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RISS 인기검색어
- 검색키워드
- 저자 : ( Kathleen E. Corey ) (검색결과 3 건)
- 무료
- 기관 내 무료
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( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Xuehong Zhang ),( Andrew T. Chan ),( Tracey G. Simon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Gut microbial dysbiosis is associated with the development of nonalcoholic fatty liver disease (NAFLD). Antibiotics can alter the composition of the gut microbiota. However, the association of antibiotic use with the risk of NAFLD has not been clarified in a population at usual risk. We investigated the association of the duration of antibiotic use in different phases of adulthood with the risk of NAFLD. Methods: This study included 68,644 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 2005). Participants were followed prospectively through 2015. In the 2005 questionnaire, women were asked to indicate the cumulative amount of antibiotic use at age 20-39 years (young adulthood) or 40-49 years (middle adulthood). Cox proportional hazard models were used to estimate multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: Over a total of 534,644 person-years, we documented 1,944 incident cases of NAFLD. Compared to women with no antibiotic use during young adulthood, use of long-term antibiotics for ≥2 months was associated with significantly increased risk of incident NAFLD (multivariable aHR 1.48, 95% CI 1.03- 2.11). In analyses focused on middle adulthood, compared to women who did not use antibiotics during middle adulthood, those with both short-term (<2 months) and long-term (≥2 months) antibiotics use had significantly increased risk of incident NAFLD (multivariable aHRs, 1.32 [95% CI 1.01-1.72] and 1.83 [95% CI 1.37-2.45], respectively). Conclusions: In conclusion, long-term antibiotic use in both young and middle adulthood was associated with a significantly increased risk of developing incident NAFLD. These findings support the potential role of the gut microbiota in the pathogenesis of NAFLD.
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( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Xiao Luo ),( Xuehong Zhang ),( Andrew T. Chan ),( Tracey G. Simon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Previous studies have suggested consumption of red meat might be associated with an increased risk of developing nonalcoholic fatty liver disease (NAFLD). However, large-scale, prospective data regarding red meat consumption in relation to the incidence of NAFLD are lacking, nor is it known whether this association is mediated by obesity. Methods: This prospective cohort study included 77,795 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 1995), who provided detailed, validated information regarding diet, including consumption of red meat, every 4 years, through 2015. Lifestyle factors, clinical comorbidities and body mass index (BMI), were updated biennially. Cox proportional hazard models were used to estimate multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: Over 1,444,637 person years of follow-up, we documented 3,130 cases of incident NAFLD. Women consuming ≥2 servings of red meat per day had a 56% higher risk of developing incident NAFLD compared to women consuming ≤1 serving per week (95% CI, 1.26-1.93), after multivariable adjustment. Similarly, significant and positive associations were observed for both unprocessed and processed red meat (both P-trend< 0.0001). However, after further adjustment for BMI, all associations for red meat, including unprocessed and processed red meat, were attenuated and not statistically significant (all P-trend >0.05). BMI was estimated to mediate 66% (95% CI, 41.9%-83.9%; P<0.0001) of the association between red meat consumption and NAFLD risk. Conclusions: Red meat consumption, including both unprocessed and processed red meat, was associated with significantly increased risk of developing NAFLD. This association was mediated largely by obesity.
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( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Mingyang Song ),( Tracey G. Simon ),( Andrew T. Chan ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Obesity is established as a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). However, the influence of changes in adiposity over the life course on NAFLD risk remains poorly understood. Methods: This study included 110,054 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 1995), who were followed prospectively through 2015. Early adulthood weight change was defined as the difference between early adulthood weight (at age 18 years) and the weight reported in the current questionnaire cycle. We used a group-based modeling approach to identify five trajectories of body shape from age 5 years up to 50. Results: We documented 3,798 incident cases of NAFLD over 20 years of follow-up (1,842,560 person-years). An elevated early adulthood body mass index (BMI) and weight gain since early adulthood were significantly and positively associated with the risk of incident NAFLD (all P trend <0.0001). Compared to women who maintained stable weight (+/-2 kg), women with ≥20 kg of early adulthood weight gain had the multivariable adjusted hazard ratio (aHR) of 6.96 (95% confidence interval [CI], 5.27-9.18), and this remained significant after further adjusting for updated BMI (P trend <0.0001). Compared to women with a medium-stable body shape trajectory, the multivariable aHRs for NAFLD risk were, 2.84 (95% CI, 2.50-3.22) for lean-marked increase, 2.60 (95% CI, 2.27-2.98) for medium-moderate increase, and 3.39 (95% CI, 2.95-3.89) for medium-marked increase. Conclusions: Both early adulthood weight gain and lifetime body shape trajectory were significantly and independently associated with excess risk of developing NAFLD. Maintaining both lean and stable weight throughout life may offer the greatest benefit for the prevention of NAFLD.
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