Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial

Manoj Kumar Sharma,Sumeet Kainth,Sachin Kumar,Ankit Bhardwaj,Hemant Kumar Agarwal,Rakhi Maiwall,Kapil Dev Jamwal,Saggere Muralikrishna Shasthry,Ankur Jindal,Ashok Choudhary,Lovkesh Anand,Rajender Mal 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2

Background/Aims: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks. Results: The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture. Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture.

Novel visible-light-driven cobalt loaded neutralized red mud (Co/NRM) composite with photocatalytic activity toward methylene blue dye degradation

Manoj Kumar Sahu,Raj Kishore Patel 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.40 No.-

Cobalt doped neutralized red mud (Co/NRM) nanocomposite materials were prepared by impregnationmethod for the photodegradation of methylene blue dye under solar light irradiation. Different Co/NRMcatalysts were prepared by varying the weight ratio of Co and NRM and characterized by differentinstrumental techniques. Under solar light 97.21% degradation was observed in the presence of 0.08 g ofCo/NRM (Co:NRM::20:80) photocatalyst within 150 min for 20 mg/L methylene blue solution at pH9. These results underline the potential use of effective, low-cost and easily available photocatalysts forthe promotion of water splitting and environmental remediation under natural sunlight.

Characterization of Ti–Al Intermetallic Synthesized by Mechanical Alloying Process

Manoj Kumar Yadav,Arshad Noor Siddiquee,Zahid A. Khan 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7

Mechanical alloying (MA) of Al60Ti40 (wt%) has been successfully done by using a planetary ball mill having mixed ballsof 5 mm and 15 mm diameter to refne the crystallite size of the elemental powder and to get the new MAed phase of AlTi. The microstructural and morphological analysis of elemental as well as the processed powder was done with help of ScanningElectron Microscope and X-Ray difraction technique. Mechanical alloying of elemental Al and Ti resulted in the formationof AlTi phases with the refection of α-Ti3Al and TiAl3. The average particle size was reduced around 7 times after 60 h ofmilling. The mean crystallite size of MAed powder was also reduced up to 85 nm after 60 h of mechanical alloying undercontrolled conditions.

VCO Design using NAND Gate for Low Power Application

Manoj Kumar 대한전자공학회 2016 Journal of semiconductor technology and science Vol.16 No.5

Voltage controlled oscillator (VCO) is widely used circuit component in high-performance microprocessors and modern communication systems as a frequency source. In present work, VCO designs using the different combination of NAND gates with three transistors and CMOS inverter are reported. Three, five and seven stages ring VCO circuits are designed. Coarse and fine tuning have been done using two different supply sources. The frequency with coarse tuning varies from 3.31 GHz to 5.60 GHz in three stages, 1.77 GHz to 3.26 GHz in five stages and 1.27 GHz to 2.32 GHz in seven stages VCO respectively. Moreover, for fine tuning frequency varies from 3.70 GHz to 3.94 GHz in three stages, 2.04 GHz to 2.18 GHz in five stages and 1.43 GHz to 1.58 GHz in seven stages VCO respectively. Results of power consumption and phase noise for the VCO circuits are also been reported. Results of proposed VCO circuits have been compared with previously reported circuits and present circuit approach show significant improvement.

Genome Organization in Coffee as Revealed by EST PCRRFLP, SNPs and SSR Analysis

Manoj Kumar Mishra,Patrizia Tornincasa,Barbara De Nardi,Elisa Asquini,René Dreos,Lorenzo Del Terra,Rajkumar Rathinavelu,Paola Rovelli,Alberto Pallavicini,Giorgio Graziosi 한국작물학회 2011 Journal of crop science and biotechnology Vol.14 No.1

An EST-based PCR-RFLP method was employed to gain insight into genome organization in eight allopolyploid Coffea arabica cultivars and seven diploid coffee species. The PCR-amplified products at 19 EST loci were digested with 46 different restriction enzymes and size fractioned in agarose gels. Most often, the sum of the fragments length was double or more than the PCR product. In arabica, this condition could be explained by assuming the presence of duplicated loci in paralogous chromosomes and this was supported by considerable evidence of multiple loci SSR amplification. Based on the RFLP analysis, 12 EST loci were polymorphic. The level of polymorphism was higher in different species compared to the arabica varieties. Sequencing of the amplified products revealed a SNP frequency of 0.021 among diploid species and of 0.007 among arabica varieties. We propose that the involvement of two genomes in C. arabica maintains a residual level of heterozygosity in the form of paralogous chromosomes, while the self-fertilization in this species tends to drive of homozygosity. The heterozygosity of paralogous chromosomes in arabica creates valuable polymorphism essential for species diversity and survival in various ecological niches, while self-fertility tends to preserve in homozygosity many genes of functional significance.

Paruthi Paal, a nutrient-rich healthy drink from cottonseed: an Indian delicacy

Manoj Kumar 한국식품연구원 2019 Journal of Ethnic Foods Vol.6 No.-

Paruthi Paal is a very nutritious drink that is very much popular in the Tamil Nadu state of India. Paruthi Paal is regarded as “triple-nutrient” as it is a very rich source of protein, essential fatty acids, and sugars and can be called as an energy drink. The present paper will be focussed on developing a process protocol for the preparation of the nutrient-rich product “Paruthi Paal” from the traditional knowledge available. The paper also focusses on typical ingredients required for making this healthy drink. Further, this paper will present various health benefits of cottonseed which includes healing of stomach ulcer, regulation of menstrual cycle, curing cold and cough, maintaining blood pressure and also acting as an antioxidant. Overall, the study leads to a development of a protocol and a traditional delicious product (Paruthi Paal) with a view to popularise among other parts of the globe.

