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Lim, Kwang Soo,Baldoví,, José,J.,Lee, Woo Ram,Song, Jeong Hwa,Yoon, Sung Won,Suh, Byoung Jin,Coronado, Eugenio,Gaita-Ariñ,o, Alejandro,Hong, Chang Seop American Chemical Society 2016 Inorganic Chemistry Vol.55 No.11
<P>The symmetry around a Dy ion is recognized to be a crucial parameter dictating magnetization relaxation dynamics. We prepared two similar square-antiprismatic complexes, [Dy(L-OMe)(2)(H2O)(2)](PF6) (1) and Dy(L-OMe)(2)(NO3) (2), where L-OMe = [CpCo{P(O)(O(CH3))(2)}(3)], including either two neutral water molecules (1) or an anionic nitrate ligand (2). We demonstrated that in this case relaxation dynamics is dramatically affected by the introduction of a charged ligand, stabilizing the easy axis of magnetization along the nitrate direction. We also showed that the application of either a direct-current field or chemical dilution effectively stops quantum tunneling in the ground state of 2, thereby increasing the relaxation time by over 3 orders of magnitude at 3.5 K.</P>
Kim, Kwang Su,Lim, Sung Ryeol,Kim, Sung-Eun,Lee, Jun Young,Chung, Chan-Hwa,Choe, Woo-Seok,Yoo, Pil J. Elsevier 2017 Sensors and actuators. B Chemical Vol.242 No.-
<P><B>Abstract</B></P> <P>Highly accurate and prompt monitoring of cortisol is imperative for the prevention of stress-related diseases. In this study, we present a novel electrochemical biosensor for cortisol detection harnessing an electrochemical sensing platform consisting of a reduced graphene oxide (rGO) electrode, a bifunctional protein interlayer, and an antibody probe that specifically recognizes cortisol molecules. A thermally denatured bovine serum albumin (d-BSA) protein layer was directly adsorbed as an interlayer onto the rGO electrode surface via pi-stacking interactions, which provides the bifunctionality of creating covalent anchoring sites for anti-cortisol antibody probes and preventing the nonspecific binding of undefined substances. Electrochemical impedance spectroscopic (EIS) measurements show that the constructed sensing platform (antibody/d-BSA/rGO) exhibits picomolar-range sensitivity cortisol detection with a wide linear dynamic range spanning 10pM–100nM. In addition, our sensor exhibits high selectivity toward cortisol with negligible cross-binding reactivity to the cortisol analogs, aldosterone and progesterone. Moreover, almost complete spike recovery was confirmed with cortisol present in human saliva samples containing several interfering compounds. The demonstrated strategy for constructing the protein/rGO composite sensing platform is simple but versatile. Therefore, it is expected to facilitate efficient interfacing of various biomolecular probes with graphene-based and/or other electrode materials with hydrophobic surfaces.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fabrication of highly sensitive and selective cortisol-detecting electrochemical sensors (detection limit ∼10pM). </LI> <LI> Introduction of bifunctional BSA for covalent anchoring with anti-cortisol antibody and preventing nonspecific binding. </LI> <LI> Almost complete spike recovery confirmed with cortisol present in human saliva samples. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jae Hyuk Kwon,Young Hwa Song,Jung Min Yoon,Eun Jung Cheon,Kyung Ok Ko,Jae Woo Lim,Hyon J. Kim 대한신생아학회 2020 Neonatal medicine Vol.27 No.4
14q12q13.3 Deletion is a rare microdeletion syndrome associated with neurodevelopmental delay, failure to thrive, seizures, and abnormal brain development. Symptoms vary depending on the sites of gene deletion, and establishing the diagnosis is often difficult, as the condition cannot be detected with routine chromosome analysis. In this report, we present a patient with intrauterine growth retardation, microcephaly, muscle weakness, seizures, and hypoplasia of the corpus callosum who underwent diagnostic tests, including karyotyping in the neonatal period without leading to a specific diagnosis. The patient was confirmed with a serious developmental disorder, and a chromosomal microarray analysis was performed at 8 months of age, revealing a 14q12q13.3 deletion. In this case, the condition was diagnosed in early infancy, in contrast to previously reported cases, and the patient had diverse and severe symptoms. Establishing the diagnosis of 14q12q13.3 deletion syndrome allows better management of patient care and genetic counseling for the parents.
Measurement of Outgassing in a Vacuum Environment
Shin, Yong Hyeon,Hong, Seung Soo,Lim, In Tae,Kim, J.H.,Seong, Dae Jin,Chung, Kwang Hwa,Moon, G.W.,Choi, Sung Woo Trans Tech Publications, Ltd. 2005 Key engineering materials Vol.277 No.-
<P>Outgassing, the evolution of gas from the material in a vacuum, is not only a source of micro contamination in a semiconductor or the flat display panel production process, but it also a limitation factor in the ultra clean process of nano-technology. The outgassing from the materials of satellites and spacecrafts must be controlled for increased safety and function because space is also a vacuum environment. Several methods are used in outgassing measurement in general, but there is no one method suitable for obtaining all outgassing data. The most suitable method for a particular application must be chosen by the experimenter or user. Three types of outgassing measurement systems were fabricated and characterized, ‘Throughput method,’ ‘Rate of Rise method’ and ‘Mass Loss Measurement method’. The outgassing rates of many kinds of materials were measured and characterized using these systems.</P>