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강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.
Nho, Seong-Won,Shin, Gee-Wook,Park, Seong-Bin,Jang, Ho-Bin,Cha, In-Seok,Ha, Mi-Ae,Kim, Young-Rim,Park, Yon-Kyoung,Dalvi, Rishikesh S.,Kang, Bong-Jo,Joh, Seong-Joon,Jung, Tae-Sung Oxford University Press 2009 FEMS microbiology letters Vol.293 No.1
<P>The etiological agents of streptococcosis were isolated from diseased olive flounder collected on the Jeju island of Korea. A total of 151 bacterial isolates were collected between 2003 and 2006. The isolates were examined using various phenotypic and proteomic analyses, including sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting, and glycoprotein assays. In addition, isolates were grown on blood agar to assess hemolytic activity, and biochemical assays were performed using the API20 Strep kit. Our results revealed that all isolates were nonmotile, Gram-positive cocci that displayed negative catalase and oxidase activities. Multiplex PCR assays revealed that 43% and 57% of the isolates were Streptococcus iniae and Streptococcus parauberis, respectively. These results were consistent with those of the SDS-PAGE and immunoblot analyses using whole-cell lysates of bacterial isolates. Significant differences were observed with respect to the Voges-Proskauer, pyrrodonyl arylamidase, alkaline phosphatase, and hemolytic activities of the S. iniae and S. parauberis isolates. Isolates of S. iniae displayed uniform profiles in the immunoblot and glycoprotein assays; however, immunoblot assays of S. parauberis isolates (using a chicken IgY antibody raised against a homologous isolate) revealed three distinct antigenic profiles. Our findings suggest that S. parauberis and S. iniae are endemic pathogens responsible for the development of streptococcosis in olive flounder.</P>
박종성,황성준,이승관,이창규,이국성,강영태 高麗大學校 倂設 保健大學 保健科學硏究所 1994 保健科學論集 Vol.20 No.1
Comparison of methods studies should compare results by new or proposed method with those by a reference quality method or other generally accepted analytical method for which the performance is documented. The least squares method is frequently used to calculate the slope and intercept of the best line through a set of data points. However, least squares regression slopes and intercepts may be incorrect if the underlying assumptions of the least squares model are not met. Latest in the line of Hitachi systems, the Hitachi 747 is a high volume, random access system. It has capabilities for running states, automatic return of samples with a smaller volume, parameters for serum/plasma and urine, and multitasking capability. We performed method comparison studies against the current method for 8 different analytes with 49 samples for each chemistry. Also, Data analysis was performed according to the Kuwa protocol. The results of statistical studies indicate an acceptable performance over a clinically relevant range. We conclude that the Hitachi 747 analyzer is a reliable, precise and accurate system for routine clinical analytes. Its convenience and simplicity make it superior to the current autoanalyzer for our clinical applications in a hospital setting.
Abnormal photoluminescence properties of GaN nanorods grown on Si(111) by molecular-beam epitaxy
Park, Young S,Kang, Tae W,Taylor, R A IOP Pub 2008 Nanotechnology Vol.19 No.47
<P>We have studied the photoluminescence properties of GaN nanorods grown on Si(111) substrates by radio-frequency plasma-assisted molecular-beam epitaxy. The hexagonal shaped nanorods with lateral average diameters from 30 to 150 nm are obtained by controlling the Ga flux with a fixed amount of nitrogen. As the diameters decrease, the main emission lines assigned as donor bound excitons are blueshifted, causing a spectral overlap of this emission line with that of the free exciton at 10 K due to the quantum size effect in the GaN nanorods. The temperature-dependent photoluminescence spectra show an abnormal behaviour with an ‘S-like’ shape for higher diameter nanorods. The activation energy of the free exciton for GaN nanorods with different diameters was also evaluated.</P>
New Prognostic Model in Hospitalized Patients with Non-Severe Alcoholic Liver Disease
( Tae Hyung Kim ),( Hyung Joon Yim ),( Eileen L. Yoon ),( Seong Hee Kang ),( Hee Yeon Kim ),( Young Chang ),( Sung Won Lee ),( Jeong-Ju Yoo ),( Baek Gyu Jun ),( Jung Gil Park ),( Tae Yeob Kim ),( Do S 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
Kang, Hye J,Lee, Seung S,Kim, Kyeong M,Choi, Tae H,Cheon, Gi J,Kim, Won S,Suh, Cheolwon,Yang, Sung H,Lim, Sang M Blackwell Pub. Asia 2011 Asia-Pacific journal of clinical oncology Vol.7 No.2
<P>Aim:??To evaluate the efficacy and safety of radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ((131) I-rituximab) for treating Korean patients with relapsed or refractory B-cell non-Hodgkin's lymphomas (NHL). Methods:??All patients received unlabeled rituximab 70?g immediately prior to the administration of a therapeutic dose (median dose: 7.3 GBq) of (131) I-rituximab. The tumor response was evaluated 1?onth later by contrast enhanced (18) F-fludeoxyglucose positron emission tomography-computed tomography. Results:??Between May 2004 and October 2006, 24 patients received single treatment with (131) I-rituximab. The overall response rate (ORR) was 29%; 46% (three complete responses, two partial responses (PR) for patients with low grade B-cell NHL (LGL) and 9% (one PR) for patients with diffuse large B-cell lymphoma (DLBCL). After a median follow-up of 55?onths, the median progression-free survival (PFS) for all the patients was 2.2?onths. The median overall survival (OS) was 11.3?onths. There were statistically significant differences between the LGL and the DLBCL for the median PFS (4.5?onths vs 1.3?onths, respectively, P????.0007) and the median OS (30.3?onths vs 6.5?onths, respectively, P????.0295). Grades 3-4 thrombocytopenia and neutropenia occurred in 33% (8/24) and 21% (5/24) of the patients, respectively. Conclusion:??RIT with (131) I-rituximab seems to be effective and tolerable for patients with refractory LGL, although this treatment had modest activity in patients with refractory DLBCL. Further studies are warranted to determine the efficacy of (131) I-rituximab for treating the patients with DLBCL.</P>