위, 십이지장 질환에서 검사방법에 따른 Helicobacter Pylori 양성율의 비교연구

류홍옥,설상영,오상훈 인제대학교 1995 仁濟醫學 Vol.16 No.2

H. pylori가 위,십이지장질환 특히 만성 활동성 위염 및 소화성 궤양의 병인이 된다는 것이 밝혀졌고, 최근에는 위궤양과 위암에서의 병인론적 역할에 대한 많은 연구가 이루어지고 있다. 위,십이지장 질환들에서 H. pylori의 감염율에 대한 보고들을 보면 보고자마다 차이가 있는데, 이는 H. pylori 감염 진단법의 민감도 차이로 설명할 수 있겠다. 이에 저자들은 H. pylori의 진단검사 즉, 조직 urease 검사(CLO 검사), Touch print 후의 Gram 염색검사, 배양검사 그리고 H & E 및 Giemsa 염색검사를 시행하여 각 위,십이지장 질환에서의 H. pylori의 감염율 및 각 검사의 민감도를 알아 보고 어떤 검사법이 임상적으로 민감도와 특이도가 높으면서 쉽게 할 수 있는 검사법인지 알아보고자 한다. Numerous studies about the pathogenic role of Helicobacter pylori(H. pylori) in gastroduodenal disease haute been carried out actively and H.pylori has been strongly implicated as a cause of chronic active gastritis and duodenal ulcer. Many detective methods of H. pylori have been developed, but few studies have been reported about the sensitivity or applicability of these detective methods. Therefore, we evaluate the sensitivity of detection methods for H. pylori Infection in gastroduodenal disease. CLO test, Gram stain of touch print, culture, and Giemsa stain were used for the detection of H. pylori in specimens obtained by endoscopic biopsy of the gastric antrum from 98 patients with gastroduodenal diseases including erosive gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. In conclusion, the most sensitive method was Giemsa stain and the next was CLO test. These two methods were effective in diagnosis of H. pylori infection. CLO test was considered to be a relatively speedy and simple detective method.

Upper gastrointestinal tract involvement of Crohn disease: clinical implications in children and adolescents

Kim, Eun Sil,Kim, Mi Jin The Korean Pediatric Society 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.1

Crohn disease (CD) is a multifactorial inflammatory disorder that can affect all segments of the gastrointestinal (GI) tract but typically involves the ileum and/or colon. To assess patient prognosis and choose appropriate treatment, it is necessary to accurately evaluate the factors influencing poor outcomes, including disease phenotype. Pediatric CD involving the upper GI (UGI) tract has become increasingly recognized with the introduction of routine upper endoscopy with biopsies for all patients and the increased availability of accurate small bowel evaluations. Most clinical manifestations are mild and nonspecific; however, UGI involvement should not be overlooked since it can cause serious complications. Although controversy persists about the definition of upper GI involvement, aphthoid ulcers, longitudinal ulcers, a bamboo joint-like appearance, stenosis, and fistula are endoscopic findings suggestive of CD. In addition, the primary histological findings, such as focally enhanced gastritis and noncaseating granulomas, are highly suggestive of CD. The association between UGI involvement and poor prognosis of CD remains controversial. However, the unstandardized definition and absence of a validated tool for evaluating disease severity complicate the objective assessment of UGI involvement in CD. Therefore, more prospective studies are needed to provide further insight into the standardized assessment of UGI involvement and long-term prognosis of CD. Our review summarizes the findings to date in the literature as well as UGI involvement in CD and its clinical implications.

