Overexpression of miR-146a and miR-155 are Potentially Biomarkers and Predict Unfavorable Relationship between Gastric Cancer and Helicobacter pylori Infection

Masoud Karimi,Abdolreza Mohammadnia,Mohammad Amin Amini,Azar Ghavimi Shamekh,Elahe Derakhshanfar,Farzaneh Hosseini 전남대학교 의과학연구소 2023 전남의대학술지 Vol.59 No.3

Gastric Cancer (GC) is one of the most dangerous malignancies in the world. This study aims to evaluate the relationship between miR-146a and miR-155 in patients with H. pylori infections with GC compared to H. pylori-infected patients and healthy subjects. Forty patients with H. pylori and GC positive diagnoses and 40 patients with H. pylori positive and GC negative diagnoses, and 40 healthy persons were selected. The expression of miR-146a and miR-155 genes in the whole blood was examined using qRT-PCR. Moreover, ROC curves were drawn to represent the sensitivity and specificity of miR-146a and miR-155 expression as biomarkers. The results showed the expression of miR-146a and miR-155 in the whole blood of patients with H. pylori and GC positive diagnoses are significantly higher than in healthy individuals and are non-significantly enhanced compared to H. pylori positive and GC negative. Also, the results stated miR-146a and miR-155 expression in the whole blood of patients who are H. pylori positive and GC negative are significantly increased compared to healthy individuals. Furthermore, the ROC curve analysis of miR-146a and miR-155 RNA level demonstrated the two miRNAs have an appropriate sensitivity and specificity for diagnostic goals. In conclusion, H. pylori infection may increase the expression of miR-146a and miR-155 in patients with H. pylori and GC positive diagnoses, which can be effective in the curbing the progression of GC. For this reason, up-regulation of miR-146a and miR-155 along with H. pylori infection might contribute to the pathogenesis of GC, and also can be suggested as biomarkers for GC diagnosis and treatment.

Incremental dynamic analyses of concrete buildings reinforced with shape memory alloy

Masoud Mirtaheri,Mehrshad Amini,Hossein Khorshidi 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.1

The use of superelastic shape memory alloys (SMAs) as reinforcements in concrete structures is gradually gaining interest among researchers. Because of different mechanical properties of SMAs compared to the regular steel bars, the use of SMAs as reinforcement in the concrete may change the response of structures under seismic loads. In this study, the effect of SMAs as reinforcement in concrete structures is analytically investigated for 3-, 6- and 8-story reinforced concrete (RC) buildings. For each concrete building, three different reinforcement details are considered: (1) steel reinforcement (Steel) only, (2) SMA bar used in the plastic hinge region of the beams and steel bar in other regions (Steel-SMA), and (3), beams fully reinforced with SMA bar (SMA) and steel bar in other regions. For each case, columns are reinforced with steel bar. Incremental Dynamic Analyses (IDA) are performed using ten different ground motion records to determine the seismic performance of Steel, Steel-SMA and SMA RC buildings. Then fragility curves for each type of RC building by using IDA results for IO, LS and CP performance levels are calculated. Results obtained from the analyses indicate that 3-story frames have approximately the same spectral acceleration corresponding with failure of frames, but in the cases of 6 and 8-story frames, the spectral acceleration is higher in frames equipped with steel reinforcements. Furthermore, the probability of fragility in all frames increases by the building height for all performance levels. Finally, economic evaluation of the three systems are compared.

The Impact of Obesity Surgery on Serum Uric Acid in People With Severe Obesity: A Retrospective Study

Leila Vafa,Masoud Amini,Hooman Kamran,Ladan Aghakhani,Seyed Vahid Hosseini,Zahra Mohammadi,Neda Haghighat 한국임상영양학회 2023 Clinical Nutrition Research Vol.12 No.1

Studies indicate an association between hyperuricemia (HUA) and metabolic syndrome risk factors. On the other hand, obesity is a major modifiable and independent risk factor for HUA and gout. However, evidence concerning the effects of bariatric surgery on serum uric acid levels is limited and not completely clarified. This retrospective study was carried out with 41 patients who underwent sleeve gastrectomy (n = 26) and Roux-en-Y gastric bypass (n = 15) from September 2019 to October 2021. Anthropometric, clinical, and biochemical data, including uric acid blood urea nitrogen and creatinine fasting blood sugar (FBS), serum triglyceride (TG), and serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), were measured preoperatively and postoperative 3, 6 and 12 months. From baseline to 6 and 12 months, bariatric surgery resulted in a significant decrease in serum uric acid of patients with severe obesity (p < 0.001). The decreases in serum FBS, TG, and cholesterol of patients were significant during 6 and 12 months of follow-up (p < 0.05). However, the HDL increase of patients was not statistically significant in 6 and 12 months (p > 0.05). Besides, although patients’ serum level of LDL decreased significantly during the 6 months of follow-up (p = 0.007), it was not significant after 12 months (p = 0.092). Bariatric surgery significantly reduces serum uric acid levels. Therefore, it may be an effective supplementary therapy for lowering serum uric acid concentrations in morbidly obese patients.

