The Application of Non-phosphorous AEC Program in Cooling Water Systems of Petrochemical Industry

( Da Gang Li ),( Mi Ke Hong ),( Gao Rong He ) 한국부식방식학회(구 한국부식학회) 2008 Corrosion Science and Technology Vol.7 No.1

Risk Factors for Anxiety in Major Depressive Disorder Patients

Li-Min Xin,Lin Chen,Zhen-Peng Ji,Suo-Yuan Zhang,Jun Wang,Yan-Hong Liu,Da-Fang Chen,Fu-De Yang,Gang Wang,Yi-Ru Fang,Zheng Lu,Hai-Chen Yang,Jian Hu,Zhi-Yu Chen,Yi Huang,Jing Sun,Xiao-Ping Wang,Hui-Chun 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3

Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. Results: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=−4.39, p<0.001), were older (t=−4.69, p<0.001), reported more lifetime depressive episodes (z=−3.24, p=0.001), were more likely to experience seasonal depressive episodes (χ2=6.896, p=0.009) and depressive episodes following stressful life events (χ2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders (χ2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. Conclusion: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.

Minimum life-cycle cost design of ice-resistant offshore platforms

Da-yong Zhang,Gang Li,Qian-jin Yue 국제구조공학회 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.31 No.1

In China, the oil and natural gas resources of Bohai Bay are mainly marginal oil fields. It is necessary to build both ice-resistant and economical offshore platforms. However, risk is involved in the design, construction, utilization, maintenance of offshore platforms as uncertain events may occur within the life-cycle of a platform under the extreme ice load. In this study, the optimum design model of the expected life-cycle cost for ice-resistant platforms based on cost-effectiveness criterion is proposed. Multiple performance demands of the structure, facilities and crew members, associated with the failure assessment criteria and evaluation functions of costs of construction, consequences of structural failure modes including damage, revenue loss, death and injury as well as discounting cost over time are considered. An efficient approximate method of the global reliability analysis for the offshore platforms is provided, which converts the implicit nonlinear performance function in the conventional reliability analysis to linear explicit one. The proposed life-cycle optimum design formula are applied to a typical ice-resistant platform in Bohai Bay, and the results demonstrate that the life-cycle cost-effective optimum design model is more rational compared to the conventional design.

Minimum life-cycle cost design of ice-resistant offshore platforms

Li, Gang,Zhang, Da-Yong,Yue, Qian-Jin Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.31 No.1

In China, the oil and natural gas resources of Bohai Bay are mainly marginal oil fields. It is necessary to build both ice-resistant and economical offshore platforms. However, risk is involved in the design, construction, utilization, maintenance of offshore platforms as uncertain events may occur within the life-cycle of a platform under the extreme ice load. In this study, the optimum design model of the expected life-cycle cost for ice-resistant platforms based on cost-effectiveness criterion is proposed. Multiple performance demands of the structure, facilities and crew members, associated with the failure assessment criteria and evaluation functions of costs of construction, consequences of structural failure modes including damage, revenue loss, death and injury as well as discounting cost over time are considered. An efficient approximate method of the global reliability analysis for the offshore platforms is provided, which converts the implicit nonlinear performance function in the conventional reliability analysis to linear explicit one. The proposed life-cycle optimum design formula are applied to a typical ice-resistant platform in Bohai Bay, and the results demonstrate that the life-cycle cost-effective optimum design model is more rational compared to the conventional design.

PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

Chen, Gang,Kim, Yong Ho,Li, Hui,Luo, Hao,Liu, Da-Lu,Zhang, Zhi-Jun,Lay, Mark,Chang, Wonseok,Zhang, Yu-Qiu,Ji, Ru-Rong NATURE AMERICA 2017 NATURE NEUROSCIENCE Vol.20 No.7

<P>Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells and suppresses immunity through the receptor PD-1 expressed on T cells. However, the role of PD-L1 and PD-1 in regulating pain and neuronal function is unclear. Here we report that both melanoma and normal neural tissues including dorsal root ganglion (DRG) produce PD-L1 that can potently inhibit acute and chronic pain. Intraplantar injection of PD-L1 evoked analgesia in naive mice via PD-1, whereas PD-L1 neutralization or PD-1 blockade induced mechanical allodynia. Mice lacking Pd1 (Pdcd1) exhibited thermal and mechanical hypersensitivity. PD-1 activation in DRG nociceptive neurons by PD-L1 induced phosphorylation of the tyrosine phosphatase SHP-1, inhibited sodium channels and caused hyperpolarization through activation of TREK2 K+ channels. PD-L1 also potently suppressed nociceptive neuron excitability in human DRGs. Notably, blocking PD-L1 or PD-1 elicited spontaneous pain and allodynia in melanoma-bearing mice. Our findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator.</P>

Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation

Yu Jian,Li Wen,Hou Guo-jun,Sun Da-peng,Yang Yuan,Yuan Sheng-xian,Dai Zhi-hui,Yin Hao-zan,Sun Shu-han,Huang Gang,Zhou Wei-ping,Yang Fu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from the third exon of transcript NM_001098801 of the FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with HBV-related HCC. Furthermore, cFAM210A reduced the proliferation, stemness, and tumorigenicity of HCC cells. Mechanistically, HBx increased the N6-methyladenosine (m6A) level of cFAM210A by promoting the expression of RBM15 (an m6A methyltransferase), thus inducing the degradation of cFAM210A via the YTHDF2-HRSP12-RNase P/MRP pathway. cFAM210A bound to YBX1 and inhibited its phosphorylation, suppressing its transactivation function toward MET. These findings suggest the important role of circular RNAs in HBx-induced hepatocarcinogenesis and identify cFAM210A a potential target in the prevention and treatment of HBV-related HCC.

Oxidation behavior of YAG-ZrB2 ceramics prepared by spark plasma sintering

Jie-Guang Song,Da-Ming Du,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.4

ZrB2 and YAG are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To make ZrB2 ceramics have better oxidation resistance, high-density YAG-ZrB2 ceramics were prepared. The oxidation behavior of YAG-ZrB2 ceramics is investigated at different temperatures. The results indicate that the enhanced weight change differs according to the temperature range, slightly in the temperature 900-1000oC, sharply from 1100-1300 and smoothly above 1300oC. The weight change rate of YAG-ZrB2 ceramics is increased by prolonging the oxidation time, but the weight change rate of YAG-ZrB2 ceramics is gradually reduced. The oxidation layer is porous as compared to the YAG-ZrB2 ceramics layer.

Preparation and properties of ZrB2-YAG-Al2O3 ceramics

Jie-Guang Song,Gang-Chang Ji,Shi-Bin Li,Yang-Liang Li,Da-Ming Du,Lian-Meng Zhang,Yin-Yan Ju 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4

ZrB2, YAG and Al2O3 are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To achieve better properties in ZrB2 ceramics, high-density ZrB2-YAG-Al2O3 ceramics were prepared. Below 1000℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is less than that of ZrB2-YAG ceramics. From 1000℃ to 1600℃, the second largest shrinkage occurs. Above 1600℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is more than that of ZrB2-YAG ceramics. The fracture toughness of sintered ceramics from coated raw materials is higher than that of sintered ceramics with mixed raw materials with the same phases and phase content, the fracture toughness of ZrB2-YAG-Al2O3 ceramics is higher than that of ZrB2-YAG ceramics with the same raw materials. The weight gain of all types of ceramics is increased with all increase in the oxidation temperature, the weight gain of ceramics is reduced with all increase in the YAG-Al2O3 content and Al2O3 proportion, especially above 1500℃. ZrB2, YAG and Al2O3 are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To achieve better properties in ZrB2 ceramics, high-density ZrB2-YAG-Al2O3 ceramics were prepared. Below 1000℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is less than that of ZrB2-YAG ceramics. From 1000℃ to 1600℃, the second largest shrinkage occurs. Above 1600℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is more than that of ZrB2-YAG ceramics. The fracture toughness of sintered ceramics from coated raw materials is higher than that of sintered ceramics with mixed raw materials with the same phases and phase content, the fracture toughness of ZrB2-YAG-Al2O3 ceramics is higher than that of ZrB2-YAG ceramics with the same raw materials. The weight gain of all types of ceramics is increased with all increase in the oxidation temperature, the weight gain of ceramics is reduced with all increase in the YAG-Al2O3 content and Al2O3 proportion, especially above 1500℃.

