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- 검색키워드
- 주제어 : Siegesbeckia orientalis (검색결과 4 건)
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김미보,박지은,우선욱,임상빈,황재관 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
High hydrostatic pressure (HHP) extractionmethod was optimized to maximize the extraction yield ofkirenol from Siegesbeckia orientalis. Operating parameterssuch as extraction pressure (100-600 MPa), pressureholding time (3-20 min), feed-to-solvent ratio (1:10-1:90(w/v)), and solvent (ethanol) concentration (0-100%) wereinvestigated individually by mono-factor experiments. Then, the optimal extraction conditions were determinedusing response surface methodology. Box-Behnken designwas applied to evaluate the effects of three independentvariables (extraction pressure, solvent concentration, andfeed-to-solvent ratio) on the extraction yield of kirenolfrom S. orientalis. Extraction pressure, solvent concentration,and feed-to-solvent ratio affected the extraction yieldssignificantly, whereas the pressure holding time had nosignificant effect. The optimal processing conditions,which gave a maximum extraction yield of 85.9% kirenolfrom the raw material, were as follows: extracting pressure320MPa, pressure holding time 5min, ethanol concentration18%, and feed-to-solvent ratio 1:76 (w/v).
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The Constituents of Siegesbeckia orientalis
Xiong, Jiang,Ma, Yunbao,Xu, Yunlong The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.1
Two new diterpenoids, orientalin A (1), and B (2), have been isolated together with six known compounds, kirenol (3), $ent-16{\beta},17-dihydroxykauran-19-oic$ acid (4), $ent-16{\beta},17-dihydroxykauran-19-oic$ $acid-16{\beta},l7-acetonide$ (5), $3,7-dimethylquercetin$ (6), ${\beta}-sitosterol$</YRC$ (7), and daucosterol (8) from the ethanol extract of Siegesbeckia orientalis (Compositae). Their chemical structures have been elucidated as $ent-15-acetoxy-2{\alpha},16,19-trihydroxypimar-8(14)-ene$ (1), $ent-16-acetoxy-2{\alpha},15,19-trihydroxypimar-8(14)-ene$ (2), respectively, on the basis of chemical and spectral evidence.
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김미보,김창희,황재관 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.11
Siegesbeckia orientalis has been reported to exhibit anti-allergic, anti-infertility, anti-inflammatory, anti-rheumatic, and immunosuppressive activities. However, there are very few studies describing its stimulatory effects on exercise capacity. This study elucidated whether S. orientalis extract (SOE) standardized to kirenol content can enhance exercise endurance by increasing mitochondrial biogenesis. SOE significantly improved the running distance and time in mice fed normal diet (ND) and high-fat diet (HFD). SOE also enhanced mitochondrial biogenesis by stimulating the mitochondrial regulatory genes including peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α), estrogen-related receptor α (ERRα), nuclear respiratory factor 1 (NRF-1), and mitochondrial transcription factor A (TFAM) in the skeletal muscles of ND and HFD mice. Furthermore, SOE upregulated the AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/PGC-1α/peroxisome proliferator-activated receptor delta (PPARδ) signaling pathway in the skeletal muscles of ND and HFD mice. Kirenol markedly increased adenosine triphosphate production and mitochondrial activity by stimulating the expression of markers of mitochondrial biogenesis and upregulating the AMPK/SIRT1/PGC-1α/PPARδ signaling pathway in L6 myotubes. These results show that SOE has the potential to be used to develop an exercise supplement capable of stimulating mitochondrial biogenesis through the AMPK/SIRT1/PGC-1α/PPARδ signaling pathway.
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산화적 스트레스에 대한 생약 추출물의 항 산화활성 검색
강경아,채성욱,강대길,김진숙,현진원 한국생약학회 2005 생약학회지 Vol.36 No.3
We screened the anti-oxidative effect on V79-4 hamster lung fibroblast cells induced by hydrogen peroxide with fifteen herbal extracts. Uncariae rhynchophylla JACKS and Rheum coreanum NAKAI were found to show DPPH radical scavenge activity (25 and 29% compared to control). Rheum coreanum NAKAI and Siegesbeckia orientalis L. were shown to scavenge intracellular reactive oxygen species (57 and 55% compared to control) which is measured by dichlorodihydrofluorescin diacetate method (DCHF-DA). Rheum coreanum NAKAI which showed the most strong intracellular reactive oxygen species scavenging activity had low DPPH radical scavenging activity compared to Uncariae rhynchophylla JACKS.
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