Calcium molybdate octahedral nanostructures, hierarchical self-assemblies controllable synthesis by coprecipitation method: Characterization and optical properties

Marziyeh Ghaed-Amini,Mehdi Bazarganipour,Masoud Salavati-Niasari 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

Calcium molybdate nanostructures have been successfully prepared via coprecipitation approach byutilizing Ca(Sal)2 (Sal = salicylidene) and ammonium heptamolybdate ((NH4)6Mo7O24 4H2O) as startingmaterials in water as solvent. The products were characterized by Fourier transform infrared (FT-IR)spectra, X-ray diffraction (XRD), energy dispersive X-ray microanalysis (EDX), photoluminescence (PL)spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Theeffects of temperature, reaction time, solvent, surfactant, calcium source and pH were considered toobtain optimum condition. It was established that morphology, particle size and phase of the finalproducts could be extremely affected via these parameters. It revealed that utilizing of water as solventand NH3 as the base, provided octahedral and hierarchical self-assemblies nanostructures, respectively.

Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management

Mohammad Amin Amini,Ashkan Karbasi,Mohammad Vahabirad,Masoud Khanaghaei,Aida Alizamir 전남대학교 의과학연구소 2023 전남의대학술지 Vol.59 No.3

One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage is divided into the exudative or neovascular form (wet AMD) and the nonexudative or atrophic form (dry AMD). Clinically, AMD primarily influences the central area of retina known as the macula. Importantly, the wet form is generally associated with more severe vision loss. AMD has a systemic component, where many factors, like aging, genetic, environment, autoimmune and non-autoimmune disorders are associated with this disease. Additionally, healthy lifestyles, regular exercise, maintaining a normal lipid profile and weight are crucial to decreasing the risk of AMD. Furthermore, therapeutic strategies for limiting AMD should encompass a variety of factors to avoid and improve drug interventions, and also need to take into account personalized genetic information. In conclusion, with the development of technology and research progress, visual impairment and legal blindness from AMD have been substantially reduced in incidence. This review article is focused on identifying and developing the knowledge about the association between genetics, and etiology with AMD. We hope that this review will encourage researchers and lecturers, open new discussions, and contribute to a better understanding of AMD that improves patients’ visual acuity, and upgrades the quality of life of AMD patients.

The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review

Mohammad Amin Amini,Masoud Karimi,Seyed Saman Talebi,Hossein Piri,Jamshid Karimi 전남대학교 의과학연구소 2022 전남의대학술지 Vol.58 No.3

Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to damage in zygote formation. ROMO1 is one of the most important proteins in the production of reactive oxygen species. This protein can enhance oxidative stress in the cells and body through cellular pathways, such as TNF-a and NF-kB routes, which will eventually lead to many diseases, especially infertility. We engage several international databases by using keywords; ROMO1, Infertility, and Reactive Oxygen Species, and gained a great quantity of information about ROMO1, Infertility, and Oxidative Stress. Although not proven, it is hypothesized that ROMO1 might elevate oxidative stress by activating NF-kB pathway in the cells, furthermore, TNF-a can arouse ROMO1 that can end up with apoptosis and cell death, which consequently can have a lot of disturbing effects on the body, especially the reproductive system. To sum up, revealing the exact cellular and molecular mechanisms of ROMO1-dependent TNF-a and NF-kB pathways in the pathogenesis of infertility might find interesting therapeutic and management strategies for this disorder.

