복벽 손상 백서에서 세가지 유형의 유착방지제의 효과

송형준(Hyung Jun Song),김종원(Jong Won Kim),박준석(Jun Seok Park),김용석(Yong Seok Kim),최유신(Yoo Shin Choi),김범규(Beom Gyu Kim),차성재(Sung Jae Cha),박성준(Sung Jun Park),장인택(In Taik Chang),박성일(Sung Il Park),박언섭(Eon Sub P 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.1

Purpose: Postsurgical adhesion formation is a significant clinical problem within every surgical specialty. Several adhesion barriers have been developed in the form of solution, membrane or film in an attempt to solve these problems. The purpose of the present study is to compare the efficacy of antiadhesive agents in the prevention of postsurgical adhesion formation in a standardized rat adhesion model. Methods: We examined forty Sprague-Dawley rats, which is a cecal abrasion with partial peritonectomy model. Three treatment groups (Group Ⅰ: Film-type Surgiwrap<SUP>ⓡ</SUP>, Group Ⅱ: Solution-type Guardix-sol<SUP>ⓡ</SUP>, Group Ⅲ: Membrane-type Interceed<SUP>ⓡ</SUP>), each consists of 10 rats, and a control group of 10 rats were used by saline. Ten days after surgery, the rats were killed, and the levels of adhesion were graded. Immunohistochemical staining for microvessel density (CD34, MVD) and macrophage (ED1) were performed in adhesion tissue. Results: The peritoneum adhesion mean scores are as follows: control group: 2.2±0.78, Group Ⅰ: 1.0±1.06, Group Ⅱ: 0.9±0.99, Group Ⅲ: 0.6±0.84. All treatment groups showed significantly less peritoneum adhesion (P=0.006), while there was no significant difference in each group. The intraperitoneal organs adhesion mean scores are as follows: control group: 2.8±0.91, Group I: 2.6±1.06, Group Ⅱ: 1.4±0.84, Group Ⅲ: 1.0±0.81. Group Ⅰ had no significant difference about intraperitoneal organs adhesion with control group, but Group Ⅱ and Group Ⅲ showed less intraperitoneal organs adhesion. The mean numbers of microvessel density are as follows: control group: 42.5±4.83, Group Ⅰ: 40.8±6.53, Group Ⅱ: 30.9±6.15, Group Ⅲ: 15.60±4.37, from which there was a significant difference between Group Ⅱ and Group Ⅲ with control group (P<0.001). The mean numbers of macrophage are as follows: control group: 223.3±33.12, Group I: 211.25±10.96, Group Ⅱ: 171.60±23.96, Group Ⅲ: 147.0±12.22, from which there was a significant difference between Group Ⅱ and Group Ⅲ with control group (P<0.001). Conclusion: In our animal model, three different types of antiadhesive agents (Surgiwrap<SUP>ⓡ</SUP>, Guardix-sol<SUP>ⓡ</SUP>, Interceed<SUP>ⓡ</SUP>) were effective in adhesion prevention, but Surgiwrap<SUP>ⓡ</SUP> had less antiadhesive effect for intraperitoneal organs adhesion. Membrane-type Interceed<SUP>ⓡ</SUP> had a better effect for microvessel density (MVD) and macrophage than solution-type Guardix-sol<SUP>ⓡ</SUP>.

백서를 이용한 복막 유착 실험 모델의 개발 및 복막 유착 예방에 관한 연구

서경호 메리놀병원 1997 메리놀病院論文集 Vol.7 No.-

Enhanced Adhesion of Color Coatings on Mg Surfaces by Ion-Beam Mixing

Hyung-Jin Kim,Zuhair Khan,Jae-Won Park 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.5

Enhanced adhesion of ceramic color coatings on Mg alloys by ion-beam mixing was studied. Siliconcarbide and ironoxide films were deposited on Mg-alloys with various thicknesses for decorative color coatings by using e-beam evaporation. Adhesion of ceramic films on Mg is poor in nature due to their different material properties To improve the weak adhesion, we applied ion-beam mixing to the interface of the film and the Mg-alloy substrate. We deposited a 100nm thinlayer film and performed 70-keV nitrogenion bombardments to induce the intermixing of the primary film and the Mg substrate. The interfacial region was analyzed with Auger electron spectroscopy (AES) to understand the mechanism of the enhanced adhesion. After the ion-beam mixing, an additional deposition of film was carried out for coloration. Enhanced adhesion was verified by using the adhesion test and a 5 % NaCl solution corrosion test. Enhanced adhesion of ceramic color coatings on Mg alloys by ion-beam mixing was studied. Siliconcarbide and ironoxide films were deposited on Mg-alloys with various thicknesses for decorative color coatings by using e-beam evaporation. Adhesion of ceramic films on Mg is poor in nature due to their different material properties To improve the weak adhesion, we applied ion-beam mixing to the interface of the film and the Mg-alloy substrate. We deposited a 100nm thinlayer film and performed 70-keV nitrogenion bombardments to induce the intermixing of the primary film and the Mg substrate. The interfacial region was analyzed with Auger electron spectroscopy (AES) to understand the mechanism of the enhanced adhesion. After the ion-beam mixing, an additional deposition of film was carried out for coloration. Enhanced adhesion was verified by using the adhesion test and a 5 % NaCl solution corrosion test.

