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복강 내 발생한 Immunoglobulin G4 연관 염증성 가성종양
모인호 ( In Ho Moh ),김진배 ( Jin Bae Kim ),신수린 ( Su Rin Shin ),정성원 ( Sung Won Jung ),박상훈 ( Sang Hoon Park ),김정원 ( Jeong Won Kim ),신미경 ( Mi Kyung Shin ),이명석 ( Myung Seok Lee ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.4
The term inflammatory pseudotumor (IPT) has been used to describe inflammatory and fibrosing tumoral processes of an undetermined cause that may involve a variety of organ system. IgG4-related disease is a newly recognized fibroinflammatory condition characterized by IgG4-producing plasma cell expansion in affected organs and, often but not always, elevated serum IgG4 concentrations. IgG4-related IPTs, a subtype of IPT, are characterized by dense infiltration of IgG4-positive plasma cells and stromal fibrosis. The association between inflammatory pseudotumor and IgG4 was first reported with a regard to sclerosing pancreatitis. Despite there are many reports on intraperitoneal IPTs including both cellular and lymphoplasmacytic type, only a few cases have been confirmed to be IgG4-related. We experienced a case of intraperitoneal IgG4-related inflammatory pseudotumor in an 83-year-old woman presenting with epigastric pain and malaise. Surgical specimens revealed an IgG4-related inflammatory pseudotumor.
Inflammatory Pseudotumor in the Lateral Ventricle with Repeated Bleeding-Case Report-
Park, Jong-Hwa,Nam, Taek-Kyun,Hwang, Sung-Nam,Park, Seung-Won The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.45 No.2
Inflammatory pseudotumor is an uncommon lesion with unknown etiology characterized by sclerosing inflammation which clinically and radiographically mimics a neoplastic lesion. A 47-year-old man presented with sudden headache and dysarthria. Brain CT scan revealed a $2.6{\times}2.2\;cm$ sized, round, and hyperdense mass in the anterolateral wall of the left lateral ventricular trigone. On MR imaging studies, the mass showed low signal intensity in the wall of the trigone on T2-weighted image, central mixed (iso- and high-) signal intensity with peripheral low-signal intensity on T1-weighted image. Subtle staining of left choroid plexus with irregular shaped distal branch of anterior choroidal artery was found on the cerebral angiography. These findings suggested a small tumorous lesion originated from the left choroid plexus. During the hospital days, the mass manifested as repeated hemorrhages. The mass was successfully removed via left occipital transcortical approach. The histopathological report of the specimen was hemorrhage and fibrosis, with dense lymphoplasma cell infiltration, suggestive of an inflammatory pseudotumor.
간의 염증성 가성종양 : A Case Report and Review of Pathogenesis 1예 보고 및 병인에 대한 고찰
정화숙,송형근,이건국,성노현 충북대학교 의과대학 충북대학교 의학연구소 1997 忠北醫大學術誌 Vol.7 No.1
염증성 가성종양은 섬유성 조직, 림프구, 조직구 및 형질세포 등으로 구성되어 종괴를 형성하는 매우 드문 양성 병변이다. 이 병변은 많은 장기 및 골·연부 조직에서 발견되어 보고된 바 있으며, 이 질병 개념의 중요성은 불필요한 과다 수술이나 처치를 피하는데 있다. 저자들은 간에서 발생한 염증성 가성종양 1예를 경험하였기에 보고하는 바이다. 환자는 57세 남자로 상 복부 동통과 발열을 주소로 내원하여 긴 세포 암종 혹은 육종 의진 하에, 간 우엽의 종괴를 절제하였다. 종괴는 4.5×4×3 cm으로 육안적으로 경계가 잘 지어졌으며, 다엽성이고, 절단면은 연황색이었다. 조직학적으로 전형적인 염증성 가성종양의 특징을 보였다. Inflammatory pseudotumor is a rate benign process being composed of fibrous tissue, lymphocytes, histiocytes and plasma cells. The occurrence of this lesion has been reported in many organs and tissues. The recognition of this entity is particularly important in order to avoid an unnecessary extensive surgery. We present a 57-year-old man with an Inflammatory pseudotumor of the liver. Grossly, the tumor was a well circumscribed, multilobulated and bright yellow mass, measuring 4.5×4×3cm. The histologic feature of this lesion was that of typical inflammatory pseudotumor. .
