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박주이 ( Ju Yee Park ),윤재영 ( Jae Young Yoon ),민선양 ( Sun Yang Min ),홍승권 ( Seung Kwon Hong ),박주상 ( Ju Sang Park ),장은정 ( Eun Jeong Jang ),백현욱 ( Hyun Wook Baik ),박상종 ( Sang Jong Park ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.3
Pneumatosis cystoides intestinalis is an uncommon condition of unknown etiology, characterized by the presence of multiple gas filled cysts in the gastrointestinal tract. Many different causes of pneumatosis cystoides intestinalis have been proposed, including mechanical, pulmonary, and bacterial causes. Approximately 85% of cases are thought to be secondary to coexisting disorders of the gastrointestinal tract or the respiratory system. The condition has been associated with the therapeutic uses of lactulose, steroids, and various cancer chemotherapeutic regimens. Lactitol is a disaccharide analogue of lactulose which is available as a pure crystalline powder. There are three previous case reports suggestive of lactulose causing pnumatosis intestinalis. We report a case of recurrent pneumatosis cystoides intestinalis associated with benign recurrent pneumoperitoneum developed probably secondary to lactitol therapy. (Korean J Gastroenterol 2007;50:188-192)
Stomach cancer incidence rates among Americans, Asian Americans and Native Asians from 1988 to 2011
Yee rae Kim,Jin ju Park,Byung Ho Nam,Mo ran Ki 한국역학회 2015 Epidemiology and Health Vol.37 No.-
Stomach cancer is the second most common cancer in Eastern Asia, accounting for approximately 50% of all new cases of stomach cancer worldwide. Our objective was to compare the stomach cancer incidence rates of Asian Americans in Los Angeles with those of native Asians to assess the etiology of stomach cancer from 1988 to 2011. To examine these differences, Asian Americans (Korean, Japanese, Chinese, and Filipino Ameri-cans living in Los Angeles, California, USA) and native Asians (from Korea, Japan, China, and the Philippines) were selected for this study. Using the Cancer Incidence in Five Continents database, stomach cancer inci-dence rates were examined. Data from the National Cancer Registry of Korea were used for native Koreans. Between native countries, the incidence rates in Japan, China, the Philippines, and the US declined over time, but the incidence in Korea has remained constant. The incidences among Asian immigrants were lower than those among native Asians. The incidence rates of males were approximately 2 times higher than those among females in Asian countries were. The effect of immigration on stomach cancer incidence suggests that lifestyle factors are a significant determinant of stomach cancer risk. However, the incidence in Korea remains the highest of these countries.
Yee Rae Park,Eu Jeen Yang,Ju Kyung Hyun,Ina Jeong,In-Sook Kim,Young Tak Lim 대한소아혈액종양학회 2023 Clinical Pediatric Hematology-Oncology Vol.30 No.2
Isolated extramedullary relapse (EMR) after allogeneic hematopoietic stem cell trans-plantation (allo-HSCT) in acute myeloid leukemia (AML) is relatively rare and the clin-ical significance is still not well characterized, particularly in children. During or after chemotherapy, an uncommon event termed lineage switch, in which the lineage at onset of leukemia converts to another lineage at a later time, is observed in a subset of leukemia patients, but it is a rare event. We report a 10-year-old boy with isolated mediastinal EMR after allo-HSCT for AML who subsequently experienced BM relapse with the cell lineage switching from AML to T-cell acute lymphoblastic leukemia.
박소현(Park, So-Hyun),유다은(Yoo, Da-Un),최이명(Choi, Yee-Myung),강현미(Kang, Hyun-Mi),김현주(Kim, Hyun-Ju) 대한건축학회 2015 대한건축학회논문집 Vol.31 No.12
The purpose of this study is to review recent causality studies on relationship between children’s play environment and play behavior in residential neighborhoods. Seven key precedent studies in the past ten years have been analyzed to understand their research design structures and procedures: research objectives, research subjects & scope, and research methods. The research findings are as follows. First, complement of research design is required that both qualitative and quantitative methods are connected for examining definitive relationship between children’s play environment and play behavior. Second, showing characteristics of children"s play behavior, researches for children’s play environment are differentiated itself from existing walkability studies of residential neighborhoods. In addition, This study highlights critical issues and methodological commonalities shared among researchers in disciplines of public health, transportation, urban planing, etc. The results of this study provides preliminary foundations and guidelines for future researches of the physical environment concerning children"s outdoor play.
Kim, Yee Hyung,Yoo, Kwang Ha,Yoo, Jee-Hong,Kim, Tae-Eun,Kim, Deog Kyeom,Park, Yong Bum,Rhee, Chin Kook,Kim, Tae-Hyung,Kim, Young Sam,Yoon, Hyoung Kyu,Um, Soo-Jung,Park, I-Nae,Ryu, Yon Ju,Jung, Jae-Woo The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.2
Background: The purpose of this study was to assess the effect of our new video-assisted asthma education program on patients' knowledge regarding asthma and asthma control. Methods: Adult asthmatics who were diagnosed by primary care physicians and followed for at least 1 year were educated via smart devices and pamphlets. The education sessions were carried out three times at 2-week intervals. Each education period lasted at most 5 minutes. The effectiveness was then evaluated using questionnaires and an asthma control test (ACT). Results: The study enrolled 144 patients (mean age, $56.7{\pm}16.7years$). Half of the patients had not been taught how to use their inhalers. After participating in the education program, the participants' understanding of asthma improved significantly across all six items of a questionnaire assessing their general knowledge of asthma. The proportion of patients who made errors while manipulating their inhalers was reduced to less than 10%. The ACT score increased from $16.6{\pm}4.6$ to $20.0{\pm}3.9$ (p<0.001). The number of asthmatics whose ACT score was at least 20 increased from 45 (33.3%) to 93 (65.3%) (p<0.001). The magnitude of improvement in the ACT score did not differ between patients who received an education session at least three times within 1 year and those who had not. The majority of patients agreed to the need for an education program (95.8%) and showed a willingness to pay an additional cost for the education (81.9%). Conclusion: This study indicated that our newly developed education program would become an effective component of asthma management in primary care clinics.
