(+)-Eldanolide의 합성에 관한 연구

강석구,이동하,이정민 성균관대학교 1990 論文集 Vol.41 No.2

출발물질로 D-타타르산 사용하여 (+)-eldanolide의 합성을 연구하였다. 이 합성에서의 중요반응은 온도를 -78℃→0℃로 하여 lithium diisopropylamide 사용하여 (2R, 3R)-1-chloro-2,3-isopropylidenedioxy-6-methy-5-heptene을 탈수소-제거반응시켜 중요한 반응 중간체인 (3R)-6-methyl-heptyn-5-en-3-ol을 합성하는 것이다. Synthetic approach to (+)-eldanolide from D-tartaric acid as starting material is described. They key reaction is the deprotonation-elemination reaction of (2R, 3R)-1-chloro-2, 3-isopropylidenedioxy-6-methyl-5-heptene with lithium diisopropylamide at -78℃→℃ and the key intermediate is (3R)-6-methyl-heptyn-5-en-3-ol.

Pd(0)를 이용한 고리 카보네이트의 친핵성 치환 반응 연구

강석구,박동철,전제호,노호식 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.2

촉매량의 Pd(0)존재하의 chiral allylic 그리고 dienylic 고리 카보네이트와 여러 가지 친핵성 치환체들의 치환 반응을 연구하였는데 이 치환 반응은 친핵체에 따라서 α-, γ-, 또는 ε-위치에 치환된 높은 위치 및 diastereoselection이 있는 반응임을 알았고 또한 이의 입체화학을 결정하였다. We studied the reactions of chiral allylic and dienylic cyclic carbonates with various nucleophiles in the presence of Pd(0)catalyst and found that substitution occurred at α-, γ-, ε-position with high regio-and diasteroselectirity depending on nucleophiles used.

높은 입체선택성을 나타내는 고리카보네이트의 친핵성 치환반응과 광학활성인 β-Hydroxy Ester의 합성

강석구,박동철,노호식,윤승현,홍덕표 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1

The nucleophilic ring opening of the cyclic carbonates of optically active threo-2,3-dihydroxy esters afforded α-substituted β-hydroxy esters with highly regio- and stereoselectivity under mild conditions. The α-substituted β-hydroxy esters were transformed to β-hydroxy esters

Pd(O)-촉매를 이용한 알릴 고리 카보네이트의 제거 및 분자간 축합반응 연구

강석구,박동철,박찬희,홍륭기 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1

The alkyl substituted allylic cyclic carbonates 1a-d undergo elimination by using a catalytic amount of Pd(0) complex to form dienols 2 a-b. However, on treatment of the unsubstituted or phenyl substituted allylic cyclic carbonates 1e and 1f with Palladium(0) catalyst, deprotonation-elimination of π-allyl Palladium complex followed by condensation with the other π-allyl Palladium complex provided the coupled products 3a and 3b, respectively.

광학활성 알릴알콜의 합성

강석구,김성규,조동규 성균관대학교 기초과학연구소 1992 論文集 Vol.43 No.2

키랄 1-chloro-2, 3-alkanediol 화합물과 CO(Im)₂과 반응에서 얻어진 Cyclic Carbonate 화합물을 Zn와 환원성 제거반응을 시켜 천연물의 합성에 유용한 광학활성 알릴알콜을 합성하였다. The cyclic carbonates obtained from reaction of 1-Chloro-2, 3-alkanediol with CO(Im)₂ was reductively eliminated with Zn to afford optically active allylic alcohols.

2-프로핀일 고리 카보네이트의 Pd(0) 촉매를 이용한 가수소분해반응연구 : (Z)-호모알릴알콜과 2-호모프로핀일 알코올의 합성 Catalyzed Hydrogenolysis of Prop-2-ynylic Cyclic Carbonates

강석구,박동철,정재욱,정경윤 성균관대학교 기초과학연구소 1994 論文集 Vol.45 No.1

삼중 결합을 갖고 있는 2-프로핀일 고리카보네이틀 Pd(acac)_2와 nBu_3P을 촉매로 하여 포름산 암모늄염을 사용한 탈카르복실화-가수소분해반응을 이용해서 (Z)-호모알릴 알콜과 2-호모프로핀일 알콜을 반응조건에 따라 각각 합성하였다. 그리고 분자끝 2-프로핀일 고리카보네이트의 가수소분해반응을 이용하여 호모알릴 알콜을 합성하였다. (2S. 4Z)-1-(p-메톡시벤질옥시)-2-히드록시-4-헵틴 2b를 광학활성 중간체로 사용하여 pyralid 나방 Aphomia gularis의 male 성페르몬을 합성하였다. The decarboxylation-hydrogenolysis of prof-2-ynylic cyclic carbonates which have an internal acetylenic bond with ammonium formate in the presence of a catalytic amount of [Pd (acac)_2] and nBu_3P afforded(Z)-homoallylic alcohols or homoprop-2-ynylic alcohols dependin on the reaction conditions. however, hydrogenolysis of terminal prop-2-ynylic cyclic carbonates gave homoallylic aicohols; using (2S, 4Z)-1-(p-Methoxybenzyloxy)-2-hydroxy-4-heptyne 2b as a chiral synthon, the male sex pheronome of the pyralid moth Aphomia gularis has been synthesized.