Helicobacter pylori의 한약 치료에 대한 연구

이승연,박상은,홍상훈,Lee, Seung-Yeon,Park, Sang-Eun,Hong, Sang-Hoon 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.1

Objectives : Many studies have shown that helicobacter pylori (H. pylori) infection is associated with gastroduodenal diseases. The purpose of this report was to evaluate recently published research on the influence of oriental herbal medicine on H. pylori infections. Methods : Recently published literature were systematically compared with their findings of how oriental herbal medical treatment affects H. pylori-associated disease. Results : The eradication rate of H. pylori in oriental herbal medicine groups was 66.93% while it was 66.02% in western medicine groups. In oriental herbal plus western medicine groups, interestingly, the rate increased to 84.78%. On the other hand, the total treatment efficacy rate of H. pylori in oriental herbal medicine groups was 91.27%. The treatment efficacy rate in oriental herbal plus western medicine groups rose to a record 93.22%, which was 15.34% higher than the rate in western medicine groups. In addition, the rate of adverse effects was 2.71%, 4.85%, 15.80% in oriental herbal medicine, western medicine, and oriental herbal plus western medicine groups, respectively. Diarrhea was most frequently observed in oriental herbal medicine groups, while nausea was most frequently observed in the other groups. Conclusions : The results of this study showed that herbal medicinal treatment can increase the rate of H. pylori eradication and improve H. pylori-related gastrointestinal symptoms. These findings suggest that herbal medicine can solve the problems including side effects due to antibiotic resistance of standard triple therapy.

위장질환과 Helocobacter pylori와의 상관관계

정동진,이정화,이상오,김재명,최태균 한국건강관리협회 1999 건협 Report Vol.2 No.-

위장질환과 Helicobacter pylori와의 상관관계

정동진 ( Dong Jin Chung ),이동춘 ( Dong Chun Lee ),이정화 ( Jung Hwa Lee ),이상모 ( Sang Mo Lee ),김재명 ( Jea Myung Kim ),최태균 ( Tae Guon Choi ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2

To know the relationship between gastroduodena1 diseases and Helicobacter pylori infection we investigated the prevelence of H. pν10ri infection in 3,248 residents of Kyungpook providence who have participated in a cancer screening program of IgG anti-H. pν10ri antibody test. Among 3,248 residents we compared the patients having gastroduodena1 diseases in X-ray films of upper gastrointestina1 series with the norma1 control group showing norma1 film. H. pν10ri infection was positive in 70.9% of 1,216 control group, and was positive in 87.5% of 1,315 gastroduodena1 disease patients. In gastroduodena1 diseases group, H. Pνlori infection was positive in 87.3% (p va1ue 0.000) of 1,240 gastritis patients, positive in 93.3% (p va1ue 0.056) of 15 gastric ulcer patients, positive in 86.2% (p va1ue 0.072) of 29 duodenitis, and positive in 93.5% (p va1ue 0.006) of 31 duodena1 ulcer patients. H. pylori infection was more frequent in gastroduodena1 disease patients than in the norma1 control group in genera1 population.

Helicobacter pylori 감염과 위장 외 질환

김병욱 대한상부위장관ㆍ헬리코박터학회 2015 Korean Journal of Helicobacter Upper Gastrointesti Vol.15 No.4

It is well known that Helicobacter pylori infection is associated with gastroduodenal diseases such as gastritis, peptic ulcer diseases, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma (MALToma). Furthermore, various extra-gastroduodenal diseases have been suggested to be related with H. pylori infection. Although the exact pathophysiologic mechanisms have not been established yet, it is plausible that certain inflammatory and immune reactions triggered by H. pylori infection might play a role. In this review, I summarized the articles which dealt with H. pylori infection and extra-gastroduodenal diseases along with their pathophysiologic mechanisms.

상부 위장관 질환에서 IL-1β 및 IL-1RN 유전자 다형성

이준홍 ( Joon Hong Lee ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),박도윤 ( Do Youn Park ),전은숙 ( Eun Sook Jun ),강대환 ( Dae Hwan Kang ),송근암 ( Geum Am Song ),조몽 ( Mong Cho ),양웅석 ( Ung Suk Yang ) 대한내과학회 2003 대한내과학회지 Vol.65 No.1