Pulmonary Inflammatory Pseudotumor with Solitary Plasmacytoma of Bone Mimicking Advanced Lung Cancer
( Chang Hoon Kim ),( Jae Seok Jeong ),( Yong Chul Lee ),( So Ri Kim ),( Yeong Hun Choe ),( Seung Yong Park ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Lung cancer has been the most commonly diagnosed type of cancer and the leading cause of cancer related mortality in Korea and worldwide. Although it is fatal, most of the lung cancer patient are asymptomatic at the time of diagnosis. Therefore, radiologic screening by chest low-dose computerized tomography (LDCT) has been recommended by lung cancer specialists for early detection and improving survival. However, clinical suspicion of lung cancer by radiologic screening is quite challenging because of its high false positive rate. A wide range of benign pulmonary diseases could be misinterpreted as lung malignancy on LDCT, including infection, benign mass-forming lesion, and inflammatory changes. Therefore, physician should consider the possibility of the benign disease entities when radiologic features suggest lung malignancy. Herein, we report a case of a 50-year-old man presenting a 4.5-cm lung mass in the right upper lobe with solitary osteolytic lesion of the right 8th rib. Under the suspicion of metastatic lung cancer, the lung mass and the right 8th rib were surgically resected for the diagnostic and curative purpose. After the tissue biopsy, unexpectedly, the lung mass was diagnosed as inflammatory pseudotumor. Furthermore, histopathology of the resected rib showed solitary plasmacytoma of the bone. Our experience highlights the importance of clinical suspicion that in patients with radiologic features compatible to advanced lung cancer could be caused by coexistence of unrelated two uncommon disease entities, which can be completely treatable with surgical resection.
안와가성종양의 임상양상과 스테로이드 반응성에 대한 분석
성미선,오한진,고병이,윤경철,Mi Sun Sung,Han Jin Oh,Byung Yi Ko,Kyung Chul Yoon 대한안과학회 2013 대한안과학회지 Vol.54 No.2
Purpose: To evaluate the clinical features and treatment outcomes of steroid therapy for orbital inflammatory pseudotumor. Methods: Sixty-four patients diagnosed with orbital inflammatory pseudotumor were reviewed retrospectively. Patients with a follow-up period of less than 6 months were excluded from the study. The pseudotumor was classified into myositic, lacrimal, anterior, diffuse, or apical type according to orbital computed tomography findings. All patients were initially treated with systemic corticosteroids and evaluated for response to the treatment. Treatment outcome was considered a “success” if the patient had complete relief of symptoms with no recurrence, and a “failure” if the patient had no or only partial relief of symptoms or showed relapse. Factors affecting the treatment outcome were analyzed. Results: The most frequent lesion subtype was myositis. Periorbital edema was the most common symptom and was evident in 53.1% of the patients. Thirty-eight patients (59.4%) showed treatment success. Age, sex, bilaterality, and mean follow- up length did not correlate with the treatment outcome. A short interval from symptom onset to treatment time and apical subtype were significantly associated with good steroid response (p < 0.05). Conclusions: In orbital inflammatory pseudotumor, myositis was the most common subtype. A short interval from symptom onset to treatment time and apical subtype were associated with good steroid response.
두개저에 동반되어 발생한 침습성 진균증과 염증성 가성종양 1예
이승신,김옥경,이자현,손지연 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.9
Skull base osteomyelitis typically arises as a complication of ear infection in older diabetic patients, but atypical skull base osteomyelitis arising from the sphenoid or occipital bones without external otitis can occur much less frequently and initially may present headache as the only symptom. Inflammatory pseudotumor is an idiopathic condition characterized by the sclerosing inflammation, which mimicks a neoplastic process. Inflammatory pseudotumor involving skull base and cervical spine is distinctly rare and usually indistinguishable from aggressive neoplasms or infection at these area. We report a case which was confirmed histologcally as invasive fungal sinusitis accompanied with inflammatory pseudotumor:the treatment consisted of amphotericin B and systemic steroid therapy but ended in a failure.
박영래 ( Young Rae Park ),박원일 ( Won Il Park ),백봉력 ( Bong Luck Paik ),조심현 ( Sim Hyun Jo ),이정화 ( Jung Hwa Lee ),이경신 ( Kyung Sin Lee ),김채규 ( Chae Kyu Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Focal myositis, a benign inflammatory pseudotumor of skeletal muscle, which was first described on a series of 16 patients by Heffner et al. in 1977. It may occur at any time from early childhood into the seventh decade, most commonly in adults, with an equal sex incidence. It is most commonly seen in the lower extremities. The etiology is unknown. Histologic features are similar to those seen in inflammatory myopathy, including muscle cell necrosis, regeneration and lymphocyte infiltration. The diagnosis can be confirmed only by biopsy and in all cases histologic features of inflammatory myopathy are observed. We report a case of focal myositis that appeared as pseudotumor.
Shien-Tung Pan,Shih-Sung Chuang,Chih-Yuan Cheng,Nie-Sue Lee,Peir-In Liang 대한병리학회 2014 Journal of Pathology and Translational Medicine Vol.48 No.2
Follicular dendritic cell (FDC) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (IPT)-like variant. Extranodal presentation is uncommon and nearly all gastrointestinal FDC tumors are of the conventional type. IPT-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with Epstein-Barr virus (EBV). Here we report the case of a 78-year-old woman with an IPT-like FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells were mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D2-40, and were positive for EBV by in situ hybridization, confirming the diagnosis. The patient was free of disease five months after polypectomy without adjuvant therapy. Although extremely rare, the differential diagnosis for colonic polyp should include FDC sarcoma to avoid an erroneous diagnosis. A review of the 24 cases of IPT-like FDC sarcoma reported in the literature reveal that this tumor occurs predominantly in females with a predilection for liver and spleen, and has a strong association with EBV.