Pd(0)과 Ni(Ⅱ)촉매하의 Grignard시약에 의한 광학활성 고리카보네이트의 알릴화 연구

강석구,조동규,박찬희 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.2

NiCl_2(dppe)또는 Pd(PPh_3)_4를 촉매로 하여 Grgnard시약과 광학 활성 알릴고리 카보네이트를 반응시켜 높은 위치 선택성과 입체선택성이 있는 알킬화된 (E)-allylic alcohol을 얻었다. Reaction of chiral allylic cyclic carbonates with Grignard reagents in the presence of NiCl_2(dppe) or Pd(PPh_3)_4 as a catalyst afforded the alkylated (E)--allylic alcohols with high regio-and diastereoselectivity.

벡터와 래스터자료의 통합관리를 위한 지적정보시스템의 개발

장용구,강동현,강인준 부산대학교 도시문제연구소 2000 都市硏究報 Vol.10 No.-

Cadastral affair is classified to Document control and Map control. Now, Cadastral affair is computated, but that have many problem because of expense and Efficacy operated dual Computation Control of Document control and Map control. To solve this problem, in the Nation is setting to Land Information System part of NGIS, but it is spending many expense and many Setting time because of not delicately divide that affair. Now, Setting of Land Information System part of NGIS is required Many time and Expense in the Nation. But Cadastral affair from ward office is open to people, Works is being much than the past. Therefore, It is need to set of Cadastral Information System that could related Land Information System and used Cadastral affair. The purpose of this study is to have related Land Information System and develope the Cadastral Map Control System which is saved vector method in this map and to process correctly and speedily Land Utilization Conformation Documents by computers.

Metal Oxide Sensor를 이용한 알코올 분석

林香住,姜東求,韓道洙,趙成棟 조선대학교 생산기술연구소 1996 生産技術硏究 Vol.18 No.2

A resistance value of the metal oxide sensor for alcohols was measured by metal oxide senor (FOX2000). T30/1 sensor showed the best response to propanols. The pattern analysis could be measured to ppm and resistance could be processed as various forms. We could find that six sensor responses for propanols were better than those of methanol, when alcohols were displayed at the same time on the radar axis plane with maximum value of △R/Ro by sensors. Alcohols and distilled water were analysed with a principle component and they could be confirmed as being separated clearly.

피로와 의료이용, 업무상 사고 및 질병결근

장세진,고상백,강동묵,김성아,정진주,이철갑,강명근,현숙정,조정진,차봉석,박종구 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study examined the relationship of fatigue to medical utilization, occupational accident and sickness absence. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002~2004). A total of 30,146 employees categorized within the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were recruited. A structured-questionnaire was used to assess the participants' sociodemo-graphics, job-related factors, health-related behaviors, personality trait, self=perceived fatigue (MFS) and the frequency of medical utilization, occupational accident and sickness absence. Data on medical utilization and occupational accident were confirmed from company health records. Chi-square test and logistic regression analysis were used to elucidate the relationship of self-perceived fatigue to medical utilization, occupational accident and sickness absence. Results: In logistic regression analyses, self-perceived fatigue was associated with medical utilization (outpatient), occupational accident and sickness absence although the strength of the associations was higher in the blue collar workers except for medical utilization. For medical utilization, the white collar worker's adjusted odds ratios of outpatient utilization for workers scoring in the third quartile and the highest quartile, compared to workers scoring in the lowest quartile were 1.50 (95% CI: 1.20-1.87) and 2.16 (95% CI: 1.69-2.75), respectively. The blue collar workers' adjusted odds ratios of outpatient utilization for workers scoring in the second (OR: 1.23, 95% CI: 1.06-1.43), third (OR: 1.42, 95% CI: 1.22-1.66) and highest quartile (OR:1.83, 95% CI: 1.55-2.17), respectively, compared to workers scoring in the lowest quartile were statistically significant. However, no associations were found between fatigue and inpatient utilization for either the white or blue collar workers. The blue collar workers' adjusted odds ratios of being injured for workers scoring in the second, third and highest quartile were 1.41 (95% CI: 1.00-2.00), 1.57 (95% CI: 1.10-2.22) and 2.41 (95% CI: 1.69-3.44), respectively, compared to those scoring in the lowest quartile, but, those of the white collar workers were not significant. There was more likely to an increased risk of sickness absence in workers scoring in the second, third and highest quartile compared to those scoring in the lowest quartile in both white and blue collar workers, but the magnitudes of risk were higher in the blue collar workers than the white collars workers. Conclusion: This result suggests that fatigue is a determinant predictor of medical utilization, occupational accident and sickness absence, and that the pattern of risks for the three outcomes differs according to the occupational type. Some limitations of this study and considerations for future study were also discussed.