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Lyu Su-Yun,Rhim Jee-Young,Park Won-Bong The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.11
Flavonoids, a group of low molecular weight phenylbenzopyrones, have various pharmacological properties including antioxidant, anticancer, bactericidal, and anti-inflammatory. We carried out anti-herpetic assays on 18 flavonoids in five classes and a virus-induced cytopathic effect (CPE) inhibitory assay, plaque reduction assay, and yield reduction assay were performed. When flavonoids were applied at various concentrations to Vero cells infected by HSV-1 and 2, most of the f1avonoids showed inhibitory effects on virus-induced CPE. Among the flavonoids, EC, ECG (flavanols), genistein (isoflavone), naringenin (flavanone), and quercetin (flavonol) showed a high level of CPE inhibitory activity. The antiviral activity of flavonoids were also examined by a plaque reduction assay. EC, ECG, galangin, and kaempferol showed a strong antiviral activity, and catechin, EGC, EGCG, naringenin, chrysin, baicalin, fisetin, myricetin, quercetin, and genistein showed moderate inhibitory effects against HSV-1. In these experiments, flavanols and flavonols appeared to be more active than flavones. Furthermore, treatment of Vero cells with ECG and galangin (which previously showed strong antiviral activities) before virus adsorption led to a slight enhancement of inhibition as determined by a yield reduction assay, indicating that an intracellular effect may also be involved.
간경변증 환자에서 도플러를 이용한 복부혈역학검사값의 초음파 장비 간 차이
지명관 ( Myeong Gwan Jee ),백순구 ( Soon Koo Baik ),박동훈 ( Dong Hun Park ),김문영 ( Moon Young Kim ),임대욱 ( Dae Wook Rhim ),조기원 ( Ki Won Jo ),홍진헌 ( Jin Hon Hong ),김재우 ( Jae Wook Kim ),김현수 ( Hyun Soo Kim ),권상옥 ( 대한간학회 2006 Clinical and Molecular Hepatology(대한간학회지) Vol.12 No.4
Dyrk1A Phosphorylates α-Synuclein and Enhances Intracellular Inclusion Formation
Kim, Eun Joo,Sung, Jee Young,Lee, Hyun Jung,Rhim, Hyewhon,Hasegawa, Masato,Iwatsubo, Takeshi,Min, Do Sik,Kim, Jongsun,Paik, Seung R.,Chung, Kwang Chul American Society for Biochemistry and Molecular Bi 2006 The Journal of biological chemistry Vol.281 No.44
Su-Yun Lyu,Jee-Young Rhim,Won-Bong Park 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.11
Flavonoids, a group of low molecular weight phenylbenzopyrones, have various pharmacological properties including antioxidant, anticancer, bactericidal, and anti-inflammatory. We carried out anti-herpetic assays on 18 flavonoids in five classes and a virus-induced cytopathic effect (CPE) inhibitory assay, plaque reduction assay, and yield reduction assay were performed. When flavonoids were applied at various concentrations to Vero cells infected by HSV-1 and 2, most of the flavonoids showed inhibitory effects on virus-induced CPE. Among the flavonoids, EC, ECG (flavanols), genistein (isoflavone), naringenin (flavanone), and quercetin (flavonol) showed a high level of CPE inhibitory activity. The antiviral activity of flavonoids were also examined by a plaque reduction assay. EC, ECG, galangin, and kaempferol showed a strong antiviral activity, and catechin, EGC, EGCG, naringenin, chrysin, baicalin, fisetin, myricetin, quercetin, and genistein showed moderate inhibitory effects against HSV-1. In these experiments, flavanols and flavonols appeared to be more active than flavones. Furthermore, treatment of Vero cells with ECG and galangin (which previously showed strong antiviral activities) before virus adsorption led to a slight enhancement of inhibition as determined by a yield reduction assay, indicating that an intracellular effect may also be involved.
유수연(Su-Yun Lyu),임지영(Jee-Young Rhim),박양호(Yang-Ho Park),서경범(Kyung-Bum Suh),박원봉(Won-Bong Park) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.1
강낭콩을 가열한 후 B. subtilis ATCC 51189로 발효시켜 새로운 활성 단백질의 생성여부를 확인하였다. 생강낭콩의 수용성 단백질은 열처리에 의하여 감소하였으며, 발효과정에서 단백질의 양은 변화하지 않았으나, 새로운 아미노산이 합성되었다. 생강낭콩의 수용성 단백질(raw protein, RP)은 분자량 118 kDa의 PHA(phytohemagglutinin)의 전형적인 모습을 보였으나, 열처리한 단백질(heated protein, HP)의 경우, RP의 band는 사라지고, 저분자 peptide로 변화되었으며, 발효과정에 의하여 분자량 18.0 kDa의 새로운 단백질(fermented protein, FP)이 생성된 것을 확인하였다. 또한, RP는 128 HU, HP는 4 HU, FP는 32 HU의 적혈구응집효과를 보였으며, 위암세포(SNU-1)에 대하여 RP 및 FP는 비교적 높은 농도(IC_(50)=50 ㎍/mL)에서 항암활성을 보였다. 그리고, RP 및 FP의 경우 1 ㎍/mL에서 림프구 증식효과를 보였고, IFN-γ, IL-12의 분비를 촉진하였다. 그러나 HP는 항암효과, 림프구 증식효과, cytokine의 분비촉진효과를 보이지 않았다. 따라서, 강낭콩 lectin은 가열에 의하여 활성물질이 파괴되나, B. subtilis에 의한 발효과정에서 새로운 cytokine 분비촉진물질이 생성되는 것을 확인할 수 있었다. Synthesis of new active protein was investigated by heat-treatment and fermentation of kidney beans with Bacillus subtilis ATCC 51189. The amount of water-soluble protein in raw kidney bean (raw protein, RP) was greatly reduced by heating (heated protein, HP) and several new amino acids were synthesized by fermentation. The molecular weights of proteins determined by SDS-PAGE were 118 kDa for RP and a new band of 18.0 kDa for protein (fermented protein, FP) in kidney beans heated and fermented with B. subtilis ATCC 51189. Hemagglutinating activities of RP, HP and FP were 128 HU, 4 HU and 32 HU respectively. Both of RP and FP showed anticancer activity against stomach cancer cell line (SNU-1) at 50 ㎍/mL and lymphocyte stimulating activity at 1 ㎍/mL, and stimulated PBMC to secrete IFN-γand IL-12. However, HP did not show any kinds of activities. Taken together, these results suggested that lectin in kidney beans was destroyed by heating, but new active lectin-like protein was derived by fermentation with B. subtilis ATCC 51189.