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Jing-Han Chen,Chi-Te Liang,Chun-Feng Huang,Da-Ren Hang,David A. Ritchie,J. C. Hsiao,Jyun-Ying Lin,Michelle Y. Simmons,Ming-Gu Lin,S. H. Lo,Tsai-Yu Huang 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.3
By applying a magnetic field perpendicular to GaAs/AlGaAs two-dimensional electron systems (2DESs), we study the low-field Landau quantization when the thermal damping is reduced with decreasing temperature. Magneto-oscillations following the Shubnikov-de Haas (SdH) formula are observed even when their amplitudes are so large that the deviation to such a formula is expected. Our experimental results show the importance of the positive magneto-resistance to the extension of the SdH formula under the damping induced by the disorder.
( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Mingyang Song ),( Tracey G. Simon ),( Andrew T. Chan ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Obesity is established as a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). However, the influence of changes in adiposity over the life course on NAFLD risk remains poorly understood. Methods: This study included 110,054 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 1995), who were followed prospectively through 2015. Early adulthood weight change was defined as the difference between early adulthood weight (at age 18 years) and the weight reported in the current questionnaire cycle. We used a group-based modeling approach to identify five trajectories of body shape from age 5 years up to 50. Results: We documented 3,798 incident cases of NAFLD over 20 years of follow-up (1,842,560 person-years). An elevated early adulthood body mass index (BMI) and weight gain since early adulthood were significantly and positively associated with the risk of incident NAFLD (all P trend <0.0001). Compared to women who maintained stable weight (+/-2 kg), women with ≥20 kg of early adulthood weight gain had the multivariable adjusted hazard ratio (aHR) of 6.96 (95% confidence interval [CI], 5.27-9.18), and this remained significant after further adjusting for updated BMI (P trend <0.0001). Compared to women with a medium-stable body shape trajectory, the multivariable aHRs for NAFLD risk were, 2.84 (95% CI, 2.50-3.22) for lean-marked increase, 2.60 (95% CI, 2.27-2.98) for medium-moderate increase, and 3.39 (95% CI, 2.95-3.89) for medium-marked increase. Conclusions: Both early adulthood weight gain and lifetime body shape trajectory were significantly and independently associated with excess risk of developing NAFLD. Maintaining both lean and stable weight throughout life may offer the greatest benefit for the prevention of NAFLD.
( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Xuehong Zhang ),( Andrew T. Chan ),( Tracey G. Simon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Gut microbial dysbiosis is associated with the development of nonalcoholic fatty liver disease (NAFLD). Antibiotics can alter the composition of the gut microbiota. However, the association of antibiotic use with the risk of NAFLD has not been clarified in a population at usual risk. We investigated the association of the duration of antibiotic use in different phases of adulthood with the risk of NAFLD. Methods: This study included 68,644 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 2005). Participants were followed prospectively through 2015. In the 2005 questionnaire, women were asked to indicate the cumulative amount of antibiotic use at age 20-39 years (young adulthood) or 40-49 years (middle adulthood). Cox proportional hazard models were used to estimate multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: Over a total of 534,644 person-years, we documented 1,944 incident cases of NAFLD. Compared to women with no antibiotic use during young adulthood, use of long-term antibiotics for ≥2 months was associated with significantly increased risk of incident NAFLD (multivariable aHR 1.48, 95% CI 1.03- 2.11). In analyses focused on middle adulthood, compared to women who did not use antibiotics during middle adulthood, those with both short-term (<2 months) and long-term (≥2 months) antibiotics use had significantly increased risk of incident NAFLD (multivariable aHRs, 1.32 [95% CI 1.01-1.72] and 1.83 [95% CI 1.37-2.45], respectively). Conclusions: In conclusion, long-term antibiotic use in both young and middle adulthood was associated with a significantly increased risk of developing incident NAFLD. These findings support the potential role of the gut microbiota in the pathogenesis of NAFLD.
( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Xiao Luo ),( Xuehong Zhang ),( Andrew T. Chan ),( Tracey G. Simon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Previous studies have suggested consumption of red meat might be associated with an increased risk of developing nonalcoholic fatty liver disease (NAFLD). However, large-scale, prospective data regarding red meat consumption in relation to the incidence of NAFLD are lacking, nor is it known whether this association is mediated by obesity. Methods: This prospective cohort study included 77,795 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 1995), who provided detailed, validated information regarding diet, including consumption of red meat, every 4 years, through 2015. Lifestyle factors, clinical comorbidities and body mass index (BMI), were updated biennially. Cox proportional hazard models were used to estimate multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: Over 1,444,637 person years of follow-up, we documented 3,130 cases of incident NAFLD. Women consuming ≥2 servings of red meat per day had a 56% higher risk of developing incident NAFLD compared to women consuming ≤1 serving per week (95% CI, 1.26-1.93), after multivariable adjustment. Similarly, significant and positive associations were observed for both unprocessed and processed red meat (both P-trend< 0.0001). However, after further adjustment for BMI, all associations for red meat, including unprocessed and processed red meat, were attenuated and not statistically significant (all P-trend >0.05). BMI was estimated to mediate 66% (95% CI, 41.9%-83.9%; P<0.0001) of the association between red meat consumption and NAFLD risk. Conclusions: Red meat consumption, including both unprocessed and processed red meat, was associated with significantly increased risk of developing NAFLD. This association was mediated largely by obesity.
Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.
논문 : 지하수로 포화된 석회석광산의 지반침하 사례연구
최우석 ( Woo Seok Choi ),김은섭 ( Eun Sup Kim ),강병천 ( Byung Chun Kang ),신동춘 ( Dong Choon Shin ),김수로 ( Soo Lo Kim ),백승한 ( Seung Han Baek ) 대한지질공학회 2015 지질공학 Vol.25 No.4
본 연구는 충청북도에 위치하는 지하수로 포화된 삼성석회석광산에서 발생한 지반침하에 대한 사례연구로서, 대상 지역의 지반조사 및 지반안정성평가를 바탕으로 침하원인을 규명하고 향후 침하가능성에 관하여 검토하였다. 조사 및 안정성평가 결과에 의하면 채굴구역은 강우 유입으로 인한 전단강도 저하로 전반적으로 불안정하게 평가되었으며, 미채굴 구역의 침하발생 주요 원인은 지하수위 하강에 기인한 것으로 판단된다. 향후 침하 가능성과 관련하여, 채굴공동 천단의암반층 두께가 얇은 구간이나 인장절리 발달이 활발한 구간이 존재하고 채굴공동 주변의 지반상태가 불량하므로 침하가발생할 경우 침하의 영향은 주변 지반으로 확산될 가능성이 있다. 또한 연구지역 내 석회암 분포지역에서는 석회암층 내자연 용식공동의 함몰이나 양수 등 인위적 요인의 영향으로 인해 지하수위 저하나 강우침투에 의한 공동에서의 유로변화 및 수위변화가 발생할 경우 추가적인 침하가 발생할 수 있으며, 이에 대한 보강 및 관리 대책이 필요할 것으로 판단된다. Groundwater causing subsidence in limestone mines is uncommon, and thus relatively poorly investigated. This case study investigated the cause and possibility of future subsidence through an evaluation of ground stability at the Samsung limestone mine, Chungcheongbuk-do. The ground near the mine area was evaluated as unstable due to rainfall permeation, and subsidence in the unmined area resulted from groundwater level drawdown. Future subsidence might occur through the diffusion of subsidence resulting from the small thickness of the mined rock roof, fracture rock joints, and poor ground conditions around the mine. In addition, the risk of additional subsidence by limestone sinkage in corrosion cavities, groundwater level drawdown due to artificial pumping, and rainfall permeation in the limestone zone necessitates reinforcements and other preventative measures.
형방지황탕(荊防地黃湯) 전탕액(煎湯液)이 산소자유기로 손상된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 영향
김경요,배영춘,노현수,김종관,한병삼,권덕윤,최용석,Kim, Kyung-Yo,Bae, Young-Chun,Lo, Hyun-Soo,Kim, Jong-Gwan,Han, Byung-Sam,Gwon, Duk-Yun,Choi, Yong-Seok 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2
The purpose of this study is to examine the toxic effects caused by glucose oxidase (GO) and the effects of Hyungbangjihwangtang (HJT) water extracts on the treatment of the toxic effects. For this purpose, experiments with the cultured hippocampal cells from new born mice were done. The results of these experiments were as follows. 1. GO decreased the survival rate of the cultured cells on MTT assay and NR assay. 2. HJT has the efficacy of decreasing the lipid peroxidation. 3. HJT has the efficacy of increasing the amount of neurofilaments. 4. HJT has the efficacy of decreasing the activation of protein kinase C(PKC). From the above results, it is concluded that HJT has marked efficacy as a treatment for the damages caused by the GO-mediated oxidative stress. Further clinical study of this pharmacological effects of H]T should be completed.
정규원(Kyu Won Chung),선희식(Hee Sik Sun),심상인(Sang In Shim),강창석(Chang Suck Kang),박수헌(Soo Heon Park),한혁준(Hyeok Jun Han),노대근(Dae Keun Lo),박진노(Jin No Park),방춘상(Chun Sang Bang),최명규(Myong Gyu Choi) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1
Hepatocellular carcinoma is one of the most common malignancies reported in ost of the Africa and South-east Asia. As hepatocellular carcinoma metastases well to distant site, half of the cases metastases to distant site at diagnosis. Hepatocellular carcinoma usually spread to regional lymph nodes around porta hepatis via lyphatics and venous metastasis can occur via intrahepatic vein. The usual sites of extrahepatic metastasis are lung, local lymph nodes, adrenal glands and bones, but epidural metastasis is very rare. Although the prognosis of the hepatocellular carcinoma was very poor in the past, the survival time seemed to be prolonged by early diagnosis and improvement of medical therapy. Therefore the importance of metastatic lesion of the hepatocellular carcinoma might be reemphasized. Recently we experienced a case of the hepatocellular carcinoma who developed paraplegia suddenly. MRI revealed ovoid epidural rnass at 6th and 7th dorsal vertebra level posteriorly. After emergency operation, the resected mass was confirmed metaststic hepatocellular carcinoma. (Korean J Gastroenterol 1997;30:119-125)