Control of Singlet Oxygen - induced Oxidative Damage in Escherichia coli )
(Sun Yee Kim),(Eun Ju Kim),(Jeen Woo Park) 생화학분자생물학회 2002 BMB Reports Vol.35 No.4
Singlet oxygen (^1O_2) is a highly reactive form of molecular oxygen that may harm living systems by oxidizing critical cellular macromolecules. The oxyR gene product regulates the expression of the enzymes and proteins that are needed for cellular protection against oxidative stress. In this study, the role of oxyR in cellular defense against a singlet oxygen was investigated using Escherichia coli oxyR mutant strains. Upon exposure to methylene blue and visible light, which generates singlet oxygen, the oxyR overexpression mutant was much more resistant to singlet oxygen-mediated cellular damage when compared to the oxyR deletion mutant in regard to growth kinetics, viability and protein oxidation. Induction and inactivation of major antioxidant enzymes, such as superoxide dismutase and catalase, were observed after their exposure to a singlet oxygen generating system in both oxyR strains. However, the oxyR overexpression mutant maintained significantly higher activities of antioxidant enzymes than did the oxyR deletion mutant. These results suggest that the oxyR regulon plays an important protective role in singlet oxygen-mediated cellular damage, presumably through the protection of antioxidant enzymes.
Streptococcus pneumoniae와 Haemophilus influenzae 임상분리주에 대한 Cefditoren의 시험관내 항균력
곽이경 ( Yee Gyung Kwak ),추은주 ( Eun Ju Choo ),박수진 ( Su Jin Park ),이정은 ( Jeong Eun Lee ),정진용 ( Jin Yong Jeong ),최상호 ( Sang Ho Choi ),김남중 ( Nam Joong Kim ),김양수 ( Yang Soo Kim ),우준희 ( Jun Hee Woo ),류지소 ( Ji 대한내과학회 2007 대한내과학회지 Vol.72 No.1
목적: 본 연구에서는 그람양성 및 음성 세균에 대해 광범위한 항균력을 나타내는 것으로 알려진 cefditoren의 임상적 유용성을 평가하기 위해 국내에서 분리된 S. pneumoniae와 H. influenzae 임상균주를 대상으로 cefditoren의 시험관내 항균력을 흔히 임상에서 사용되고 있는 다른 경구용 항균제들과 비교하고자 하였다. 방법: 2000년 1월부터 2004년 3월까지 서울아산병원에서 분리된 S. pneumoniae 120균주와 H. influenzae 80 균주를 대상으로 미국임상검사표준화협회의 방법에 따라 cefditoren과 다른 경구용 항균제에 대한 최소억제농도를 측정하였다. 결과: 모든 S. pneumoniae 균주는 cefditoren 농도 1 μg/mL 이하에서 억제되어 (MIC50/MIC90 0.25/1 μg/mL; range 0.015~1 μg/mL) cefditoren의 감수성 기준을 1 μg/mL로 하였을 때 penicillin에 대한 감수성 여부에 상관없이 모든 균주가 cefditoren에 감수성을 보였다. Penicillin 감수성 균주에서 cefditoren의 MIC (0.015~0.03 μg/mL)는 penicillin 중간 내성 (0.03~0.5 μg/mL) 및 내성 균주 (0.5~1 μg/mL)에 비해 낮았으며, H. influenzae에 대해서는 ampicillin 감수성 및 내성 H. influenzae 모두에서 우수한 항균력을 보였다 (MIC50/MIC90 0.015/0.03 μg/mL; range <0.008~0.03 μg/mL). 결론: Cefditoren은 penicillin이나 ampicillin에 대한 내성 여부에 상관없이 원외 호흡기 감염증의 흔한 원인 균인 S. pneumoniae와 H. influenzae에 대해 우수한 시험관내 항균력을 보였고 따라서 원외 호흡기 감염증 치료를 위한 경구용 항균제로 유용할 것으로 생각된다. Background: The aim of this study was to determine the in vitro activity of cefditoren, an oral third-generation aminothiazolyl cephalosporin, against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates in a tertiary hospital. Methods: We have studied the in vitro activities of cefditoren and other oral antibiotics against 120 S. pneumoniae isolates, including 80 penicillin non-susceptible isolates and 80 H. influenzae isolates from clinical specimens of patients at the Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by the agar dilution method. Results: All S. pneumoniae strains tested were inhibited by 1 g/mL of cefditoren (MIC50/MIC90 0.25/1 μg/mL; range 0.015~1 μg/mL). The MICs were lower for penicillin-susceptible S. pneumoniae (MIC90 0.015 g/mL) as compared to penicillin-intermediate resistant (MIC90 0.5 g/mL) or penicillin-resistant strains (MIC90 1 μg/mL). Cefditoren was active against all tested H. influenzae strains (MIC50/MIC90 0.015/0.03 μg/mL; range <0.008~0.03 g/mL) and its activity was comparable to levofloxacin and cefixime. Conclusions: Cefditoren had an excellent activity against S. pneumoniae and H. influenzae irrespective of penicillin or ampicillin resistance, respectively. The results of this study suggest that cefditoren is a good choice of an antibiotic to use for empirical oral treatment of community-acquired respiratory tract infections. (Korean J Med 72:68-73, 2007)