대장암 세포주 KM12C 및 아세포주의 흡착력과 당구조

이봉화,김영식 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.4

가토의 굴곡건 손상모델에서 Mitomycin-C가 인대 유착 방지에 미치는 영향

성정화,강소라,김양우,Sung, Jung-Hwa,Kang, So-Ra,Kim, Yang-Woo 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: Adhesion after flexor tendon injury is a result of fibrosis between tendon and tendon sheath. This, finally interfere with gliding mechanism of tendon and results in functional problem of hands. Therefore, there have been many trials to reduce adhesion around the tendon. However, there is no standard procedure clinically practiced in hospitals. Mitomycin-C is an antineoplastic alkylating agent that decrease fibroblast proliferation and scar formation. It is commonly used in many surgery to reduce postoperative adhesion. This study was designed to observe the effect of Mitomycin-C on preventing adhesion in injured flexor tendon. Methods: The deep flexor tendon of digit 2 and 4 in the left forepaw of 15 New Zealand White rabbits were subjected to partial tenotomy. In study group, injury site was exposed to a single 5-minute application of Mitomycin-C, and in control group was left untreated. Digit 2 and 4 in the right forepaw of each rabbit were considered as nonadhesion control group. After 2 weeks, the animals were sacrificed and digits were amputated for biomechanical test and histological study. Results: In biomechanical study to measure yield point, mean yield point of non-adhesion control was $17.43{\pm}2.33$ and $25.07{\pm}4.03$ for adhesion control, which proves increase of adhesion in adhesion control group (p<0.05) in 95% confidence. In Mitomycin-C group, mean yield point was $12.71{\pm}4.97$. Compared with adhesion control, there was decrease in adhesiveness in Mitomycin-C group (p<0.05) in 95% confidence. In histological study, the result of adhesion control revealed massive adhesions of bony structure, fibrotic tissue and tendon structure with ablation of the border. However in Mitomycin-C group, we could find increased fibrotic tissue, but adhesion is much lesser than adhesion group and borders between structures remain intact. Conclusion: This study suggests that Mitomycin-C can significantly reduce adhesion of injured flexor tendon in rabbit model.

Effect of atmospheric-pressure plasma treatment on the adhesion properties of a thin adhesive layer in a selective transfer process

Yoon, Min-Ah,Kim, Chan,Hur, Min,Kang, Woo Seok,Kim, Jaegu,Kim, Jae-Hyun,Lee, Hak-Joo,Kim, Kwang-Seop Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.428 No.-

<P><B>Abstract</B></P> <P>The adhesion between a stamp and thin film devices is crucial for their transfer on a flexible substrate. In this paper, a thin adhesive silicone layer on the stamp was treated by atmospheric pressure plasma to locally control the adhesion strength for the selective transfer. The adhesion strength of the silicone layer was significantly reduced after the plasma treatment, while its surface energy was increased. To understand the inconsistency between the adhesion strength and surface energy changes, the surface properties of the silicone layer were characterized using nanoindentation and X-ray photoelectron spectroscopy. These techniques revealed that a thin, hard, silica-like layer had formed on the surface from plasma-enhanced oxidation. This layer played an important role in decreasing the contact area and increasing the interfacial slippage, resulting in decreased adhesion. As a practical application, the transfer process was demonstrated on GaN LEDs that had been previously delaminated by a laser lift-off (LLO) process. Although the LEDs were not transferred onto the treated adhesive layer due to the reduced adhesion, the untreated adhesive layer could readily pick up the LEDs. It is expected that this simple method of controlling the adhesion of a stamp with a thin adhesive layer would enable a continuous, selective and large-scale roll-to-roll selective transfer process and thereby advance the development of flexible, stretchable and wearable electronics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A thin adhesive silicone layer was treated by atmospheric pressure plasma to control the adhesion strength. </LI> <LI> The adhesion strength of the layer was reduced after the plasma treatment, while its surface energy was increased. </LI> <LI> It was confirmed that a thin, hard, silica-like layer had formed on the surface from plasma-enhanced oxidation. </LI> <LI> The silica-like layer played an important role in increasing the interfacial slippage, resulting in decreased adhesion. </LI> <LI> The usefulness of the plasma treatment was demonstrated for the selective transfer process of GaN LEDs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Adhesion strength of die attach film for thin electronic package at elevated temperature

