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Semi Yu,Enkhzaya Davaa,Gyeong-Rok Lee,Eun Joo Lee,Jeong-Sook Park 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-
The objective of this study was to validate a reliable analytical method for the determination of rosiglitazone in human plasma by a semi-micro high performance liquid chromatography (HPLC) system with UV detection. Rosiglitazone was dissolved in methanol. Separation was performed on a SPcolumn C18 UG120 (4.6 mm × 150 mm) using mobile phase of acetonitrile, methanol and acetate buffer (pH 4.0) at a volume ratio of 20:10:70. The signals were monitored by UV detector at 214 nm with flow-rate of 1 ml/min. The intra- and inter-day precision expressed as the relative standard deviation was less than 15%. The retention time of rosiglitazone was 7.6 min. The detection limit of rosiglitazone in human plasma was 2 μg/ml and the limit of quantification was 5 μg/ml. The calibration curve was linear in the concentration range of 5~100 μg/ml (r2=0.999). The accuracy was from 1.0% to 13.5% while the intra-day and inter-day coefficient of variation of the same concentration range was less than 15%. This analytical method should be improved to be applied to determine rosiglitazone in human plasma.
Lee, Semi,Park, Sangeun,Kim, Kyung Mi,Chang, Jinho Elsevier 2018 ELECTROCHIMICA ACTA Vol.271 No.-
<P><B>Abstract</B></P> <P>In this article, we present stochastic electrochemical analyses for the semi-quantitative determination of ion transfers (ITs) at an interface between water and electrochemically generated quaternary ammonium polybromide (QBr<SUB>2n+1</SUB>) droplets (water|QBr<SUB>2n+1</SUB>) in QBr aqueous solutions containing different acids (HAs).</P> <P>The concentration of Br<SUP>−</SUP> in QBr<SUB>2n+1</SUB>, <SUB> C B <SUP> r − </SUP> ( Q B <SUB> r 2 n + 1 </SUB> ) </SUB> is linearly proportional to <SUB> C <SUP> A − </SUP> ( a q ) </SUB> with the proportionality constant, which was estimated from the difference between the two partition coefficients of H<SUP>+</SUP> and A<SUP>−</SUP> from water toward QBr<SUB>2n+1</SUB>, <SUB> K <SUP> H + </SUP> </SUB> − <SUB> K <SUP> A − </SUP> </SUB> , and the ratio of the mean activity coefficient of the aqueous over that of the QBr<SUB>2n+1</SUB> phase, <SUB> γ ± , a q </SUB> / <SUB> γ ± , Q B <SUB> r 2 n + 1 </SUB> </SUB> . <SUB> C B <SUP> r − </SUP> ( Q B <SUB> r 2 n + 1 </SUB> ) </SUB> also shows the linear function of <SUB> C <SUP> Q + </SUP> ( a q ) </SUB> with ( <SUB> γ ± , a q </SUB> / <SUB> γ ± , Q B <SUB> r 2 n + 1 </SUB> </SUB> ) <SUB> K <SUP> Q + </SUP> </SUB> as its proportionality constant.</P> <P>The stochastic chronoamperometric analyses of QBr<SUB>2n+1</SUB> droplets during their particle-impacts on Pt UME in acidic solutions containing either <I>N</I>-methyl-<I>N</I>-ethyl pyrrolidinium bromide (MEPBr) or ethylpyridinium bromide (EPyBr) as model QBrs can provide indirect information about <SUB> C B <SUP> r − </SUP> ( Q B <SUB> r 2 n + 1 </SUB> ) </SUB> , and we estimated the relative order to be <SUB> K <SUP> C + </SUP> ( L <SUP> i + </SUP> o r N <SUP> a + </SUP> ) </SUB> , <SUB> K <SUP> H + </SUP> </SUB> , and <SUB> K <SUP> A − </SUP> </SUB> : <SUB> K <SUP> C + </SUP> ( L <SUP> i + </SUP> o r N <SUP> a + </SUP> ) </SUB> < <SUB> K <SUP> H + </SUP> </SUB> < <SUB> K <SUP> A − </SUP> </SUB> , where <SUB> K H S O 4 − </SUB> < <SUB> K C l O 4 − </SUB> < <SUB> K C <SUP> l − </SUP> </SUB> in <SUB> K <SUP> A − </SUP> </SUB> and <SUB> K N <SUP> a + </SUP> </SUB> < <SUB> K L <SUP> i + </SUP> </SUB> in <SUB> K <SUP> C + </SUP> </SUB> . Also, we found that Br<SUP>−</SUP>-IT at water|QBr<SUB>2n+1</SUB> is effectively limited by A<SUP>−</SUP>-IT in the acidic solutions, and Cl<SUP>−</SUP> is most significantly transferred to QBr<SUB>2n+1</SUB>, leading to the complete inhibition of Br<SUP>−</SUP>-IT into QBr<SUB>2n+1</SUB>.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Radiotherapy Prolongs Biliary Metal Stent Patency in Malignant Pancreatobiliary Obstructions
( Semi Park ),( Jeong Youp Park ),( Seungmin Bang ),( Seung Woo Park ),( Jae Bock Chung ),( Si Young Song ) 대한소화기학회 2013 Gut and Liver Vol.7 No.4
