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      • KCI등재

        An Investigation on Stress States of the Cataclastic Rock Specimen under Confined Compression Based on Modified Thick-walled Cylinder Model

        Jin Zhang,Ronggui Deng,Zhibin Zhong,Peipei Wu,Shaoli Qi 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10

        In high in-situ stress zones, cataclastic rocks have exerted a significant influence on the stability of engineering structures. However, the mechanical properties of cataclastic rocks can not be accurately studied due to difficulties in sampling and laboratory testing. In this paper, laterally confined compression tests for specimens that were obtained by the developed in-situ sampling devices were performed to investigate the stress states. A modified thick-walled cylinder model considering axial shear stress was introduced. The interaction mechanics model for a compressed sample and an equivalent single-layer cylinder was established. Based on the principle of elasticity, the laterally confined stress, the axial shear stress, and the axial stress of the sample were derived and obtained. Moreover, the effects of mechanical and geometric parameters of the equivalent cylinder on the force condition of the specimen were analyzed. The results show that the confined stress is positively correlated with the equivalent elastic modulus and the geometric factor. Therefore, the confined stress can be strengthened by increasing the elastic modulus, alternatively, increasing the outer diameter and decreasing the inner diameter. However, the axial stress is little affected by the equivalent elastic modulus and the geometric factor and is not affected by the equivalent Poisson's ratio. As the distance from the center height increases, the axial stress decreases linearly and the difference in axial stress becomes larger considering axial shear stress and ignoring axial shear stress.

      • KCI등재

        Family History and Stroke Risk in China: Evidence from a Large Cohort Study

        Tian Tian,Guangfu Jin,Canqing Yu,Jun Lv,Yu Guo,Zheng Bian,Ling Yang,Yiping Chen,Hongbing Shen,Zhengming Chen,Zhibin Hu,Liming Li 대한뇌졸중학회 2017 Journal of stroke Vol.19 No.2

        Background and Purpose Large cohort studies on relationship between family history of stroke(FHS) and stroke risk are lacking in Asians. We aimed to systematically evaluate the association ofFHS with stroke risk in a cohort study of 0.5 million Chinese adults. Methods Information about FHS was self-reported. The median follow-up time was 7.16 years andthe end-point of follow-up was incident stroke, which was entered directly into the China KadoorieBiobank system. Multivariate analyses were performed with Cox proportional hazards model, andinteraction analyses were carried using likelihood-ratio tests. Results Compared with participants without FHS, the hazard ratio (HR) (95% confidence interval,CI) of stroke for participants with FHS was 1.50 (1.46-1.55). The HRs increased with the number offirst degree relatives with stroke (HRs=1.41, 1.98 and 2.47 for 1, 2 and ≥3 relatives, respectively,Ptrend <0.001). The HRs were 1.57 (95% CI: 1.50-1.66) and 1.49 (95% CI: 1.45-1.54) for siblinghistory and parental history, respectively. Similar associations with offspring stroke risk wereobserved between paternal history (HR=1.48, 95% CI: 1.43-1.54) and maternal history (HR=1.49,95% CI: 1.43-1.55). Moreover, significant interactions were detected between FHS and health-riskbehaviors (tobacco smoking and alcohol drinking). Conclusions FHS is an independent risk factor for stroke in Chinese. The more first degree relativesare affected by stroke, the higher are individuals’ risk of suffering from stroke. The management ofthe health-risk behaviors for reducing stroke should be highlighted, especially for the individualswith FHS.

      • KCI등재

        Mutations of ARX and non-syndromic intellectual disability in Chinese population

        Yufei Wu,Huan Zhang,Xiaofen Liu,Zhangyan Shi,Hongling Li,Zhibin Wang,Xiaoyong Jie,Shao-Ping Huang,Fu-Chang Zhang,Junlin Li,Ke-Jin Zhang,Xiao-Cai Gao 한국유전학회 2019 Genes & Genomics Vol.41 No.1

        Mutations of Aristaless-related homeobox (ARX) gene were looked as the third cause of non-syndromic intellectual disability (NSID), while the boundary between true disease-causing mutations and non-disease-causing variants within this gene remains elusive. To investigate the relationship between ARX mutations and NSID, a panel comprising six reported causal mutations of the ARX was detected in 369 sporadic NSID patients and 550 random participants in Chinese. Two mutations, c.428_451 dup and p.G286S, may be disease-causing mutations for NSID, while p.Q163R and p.P353L showed a great predictive value in female NSID diagnosis with significant associations (X2 = 19.60, p = 9.54e−6 for p.Q163R; X2 = 25.70, p = 4.00e−07 for p.P353L), carriers of these mutations had an increased risk of NSID of more than fourfold. Detection of this panel also predicted significant associations between genetic variants of the ARX gene and NSID (p = 3.73e−4). The present study emphasized the higher genetic burden of the ARX gene on NSID in the Chinese population, molecular analysis of this gene should be considered for patients presenting NSID of unknown etiology.

      • KCI등재

        Distribution of shear force in perforated shear connectors

        Xing Wei,M. Shariati,Y. Zandi,Shiling Pei,Zhibin Jin,S. Gharachurlu,M.M. Abdullahi,M.M. Tahir,M. Khorami 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.3

        A perforated shear connector group is commonly used to transfer shear in steel–concrete composite structures when the traditional shear stud connection is not strong enough. The multi-hole perforated shear connector demonstrates a more complicated behavior than the single connector. The internal force distribution in a specific multi-hole perforated shear connector group has not been thoroughly studied. This study focuses on the load-carrying capacity and shear force distribution of multi-hole perforated shear connectors in steel.concrete composite structures. ANSYS is used to develop a three-dimensional finite element model to simulate the behavior of multi-hole perforated connectors. Material and geometric nonlinearities are considered in the model to identify the failure modes, ultimate strength, and load–slip behavior of the connection. A three-layer model is introduced and a closed-form solution for the shear force distribution is developed to facilitate design calculations. The shear force distribution curve of the multi-hole shear connector is catenary, and the efficiency coefficient must be considered in different limit states.

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