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Roshan R. Kulkarni,김장훈,김영호,오상택,나민균 한국생약학회 2015 Natural Product Sciences Vol.21 No.1
In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation of four uncommon small molecules and five nucleosides. Their structures were determined to be 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one (1), 5-chlorocavernicolin (2), maleimide-5-oxime (3), 3-methylmalei- mide-5-oxime (4), uridine (5), 2'-deoxyuridine (6), thymidine (7), adenine (8), and adenosine (9) by spectroscopic analyses. The isolated compounds were evaluated for inhibitory activity against soluble epoxide hydrolase (sEH) as well as the Wnt/b-catenine signaling pathway.
Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
Roshan R. Kulkarni,조아름,김영호,나민균 한국생약학회 2015 Natural Product Sciences Vol.21 No.4
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 ± 1.0 μM.
Complete NMR assignments of undegraded asterosaponins from Asterias amurensis
황인현,Roshan Kulkarni,양민혜,조수진,Wei Zhou,이상명,장태수,정길생,장현욱,나민균 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Four asterosaponins, thornasteroside A (1),versicoside A (2), anasteroside B (3), and asteronylpentaglycosidesulfate (4), were isolated from the predatorystarfish Asterias amurensis Lu¨tken. Unlike previous studiesfocusing on structure elucidation by degradation of thecomplex saponin molecules, complete nuclear magneticresonance (NMR) assignment for the intact molecules wasaccomplished using 600 MHz high magnetic field NMR. The complete set of NMR assignments can help in thestructure elucidation of asterosaponins isolated in lowyields without resorting to chemical degradation. Furthermore,this approach can be extended to other complexsteroidal saponins, which may accelerate the discovery ofbioactive secondary metabolites from this invasive starfishspecies.
( In Hyun Hwang ),( Roshan Kulkarni ),( Min Hye Yang ),( Soo Jin Choo ),( Wei Zhou ),( Sang Myung Lee ),( Tae Su Jang ),( Gil Saeng Jeong ),( Hyeun Wook Chang ),( Min Kyun Na ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Four asterosaponins, thornasteroside A (1), versicoside A (2), anasteroside B (3), and asteronylpentaglycoside sulfate (4), were isolated from the predatory starfish Asterias amurensis Lu¨tken. Unlike previous studies focusing on structure elucidation by degradation of the complex saponin molecules, complete nuclear magnetic resonance (NMR) assignment for the intact molecules was accomplished using 600 MHz high magnetic field NMR. The complete set of NMR assignments can help in the structure elucidation of asterosaponins isolated in low yields without resorting to chemical degradation. Furthermore, this approach can be extended to other complex steroidal saponins, which may accelerate the discovery of bioactive secondary metabolites from this invasive starfish species.