목적 : H. pylori 감염은 위,십이지장궤야, 위암 등 여러 종류의 상부 위장관 질환과 연관이 있다고 알려져 있으나, 일부의 감염자들에서만 병변을 일으킨다. 일한 H. pylori의 다양하고 예측하기 어려운 병인을 주로 세균의 병독성의 차이로 설명하려는 시도가 활발히 이루어져 왔으나 아직 확실한 결과를 얻지 못하고 있는 실정이다. 최근 연구에 의하면 IL-1β및 IL-1RN 유전자 다형성은 위산 분비, 장형화생, 만성 위축성 위염과 위암의 발생과 Background : IL-1 β and IL-1 receptor antagonist (IL-1RN) genetic polymorphisms have been associated with development of gastric atrophy and increased risk of gastric carcinoma. This study aimed to determine the effects of these polymorphisms in gastroduo

위, 십이지장 질환에 적용한 복강경 수술 27예 분석

황찬규(Chan Kyu Hwang),김형호(Hyung Ho Kim),조세현(Se Heon Cho),김상순(Sang Soon Kim),최석렬(Suk Yul Choi),박한석(Han Suk Park) 대한외과학회 2000 Annals of Surgical Treatment and Research Vol.58 No.4

양성질환으로 위부분절제후 발생한 잔위암

문덕주(Duk Ju Moon),류창학(Chang Hak Yoo),노성훈(Sung Hoon Noh),민진식(Jin Sik Min) 대한외과학회 1999 Annals of Surgical Treatment and Research Vol.56 No.2

Novel single nucleotide polymorphism of the <i>VEGF</i> gene as a risk predictor for gastroduodenal ulcers

Kim, Yong Seok,Park, Sang Woon,Kim, Min Ho,Jang, Eun Jeong,Park, Ju Sang,Park, Sang Jong,Baik, Hyun Wook,Chung, Gregory,Hahm, Ki Baik Blackwell Publishing Asia 2008 Journal of gastroenterology and hepatology Vol.23 No.suppl2

<P>Abstract</P><P>Background and Aim: </P><P>The gastroduodenal ulcer (GDU) mostly develops on the lesser curvature side of stomach and the anterior wall of duodenal bulb, irrespective of the etiologies including <I>Helicobacter pylori</I> infection, non-steroidal anti-inflammatory drugs, alcohol, etc. However, a clear explanation as to why ulcers are prevalent in these areas has still not been given. The current study was designed to evaluate whether the vascular endothelial growth factor (VEGF) polymorphism could predict susceptibility to GDU through deranged angiogenic activities.</P><P>Methods: </P><P>A large scale case-control study based on known single nucleotide polymorphisms (SNP) of VEGF and another case control study based on the novel SNP of VEGF was performed through the SNP-IT assay using the SNP stream 25 k system. A site-directed mutagenesis and functional assay was executed to document the biological effect of a novel VEGF SNP on angiogenesis.</P><P>Results: </P><P>Even though the case-control study between non-ulcer dyspepsia (NUD) and gastric ulcer (GU) patients was done in 10 SNP of the <I>VEGF</I> gene including −2488C/T, −634G/C, −7C/T, 3436G/C, 6112C/A, 6894C/T, 9374G/A, 9812C/T, 13128C/T, and 13553C/T, the analysis showed no statistically significant association between NUD and GU. Denaturing high-performance liquid chromatography analysis could identify two novel SNP of the <I>VEGF</I> gene, −1780T/C and <I>IVS-</I>99 G/C, among which −1780T/C showed a very strong association between NUD and GDU, presenting with OR = 2.93 on codominant analysis (<I>P</I> < 0.001), OR = 8.62 on dominant analysis (<I>P</I> < 0.001), and OR = 3.21 on recessive analysis (<I>P</I> < 0.001). The promoter assay using a site-directed mutagenesis and <I>in vitro</I> angiogenesis assay showed repressed transcription of the <I>VEGF</I> gene in gastric epithelial cells and defective tube formation in endothelial cells, both transfected with a plasmid containing −1780C/C mutant of VEGF gene.</P><P>Conclusion: </P><P>The novel VEGF polymorphism −1780T/C could significantly predict the predisposition to GDU after the exposure to etiologic risks, based on defective angiogenic activity.</P>