A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

Zhao, Jian,Ma, Jianyang,Deng, Yun,Kelly, Jennifer A,Kim, Kwangwoo,Bang, So-Young,Lee, Hye-Soon,Li, Quan-Zhen,Wakeland, Edward K,Qiu, Rong,Liu, Mengru,Guo, Jianping,Li, Zhanguo,Tan, Wenfeng,Rasmussen, Nature Pub. Co 2017 Nature genetics Vol.49 No.3

<P>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a strong genetic component characterized by autoantibody production and a type 1 interferon signatures. Here we report a missense variant (g.74779296G>A; p.Arg90His) in NCF1, encoding the p47phox subunit of the phagocyte NADPH oxidase (NOX2), as the putative underlying causal variant that drives a strong SLE-associated signal detected by the lmmunochip in the GTF2IRD1-GTF2I region at 7q11.23 with a complex genomic structure. We show that the p.Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production(2), predisposes to SLE (odds ratio (OR) = 3.47 in Asians (P-meta = 3.1 x 10(-104)), OR = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, including primary Sjogren's syndrome (OR = 2.45 in Chinese, OR = 2.35 in European Americans) and rheumatoid arthritis (OR = 1.65 in Koreans). Additionally, decreased and increased copy numbers of NCF1 predispose to and protect against SLE, respectively. Our data highlight the pathogenic role of reduced NOX2-derived ROS levels in autoimmune diseases.</P>

Numerical study of a variable camber plunge airfoil under wind gust condition

Jianyang Zhu,Lin Jiang,Hui Zhao,Bo Tao,Bin Lei 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.11

Variable camber deformation is observed during the flight of some insects and bird species; however, the effect of this special airfoilshape motion on the aerodynamic characteristics of the airfoil is not well understood, especially for the airfoil under gust wind. We did anumerical study to investigate the aerodynamic characteristics of a variable camber plunge airfoil under wind gusts. A weak couplingprogram was developed to simulate the interaction between the variable camber plunge airfoil and fluid, and the flow field, aerodynamicforce and energy efficiency of different camber airfoils under different wind gust conditions are investigated. It was found that camberdeformation influences the aerodynamic characteristics of the airfoil greatly. If the airfoil has an appropriate camber deformation, thedeformation can increase the mean thrust and the propulsive efficiency of the airfoil. Moreover, the aerodynamic characteristics of theappropriate camber airfoils are not significantly affected by the gust frequency, and there exists a range of gust amplitude where the aerodynamiccharacteristics of the airfoils are also not significantly affected by the gust amplitude, which may be beneficial for aerodynamicstability of the airfoil. The results also show that appropriate camber deformation can suppress leading edge vortex separation, whichimproves the aerodynamic characteristics of the airfoil.

Numerical analysis of the seismic performance of RHC-PVCT short columns

Xue, Jianyang,Zhao, Xiangbi,Ke, Xiaojun,Zhang, Fengliang,Ma, Linlin Techno-Press 2019 Advances in concrete construction Vol.8 No.4

This paper presents the results of cyclic loading tests on new high-strength concrete (HC) short columns. The seismic performance and deformation capacity of three reinforced high-strength concrete filled Polyvinyl Chloride tube (RHC-PVCT) short columns and one reinforced high-strength concrete (RHC), under pseudo-static tests (PSTs) with vertical axial force was evaluated. The main design parameters of the columns in the tests were the axial compression ratio, confinement type, concrete strength, height-diameter ratio of PVCT. The failure modes, hysteretic curves, skeleton curves of short columns were presented and analyzed. Placing PVCT in the RHC column could be remarkably improved the ultimate strength and energy dissipation of columns. However, no fiber element models have been formulated for computing the seismic responses of RHC-PVCT columns with PVT tubes filled with high-strength concrete. Nonlinear finite element method (FEM) was conducted to predict seismic behaviors. Finite element models were verified through a comparison of FEM results with experimental results. A parametric study was then performed using validated FEM models to investigate the effect of several parameters on the mechanical properties of RHC-PVCT short columns. The parameters study indicated that the concrete strength and the ratio of diameter to height affected the seismic performance of RHC-PVCT short column significantly.

Experimental research on seismic behavior of SRC-RC transfer columns

Kai Wu,Jianyang Xue,Yang Nan,Hongtie Zhao 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.1

It was found that the lateral stiffness changes obvious at the transfer position of the section configuration from SRC to RC. This particular behavior leads to that the transfer columns become as the important elements in SRC-RC hybrid structures. A comprehensive study was conducted to investigate the seismic behavior of SRC-RC transfer columns based on a low cyclic loading test of 16 transfer columns compared with 1 RC column. Test results shows three failure modes for transfer columns, which are shear failure, bond failure and bend failure. Its seismic behavior was completely analyzed about the failure mode, hysteretic and skeleton curves, bearing capacity deformation ability, stiffness degradation and energy dissipation. It is further determined that displacement ductility coefficient of transfer columns changes from 1.97 to 5.99. The stiffness of transfer columns are at the interval of SRC and RC, and hence transfer columns can play the role of transition from SRC to RC. All specimens show similar discipline of stiffness degradation and the process can be divided into three parts. Some specimens of transfer column lose bearing capacity swiftly after shear cracking and showed weak energy dissipation ability, but the others show better ability of energy dissipation than RC column.