Biological Upgrading of Heavy Crude Oil

Manoj Kumar,a),Vladimir Leon,a) 한국생물공학회 2005 Biotechnology and Bioprocess Engineering Vol.10 No.6

Heavy crudes (bitumen) are extremely viscous and contain high concentrations of asphaltene, resins, nitrogen and sulfur containing heteroaromatics and several metals, particularly nickel and vanadium. These properties of heavy crude oil present serious operational problems in heavy oil production and downstream processing. There are vast deposits of heavy crude oils in many parts of the world. In fact, these reserves are estimated at more than seven times the known remaining reserves of conventional crude oils. It has been proven that reserves of conventional crude oil are being depleted, thus there is a growing interest in the utilization of these vast resources of unconventional oils to produce refined fuels and petrochemicals by upgrading. Presently, the methods used for reducing viscosity and upgradation is cost intensive, less selective and environmentally reactive. Biological processing of heavy crudes may provide an eco-friendly alternative or complementary process with less severe process conditions and higher selectivity to specific reactions to upgrade heavy crude oil. This review describes the prospects and strengths of biological processes for upgrading of heavy crude oil.

Accurate Computation of Interlaminar Stresses in Composite Blades Using Multifield Variational Formulation

Manoj Kumar Dhadwal,Sung Nam Jung(정성남) 한국항공우주학회 2018 한국항공우주학회 학술발표회 논문집 Vol.2018 No.11

Effect of oxygen ambient on structural, optical and electrical properties of epitaxial Al-doped ZnO thin films on r-plane sapphire by pulsed laser deposition

Manoj Kumar,최세영,R.M. Mehra 한국물리학회 2009 Current Applied Physics Vol.9 No.4

Al-doped ZnO (ZnO:Al) thin films were grown epitaxially on r-plane sapphire substrate by pulsed laser deposition. Substrate temperature of 400 ℃ and pulsed repetition rate of 5 Hz was kept constant during the deposition. The effect of oxygen ambient pressure from 0.1 to 10 mTorr on structural, optical and electrical properties of the ZnO:Al films were investigated. The lowest resistivity was found to be 2.14 × 10-3 Ω-cm with a carrier concentration of 6.89 × 1019 cm-3 for the film deposited in 1 mTorr of oxygen pressure. ZnO:Al film revealed smoother surface obtained at oxygen ambient pressure of 1 mTorr. The epitaxial relationship between ZnO:Al films and r-plane sapphire was found to be (0001)ZnO // (0112)sapp and [1010]ZnO // [0111]sapp. Photoluminescence spectra of the film grown at the oxygen ambient pressure of 1 mTorr exhibited peak at 3.34 eV, without any deep level. Al-doped ZnO (ZnO:Al) thin films were grown epitaxially on r-plane sapphire substrate by pulsed laser deposition. Substrate temperature of 400 ℃ and pulsed repetition rate of 5 Hz was kept constant during the deposition. The effect of oxygen ambient pressure from 0.1 to 10 mTorr on structural, optical and electrical properties of the ZnO:Al films were investigated. The lowest resistivity was found to be 2.14 × 10-3 Ω-cm with a carrier concentration of 6.89 × 1019 cm-3 for the film deposited in 1 mTorr of oxygen pressure. ZnO:Al film revealed smoother surface obtained at oxygen ambient pressure of 1 mTorr. The epitaxial relationship between ZnO:Al films and r-plane sapphire was found to be (0001)ZnO // (0112)sapp and [1010]ZnO // [0111]sapp. Photoluminescence spectra of the film grown at the oxygen ambient pressure of 1 mTorr exhibited peak at 3.34 eV, without any deep level.

Effect of grain size on wear behavior in Y-TZP ceramics

Kumar, B. Venkata Manoj,Kim, Won-Sik,Hong, Seong-Hyeon,Bae, Hung-Tak,Lim, Dae-Soon Elsevier 2010 Materials science & engineering. properties, micro Vol.527 No.3

<P><B>Abstract</B></P><P>The influence of grain size on the wear behavior of zirconia ceramics was investigated when slided against steel in dry unlubricated conditions. Fully densified Y-TZP ceramics (≥98% of theoretical density) with a wide range of grain size from 75 to 1470nm were developed using spark plasma sintering (SPS), microwave sintering (MS), and conventional pressureless sintering (CS) methods. SPS was effective in producing fully densified nanocrystalline zirconia at low temperature and short sintering time. The steady state coefficient of friction (COF) varied in a range of 0.35–0.44, but the wear rate reduced from 3.5 to 0.88×10<SUP>−6</SUP>mm<SUP>3</SUP>/Nm with decreasing grain size. The plastic deformation and microcracking lead to a mild wear for the nanocrystalline zirconia, whereas the delamination/spalling results in the increased wear for the coarser zirconia.</P>