traditional signal processing methods. In this study, a joint sensing dictionary based compressed sensing and adaptive iterative optimization algorithm is proposed to counter suppressive jamming in information domain. Prior information of the linear frequency modulation (LFM) and suppressive jamming signals are fully used by constructing a joint sensing dictionary. The jamming sensing dictionary is further adaptively optimized to perfectly match actual jamming signals. Finally, through the precise reconstruction of the jamming signal, high detection precision of the original LFM signal is realized. The construction of sensing dictionary adopts the Pei type fast fractional Fourier decomposition method, which serves as an efficient basis for the LFM signal. The proposed adaptive iterative optimization algorithm can solve grid mismatch problems brought on by undetermined signals and quickly achieve higher detection precision. The simulation results clearly show the effectiveness of the method.

      • KCI등재

        Anti-tumor effect of novel amino acid Schiff base nickel (II) complexes on oral squamous cell carcinoma cells (CAL-27) in vitro

        Zhao Peng,Qiu Haiming,Wei Qiang,Li Yang,Gao Lei,Zhao Peiran 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2

        Background Oral squamous cell carcinoma (OSCC) is a common skin/oral malignant tumor. In recent years, advancements in the fi eld of medical technology resulted in signifi cant improvement in the treatment and management of OSCC. However, adverse reactions associated with the application of radiotherapy and chemotherapeutic drugs resulted in a low overall survival rate. Therefore, it is important to develop and explore alternative chemotherapy drugs, which can eff ectively treat OSCC, and clarify their mechanism of action. Objective The present study aimed to investigate the eff ect of three hexa-coordinated octahedral nickel (II) complexes, namely [Ni(sal- L -phe)(phen)(CH 3 OH)] CH 3 OH ( 1 ), [Ni(naph- L -phe)(phen)(CH 3 OH)] ( 2 ), and [Ni( o -van- L -phe)(phen) (CH 3 OH)] 5CH 3 OH ( 3 ), on proliferation, migration, and apoptosis of CAL-27 cells. Results The results of the study showed that complex 3 exhibited sensitive/signifi cant cytotoxicity toward CAL-27 cells, with an IC 50 value of 15.90 mΜ. Further, an assessment of the underlying mechanism showed that complex 3 could signifi cantly increase autophagy and reactive oxygen species (ROS) levels in CAL-27 cells. At the same time, it reduced mitochondrial membrane potential (MMP) in a dose-dependent manner. Additionally, complex 3 might act via inhibition of proliferation and migration of CAL 27 cells and induction of apoptosis, which was mediated via regulation of the expression of Bcl-2 family proteins in vitro. Conclusion The results of the study showed that nickel complexes could potently inhibit the growth of CAL-27 cells, which was mediated via mitochondrial dysfunction, intracellular ROS accumulation, and ROS-mediated DNA damage. Altogether, the fi ndings of the study would provide new leads for the designing and synthesis of novel metal drugs for OSCC.

      • KCI등재

        Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARa partially through the ubiquitin–proteasome pathway

        Yang Hai,Xin Wang,Peng Song,Jian-yin Li,Longhe Zhao,Fei Xie,Xiang-min Tan,Qin-Jian Xie,Lan Yu,Yang Li,Zhengrong Wu,Hong Yu Li 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.8

        PML/retinoic acid receptor alpha (RARa), as ahallmark of acute promyeloid leukemia (APL), is directlyrelated to the outcome of clinical APL remedy. It isreported that arsenicals can effectively degrade PML/RARa, such as arsenic trioxide and realgar. However, thehigh toxicity or insolubility have hampered their clinicalapplications. Realgar transforming solution (RTS) wasproduced from realgar by bioleaching process in our lab. Previous studies demonstrated that RTS had a significantanti-cancer ability on chronic myeloid leukemia throughoncoprotein degradation. The capacity of RTS on treatingAPL is what is focused on in this study. The results showedthat RTS had a noticeable sensitivity in NB4 cell, and RTSremarkably down-regulated PML/RARa expression andinduced cell differentiation. Further, RTS could accumulatePML/RARa into the nuclear bodies and then executedegradation, which could be reversed by proteasomeinhibitor MG132. The results also exhibited that thereduction of RTS-induced PML/RARa expression accompaniedby the elevation of ubiquitin and SUMO-1 proteinexpression. Finally, PML and SUMO-1 had been demonstratedto be co-localized after RTS treatment byimmunofluorescence co-localization assay and immunoprecipitationassay. In conclusion, these results suggestedthat RTS-induced cell differentiation may attribute to thePML/RARa degradation partially through the ubiquitin–proteasome pathway.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