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Kim, Kwangwook,Sohn, Hosung,Kim, Jong‐,Seok,Choi, Han‐,Gyu,Byun, Eui‐,Hong,Lee, Kang‐,In,Shin, Sung Jae,Song, Chang‐,Hwa,Park, Jeong‐,Kyu,Kim, Hwa‐,Jung Blackwell Publishing Ltd 2012 Immunology Vol.136 No.2
<P><B>Summary</B></P><P>Mycobacterial proteins interact with host macrophages and modulate their functions and cytokine gene expression profile. The protein Rv0652 is abundant in culture filtrates of <I>Mycobacterium tuberculosis</I> K‐strain, which belongs to the Beijing family, compared with levels in the H37Rv and CDC1551 strains. Rv0652 induces strong antibody responses in patients with active tuberculosis. We investigated pro‐inflammatory cytokine production induced by Rv0652 in murine macrophages and the roles of signalling pathways. In RAW264.7 cells and bone marrow‐derived macrophages, recombinant Rv0652 induced predominantly tumour necrosis factor (TNF) and monocyte chemoattractant protein (MCP)‐1 production, which was dependent on mitogen‐activated protein kinases and nuclear factor‐κB. Specific signalling pathway inhibitors revealed that the extracellular signal‐regulated kinase 1/2 (ERK1/2), p38 and phosphatidylinositol 3‐kinase (PI3K) pathways were essential for Rv0652‐induced TNF production, whereas the ERK1/2 and PI3K pathways, but not the p38 pathway, were critical for MCP‐1 production in macrophages. Rv0652‐stimulated TNF and MCP‐1 secretion by macrophages occurred in a Toll‐like receptor 4‐dependent and MyD88‐dependent manner. In addition, Rv0652 significantly up‐regulated the expression of the mannose receptor, CD80, CD86 and MHC class II molecules. These results suggest that Rv0652 can induce a protective immunity against <I>M.?tuberculosis</I> through the macrophage activation.</P>
( Kwangwook Kim ),( Byeonghyeon Kim ),( Hyunjin Kyoung ),( Yanhong Liu ),( Joy M. Campbell ),( Minho Song ),( Peng Ji ) 한국축산학회 2021 한국축산학회지 Vol.63 No.5
The study was conducted to evaluate the effects of spray-dried plasma (SDP) supplementation during late gestation and lactation on productive performance and immune responses of sows and their litters. Twelve sows (227.78 ± 2.16 kg average body weight; 2.0 average parity) were randomly allotted to two dietary treatments: a basal diet (CON) and the basal diet supplemented with 1% SDP. Sows were fed experimental diets from d 30 before farrowing to weaning of their piglets. Blood samples were collected from sows on d 1, 3, and 7 of lactation and from two randomly selected nursing pigs per litter on d 3 and 7 after birth, and d 1, 3, and 7 after weaning. Productive performance and immune responses of sows and their piglets were measured. There was a trend of less body weight loss in sows supplemented with SDP (p < 0.10) during the lactation period and a trend of greater (p < 0.10) average daily gain in SDP piglets compared to those in the CON group. Sows in the SDP group tended to have lower (p < 0.10) serum concentrations of tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), and cortisol on d 3 and lower serum concentration of TNF-α on d 7 compared with sows in CON group. In comparison with CON piglets, piglets from SDP sows tended to have lower (p < 0.10) serum concentrations of TNF-α, TGF-β1, and cortisol on d 7 after birth, lower (p < 0.10) serum TNF-α and C-reactive protein on d 3 and 7 after weaning, and greater (p < 0.10) average daily gain after weaning. Moreover, weaned pigs from sows fed SDP had significantly lower (p < 0.05) serum concentrations of cortisol and TGF-β1 on d 3 and 7 postweaning, respectively, than CON piglets. In conclusion, SDP supplementation in sow diets from late gestation to weaning improved the productive performance of sows and their offspring; the beneficial effects of SDP may be mediated in part through modulation of immune responses of both sows and piglets.
Impact of Sound Insulation in a Combine Cabin
Kim, Chiho,Jung, Ho Jun,Jo, Jin Seok,Kim, Myong il,Lee, Bongho,Park, Tae Jong,Seo, Kwangwook,Kim, Hyeon Tae Korean Society for Agricultural Machinery 2015 바이오시스템공학 Vol.40 No.3
Purpose: Recently, environmental pollution and safety problems in agricultural production have become important issues. Initially, bio-production machines focused on high production efficiency rather than workers' safety and comfort, but this trend slowly has changed as time went on. Methods: This study was carried out to identify sound efficiently and reliably for noise reduction by using a combine cabin model. Ethylene propylene diene monomer (M-class) rubber (EPDM) was applied to improve noise reduction performance from parts connected directly to the front, rear, left side, and bottom side of the cabin. Results: As a result, an average noise reduction of 1.85 dB was achieved in the normal hearing range between 500 Hz to 2 kHz. Conclusions: Reducing the cabin noise levels can reduce a worker's fatigue, improve working environment, and contribute to future low-noise and high-quality cabin environment.