Impact of Dissection after Drug-Coated Balloon Treatment of De Novo Coronary Lesions: Angiographic and Clinical Outcomes

Lin Hui,신은석,전은정,백영준,Scot Garg,김태현,손창배,최병주,Liu Kun,Song Lin Yuan,Wang Zhi,Jiang Hao,Shi Zhentao,Tang Qiang 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.12

Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with ahigh risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections andsubsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novocoronary lesions. Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) followingDCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vesselfailure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vesselthrombosis). Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differencesin LLL (90.8%) returning for angiography at 6 months (0.05±0.19 mm in non-dissection and 0.05±0.30 mm in dissection group, p=0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariateanalysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completelyhealed, and there was no newly developed dissection at 6-month angiography. Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associatedwith an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).

ON GENERALIZED ZERO-DIFFERENCE BALANCED FUNCTIONS

Jiang, Lin,Liao, Qunying Korean Mathematical Society 2016 대한수학회논문집 Vol.31 No.1

In the present paper, by generalizing the definition of the zero-difference balanced (ZDB) function to be the G-ZDB function, several classes of G-ZDB functions are constructed based on properties of cyclotomic numbers. Furthermore, some special constant composition codes are obtained directly from G-ZDB functions.

Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma

Lin Lin,Jinquan Cai,Zixiao Tan,Xiangqi Meng,Ruiyan Li,Yang Li,Chuanlu Jiang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2

Purpose Isocitrate dehydrogenase 1 (IDH1) mutations are the most common genetic abnormalities in low-grade gliomas and secondary glioblastomas. Glioma patients with these mutations had better clinical outcomes. However, the effect of IDH1 mutation on drug sensitivity is still under debate. Materials and MethodsIDH1-R132H mutant cells were established by lentivirus. IDH1-R132H protein expression was confirmed by western blot. The expression of ataxia telangiectasia mutated (ATM) signaling pathway and apoptosis-related proteins were detected by immunofluorescence and western blot. Temozolomide (TMZ) induced cell apoptosis was detected by flow cytometry. Tumor cell proliferation was detected by Cell Counting Kit-8. In vivo nude mice were used to confirm the in vitro roles of IDH1 mutation.ResultsWe established glioma cell lines that expressed IDH1-R132H mutation stably. We found that TMZ inhibited glioma cells proliferation more significantly in IDH1 mutant cells compared to wild type. The IC50 of TMZ in IDH1-R132H mutant group was less than half that of wild-type group (p < 0.01). TMZ significantly induced more DNA damage (quantification of γH2AX expression in IDH1 mutation vs. wild type, p < 0.05) and apoptosis (quantification of AnnexinV+propidium iodide–cells in IDH1 mutation versus wild type, p < 0.01) in IDH1 mutant gliomas compared to wild-type gliomas. The ATM-associated DNA repair signal was impaired in IDH1 mutant cells. Inhibiting the ATM/checkpoint kinase 2DNA repair pathway further sensitized IDH1 mutant glioma cells to chemotherapy. We found that IDH1 mutation significantly inhibited tumor growth in vivo (the tumor size was analyzed statistically, p < 0.05). Moreover, we confirmed that gliomas with IDH1 mutation were more sensitive to TMZ in vivo compared to wild type significantly and the results were consistent with the in vitro experiment. ConclusionThese results provide evidence that combination of TMZ and ATM inhibitor enhances the antitumor effect in IDH1 mutant gliomas.

A Voronoi path planning extracted from improved skeleton for dynamic environments

Lin Jiang,Jun Li,Yuxin Hu,Feng Pan,Jianyang Zhu,Bin Lei,Rui Lin 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4