Background/Aims: Biliary stenting is the most effective decompressive method for treating malignant biliary obstructive jaundice. Although the main cause of stent occlusion is tumor growth, few studies have investigated whether stent patency is affected by the combination of cancer-treatment modalities. The aim of this study was to evaluate the effects of local radiotherapy on metal-stent patency in patients with malignant biliary obstruction. Methods: Patients who underwent self-expandable biliary metallic stenting for malignant biliary obstruction from 1999 to 2007 were included. Forty patients received chemotherapy and radiation therapy (radiation group, RG), and 31 patients received only chemotherapy (nonradiation group, NRG). Results: The cumulative median stent patency was significantly longer in the RG than in the NRG (17.7 months, 95% confidence interval [CI], 1.8 to 33.6 months vs 8.7 months; 95% CI, 4.9 to 12.5 months; p=0.025). Stent occlusion caused by tumor growth or stent migration occurred in two (5%) and three (7.5%) cases in the RG and in six (19.3%) and two (6.5%) cases in the NRG, respectively. Conclusions: The patency of biliary metal stents in pancreatobiliary cancer patients who receive chemoradiation therapy is significantly longer than that in patients who do not receive radiotherapy, which suggests that local cancer control significantly affects stent patency. (Gut Liver 2013; 7:480-485)
( Semi Park ),( Moon Jae Chung ),( Jeong Youp Park ),( Jae Bock Chung ),( Seungmin Bang ),( Seung Woo Park ),( Si Young Song ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: Erlotinib and gemcitabine combined chemotherapy is becoming the treatment of choice in ad-vanced pancreatic cancer. We evaluated the effectiveness of treatment with erlotinib plus gemcitabine and the prognostic factors for chemotherapeutic response in Korean pancreatic cancer patients. Methods: Sixty-nine patients with advanced pancreatic cancer who were treated with daily erlotinib 100 mg orally and gemcitabine 1,000 mg/m2/30 min intrave-nous infusion on days 1, 8, and 15 of each 4-week cycle from 2006 to 2009 were included in this study. This study was a phase II single-center trial. Results: All 69 patients with advanced pancreatic cancer were chemotherapy-naive. The objective response rate was 18.8%, and the overall tumor-stabilization rate was 49.2%. The median overall sur-vival was 7.7 months (95% confidence interval [CI], 6.0 to 9.4 months). The median progression-free survival was 1.9 months (95% CI, 1.4 to 2.5 months). Prognostic factors for good chemotherapeutic response were good performance status and the presence of skin rash during chemotherapy. Patients with lower performance scores showed worse che-motherapeutic responses (odds ratio [OR], 7.6; 95% CI, 2.4 to 24.8). Poor responses were predicted by the absence of skin rash during chemotherapy (OR, 3.0; 95% CI, 1.4 to 6.3). Conclusions: Erlotinib and gemcitabine chemotherapy is a tolerable treatment regimen and has a favorable therapeutic effect in Korean patients with advanced pancreatic cancer. (Gut Liver 2013;7:611-615)
( Semi Jeon ),( Nara Lim ),( Sanghee Park ),( Misun Park ),( Seonghan Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.2
Two molecular epidemiologic methods, IS6110 restriction fragment length polymorphism (IS6110-RFLP) and 24-locus mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR), are used worldwide in studies of Mycobacterium tuberculosis (MTB). Conversely, because of its poor resolution, pulsed-field gel electrophoresis (PFGE) is not widely used for MTB. In this study, we improved the 24-locus MIRU-VNTR and PFGE protocols and compared the effectiveness of these approaches for the molecular typing of MTB using 75 clinical isolates obtained from a cohort investigation of high-risk populations infected with MTB. The 24-locus MIRU-VNTR method demonstrated superior discriminatory ability, followed by PFGE and IS6110-RFLP. Next, we analyzed six isolates with clear epidemiologic connections; that is, isolates from patients who attended the same school. IS6110-RFLP and PFGE identified these samples as the same type. By contrast, according to MIRU-VNTR, two isolates differed from four other isolates at one locus each; one isolate was identified as Mtub29 and the other as QUB-26. In summary, the 24-locus MIRU-VNTR assay was the most useful molecular typing method among the three methods investigated due to its discriminatory power, short time required, and availability as an epidemiologic investigation tool. PFGE was the second-best method. Compared with the other loci assessed in the 24-locus MIRU-VNTR assay, the Mtub29 and QUB-26 loci appeared to exhibit greater variability during transmission.