Analysis on Extension Length of Shape Steel in Transfer Columns of SRC–RC Hybrid Structures

Kai Wu,Jianyang Xue,Yang Nan,Hong-tie Zhao 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.3

Seismic performance of SRC–RC transfer column was analyzed based on the experiment of 16 transfer columns specimens under low cyclic reversed loading, which mainly focus on the extension length of shape steel. Analysis of ductility, bearing capacity, energy dissipation capacity and degeneration ratio of strength were completed. Displacement ductility promotes at fi rst and then reduces with increasing of extension length of shape steel, reaching the peak value when extension length gets close to three fi fths of column height. Extension length of shape steel has little eff ect on bearing capacity, while energy dissipation capacity of transfer columns is infl uenced by many factors. Three fi fths of column height is the rational extension length of shape steel, of which specimens have advanced in energy dissipation, good stability of stiff ness and strength. The bond performance between concrete and shape steel decreases with the increasing of extension length of shape steel, and hence the stability of strength decreases. Minimum extension length of shape steel was confi rmed and the calculation method was proposed, which is mainly used to ensure the bend yielding of shape steel at bottom section. Moment at the truncation section leads to pull-out eff ect of steel bars, which enhances with increasing of the moment and section ratio of shape steel. Contrafl exure point is at three fi fths of column height. If the shape steel extends to contrafl exure point, moment of steel truncation section will reach minimum. So the reduce the concrete damage with better deformation ability and mechanical behavior of transfer column.

Identity-based Deniable Authenticated Encryption for E-voting Systems

( Chunhua Jin ),( Guanhua Chen ),( Jianyang Zhao ),( Shangbing Gao ),( Changhui Yu ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.6

Deniable authentication (DA) is a protocol in which a receiver can generate an authenticator that is probabilistically indistinguishable from a sender. DA can be applied in many scenarios that require user privacy protection. To enhance the security of DA, in this paper, we construct a new deniable authenticated encryption (DAE) scheme that realizes deniable authentication and confidentiality in a logical single step. Compared with existing approaches, our approach provides proof of security and is efficient in terms of performance analysis. Our scheme is in an identity-based environment; thus, it avoids the public key certificate-based public key infrastructure (PKI). Moreover, we provide an example that shows that our protocol is applicable for e-voting systems.

Experimental study on shear damage and lateral stiffness of transfer column in SRC-RC hybrid structure

Kai Wu,Jiangpeng Zhai,Jianyang Xue,Fangyuan Xu,Hongtie Zhao 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.23 No.5

A low-cycle loading experiment of 16 transfer column specimens was conducted to study the influence of parameters, likes the extension length of shape steel, the ratio of shape steel, the axial compression ratio and the volumetric ratio of stirrups, on the shear distribution between steel and concrete, the concrete damage state and the degradation of lateral stiffness. Shear force of shape steel reacted at the core area of concrete section and led to tension effect which accelerated the damage of concrete. At the same time, the damage of concrete diminished its shear capacity and resulted in the shear enlargement of shape steel. The interplay between concrete damage and shear force of shape steel ultimately made for the failures of transfer columns. With the increase of extension length, the lateral stiffness first increases and then decreases, but the stiffness degradation gets faster; With the increase of steel ratio, the lateral stiffness remains the same, but the degradation gets faster; With the increase of the axial compression ratio, the lateral stiffness increases, and the degradation is more significant. Using more stirrups can effectively restrain the development of cracks and increase the lateral stiffness at the yielding point. Also, a formula for calculating the yielding lateral stiffness is obtained by a regression analysis of the test data.

Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine

Fang Yan,Zhong Li,Yongting Hu,Jianyang Qiu,Wenxin Lei,Wenhui Ji,Xuying Li,Qian Wu,Xiumin shi,Yujun Zhao 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.1

The protective efficacy of DNA plasmids encoding avian infectious bronchitis virus (IBV) S1, N, or M protein was investigated in chickens. Chickens were inoculated monovalently (with plasmid pVAX1-16S1, pVAX1-16M, or pVAX1-16N alone) or multivalently (combination of the three different plasmids, pVAX1-16S1/M/N). A prime-boost immunization protocol against IBV was developed. Chickens were immunized with the multivalent DNA vaccine twice and then boosted with an inactivated vaccine once. Antibody titers of the chickens immunized with pVAX1-16S1/M/N were much higher than those of the monovalent groups (p < 0.01). A protective rate up to 90% was observed in the pVAX1-16S1/M/N group. The serum antibody titers in the prime-boost birds were significantly higher than those of the multivalent DNA vaccine group (p < 0.01) but not significantly different compared to the inactivated vaccine group at 49 days of age. Additionally, the prime-boost group also showed the highest level of IBV-specific cellular proliferation compared to the monovalent groups (p < 0.01)but no significant difference was found compared to the multivalent DNA vaccine group, and the prime-boost group completely protected from followed viral challenge.

An Efficient Indexing Structure for Multidimensional Categorical Range Aggregation Query

( Jian Yang ),( Chongchong Zhao ),( Chao Li ),( Chunxiao Xing ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.2

Categorical range aggregation, which is conceptually equivalent to running a range aggregation query separately on multiple datasets, returns the query result on each dataset. The challenge is when the number of dataset is as large as hundreds or thousands, it takes a lot of computation time and I/O. In previous work, only a single dimension of the range restriction has been solved, and in practice, more applications are being used to calculate multiple range restriction statistics. We proposed MCRI-Tree, an index structure designed to solve multi-dimensional categorical range aggregation queries, which can utilize main memory to maximize the efficiency of CRA queries. Specifically, the MCRI-Tree answers any query in O(nkn-1) I/Os (where n is the number of dimensions, and k denotes the maximum number of pages covered in one dimension among all the n dimensions during a query). The practical efficiency of our technique is demonstrated with extensive experiments.