Overexpression of NDRG2 Can Inhibit Neuroblastoma Cell Proliferation through Negative Regulation by CYR61

Zhang, Zhi-Guo,Li, Gang,Feng, Da-Yun,Zhang, Jian,Zhang, Jing,Qin, Huai-Zhou,Ma, Lian-Ting,Gao, Guo-Dong,Wu, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Several recent studies have showed that the n-myc downstream regulated gene 2 (NDRG2) is a new tumor suppressor gene, and that it plays an important role in tumor suppression in several cancers or cancer cell lines. However, few studies focused on its function in neuroblastoma cells. In the present investigation, we demonstrated that NDRG2 overexpression inhibited their proliferation. Using a cDNA microarray, we found that overexpression of NDRG2 inhibited the expression of cysteine-rich protein 61 (CYR61), a proliferation related gene. From our research, CYR61 may partially hinder NDRG2-mediated inhibition of cell proliferation. Overexpression of NDRG2 resulted in accumulation of cells in the G1 phase, which was accompanied by upregulation of p21 and p27 and downregulation of CDK4 and cyclin D1. Taken together, these data indicate that NDRG2 inhibits the proliferation of neuroblastoma cells partially through suppression of CYR61. Our findings offer novel insights into the physiological roles of NDRG2 in neuroblastoma cell proliferation, and NDRG2 may prove to be effective candidate for the treatment of children with neuroblastoma.

Ginsenoside $R_e$ Increases Fertile and Asthenozoospermic Infertile Human Sperm Motility by Induction of Nitric Oxide Synthase

Zhang Hong,Zhou Qing-Ming,Li Xiao-Da,Xie Yi,Duan Xin,Min Feng-Ling,Liu Bing,Yuan Zhi-Gang The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.2

We investigated the effects of Ginsenoside $R_e$ on human sperm motility in fertile and asthenozoospermic infertile individuals in vitro and the mechanism by which the Ginsenosides play their roles. The semen samples were obtained from 10 fertile volunteers and 10 asthenozoospermic infertile patients. Spermatozoa were separated by Percoll and incubated with 0, 1, 10 or $100\;{\mu}M$ of Ginsenoside $R_e$. Total sperm motility and progressive motility were measured by computer-aided sperm analyzer (CASA). Nitric oxide synthase (NOS) activity was determined by the $^{3}H$-arginine to $^{3}H$-citrulline conversion assay, and the NOS protein was examined by the Western blot analysis. The production of sperm nitric oxide (NO) was detected using the Griess reaction. The results showed that Ginsenoside $R_e$ significantly enhanced both fertile and infertile sperm motility, NOS activity and NO production in a concentration-dependent manner. Sodium nitroprusside (SNP, 100 nM), a NO donor, mimicked the effects of Ginsenoside $R_e$. And pretreatment with a NOS inhibitor $N^{w}$-Nitro-L-arginine methyl ester (L-NAME, $100\;{\mu}M$) or a NO scavenger N-Acetyl-L-cysteine (LNAC, 1 mM) completely blocked the effects of Ginsenoside $R_e$. Data suggested that Ginsenoside $R_e$ is beneficial to sperm motility, and that induction of NOS to increase NO production may be involved in this benefit.