Park, Ji-Yeon,Lee, Jeong-Woo,Chung, Jin-Beom,Choi, Kyoung-Sik,Kim, Yon-Lae,Park, Byung-Moon,Kim, Youhyun,Kim, Jungmin,Choi, Jonghak,Kim, Jae-Sung,Hong, Semie,Suh, Tae-Suk Oxford University Press 2012 Journal of radiation research Vol.53 No.6
<P>A bio-anatomical quality assurance (QA) method employing tumor control probability (TCP) and normal tissue complication probability (NTCP) is described that can integrate radiobiological effects into intensity-modulated radiation therapy (IMRT). We evaluated the variations in the radiobiological effects caused by random errors (r-errors) and systematic errors (s-errors) by evaluating TCP and NTCP in two groups: patients with an intact prostate (G<SUB>intact</SUB>) and those who have undergone prostatectomy (G<SUB>tectomy</SUB>). The r-errors were generated using an isocenter shift of ±1 mm to simulate a misaligned patient set-up. The s-errors were generated using individual leaves that were displaced inwardly and outwardly by 1 mm on multileaf collimator field files. Subvolume-based TCP and NTCP were visualized on computed tomography (CT) images to determine the radiobiological effects on the principal structures. The bio-anatomical QA using the TCP and NTCP maps differentiated the critical radiobiological effects on specific volumes, particularly at the anterior rectal walls and planning target volumes. The s-errors showed a TCP variation of –40–25% in G<SUB>tectomy</SUB> and –30–10% in G<SUB>intact</SUB>, while the r-errors were less than 1.5% in both groups. The r-errors for the rectum and bladder showed higher NTCP variations at ±20% and ±10%, respectively, and the s-errors were greater than ±65% for both. This bio-anatomical method, as a patient-specific IMRT QA, can provide distinct indications of clinically significant radiobiological effects beyond the minimization of probable physical dose errors in phantoms.</P>
A Study on 3D Locomotion of Intravascular Therapeutic Microrobot using EMA System
Semi Jeong,Hyunchul Choi,Cheong Lee,Kiduk Kwon,Gwangjun Go,Doo Sun Sim,Kyung Seob Lim,Myung Ho Jeong,Seong Young Ko,Jong-oh Park,Sukho Park 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
In this paper, we proposed an intravascular microrobot using an EMA system with bi-plane X-ray fluoroscopy. The proposed EMA system consists of a pair of stationary Helmholtz-Maxwell coils in x-axis and a pair of rotational uniform-gradient saddle coils on x-axis. The microrobot using the EMA system can be aligned to the desired direction by the uniform magnetic field from the Helmholtz-uniform saddle coil pairs and can be propelled to the aligned direction by the uniform gradient magnetic field from the Maxwell-gradient saddle coil pairs. Based on this actuating principle, we developed the microrobot which can move and have a treatment function in blood vessel. For the position recognition of the microrobot, a bi-plane X-ray fluoroscopy was installed in the EMA system. The bi-plane X-ray fluoroscopy can provide frontal and lateral views of mini-pig and the image of the microrobot. In addition, the bi-plane X-ray fluoroscopy can be rotated together with the pair of rotational uniform-gradient saddle coils on x-axis. Through various in-vitro and in-vivo experiments, we could verify the feasibility of the proposed intravascular therapeutic microrobot.
Semi Park,신상준,안중배,정희철,라선영,이상길,정현철 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2
Malignant obstruction develops frequently in advanced gastric cancer. Although it is primarily the gastric outlet that isobstructed, there are occasional reports of colonic obstruction. Treating intestinal obstruction usually requires emergencysurgery or stent insertion. There are several kinds of complications with stent insertion, such as bowel perforation, stentmigration, bleeding, abdominal pain and reobstruction. Nevertheless, endoscopic stent insertion could be a better treatmentthan emergency surgery in cases of malignant bowel obstruction in cancer patients with poor performance status. We reporta case of advanced gastric cancer with carcinomatosis in which a recurrent colonic stent was inserted at the same sitebecause of cancer growth into the stent. The patient maintained a good condition for chemotherapy, thus improving theirchances for survival.