Optimal Control of Steel Structures by Improved Particle Swarm

Saeid Aghajanian,Hadi Baghi,Fereidoun Amini,Masoud Zabihi Samani 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.2

Active control is one of the modern approaches in seismic design of steel structures. Recently, induced by economicconsiderations, especially high expenses of control systems, optimality has become an important issue. In this paper an activesystem is used to control a steel structure’s displacements by a simplified pole assignment method. To optimize the number,the locations, and the total driving force of the required actuators, an improved particle swarm algorithm is presented focusingon the parameters of the velocity equation. A Geographical neighborhood topology and an adaptive inertia weight are used toimprove the standard PSO algorithm. In addition to the local and global best solutions, the positions of the best particles inthe geographical neighborhood are mathematically represented in an additional term. The performance of the proposedalgorithm is compared with the traditional Genetic Algorithm (GA) and the standard particle swarm considering the optimalcontrol of a 12-story steel structure as a numerical example. High capabilities of the proposed method in terms of the controltarget, convergence rate, and accuracy are simultaneously clarified by the results.

Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension

Mohsen Janghorbani,Mohammad Reza Salamat,Ashraf Aminorroaya,Masoud Amini 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.2

Background: The aim of this study was to assess the utility of the visceral adiposity index (VAI) and the hypertriglyceridemic waist (HTGW) phenotype as possible hypertension (HTN) predictors in a high-risk population without diabetes and HTN. Methods: Incident HTN over a 7-year follow-up was assessed among 1,375 first-degree non-diabetic and non-hypertensive relatives of consecutive patients with type 2 diabetes who were 30 to 70 years of age. HTN was defined as a blood pressure reading ≥140/90 mm Hg or the use of antihypertensive medications. We examined the incidence of HTN across VAI quintiles and four groups defined according to baseline fasting serum triglyceride (TG) levels and waist circumference (WC). Results: The VAI and the HTGW phenotype at baseline were related to an increased risk for HTN. In comparison with the lowest VAI quintile, the highest VAI quintile showed a significant associated with HTN in an age- and gender-adjusted model (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.07 to 2.55). Those with HTGW were 2.3 times (OR, 2.27; 95% CI, 1.54 to 3.35) more likely to develop HTN than those with a normal WC and normal TG levels. Conclusion: Greater VAI values weakly predicted HTN, whereas the HTGW phenotype was a stronger predictor of incident HTN in an Iranian high-risk population.

Disorders of Liver : In Vivo Protoscolicidal Effect Of Hypertonic Glucose On Protoscolices Of Hydatid Cyst

( Syed Vahid Hosseini ),( Seyed Mahmoud Adjjadi ),( Davood Mehrabani ),( Kurosh Ghanbarzaden ),( Zahra Barzin ),( Nader Tanideh ),( Masoud Amini ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: The treatment of choice for Hydatidosis is surgery, but before evacuation of a cyst, protoscolicidal agents are needed to be injected to prevent a secondary cyst formation and the spreading of the disease. This study was performed to determine the protoseolicidal effect of various concentrations of hypertonic glucose in an animal model infected to hydatid cyst. Methods: Sheep liver hydatid cyst surface were sterilized by heat and the cyst contents were evacuated completely and transferred into falcon tubes, where protoscolices were precipitated and separated. The viability of protoseolices was determined by using eosin stain method. A total of 1500 protoscolices were exposed to 0.5% cetrimide, 0.5% silver nitrate, 0.9% and 20% sodium chloride and 10%, 15%, 25%, and 50% concentrations of glucose with exposure times of one, 2 and 5 minutes and were injected into the peritoneal cavity of 5 BALB/c mice for each agent. The animals were kept for 9 months and then were autopsied. Blood sample for countercurrent immunoelectrophoresis (CCIEP) was provided and the animals were examined for presence of any cyst in peritoneal cavity and recorded. Results: A total of 40 BALB/C mice were used in all exposure times while 24, 21 and 32 mice survived when exposed to different protoscilicidal agents after 1, 2 and 5 minutes respectively. None of the mice were infected to cysts after exposure to 50% hypertonic glucose solution. Identical to 50% glucose solution no infection was noticed for 0.5% cetrimide and 20% sodium chloride solutions too. The CCIEP results of animals indicating to cyst formation confirmed the presence of antibody in the circulation. Conclusions: Similarity of 50% glucose solution and cetrimide and 20% sodium chloride in complete killing of protoscolices present it as potent protoscolicidal agent and the side effects of cetrinide and hypertonic sodium chloride indicate to further studies on probable side effects.

Stem Cell Tracing Through MR Molecular Imaging

Rasoul Yahyapour,Bagher Farhood,Ghazale Graily,Abolhasan Rezaeyan,Saeed Rezapoor,Hamid Abdollahi,Mohsen Cheki,Peyman Amini,Hengameh Fallah,Masoud Najafi,Elahe Motevaseli 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.3

Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent’s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI.