Preliminary Methodology for Linking Data

Eunhee Ha,Jueun Lee,Byung-Hak Jeon,Myeongjee Lee 환경독성보건학회 2015 한국독성학회 심포지움 및 학술발표회 Vol.2015 No.10

Leaping Forward in the Era of Artificial Intelligence with a Focus on Educating Medical Scientists and Strengthening Research Capabilities

Eunhee Ha 이화여자대학교 의과학연구소 2022 EMJ (Ewha medical journal) Vol.45 No.1

Effects of maternal and cord blood PFC concentrations on birth outcome and postnatal growth at age of 36 month

( Eunhee Ha ),( Myeongjee Lee ),( Eun Mi Jung ),( Eun Jin Kwon ),( Surabhi Shah-kulkarni ) 한국모자보건학회 2016 한국모자보건학회 학술대회 연제집 Vol.2016 No.2

Background and Aim Perfluorinated compound (PFC) is a widely distributed class of chemical in consumer and industrial products including surfactants, paper coating, fabric, food packaging, and surface protectants. The aim of this study is to compare the PFC concentrations between mothers and their children and examine the effects of maternal and cord blood PFC concentrations on birth outcome and postnatal growth at age of 36 month. Method We collected blood samples and data from 30 pregnant women and newborn through a retrospective cohort study of Ewha Birth & Growth between 2006 and 2010 in Ewha Womans Medical care. Outcomes were included anthropometry and body composition at birth and at age of 3 years of children were obtained from medical records after birth and automatic electronic scale by trained nurses. We analyzed maternal and cord samples for perfluorinated compounds (PFCs) by high-performance liquid chromatograph coupled with a Triple Quad LC-MS/MS system. Multiple linear regression analysis and generalized estimating equation model were used to estimate the association between PFCs exposure and child growth after adjusting for maternal age, maternal height and weight, gestational age, parity and gender. Results Among PFCs, PFHxA, PFBS, and PFDS were not detected. PFTeDA, PFHpA, and PFNA were significantly correlated between mother and child, and PFTrDA showed borderline significance. Higher concentration of maternal PFDoDA decreased child's weight at birth by -1.13 (-1.63 - 0.63) and height by -4.80 (-7.63 - 1.96), but higher concentration of maternal PFDA increased child height at the 36-month time point by 4.75 (0.28 - 9.22), In the analyses using GEE, which concerns the time from birth to 36 months, higher concentrations of maternal PFOA and PFDA increased child's weight by 0.23 (0.008 - 0.44) and 1.12 (0.41 - 1.84), respectively. Higher concentration of maternal PFDA also increased child’ s height by 2.58 (1.23 - 3.94) in the GEE model. Higher concentration of cord blood PFCs increased child’ s abdominal circumference by 1.40 (0.003 - 2.81) as well. On the other hands, higher cord blood PFOA concentration decreased child’ s height at the age of 36 months with borderline significance (-0.94 (-1.96 - 0.08)),and in the GEE model, higher concentration of PFOA in cord blood decreased child’ s height by -0.65 (-1.06 - 0.23). Conclusion Our finding indicates that higher concentration of maternal PFDoDA may negatively affect birth weight. However, it also may positively affect postnatal growth. Further studies with a larger sample size are need to be conducted to examine the biological plausibility of these effects.

EMJ, A Research Platform for “Future Ready, Ewha Medicine”

Eunhee Ha Ewha Womans University School of Medicine 2022 EMJ (Ewha medical journal) Vol.45 No.3

도덕적 이슈에 관한 사회적 구성(Social Construction)과 정책과정 분석 - 연명의료결정법 제정 사례를 중심으로 -

하은희 ( Eunhee Ha ),박선주 ( Sunjoo Park ) 한국정책학회 2018 韓國政策學會報 Vol.27 No.1

본 연구는 제도화되기 힘든 도덕적 이슈의 정책과정을 사회적 구성주의(social constructivism)의 관점에서 분석하였다. 이를 위해 소극적 안락사라는 도덕적 이슈를 법제화한 연명의료결정법의 제정사례를 중심으로, 도덕적 이슈가 법률로서 제정·시행되기까지의 정책과정과 정책대상집단(환자, 환자가족, 의료인 및 의료기관)에 대한 사회적 구성의 변화를 시계열적으로 비교하였다. 특히 정책대상 집단의 사회적 정체성이 어떻게 인식되고 구성되어왔는지 그 변화과정과 영향요인을 살펴봄으로써 정책대상에 대한 사회적 구성과 정책 변동 간의 관련성 및 선후관계, 정책대상 집단 간 사회적 구성 유형의 차이 또는 일치가 정책결정에 미치는 영향에 대해 알아보았다. 분석결과, 각 집단에 대한 사회적 구성이 정책결정 커뮤니티의 외부적 사건과 행위자에 의해 변화되었고, 이렇게 변화된 사회적 구성은 정책형성과정에 영향을 미치는 것으로 나타났다. 또한 정책대상 집단에 대한 사회적 인식이 대치·혼재되었던 시기에는 정책의제화 단계에서 어려움을 겪었으나, 정책대상 집단에 대한 인식이 긍정적인 방향으로 전환되어 모두 동일한 사회적 구성의 영역으로 이동한 시기에는 사회적 합의를 통한 정책형성이 이루어질 수 있었다. This study analyzes the policy process of passive euthanasia, one of the ethical issues that have been considered to hardly be institutionalized, from the perspective of social constructivism. We compare the policy process of the enactment of the Hospice, Palliative Case, and Life-sustaining Treatment Decision-making Act and the changes of social constructions of targeted policy groups (patients, patient families, and medical practitioners) in chronological order to find the relations of those two streams. In particular, this study focuses on the effect of similarities and differences in social constructions among policy target groups on policy decision making. We find that social identities of policy target groups are constructed by external actors and events outside the policy community, while those changed social constructions influence the policy decision making. This analysis suggests that the mixed and adversarial social constructions among policy target groups would impede policy agenda setting of ethical issues such as passive euthanasia while having similar and positive social constructions among policy target groups help achieve successful policy making through social consensus.

의학통계학 교육모형 개발

하은희(Eunhee Ha),박혜숙(Hyesook Park),조희숙(Heuisug Jo),이보은(Boeun Lee),김정연(Jeoungyoun Kim),채유미(Yoomi Chae),이선희(Sunhee Lee) 한국의학교육학회 2001 Korean journal of medical education Vol.13 No.1

In order to solve the problems of traditional teaching model for medical statistics based on theoretical lecture, we developed new teaching model for medical statistics. The model was consisted of theoretical and practical lecture for 2nd grade of premedical students, Ewha Womans University. For theoretical lecture, we introduced basic concepts of medical statistics, data description and social survey method with questionnaire development. For practical lecture, we introduced the whole process from the selection for research topic to sampling, survey, data analysis, and report writing. Although students participated this class pointed out some trivial problems, they gave positive evaluation, particularly on practical lecture. We think this new model will be a good model and let medical students have ability to do medical research through basic knowledge and practical skill.

산업의학 전공의 수련의 현황

하은희(Eunhee Ha),박혜숙(Hyesook Park),정최경희(Kyunghee Jungchoi),손지언(Jieun Son),김일용(Ilryong Kim),이종태(Jongtae Lee),조수헌(Soohun Cho) 한국의학교육학회 2002 Korean journal of medical education Vol.14 No.1

Purpose: This study was performed to obtain baseline information about the occupational and environmental medicine (OEM) residency programs in Korea. Methods: We surveyed 39 residents for the present training condition, satisfaction, vision of OEM, the condition and satisfaction after residency programs by self- administered questionnaire. Results: Residents want to get appropriate clinical and practical training to be a medical director in a factory or specialist of the occupational medicine based at a hospital. They report, however, that current system for OEM residency training program is not appropriate. The curricula, duration of the each curriculum, level of training hospital or institute need to be reconsidered. Conclusions: We need to develop more systematic residency program with support from government and OEM society.

Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction, and angina pectoris in Korean population

Sung Keun Park(Sung Keun Park),Ju Young Jung(Ju Young Jung),Min-Ho Kim(Min-Ho Kim),Chang-Mo Oh(Chang-Mo Oh),Eunhee Ha(Eunhee Ha),Eun Hye Yang(Eun Hye Yang),Hyo Choon Lee(Hyo Choon Lee),Soonsu Shin(Soo 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease. METHODS: The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative → negative; resolved: proteinuria ≥1+ → negative; incident: negative → proteinuria ≥1+; persistent: proteinuria ≥1+ → proteinuria ≥1+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris. RESULTS: The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]). CONCLUSIONS: Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.

Radiation Dose Reduction in Digital Mammography by Deep-Learning Algorithm Image Reconstruction: A Preliminary Study

Ha Su Min,Kim Hak Hee,Kang Eunhee,Seo Bo Kyoung,Choi Nami,Kim Tae Hee,Ku You Jin,Ye Jong Chul 대한영상의학회 2022 대한영상의학회지 Vol.83 No.2

Purpose To develop a denoising convolutional neural network-based image processing technique and investigate its efficacy in diagnosing breast cancer using low-dose mammography imaging. Materials and Methods A total of 6 breast radiologists were included in this prospective study. All radiologists independently evaluated low-dose images for lesion detection and rated them for diagnostic quality using a qualitative scale. After application of the denoising network, the same radiologists evaluated lesion detectability and image quality. For clinical application, a consensus on lesion type and localization on preoperative mammographic examinations of breast cancer patients was reached after discussion. Thereafter, coded low-dose, reconstructed full-dose, and full-dose images were presented and assessed in a random order. Results Lesions on 40% reconstructed full-dose images were better perceived when compared with low-dose images of mastectomy specimens as a reference. In clinical application, as compared to 40% reconstructed images, higher values were given on full-dose images for resolution (p < 0.001); diagnostic quality for calcifications (p < 0.001); and for masses, asymmetry, or architectural distortion (p = 0.037). The 40% reconstructed images showed comparable values to 100% full-dose images for overall quality (p = 0.547), lesion visibility (p = 0.120), and contrast (p = 0.083), without significant differences. Conclusion Effective denoising and image reconstruction processing techniques can enable breast cancer diagnosis with substantial radiation dose reduction.

Development of a Conditional Replication Competent Adenovirus, Controlled by the Human Telomerase Promoter(hTERT)

Eunhee Kim,Joo-Hang Kim,Ha-Youn Shin,Han Saem Lee,Joo-Hyuk Sohn,양재명,김정호,Chae-Ok Yun 대한암학회 2003 Cancer Research and Treatment Vol.35 No.3

Purpose: This study has been planned to generate a replication-competent adenovirus which replicates in a cancer cell-specific manner, thus minimizing the side effects and toxicity of cancer gene therapy.Materials and Methods: we have generated an E1B 19 kD attenuated recombinant adenoviruses, Ad-TERT-19 and Ad-mTERT-19, which encode E1A gene driven by the wild type hTERT and modified m-hTERT promoter containing additional c-myc and Sp1 binding sites in the backbone of Ad-E1B19. The in vitro efficacy and specificity of the hTERT and m-hTERT promoter have been evaluated by the comparison of viral replication and cytopathic effect in cancer cells and normal cell lines. To assess anti-tumor effect and safety of hTERT or m-hTERT promoter driven replication competent adenoviruses, tumor regression after subcutaneous injection in subcutaneous C33A xenografts and lacZ expression after systemic injection in organs were examined.Results: The activation of hTERT or m-hTERT promoter was significantly up-regulated only in hTERT-positive cells, but not in hTERT-negative cells. Moreover, the activity of m-hTERT promoter was substantially increased in hTERT-positive cancer cells, but not in hTERT-negative cells. While Ad-TERT-19 replicated in and induced cytopathic effect in cancer and in some normal cell lines, Ad-mTERT-19 enhanced viral replication and cytopathic effect in cancer cells only. Furthermore, the growth of established human cervical carcinoma in nude mice was significantly suppressed by intratumoral injection of Ad-mTERT-19.Conclusions: The use of m-hTERT promoter is not only useful in the regulation of therapeutic gene expression but also that replication-competent oncolytic adenovirus under the control of m-hTERT promoter may be a new promising tool for the treatment of human malignancies.(Cancer Res Treat. 2003;35:191-206)