해양플랜트 플로트오버 설치 공법용 수동형 갑판 지지 프레임의 최소중량설계와 민감도 평가를 위한 실험계획법 응용

김훈관,이강수,송창용 해양환경안전학회 2021 해양환경안전학회지 Vol.27 No.1

본 연구에서는 20,000 톤급 해양플랜트 상부구조물(Topside)의 플로트오버 설치작업을 위해 개발된 수동형 갑판 지지 프레임 (Deck support frame)의 구조설계에 대해 다양한 실험계획법을 이용한 최소중량설계와 민감도 평가의 비교연구를 수행하였다. 수동형 갑판 지지 프레임의 주요 구조부재의 두께 치수 변수는 설계인자로 고려하였고, 응답치는 중량과 강도성능으로 선정하였다. 최소중량설계와 민감도 평가의 비교연구에 사용한 실험계획법은 직교배열설계법, Box-Behnken 설계법, 그리고 Latin hypercube 설계법이다. 실험계획법의 설계공간 탐색의 근사화 성능을 평가하기 위해 반응표면법을 각 실험계획법 별로 생성하여 근사화 정확도 특성을 검토하였다. 또한 최소 중량설계를 위해 최상 설계안의 결과로 부터 실험계획법의 특성에 따른 수치계산 비용, 중량감소 효과 등을 평가하였다. 수동형 갑판 지지 프레임의 구조설계에 대해 Box-Behnken 설계법이 가장 적합한 설계 결과를 나타내었다. This paper presents the findings of a comparative study on minimum weight design and sensitivity evaluation using different experimental design methods for the structural design of an active-type deck support frame (DSF) developed for the float-over installation of an offshore plant topside. The thickness sizing variables of the structural members of a passive-type DSF were considered the design factors, and the output responses were defined using the weight and strength performances. The design of the experimental methods applied in the comparative study of the minimum weight design and the sensitivity evaluation were the orthogonal array design, Box– Behnken design, and Latin hypercube design. A response surface method was generated for each design of the experiment to evaluate the approximation performance of the design space exploration according to the experimental design, and the accuracy characteristics of the approximation were reviewed. Regarding the minimum weight design, the design results, such as numerical costs and weight minimization, of the experimental design for the best design case, were evaluated. The Box– Behnken design method showed the optimum design results for the structural design of the passive-type DSF.

반응표면분석법을 이용한 식품제조프로세스의 최적화

심철호 ( Chol Ho Sim ) 한국산업식품공학회 2011 산업 식품공학 Vol.15 No.2

A review about the application of response surface methodology in the optimization of food technology is presented. The theoretical principles of response surface methodology and steps for its application are described. The response surface methodologies: three-level full factorial, central composite, Box-Behnken, and Doehlert designs are compared in terms of characteristics and efficiency. Furthermore, recent references of their uses in food technology are presented. A comparison between the response surface designs (three-level full factorial, central composite, Box-Behnken and Doehlert design) has demonstrated that the Box-Behnken and Doehlert designs are slightly more efficient than the central composite design but much more efficient than the three-level full factorial designs.

Box-Behnken법에 의한 원통곡면의 가공오차에 관한 연구

조병무(B.M. Cho),이동주(D.J. Lee),김형철(H.C. Kim) 한국생산제조학회 2010 한국생산제조시스템학회 학술발표대회 논문집 Vol.2010 No.10

It is not easy to find and apply an efficient cutting process for ball-end mill because of its geometric feature, that is, its end is hemispherical. This study determines cutting conditions including cutting speed, feed rate and depth of cut which can affect geometric accuracy while processing semi-cylindrical surface of STD11 with ball-end mill by using a vertical machining center, employs a recently widely used response surface design, Box-Behnken designs, in order to find out machining errors and surface roughness which can impact on geometric accuracy and obtains following results.

Box-Behnken Design을 이용한 수용액 중의 Trimethoprim에 대한 폐감귤박 자성활성탄의 흡착 특성

이창한,이민규,허철구,감상규 한국환경과학회 2022 한국환경과학회지 Vol.31 No.8

Magnetic activated carbon was prepared by adding a magnetic material to activated carbon that had been prepared from waste citrus peel in Jeju. The adsorption characteristics of an aqueous solution of the antibiotic trimethoprim (TMP) were investigated using the magnetic activated carbon, as an adsorbent, and response surface methodology (RSM). Batch experiments were carried out according to a four-factor Box-Behnken experimental design affecting TMP adsorption with their input parameters (TMP concentration: 50~150 mg/L; pH: 4~10; temperature: 293~323 K; adsorbent dose: 0.05~0.15 g). The significance of the independent variables and their interaction was assessed by ANOVA and t-test statistical techniques. Statistical results showed that TMP concentration was the most effective parameter, compared with others. The adsorption process can be well described by the pseudo-second-order kinetic model. The experimental isotherm data followed the Langmuir isotherm model. The maximum adsorption capacities of TMP, estimated with the Langmuir isotherm model were 115.9-130.5 mg/g at 293-323 K. Also, both the thermodynamic parameters, △H and △G, have both positive values, indicating that the adsorption of TMP by the magnetic activated carbon is an endothermic reaction and proceeds via an involuntary process.

Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)

( Dong Won Lee ),( Nirmal Marasini ),( Bijay Kumar Poudel ),( Jeong Hwan Kim ),( Hyuk Jun Cho ),( Bo Kyung Moon ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

This study was designed to optimize a fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS) by using a response surface methodology. Box-Behnken design (BBD) and its desirability function were used to optimize the SMEDDS. The independent factors were the amounts of Labrafil M 1944 CS, Labrasol, and Capryol PGMC and the dependent variables were droplet size, cumulative percentage of drug released in 30min and equilibrium solubility of fenofibrate in SMEDDS. Various response surface graphs were used to understand the effects of each factor, and the desirability function was then adjusted to optimize SMEDDS formulation. The experimental values of optimized formulation were in close agreement with predicted values. Furthermore, in vivo pharmacokinetic study of the optimized formulation showed significant increase in relative oral bioavailability compared to that of the powder suspension. In conclusion, the BBD demonstrated its effectiveness in optimizing the SMEDDS formulation and in identifying the effects of formulation variables.

Box-Behnken법에 의한 원통곡면의 가공오차에 관한 연구

조병무(B.M. Cho),이동주(D.J. Lee),김형철(H.C. Kim) 한국생산제조학회 2010 한국공작기계학회 추계학술대회논문집 Vol.2010 No.-

It is not easy to find and apply an efficient cutting process for ball-end mill because of its geometric feature, that is, its end is hemispherical. This study determines cutting conditions including cutting speed, feed rate and depth of cut which can affect geometric accuracy while processing semi-cylindrical surface of STD11 with ball-end mill by using a vertical machining center, employs a recently widely used response surface design, Box-Behnken designs, in order to find out machining errors and surface roughness which can impact on geometric accuracy and obtains following results.

Box-Behnken Design 기반 반류수 응집처리 시 최적인자 도출에 관한 연구

김태영 ( Tae-young Kim ),이재정 ( Jea-joung Lee ),장순웅 ( Soon-woong Chang ) 한국폐기물자원순환학회 2019 한국폐기물자원순환학회지 Vol.36 No.1

With the improvement in the water quality standards of sewage treatment plants to treat effluent resulting in recycled water, the introduction of total phosphorus treatment and anaerobic digestion (at pretreatment facilities) have been recently introduced to maintain the quality and reduce the costs of the recycled water. Indeed, recycled water treatment has become a rising issue in the environmental field. However, a high concentration of recycled water may adversely affect a downstream industrial bioreactor. In this study, the amount of recycled water generated at the sewage treatment plant in D city was estimated and analyzed to determine its concentrations in downstream recycled water during different months and seasons. Also, coagulation pretreatment was analyzed, and was found to be achieved via a 17% PAC; the recycled water and its associated optimal flocculant amount were analyzed before it entered the bioreactor. In order to derive the optimum conditions for the coagulation reaction, the Box-Behnken Experimental Design Method was used. Regression, residual, and contour diagram analyses were used to evaluate the removal of COD_cr, SS, T-N, and T-P. Consequently, results showed the optimum conditions to undergo the process were determined to be a pH 9 with a rapid stirring at 150 rpm followed by a slow stirring at 50 rpm.

Optimization of self-microemulsifying drug delivery system for telmisartan using Box-Behnken design and desirability function

( Hyuk Jun Cho ),( Dong Won Lee ),( Nirmal Marasini ),( Bijay Kumar Poudel ),( Jeong Hwan Kim ),( Thiruganesh Ramasamy ),( Bong Kyu Yoo ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Objectives: To develop and optimize the novel self-microemulsifying drug delivery system (SMEDDS) formulation for enhanced water solubility and bioavailability of telmisartan (TMS) using the Box-Behnken design (BBD) and desirability function. Method: TMS-SMEDDS formulation consisted of the mixture of oil (Peceol), surfactant (Labrasol), co-surfactant (Transcutol), TMS and triethanolamine. A three-level BBD was applied to explore the main effect, interaction effect and quadratic effect of three independent variables, including the amount of Peceol (X1), Labrasol (X2) and Transcutol (X3). Determined conditions were 20<X1 <40, 50<X2 <80 and 5<X3 <30. The response variables were droplet size (Y1), polydispersity index (Y2) and dissolution percentage of TMS after 15min (Y3). KEY FINDINGS: The optimized conditions were 28.93, 80 and 28.08 (mg) for X1 , X2 and X3 , respectively, and the response variables were predicted to be 159.8nm, 0.241 and 85.8% for Y1 , Y2 and Y3 , respectively. The actual values from the optimized formulation showed good agreement with predicted values. The optimized TMS-SMEDDS formulation showed faster drug dissolution rate and higher bioavailability than TMS powder. Conclusions: Our results suggest that response surface methodology using BBD and desirability function is a promising approach to understand the effect of SMEDDS variables and to optimize the formulation.

