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김민경,이인환,신애숙,김나희,김혜미,심소라,나병조,조승연,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Min-kyung,Lee, ln-whan,Shin, Ae-sook,Kim, Na-hee,Kim, Hye-mi,Shim, So-ra,Na, Byung-Jo,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo Sang 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1
Object : This study was conducted as part of the national project to standardize stroke diagnosis in Korean medicine. In this study, we aimed to evaluate the characteristics of acute stroke between heat pattern group and cold pattern group. Methods : We recruited stroke patients from 5 universities(Kyung-Hee University oriental medical center, Kyung-Hee University East-West Neo medical center, Kyungwon university lncheon oriental medical center, Kyungwon university Songpa oriental medical center and DongGuk university llsan oriental medical center) from April, 2007 until February, 2010. We diagnosed them and selected 463 heat pattern patients and 182 cold pattern patients. Results : We find that the risk factor of smoking, alcohol, diet(prefer to meat) are more associated with the heat pattern group. On the other hand, inflammation history in recent 3 months and diet(prefer to sea food) are more associated with the cold pattern group. RBC, Hg, Hct, TG, CK and Cl are more related to the heat pattern group. CPT, total cholesterol and HDL are more related to the cold pattern group. Tae-eum type takes high distribution of the heat pattern group, and So-eum type takes high distribution of the cold pattern group. Conclusions : This study provides evidence that the heat pattern group have more risk factor than the cold pattern group.
Jo, Kyung-Wook,Lee, Soyeon,Kang, Mi Ran,Sung, Heungsup,Kim, Mi-Na,Shim, Tae Sun The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3
Background: A disputed rpoB mutation is a specific type of rpoB mutation that can cause low-level resistances to rifampin (RIF). Here, we aimed to assess the frequency and types of disputed rpoB mutations in Mycobacterium tuberculosis isolates from South Korea. Methods: Between August 2009 and December 2015, 130 patients exhibited RIF resistance on the MTBDRplus assay at Asan Medical Center. Among these cases, we identified the strains with disputed rpoB mutation by rpoB sequencing analysis, as well as among the M. tuberculosis strains from the International Tuberculosis Research Center (ITRC). Results: Among our cases, disputed rpoB mutations led to RIF resistance in at least 6.9% (9/130) of the strains that also exhibited RIF resistance on the MTBDRplus assay. Moreover, at the ITRC, sequencing of the rpoB gene of 170 strains with the rpoB mutation indicated that 23 strains (13.5%) had the disputed mutations. By combining the findings from the 32 strains from our center and the ITRC, we identified the type of disputed rpoB mutation as follows: CTG511CCG (L511P, n=8), GAC516TAC (D516Y, n=8), CTG533CCG (L533P, n=8), CAC526CTC (H526L, n=4), CAC526AAC (H526N, n=3), and ATG515GTG (M515V, n=1). Conclusion: Disputed rpoB mutations do not seem to be rare among the strains exhibiting RIF resistance in South Korea.
( Kyung Hee Lee ),( You Jin Lim ),( Jong Shim Lee ),( Mi Sung Kim ),( Jeong Hyeon Jo ),( Kyu Rae Kim ),( Jeong Yeol Park ),( Jong Hyeok Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.11
Androgen insensitivity syndrome cases have an increased risk of developing testicular cancer due to many factors such as mutations, hormonal disturbances involving gonadotropins and cryptorchidism. However, malignant germ cell tumor is relatively rarely found compared to those seen in other types of intersex. Recently, the authors experienced a case of malignant mixed germ cell tumor with lymph node metastasis and chemotherapy resistance which was developed in a 31-year-old patient with complete androgen insensitivity syndrome.