Aiming at the problems that the robot being in the process of navigation cannot meet the requirements of real-time and accuracy at the same time, moreover is too close to obstacles and lacks the initiative to avoid obstacles, a Voronoi diagram algorithm for improved skeleton extraction suitable for dynamic environment is proposed. On the one hand, firstly the grid map is preprocessed by binarization, corrosion and expansion, so the reduced skeleton map suitable for navigation is obtained, then the reduced skeleton map is extracted for searching the global path, finally the improved cubic spline smoothing algorithm is used to optimize the global path each planned, thus overcoming the defects of bloated and tortuous in the path obtaining by original Voronoi diagram algorithm. On the other hand, the position information of all obstacles is obtained by a single scan lidar. Firstly, segmenting and linearly fitting all laser point clouds to remove the known obstacles in the map. Then to mark new possible dynamic obstacles with circles of appropriate size. Secondly detecting dynamic obstacles by the alteration of their center coordinates, moreover, solving their motion equations. Finally expanding the cost map along the speed direction of dynamic obstacles and combining DWA dynamic window method to realize dynamic obstacle avoidance. Compared with the original DWA algorithm, it can predict the motion state of dynamic obstacles in advance, which improves the safety of the robot in the dynamic environment. Moreover, the effectiveness of the algorithm is verified by many simulation experiments and real environment experiments.

A Practical Stability Control Strategy for DC/DC Converters

Jiang, Lin,Li, Po The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.3

This paper aims at designing an intelligent controller, based on control Lyapunov Function strategy integrated with fabricating discrete model of Buck and Boost converters and analyzing energy changes during the DC/DC progress to realize tracing reference current on Buck and Boost converters. In addition, practical stability phenomenon research and transient performance analysis has been proposed to give an insight to the influence of controller parameters in achieving an enhanced output performance and how the time of sample period affect the error of practical stability will be illustrated. The novelty of this controller in comparison to other schemes lies in the improved performance of practical stability.

Different fates of oocytes with DNA double-strand breaks in vitro and in vivo

Lin, Fei,Ma, Xue-Shan,Wang, Zhen-Bo,Wang, Zhong-Wei,Luo, Yi-Bo,Huang, Lin,Jiang, Zong-Zhe,Hu, Meng-Wen,Schatten, Heide,Sun, Qing-Yuan Taylor Francis 2014 Cell Cycle Vol.13 No.17

A Practical Stability Control Strategy for DC/DC Converters

Lin Jiang,Po Li 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3

This paper aims at designing an intelligent controller, based on control Lyapunov Function strategy integrated with fabricating discrete model of Buck and Boost converters and analyzing energy changes during the DC/DC progress to realize tracing reference current on Buck and Boost converters. In addition, practical stability phenomenon research and transient performance analysis has been proposed to give an insight to the influence of controller parameters in achieving an enhanced output performance and how the time of sample period affect the error of practical stability will be illustrated. The novelty of this controller in comparison to other schemes lies in the improved performance of practical stability.

Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro

Jiang, Hu Lin,Arote, Rohidas B.,Quan, Ji Shan,Yoo, Mi Kyong,Kim, You Kyoung,Kim, In Yong,Hong, Zhong Shan,Lee, Hong Gu,Jin, Xun,Choi, Yun Jaie,Cho, Chong Su Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342 No.-

<P>Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.</P>

Immune stimulating activity of an atrophic rhinitis vaccine associated to pegylated chitosan microspheresin vitro

Jiang, Hu-Lin,Park, In-Kyu,Kang, Mi-Lan,Yoo, Han-Sang,Choi, Yun-Jaie,Akaike, Toshihiro,Cho, Chong-Su JOHN WILEY & SONS LTD 2007 POLYMERS FOR ADVANCED TECHNOLOGIES Vol.18 No.3

ANALYSIS OF SOME PROJECTION METHODS FOR THE INCOMPRESSIBLE FLUIDS WITH MICROSTRUCTURE

Jiang, Yao-Lin,Yang, Yun-Bo Korean Mathematical Society 2018 대한수학회지 Vol.55 No.2

In this article, some projection methods (or fractional-step methods) are proposed and analyzed for the micropolar Navier-Stokes equations (MNSE). These methods allow us to decouple the MNSE system into two sub-problems at each timestep, one is the linear and angular velocities system, the other is the pressure system. Both first-order and second-order projection methods are considered. For the classical first-order projection scheme, the stability and error estimates for the linear and angular velocities and the pressure are established rigorously. In addition, a modified first-order projection scheme which leads to some improved error estimates is also proposed and analyzed. We also present the second-order projection method which is unconditionally stable. Ample numerical experiments are performed to confirm the theoretical predictions and demonstrate the efficiency of the methods.