회화나무꽃 추출물이 함유된 Cosmeceuticals의 제조: Box-Behnken 설계모델을 이용한 최적화

유봉호 ( Bong-ho Yoo ),줘청량 ( Chengliang Zuo ),이승범 ( Seung Bum Lee ) 한국공업화학회 2020 공업화학 Vol.31 No.4

본 연구에서는 Box-Behnken 설계모델(BBD-RSM)을 사용하여 회화나무꽃 추출물을 첨가한 cosmeceuticals 유화액의 안정성 조건을 최적화하였다. BBD-RSM의 독립변수로는 유화제의 첨가량, 회화나무꽃 추출물 첨가량, 유화시간, 유화속도 등을 설정하고, 반응치로는 O/W 유화액의 평균액적크기(MDS), 점도 및 유화안정도지수(ESI)를 설정하였다. BBD-RSM 최적화 분석결과 세 가지 반응치를 동시에 부합하는 최적조건은 유화시간(17.8 min), 유화속도(5505 rpm), 유화제의 첨가량(2.28 wt.%), 회화나무꽃 추출물 첨가량(1.05 wt.%)으로 산출되었으며, 이 조건에서의 BBD-RSM 예측결과는 MDS (1875.5 nm), 점도(1789.7 cP), ESI (93.8%)로 얻었다. 또한 이 조건에서 실제 실험을 통해 얻은 결과는 이론 결과에 비래 평균오차율은 5% 이하로 나타났다. 따라서 본 연구에서 BBD-RSM 최적화 분석을 적용할 경우 비교적 높은 유의수준의 만족하는 결과를 얻을 수 있었다. In this study, the stability criteria of cosmeceuticals emulsion containing Flos Sophorae Immaturus extracts was established using the Box-Behnken design model (BBD-RSM). As optimization conditions of the emulsification using the BBD-RSM, the amount of surfactant and additive, and emulsification time and speed were used as quantitative factors while mean droplet size (MDS), viscosity and emulsion stability index (ESI) were used as reaction values. According to the result of BBD-RSM, optimum conditions for the emulsification were as follows; the emulsification time and speed of 17.8 min and 5505 rpm, respectively and amounts of the emulsifier and additive of 2.28 and 1.05 wt.%, respectively. Under these conditions, the MDS, viscosity, and ESI after 7 days from the reaction were estimated as 1875.5 nm, 1789.7 cP, and 93.8%, respectively. The average error value from our actual experiments for verifying the conclusions was below 5%, which is mainly due to the fact that the BBD-RSM was applied to the optimized cosmeceuticals emulsification.

반응표면분석법(RSM)을 이용한 골탄의 불소 흡착 조건 최적화

황지연,Chhuon Rachanca,Victory FiiFi Dsane,김준영,최영균,신귀암 적정기술학회 2019 적정기술학회지(Journal of Appropriate Technology) Vol.5 No.2

반응표면분석법(Response surface methodology, RSM)의 Box-Benhken Design (BBD) 모델을 사용하여, 350oC로 가열한 골탄의 수중 불소 흡착 조건을 최적화하였다. 최적화 변수로 수온, pH, 접촉시간, 초기불소농도를 선택하였고, Box-Behnken Design에 의한 29회의 매트릭스 실험값으로부터 2차 반응 표면식을 얻었다. 이 반응 모델식의 결정계수(R2) 는 0.9249였고 모델의 p-value는 <0.0001로 나타나 실험 변수들이 흡착결과에 매우 유의미한 영향을 미친다는 것을 알 수 있었다. 반응 표면식에 의해 예측된 골탄의 불소 흡착 최적 조건은 수온 39.68oC, pH 6.25, 접촉시간 88.81 min, 초기불소농도 14.64 mgF/L이었으며 이때의 불소 흡착용량(adsorption capacity)은 6.46 mgF/g인 것으로 분석되었다. The Box-Benhken Design (BBD) model of response surface methodology (RSM) was used to optimize fluoride adsorption conditions in water using a 350°C thermally treated cow bone. Water temperature, pH, contact time, and initial fluoride concentration were selected as variables to be optimized. A second order reaction equation was obtained from a Box-Behnken Design DoE experimental matrix of 29 runs. R2 and p-value of the model were 0.9242 and <0.0001, respectively, ndicating that the selected variables had a very substantial effect on the adsorption results. The optimized adsorption capacity of the thermally synthesized bone char was estimated to be 6.46 mgF/g at the water temperature of 39.68oC, pH 6.25, contact time of 88.81 minutes and an initial fluorine concentration of 14.64 mgF/L.