Jo, Hanggochnuri,Sohn, Ahrum,Shin, Kyung-Sik,Kumar, Brijesh,Kim, Jae Hyun,Kim, Dong-Wook,Kim, Sang-Woo American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.2
<P>An efficient approach to producing hexagonally self-assembled and well-dispersed gold (Au) nanoparticles (NPs) in the pores of porous anodic aluminum oxide (AAO) is reported. This approach is particularly useful for tuning the surface plasmon resonance frequency of Au NPs by varying the effective dielectric constant of AAO. A strongly enhanced Raman spectrum of dye molecule rhodamine 6G using these well-dispersed Au NPs revealed that such a self-assembled Au NP array can induce a strong plasmonic field. Furthermore, we demonstrated a new architecture of plasmon excitation in a bulk heterojunction (BHJ) inverted organic solar cell (IOSC) using the Au NP array with AAO. The optical response of an active layer poly(3-hexylthiophene):(6,6)-phenyl-C<SUB>61</SUB>-butyric acid methyl ester was enhanced by this strong plasmonic field associated a well-dispersed Au NP array. A comparative study of AAO with and without Au NPs confirmed plasmonic improvement of the BHJ IOSC. Simulation results showed that Au NPs concentrate the incoming light into a strongly localized field and enhance light absorption in a wide wavelength range.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-2/am4045585/production/images/medium/am-2013-045585_0006.gif'></P>
Jo, Eun-Hye,Lee, Soo-Jin,Ahn, Nam-Shik,Park, Joon-Suk,Hwang, Jae-Woong,Kim, Sung-Hoon,Aruoma, Okezie I.,Lee, Yong-Soon,Kang, Kyung-Sun Lippincott Williams & Wilkins 2007 EUROPEAN JOURNAL OF CANCER PREVENTION Vol.16 No.4
Oligonol is a novel catechin-rich biotechnology product. The role of oligonol in modulating intracellular signaling mechanisms was investigated with the view of demonstrating its potential chemopreventive effect and the ability to inhibit cell proliferation using the estrogen-responsive MCF-7 and the estrogen-unresponsive MDA-MB-231 human breast cancer cell lines. Cell survival assay indicated that Oligonol was cytotoxic to both cells. Oligonol triggered apoptosis as revealed by the morphological features typical of nucleus staining and the accumulation of sub-G1 peak. Treatment with 25 μg/ml Oligonol resulted in an activation of caspase-7 and up-regulation of Bad on MCF-7 cells, while the Oligonol (20 μg/ml) induced up-regulation of Bcl-2 protein in a time–response manner on MDA-MB-231 cells. ERK1/2 in both cells were inactivated after Oligonol treatment in a time-dependent manner, and also inactivated upstream MEK1/2. Oligonol triggers apoptosis in MCF-7 and MDA-MB-231 cells through the modulation of pro-apoptotic Bcl-2 family proteins and MEK/ERK signaling pathway.
Review of Site Characterization Methodology for Deep Geological Disposal of Radioactive Waste
Kyung-Woo Park,Kyung-Su Kim,Yong-Kwon Koh,Yeonguk Jo,Sung-Hoon Ji 한국방사성폐기물학회 2017 방사성폐기물학회지 Vol.15 No.3
방사성폐기물 지층 처분을 위한 부지 선정 과정에서 심층 처분장의 안전성을 평가하는데 필요한 입력 자료를 제공하기 위해 부지특성조사를 수행한다. 본 논문에서는 부지특성조사를 선도하여 수행하였던 해외 사례를 분석하고, 국내에서 방사성폐 기물 처분을 위해 수행해야 할 부지특성조사 방법을 제안하고자 하였다. IAEA가 고려하는 부지특성조사 방법은 단계별 부 지특성조사로 본 논문에서 소개된 해외의 경우도 이 방법을 따르고 있는데, 부지특성조사는 시기별, 조사 항목별로 다수의 지역에서 개략적인 부지의 정보를 도출하는 예비 부지특성조사와 조사 결과 선정된 지역에서 보다 자세한 부지특성자료를 생산하기 위한 상세 부지특성조사로 구분할 수 있다. 특히, 상세 부지특성조사 단계에서는 조사지역에 장심도 시추공을 굴 착하여 심부 영역에 대한 지질 특성을 바탕으로, 수리지질, 수리-지화학, 암석역학, 열, 용질이동에 대한 특성을 도출해야 한 다. 단계별 부지특성조사를 통해 도출된 부지 고유의 지질환경 특성은 부지특성모델로 구축되어야 하는데, 이를 종합하여 해석해야 비로소 조사지역의 부지특성을 이해하고, 지층 처분에 보다 유리한 부지를 최종 후보지역으로 선정할 수 있는 것 이다. 해외 사례를 살펴본 결과, 부지특성조사 단계에 소요되는 시간은 대략 7~8년이 소요될 것으로 예상되나, 이를 계획하 고 수행하는 시스템이 뒷받침 되지 않을 경우 보다 지연될 수 있을 것이다. In the process of site selection for a radioactive waste disposal, site characterization must be carried out to obtain input parameters to assess the safety and feasibility of deep geological repository. In this paper, methodologies of site characterization for radioactive waste disposal in Korea were suggested based on foreign cases of site characterization. The IAEA recommends that site characterization for radioactive waste disposal should be performed through stepwise processes, in which the site characterization period is divided into preliminary and detailed stages, in sequence. This methodology was followed by several foreign countries for their geological disposal programs. General properties related to geological environments were obtained at the preliminary site characterization stage; more detailed site characteristics were investigated during the detailed site characterization stage. The results of investigation of geology, hydro-geology, geochemistry, rock mechanics, solute transport and thermal properties at a site have to be combined and constructed in the form of a site descriptive model. Based on this site descriptive model, the site characteristics can be evaluated to assess suitability of site for radioactive waste disposal. According to foreign site characterization cases, 7 or 8 years are expected to be needed for site characterization; however, the time required may increase if the no proper national strategy is provided.