Mose, Bruno R.,Son, In-Seo,Shin, Dong-Kil Elsevier 2018 Microelectronics and reliability Vol.91 No.1

<P><B>Abstract</B></P> <P>Adhesion strength of a thin film for electronic packaging was investigated. The effects of temperature and loading rate on the adhesion were observed considering the viscoelasticity of adhesive. Various temperature conditions over the glass transition temperature of the adhesive were applied with controlled loading rates. A small hot plate was specially designed to control the temperature. Loading rate was controlled by a servo motor. A cantilever specimen was fabricated by two rectangular silicon chips. The adhesion was measured by a modified single cantilever beam method. Bending force was applied to the cantilever using rotatable jig. Adhesion strength was found to strongly depend on the temperature and loading rate. Below the glass transition temperature (T<SUB>g</SUB>), the adhesion strength was increased with increasing loading rate. Near the Tg, the adhesion strength was decreased with increasing loading rate. Above the T<SUB>g</SUB>, the adhesion strength did not significantly depend on the loading rate.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Single cantilever beam method measures mode-I adhesion of die attach film. </LI> <LI> Hot plate controls the specimen temperature easily. </LI> <LI> Below the glass transition temperature, the adhesion strength increases with increasing loading rate. </LI> <LI> Near the glass transition temperature, the adhesion strength decreases with increasing loading rate. </LI> </UL> </P>

관절원판 유착을 동반한 악관절 내장증 환자의 수술후 증상의 변화

김형곤,남광현,박광호,허종기,김일수,최희수 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Purpose: The aim of this study was to find the clinical characteristics of the patients who had temporo-mandibular joint internal derangement(ID) with disc adhesion(adhesion group) compared to only disc displacement without disc adhesion, perforation, hyperemia, and so on(ID group) . Materials and methods: Thirty seven joints were included in adhesion group and 54 joints in ID group of all 174 patients(174 joints) treated surgically and had been checked periodically over 12 months at TMJ clinic of Yongdong Severance Hospital, Yonsei University, between 1992 and 1997. Mouth opening range, pain during mouth opening and biting, headache, neck/shoulder pain and TMJ sound were checked his/her every visit before and after surgery. Results: The maximum mouth opening was improved significantly after postoperative 3 months in two groups(p<0.01), but adhesion group was less improved. Pain during mouth opening was improved significantly over 3 months after surgery in adhesion group(p<0.01), but in ID group 1 month after surgery. Biting pain was improved and maintained it after surgery and not significant difference between two groups. Headache and neck/shoulder pain were much improved after surgery(p<0.01) , but slight relapse was found in adhesion group after 12 months. TMJ sound was more found in adhesion group after 1 month(p<0.05), but after 3 months, no significant difference was found between two groups. Conclusions: The postoperative results of adhesion group were worse than ID group. Therefore, it is considered more carefully to diagnose and treat in cases of internal derangement with adhesion.

Adhesion of clay to metal surface; Normal and tangential measurement

Basmenj, Amir Khabbazi,Ghafoori, Mohammad,Cheshomi, Akbar,Azandariani, Younes Karami Techno-Press 2016 Geomechanics & engineering Vol.10 No.2

Adhesion in geotechnical engineering is the interaction between cohesive soil and a solid surface which can cause clogging in mechanized tunnelling through clayey formations. Normal piston pull out and modified direct shear tests were performed on clayey soil samples to determine which type of adhesion stress, normal or tangential, could be most effectively measured. Measured values for normal adhesion ranged from 0.9 to 18 kPa. The range of tangential adhesion was 2.4 to 10 kPa. The results indicate normal adhesion results were more accurate than those for the modified direct shear test that measure tangential adhesion. Direct shear test on identical samples did not show any correlation between measured cohesion and normal adhesion values. Normal adhesion values have shown significantly meaningful variation with consistency index and so are compatible with the base of field clogging assessment criteria. But tangential adhesion and cohesion were not compatible with these assessment criteria.

Characterization of Adhesion of Bifidobacterium sp. BGN4 to Human Enterocyte-Like Caco-2 Cells

( In Hee Kim ),( Myung Soo Park ),( Geun Eog Ji ) 한국미생물생명공학회 2003 Journal of microbiology and biotechnology Vol.13 No.2